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The map label for this gene is dapE [H]

Identifier: 170748850

GI number: 170748850

Start: 2595858

End: 2597045

Strand: Reverse

Name: dapE [H]

Synonym: Mrad2831_2432

Alternate gene names: 170748850

Gene position: 2597045-2595858 (Counterclockwise)

Preceding gene: 170748861

Following gene: 170748847

Centisome position: 42.73

GC content: 66.75

Gene sequence:

>1188_bases
ATGCGTGCCCTGGAGACCGCCGTCGGCAACGGCACGAAATTTCACGTGGAAGCACCGATGCCCCTCAACGCTGTCGACCT
CGCGAAGCAGCTCATCCGGTTCCGGTCGATCAATCCTCCGGGTGAGGAGAAGGAATGTTCCGAGTTCATCGCTCGCCTGC
TGACCGGATACGGGTTCGATGTCGTCAGCTACGAATTCGCCAGGGATCGGCCAACGCTGGTCGCGCGCATGCCTGGGACG
GCCAACGGCAAGCCGCTCTGCTTCACTGGGCACATAGACGTCGTGCCACTCGGGTCGAACGAGTGGCAATTCCCTCCCTT
CGACGGGATCGTGCAGGATGGCCGGCTGTACGGCCGCGGCGCCAGCGACATGAAGGCGGGCGTGGCCGCGTTCGTGGCGG
CTGCGTGCAACTTGATCGAGGACGGGCGCAGCTTTCACCGCGGTATCACGCTCGTGATCACCGCCGGAGAGGAGACCGGA
TGCGAGGGCGCATTCCACGTCGCCCGCGAGAAGGGTCTCGGGCCCGCCGAACTCCTGATCGTGGCAGAGCCGACGTCGAA
TGCCGCCCTCTTCGCCCATAAGGGCTCTCTCCGCGTCGTCGTGACCGCGCGCGGGCGGACGGCGCATTCCTCGATGCCGC
ACGAGGGCGAGAACGCGATCAGCAAGGTCGCGGAGTGGATCCGGAGGCTCGAAGGCTACGATTTCGGCGCCCGTCATCCA
CTGCTGGGCAGCGCCACGGCCTGCGTCACCACCGTCCGCGGTGGAGAGAATATCAACTCCGTCCCTGACTGCGCCGAGTT
CACCGTGGATATCCGGACCCTCCCGGATCAGAGACACGCGGCGCTCGTCGCCGAACTCGGCCGCCTCTTCGGATCCGAGG
CCGAGATCCGGATCGTCACGAGCTTCCCGGGCTTCGCGACCGAGCCGGACGATCCGTCCGCTGCCCCGCTCCTGGCGCTG
CTGCGAGAGCGGACGGGGGCAGCGGCGGAACCGGCCGGGGCACCCTACTTCACCGATGCGTCGGCTCTCGTGCCGGCTTT
TGACGGTGTCGCCACGCTGATCGTCGGCCCCGGCGAGGCGGCGCAGTGCCACAAGACTGATGAGTATTGCCTCGTGGAAC
GGATCGAGGAGGCGCAGGCCATCTACAGAGACTTGATGCTCCGCATGTGCTGCGGCCGCGCCGAGTGA

Upstream 100 bases:

>100_bases
AGCGGTCATTCCGCACGCGACCCAGCCCGGTCGCCCGAACCGCTCGGGCCCTCCCGAGCGCGGTCCATCGCCGATGAAGC
TGCAGGGTCGTCGTCTTGAC

Downstream 100 bases:

>100_bases
GGCCCAGCGACAGGCGCCGTTCCCCCCTTCGGAATCGTGACCCGGGGAGTCCGCGGTTCGGATGCCGCCGCGCCGACCGC
TCCTCGTCCGCGACAAGCGA

Product: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase

Products: NA

Alternate protein names: SDAP desuccinylase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MRALETAVGNGTKFHVEAPMPLNAVDLAKQLIRFRSINPPGEEKECSEFIARLLTGYGFDVVSYEFARDRPTLVARMPGT
ANGKPLCFTGHIDVVPLGSNEWQFPPFDGIVQDGRLYGRGASDMKAGVAAFVAAACNLIEDGRSFHRGITLVITAGEETG
CEGAFHVAREKGLGPAELLIVAEPTSNAALFAHKGSLRVVVTARGRTAHSSMPHEGENAISKVAEWIRRLEGYDFGARHP
LLGSATACVTTVRGGENINSVPDCAEFTVDIRTLPDQRHAALVAELGRLFGSEAEIRIVTSFPGFATEPDDPSAAPLLAL
LRERTGAAAEPAGAPYFTDASALVPAFDGVATLIVGPGEAAQCHKTDEYCLVERIEEAQAIYRDLMLRMCCGRAE

Sequences:

>Translated_395_residues
MRALETAVGNGTKFHVEAPMPLNAVDLAKQLIRFRSINPPGEEKECSEFIARLLTGYGFDVVSYEFARDRPTLVARMPGT
ANGKPLCFTGHIDVVPLGSNEWQFPPFDGIVQDGRLYGRGASDMKAGVAAFVAAACNLIEDGRSFHRGITLVITAGEETG
CEGAFHVAREKGLGPAELLIVAEPTSNAALFAHKGSLRVVVTARGRTAHSSMPHEGENAISKVAEWIRRLEGYDFGARHP
LLGSATACVTTVRGGENINSVPDCAEFTVDIRTLPDQRHAALVAELGRLFGSEAEIRIVTSFPGFATEPDDPSAAPLLAL
LRERTGAAAEPAGAPYFTDASALVPAFDGVATLIVGPGEAAQCHKTDEYCLVERIEEAQAIYRDLMLRMCCGRAE
>Mature_395_residues
MRALETAVGNGTKFHVEAPMPLNAVDLAKQLIRFRSINPPGEEKECSEFIARLLTGYGFDVVSYEFARDRPTLVARMPGT
ANGKPLCFTGHIDVVPLGSNEWQFPPFDGIVQDGRLYGRGASDMKAGVAAFVAAACNLIEDGRSFHRGITLVITAGEETG
CEGAFHVAREKGLGPAELLIVAEPTSNAALFAHKGSLRVVVTARGRTAHSSMPHEGENAISKVAEWIRRLEGYDFGARHP
LLGSATACVTTVRGGENINSVPDCAEFTVDIRTLPDQRHAALVAELGRLFGSEAEIRIVTSFPGFATEPDDPSAAPLLAL
LRERTGAAAEPAGAPYFTDASALVPAFDGVATLIVGPGEAAQCHKTDEYCLVERIEEAQAIYRDLMLRMCCGRAE

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=282, Percent_Identity=26.9503546099291, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790395, Length=351, Percent_Identity=27.9202279202279, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788816, Length=251, Percent_Identity=27.8884462151394, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789236, Length=376, Percent_Identity=22.8723404255319, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538642, Length=284, Percent_Identity=25.7042253521127, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17551016, Length=286, Percent_Identity=25.8741258741259, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24649206, Length=389, Percent_Identity=24.9357326478149, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 42265; Mature: 42265

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALETAVGNGTKFHVEAPMPLNAVDLAKQLIRFRSINPPGEEKECSEFIARLLTGYGFD
CCCHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCH
VVSYEFARDRPTLVARMPGTANGKPLCFTGHIDVVPLGSNEWQFPPFDGIVQDGRLYGRG
HEEEHHHCCCCCEEEECCCCCCCCEEEEECCEEEEECCCCCCCCCCCCCEECCCEEECCC
ASDMKAGVAAFVAAACNLIEDGRSFHRGITLVITAGEETGCEGAFHVAREKGLGPAELLI
CHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEECCCCCCCCHHHHHHHHCCCCCEEEEE
VAEPTSNAALFAHKGSLRVVVTARGRTAHSSMPHEGENAISKVAEWIRRLEGYDFGARHP
EECCCCCCEEEEECCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
LLGSATACVTTVRGGENINSVPDCAEFTVDIRTLPDQRHAALVAELGRLFGSEAEIRIVT
CCCCCHHHEEEECCCCCCCCCCCHHHEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEE
SFPGFATEPDDPSAAPLLALLRERTGAAAEPAGAPYFTDASALVPAFDGVATLIVGPGEA
ECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCEEEEEECCCCC
AQCHKTDEYCLVERIEEAQAIYRDLMLRMCCGRAE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRALETAVGNGTKFHVEAPMPLNAVDLAKQLIRFRSINPPGEEKECSEFIARLLTGYGFD
CCCHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCH
VVSYEFARDRPTLVARMPGTANGKPLCFTGHIDVVPLGSNEWQFPPFDGIVQDGRLYGRG
HEEEHHHCCCCCEEEECCCCCCCCEEEEECCEEEEECCCCCCCCCCCCCEECCCEEECCC
ASDMKAGVAAFVAAACNLIEDGRSFHRGITLVITAGEETGCEGAFHVAREKGLGPAELLI
CHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEECCCCCCCCHHHHHHHHCCCCCEEEEE
VAEPTSNAALFAHKGSLRVVVTARGRTAHSSMPHEGENAISKVAEWIRRLEGYDFGARHP
EECCCCCCEEEEECCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
LLGSATACVTTVRGGENINSVPDCAEFTVDIRTLPDQRHAALVAELGRLFGSEAEIRIVT
CCCCCHHHEEEECCCCCCCCCCCHHHEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEE
SFPGFATEPDDPSAAPLLALLRERTGAAAEPAGAPYFTDASALVPAFDGVATLIVGPGEA
ECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCEEEEEECCCCC
AQCHKTDEYCLVERIEEAQAIYRDLMLRMCCGRAE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA