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The map label for this gene is glmU [H]

Identifier: 170748837

GI number: 170748837

Start: 2582102

End: 2583478

Strand: Reverse

Name: glmU [H]

Synonym: Mrad2831_2419

Alternate gene names: 170748837

Gene position: 2583478-2582102 (Counterclockwise)

Preceding gene: 170748838

Following gene: 170748836

Centisome position: 42.51

GC content: 75.53

Gene sequence:

>1377_bases
ATGACCCCGACCGGAACGCCCTCGCGCAGCCTCACCGCCATCGTGCTCGCGGCCGGGAAGGGCACGCGGATGCGCTCCGA
CCTGCCGAAGGTGCTGCACCGGATCGCCGGCCGCAGCATGCTCGGCCACGTCCTGGCCGCCGTGCAGGCGGCGGGCGCGG
GCCGGATCGCCGTGGTGGCCGAGCCCGGCCGCGACGACGTCGCCGCCGAGATCGCCCGGGCGGCCCCCGGCGCCCGGGTC
TTCCCGCAGGCCGAGCGCCTCGGCACCGCCCACGCGGTCCTGGCCGCCCGGGAGATCCTGGCCGACCCGGACGACGACGT
GGTGATCGCCTTCGGCGACACGCCGCTCGTCTCGGCCGACACCTTCCTGCGCCTCCGCGCGCCCCTGGCCGACGGCGCCG
CGGTGGCCGTGCTGGCCTTCGAGACGGCGACGCCCGCCGGCTACGGACGGGTGCTGACCGAGGGCGACCGCGTGCTCGCC
ATCCGCGAGGAGAAGGACGCGAGCGCGGCCGAGCGGGCCGTGACCCTGTGCAATGCCGGGCTGATGGCGCTCGCCGGACG
GCACGCCCTGGCGCTGCTCGCCCGCATCGGCAACGACAACGCCGCCGGCGAGTACTACCTGCCCGACGCGGTGGCGCTGG
CGGTCGCCGACGGGCTGCCCGTCACGGTCGTGCCGGTGGACGAGGCCGAGGCGCAGGGCGTCAACGACCGGGTGCAGCTC
AGCGTGGCGGAGGCCGCGATCCAGGCGCAGCTGCGCCGCAGCGCCATGCTGGGCGGCGCGACGCTGATCGCGCCCGAGAC
GGTGTTCCTCAGCCACGACACGGTGCTGGGGCGCGACGTGATCGTGGAGCCCCACGTGGTGTTCGGCCCCGGCGTGCGGG
TCGCGGAGGGCTGCACCGTGCGCGCCTTCGCGCATCTCACCGAGACCAGCCTGGAGGCGGGCGTGAAGGTCGGGCCGTTC
GTGCGGCTGCGCGGCCACGCCGTGCTGGAGGCCGGCGCGGAGCTCGGCAATTTCGTCGAGCTGAAGAACGCCCGGATGGG
GGCCGGCGCCAAGGCCGCGCACCTCACCTATCTCGGCGACGCGGAGATCGGCGCCAAGGCCAATATCGGCGCCGGCACGA
TCACCTGCAATTACGACGGCGTGCTCAAGCACCGGACGACGATCGGCGCGGGCGCGTTCATCGGCTCGAACTCGGCCCTG
GTCGCCCCCGTCTCGGTGGGGGAGGGCGCCTACGTCGCCTCGGGCTCTGTGATCACCGACGACGTGCCGGCGGACGCCAT
GGCGGTGGCCCGGGGCCGGCAGGCGGTGAAGCCGGGCTGGGCCAGGGAGAAGCGGGCGGCGCTGCAGGCCGAGAAGGCGC
GGCGCGGGAAGGCGTGA

Upstream 100 bases:

>100_bases
GCACGTCGCCCTGGCGCTGCGCTGATCGCTCCGGACGGGGTTGCGCCGGGCGCCCGTCCGGCCCATCCGTCGTGGCCTTC
GATCGACGCCTGGACCTGCG

Downstream 100 bases:

>100_bases
GCGCGAAGGGCCGCGTGACCGGGGCTGGCCCTGCGCCGTCCCGATCCGGTAGAAGTCCCGCTCGGCCCCGCACGGCGCGG
GGCGGCCCGGACCTTGCGCA

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MTPTGTPSRSLTAIVLAAGKGTRMRSDLPKVLHRIAGRSMLGHVLAAVQAAGAGRIAVVAEPGRDDVAAEIARAAPGARV
FPQAERLGTAHAVLAAREILADPDDDVVIAFGDTPLVSADTFLRLRAPLADGAAVAVLAFETATPAGYGRVLTEGDRVLA
IREEKDASAAERAVTLCNAGLMALAGRHALALLARIGNDNAAGEYYLPDAVALAVADGLPVTVVPVDEAEAQGVNDRVQL
SVAEAAIQAQLRRSAMLGGATLIAPETVFLSHDTVLGRDVIVEPHVVFGPGVRVAEGCTVRAFAHLTETSLEAGVKVGPF
VRLRGHAVLEAGAELGNFVELKNARMGAGAKAAHLTYLGDAEIGAKANIGAGTITCNYDGVLKHRTTIGAGAFIGSNSAL
VAPVSVGEGAYVASGSVITDDVPADAMAVARGRQAVKPGWAREKRAALQAEKARRGKA

Sequences:

>Translated_458_residues
MTPTGTPSRSLTAIVLAAGKGTRMRSDLPKVLHRIAGRSMLGHVLAAVQAAGAGRIAVVAEPGRDDVAAEIARAAPGARV
FPQAERLGTAHAVLAAREILADPDDDVVIAFGDTPLVSADTFLRLRAPLADGAAVAVLAFETATPAGYGRVLTEGDRVLA
IREEKDASAAERAVTLCNAGLMALAGRHALALLARIGNDNAAGEYYLPDAVALAVADGLPVTVVPVDEAEAQGVNDRVQL
SVAEAAIQAQLRRSAMLGGATLIAPETVFLSHDTVLGRDVIVEPHVVFGPGVRVAEGCTVRAFAHLTETSLEAGVKVGPF
VRLRGHAVLEAGAELGNFVELKNARMGAGAKAAHLTYLGDAEIGAKANIGAGTITCNYDGVLKHRTTIGAGAFIGSNSAL
VAPVSVGEGAYVASGSVITDDVPADAMAVARGRQAVKPGWAREKRAALQAEKARRGKA
>Mature_457_residues
TPTGTPSRSLTAIVLAAGKGTRMRSDLPKVLHRIAGRSMLGHVLAAVQAAGAGRIAVVAEPGRDDVAAEIARAAPGARVF
PQAERLGTAHAVLAAREILADPDDDVVIAFGDTPLVSADTFLRLRAPLADGAAVAVLAFETATPAGYGRVLTEGDRVLAI
REEKDASAAERAVTLCNAGLMALAGRHALALLARIGNDNAAGEYYLPDAVALAVADGLPVTVVPVDEAEAQGVNDRVQLS
VAEAAIQAQLRRSAMLGGATLIAPETVFLSHDTVLGRDVIVEPHVVFGPGVRVAEGCTVRAFAHLTETSLEAGVKVGPFV
RLRGHAVLEAGAELGNFVELKNARMGAGAKAAHLTYLGDAEIGAKANIGAGTITCNYDGVLKHRTTIGAGAFIGSNSALV
APVSVGEGAYVASGSVITDDVPADAMAVARGRQAVKPGWAREKRAALQAEKARRGKA

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=453, Percent_Identity=41.280353200883, Blast_Score=331, Evalue=6e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 46889; Mature: 46758

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTGTPSRSLTAIVLAAGKGTRMRSDLPKVLHRIAGRSMLGHVLAAVQAAGAGRIAVVA
CCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEE
EPGRDDVAAEIARAAPGARVFPQAERLGTAHAVLAAREILADPDDDVVIAFGDTPLVSAD
CCCCCHHHHHHHHCCCCCCCCCCHHHHCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
TFLRLRAPLADGAAVAVLAFETATPAGYGRVLTEGDRVLAIREEKDASAAERAVTLCNAG
CEEEEECCCCCCCEEEEEEEECCCCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHCCC
LMALAGRHALALLARIGNDNAAGEYYLPDAVALAVADGLPVTVVPVDEAEAQGVNDRVQL
HHHHHHHHHHHHHHHHCCCCCCCCEECCCCEEEEEECCCCEEEEECCCHHHCCCCCCEEE
SVAEAAIQAQLRRSAMLGGATLIAPETVFLSHDTVLGRDVIVEPHVVFGPGVRVAEGCTV
HHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCEECCCEEECCEEEECCCCEEECCCEE
RAFAHLTETSLEAGVKVGPFVRLRGHAVLEAGAELGNFVELKNARMGAGAKAAHLTYLGD
EHHHHHHHHHHHCCCEECCEEEECCCCHHHHHHHHCCEEEECCCCCCCCCCEEEEEEECC
AEIGAKANIGAGTITCNYDGVLKHRTTIGAGAFIGSNSALVAPVSVGEGAYVASGSVITD
CCCCCCCCCCCCEEEECCCCEEEECEEECCCEEECCCCCEEEEEECCCCCEEECCCEEEC
DVPADAMAVARGRQAVKPGWAREKRAALQAEKARRGKA
CCCCHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TPTGTPSRSLTAIVLAAGKGTRMRSDLPKVLHRIAGRSMLGHVLAAVQAAGAGRIAVVA
CCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEE
EPGRDDVAAEIARAAPGARVFPQAERLGTAHAVLAAREILADPDDDVVIAFGDTPLVSAD
CCCCCHHHHHHHHCCCCCCCCCCHHHHCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
TFLRLRAPLADGAAVAVLAFETATPAGYGRVLTEGDRVLAIREEKDASAAERAVTLCNAG
CEEEEECCCCCCCEEEEEEEECCCCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHCCC
LMALAGRHALALLARIGNDNAAGEYYLPDAVALAVADGLPVTVVPVDEAEAQGVNDRVQL
HHHHHHHHHHHHHHHHCCCCCCCCEECCCCEEEEEECCCCEEEEECCCHHHCCCCCCEEE
SVAEAAIQAQLRRSAMLGGATLIAPETVFLSHDTVLGRDVIVEPHVVFGPGVRVAEGCTV
HHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCEECCCEEECCEEEECCCCEEECCCEE
RAFAHLTETSLEAGVKVGPFVRLRGHAVLEAGAELGNFVELKNARMGAGAKAAHLTYLGD
EHHHHHHHHHHHCCCEECCEEEECCCCHHHHHHHHCCEEEECCCCCCCCCCEEEEEEECC
AEIGAKANIGAGTITCNYDGVLKHRTTIGAGAFIGSNSALVAPVSVGEGAYVASGSVITD
CCCCCCCCCCCCEEEECCCCEEEECEEECCCEEECCCCCEEEEEECCCCCEEECCCEEEC
DVPADAMAVARGRQAVKPGWAREKRAALQAEKARRGKA
CCCCHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA