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The map label for this gene is irlR [H]

Identifier: 170748302

GI number: 170748302

Start: 2011573

End: 2012241

Strand: Reverse

Name: irlR [H]

Synonym: Mrad2831_1884

Alternate gene names: 170748302

Gene position: 2012241-2011573 (Counterclockwise)

Preceding gene: 170748303

Following gene: 170748301

Centisome position: 33.11

GC content: 76.38

Gene sequence:

>669_bases
GTGCGCGTCCTGATCGTCGAGGACGAGCCGCGCATCGCCGCCGACATCCGGCAGGGGCTGGAGAGGGCCGGCTACGTCGC
CGACGTGGTGGCGGACGGCGAGGCGGCGTGGTTCCGCGCCGAGACCGAGACGTACGACGCCATGGTGCTGGATCTCGGCC
TGCCGCGCCTCGACGGTCTCGGCGTGCTGCGCCGCCTGCGCGCCGCCGAGGTCGCCCTGCCGGTCCTGATCCTCACCGCC
CGCGACGGCTGGCGCGAGCGCGTCGAGGGCATCGACGCCGGCGCCGACGACTACCTCGCCAAGCCGTTCCGCATGGAGGA
GCTGGTGGCGCGGCTCCGGGCGATCCTGCGGCGCACCGCCGGGCACGCCGCGCCGGTGCTGCGCGCCGGCGCGGTGGAGC
TCGACACCCGCACCCGCGCGGTCAGCGTCGACGGACGGCCCGCGGAGCTGACCGCCCTGGAATACCGGCTGCTGGCCTTC
CTGCTGCACCGGCCGGGGCAGGTCGTGCCGGCGGGCGAGCTGCTCGACCACCTCCACGGGGTCGGGACCGAGCGCGAGGC
CAACGCCCTGGAGGCGCTCCTGACCCGCCTGCGCCGCAAGCTCGGGCCGGGGGTGATCGAGACCCGGCGCGGCCAGGGCT
ACCTCATCGCCGGACCGGGCGGATCGTGA

Upstream 100 bases:

>100_bases
GCGCATCCTCGGGGCCGACGGGAAGCGCCGGACCGTGAAGGTCGATGCCGGCACGCTCAAGATCCTGGACGAGGACGACG
ATGATTGAGGGGGCCGGCCC

Downstream 100 bases:

>100_bases
GGCGCGACTCCCTCCGCCTCCGGCTCGGCCTCGCGGCGTCCGGCCTGATCGCGCTGGCGCTGGTGCTGGCCGGGATCGGC
CTCACGGTGATCCTCGACCG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MRVLIVEDEPRIAADIRQGLERAGYVADVVADGEAAWFRAETETYDAMVLDLGLPRLDGLGVLRRLRAAEVALPVLILTA
RDGWRERVEGIDAGADDYLAKPFRMEELVARLRAILRRTAGHAAPVLRAGAVELDTRTRAVSVDGRPAELTALEYRLLAF
LLHRPGQVVPAGELLDHLHGVGTEREANALEALLTRLRRKLGPGVIETRRGQGYLIAGPGGS

Sequences:

>Translated_222_residues
MRVLIVEDEPRIAADIRQGLERAGYVADVVADGEAAWFRAETETYDAMVLDLGLPRLDGLGVLRRLRAAEVALPVLILTA
RDGWRERVEGIDAGADDYLAKPFRMEELVARLRAILRRTAGHAAPVLRAGAVELDTRTRAVSVDGRPAELTALEYRLLAF
LLHRPGQVVPAGELLDHLHGVGTEREANALEALLTRLRRKLGPGVIETRRGQGYLIAGPGGS
>Mature_222_residues
MRVLIVEDEPRIAADIRQGLERAGYVADVVADGEAAWFRAETETYDAMVLDLGLPRLDGLGVLRRLRAAEVALPVLILTA
RDGWRERVEGIDAGADDYLAKPFRMEELVARLRAILRRTAGHAAPVLRAGAVELDTRTRAVSVDGRPAELTALEYRLLAF
LLHRPGQVVPAGELLDHLHGVGTEREANALEALLTRLRRKLGPGVIETRRGQGYLIAGPGGS

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=38.1818181818182, Blast_Score=162, Evalue=1e-41,
Organism=Escherichia coli, GI1789402, Length=216, Percent_Identity=41.6666666666667, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=36.1233480176211, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=37.8995433789954, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1790552, Length=217, Percent_Identity=40.0921658986175, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=36.7713004484305, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=33.1818181818182, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=36.8181818181818, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=33.0472103004292, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=35.2173913043478, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=30.8035714285714, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788394, Length=207, Percent_Identity=34.2995169082126, Blast_Score=100, Evalue=5e-23,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=30.0429184549356, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=26.7241379310345, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=133, Percent_Identity=29.3233082706767, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790437, Length=117, Percent_Identity=29.9145299145299, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=29.9065420560748, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=31.4814814814815, Blast_Score=60, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24205; Mature: 24205

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIVEDEPRIAADIRQGLERAGYVADVVADGEAAWFRAETETYDAMVLDLGLPRLDGL
CEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCHHEEEEECCCCCCCHH
GVLRRLRAAEVALPVLILTARDGWRERVEGIDAGADDYLAKPFRMEELVARLRAILRRTA
HHHHHHHHHHHHHEEEEEECCCCHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHC
GHAAPVLRAGAVELDTRTRAVSVDGRPAELTALEYRLLAFLLHRPGQVVPAGELLDHLHG
CCCCHHHHCCCEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHC
VGTEREANALEALLTRLRRKLGPGVIETRRGQGYLIAGPGGS
CCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCC
>Mature Secondary Structure
MRVLIVEDEPRIAADIRQGLERAGYVADVVADGEAAWFRAETETYDAMVLDLGLPRLDGL
CEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCHHEEEEECCCCCCCHH
GVLRRLRAAEVALPVLILTARDGWRERVEGIDAGADDYLAKPFRMEELVARLRAILRRTA
HHHHHHHHHHHHHEEEEEECCCCHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHC
GHAAPVLRAGAVELDTRTRAVSVDGRPAELTALEYRLLAFLLHRPGQVVPAGELLDHLHG
CCCCHHHHCCCEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHC
VGTEREANALEALLTRLRRKLGPGVIETRRGQGYLIAGPGGS
CCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]