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The map label for this gene is pleC [H]

Identifier: 170748167

GI number: 170748167

Start: 1860314

End: 1861849

Strand: Reverse

Name: pleC [H]

Synonym: Mrad2831_1749

Alternate gene names: 170748167

Gene position: 1861849-1860314 (Counterclockwise)

Preceding gene: 170748173

Following gene: 170748165

Centisome position: 30.63

GC content: 71.68

Gene sequence:

>1536_bases
ATGTCCGATCTCACCGTCGAGATGGTCCAGCGCGGTCGCGGCCCCTCGACGGAGGAGGCGGCGCGCCGCCTCGGGGTTGC
CCGCGAGATCCGCTCGGCCCGCGAGAAGCTGACCTCGCAGACCGGACTTGAGCGGGCCTTCGACTACGAGCTGCTGCGCC
ACTACGCCCAGTACCGGGTCGGGGCGGGCATCCCGCTGGCGGGGTTCGCGGCGGCGCTGGCCGCGGCGGCGACCTTCTGG
ATCGCGCCGCCGGTGGCGGCGGCCTGGGCGCTCGGCGTCTTCCTCATGATCACGCTCAACACGACGTTGAGCCGGCGCTT
CCTCCGCGCCGACCCGGCGACGATCCCGCTCGCCCGCTGGCGCCGCCGCTTCCTGGTCGGCGAGGTGCTGCAGAGCCTGT
CGTGGGCCGCGATGATCGGGCTCGGCACCACCGGCGGCTGGACCTTCGCGCTGTTCGGCCTCGTCATCGCCTCCGCGGTC
ACAACCATGCTGGCCGCGACGGTGCCGCTCGCCGCCGTCGCCGCCCTGGTGCCGCTGGCCCTCGCCACCGCCTCGCTCGC
GGCCTTCTCCCGCGGGATGGACCTGCTGATGCTGGTGGTGATGGCCGGCGGCGCGCAGGTCTTCTTCCTCGGCCTGTCCC
GCCGCCTCTACACCTCGACGGTGGGCGCCCTGCGCTCCCGCGCCGAGAAGGACGCGGTGTTCGGCGAGCTGGAGCAGGCC
AAGGCCAACTCGGACGAGGCCCGCCGCCGGGCCGAGGAGGCCAACCTCGCCAAGTCGCGGTTCCTGGCCACGATGAGCCA
CGAGCTGCGCACGCCGCTCAACGCCATCCTGGGCTTCTCGGAGGTGATGAAGAACGAGGTGTTCGGCACCCACACGGCAC
CGTCCTACCGCGAGTACTCGCACGACATCCACGACAGCGGGATGCACCTCCTGAACCTGATCAACGAGATCCTCGACCTG
TCGCGGATCGAGGCGGGGCGCTACGAGCTCAACGAGGAGCCGGTGCAGCTCGCCCACGTGGTCGAGGAGTGCCGCCACAT
GATGGGCCTGCGGGCCAAGGCGAAGAACCAGACCTTCCACGACCTCGTCGACGGCTCGCTGCCGCGGCTCTGGGCCGACG
AGCGGGCGCTGCGCCAGATCGTCCTGAACCTCCTGTCGAACGCCGTGAAGTTCACGCCCCCGGGCGGCGAGATCTGGCTG
AAGGTCGGCTGGACCGCCTCCGGCGGGCAGTACGTGTCGGTGAAGGACAGCGGCCCGGGCATCCCCGAGGACGAGCTCGG
CACGGTCCTGTCCTCGTTCGGGCGCGGCTCGCTCGCGATCAAGACCGCCGAGCAGGGCTCCGGCCTGGGGTTGCCGATCG
TGAAGGGGCTGGTGGAGCTGCACGGCGGGCAGTTCCAGCTGTCCTCCAAGCCCCGCGAGGGCACCGAGGTGGTGGTGACC
CTGCCGGCCAGCCGAGTCATGGACACGCTGCCGCCGGTCGATGTCGAGCCGGAATTCATGGGGCCCGTGCGCGGCCCCCT
CAACCGCGCGGCCTGA

Upstream 100 bases:

>100_bases
ATGTCGGCAGCCGCTTCTTAACACATCCACCCCATCCTCACGGAGTGCTTCCCAGCCACCGCCGCCCGTCCGCGCATTCG
AGCCGAGTTTCAAGACGCGC

Downstream 100 bases:

>100_bases
GCCGGCCGTCGGGCGGCGCGCCGCGGCTCAGCCGAGACCGCCGAGCGCGCAGACCCGCGCCCACTCGGCCTCGGTTACCG
GCTGCACCGACAGGCGGGAA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MSDLTVEMVQRGRGPSTEEAARRLGVAREIRSAREKLTSQTGLERAFDYELLRHYAQYRVGAGIPLAGFAAALAAAATFW
IAPPVAAAWALGVFLMITLNTTLSRRFLRADPATIPLARWRRRFLVGEVLQSLSWAAMIGLGTTGGWTFALFGLVIASAV
TTMLAATVPLAAVAALVPLALATASLAAFSRGMDLLMLVVMAGGAQVFFLGLSRRLYTSTVGALRSRAEKDAVFGELEQA
KANSDEARRRAEEANLAKSRFLATMSHELRTPLNAILGFSEVMKNEVFGTHTAPSYREYSHDIHDSGMHLLNLINEILDL
SRIEAGRYELNEEPVQLAHVVEECRHMMGLRAKAKNQTFHDLVDGSLPRLWADERALRQIVLNLLSNAVKFTPPGGEIWL
KVGWTASGGQYVSVKDSGPGIPEDELGTVLSSFGRGSLAIKTAEQGSGLGLPIVKGLVELHGGQFQLSSKPREGTEVVVT
LPASRVMDTLPPVDVEPEFMGPVRGPLNRAA

Sequences:

>Translated_511_residues
MSDLTVEMVQRGRGPSTEEAARRLGVAREIRSAREKLTSQTGLERAFDYELLRHYAQYRVGAGIPLAGFAAALAAAATFW
IAPPVAAAWALGVFLMITLNTTLSRRFLRADPATIPLARWRRRFLVGEVLQSLSWAAMIGLGTTGGWTFALFGLVIASAV
TTMLAATVPLAAVAALVPLALATASLAAFSRGMDLLMLVVMAGGAQVFFLGLSRRLYTSTVGALRSRAEKDAVFGELEQA
KANSDEARRRAEEANLAKSRFLATMSHELRTPLNAILGFSEVMKNEVFGTHTAPSYREYSHDIHDSGMHLLNLINEILDL
SRIEAGRYELNEEPVQLAHVVEECRHMMGLRAKAKNQTFHDLVDGSLPRLWADERALRQIVLNLLSNAVKFTPPGGEIWL
KVGWTASGGQYVSVKDSGPGIPEDELGTVLSSFGRGSLAIKTAEQGSGLGLPIVKGLVELHGGQFQLSSKPREGTEVVVT
LPASRVMDTLPPVDVEPEFMGPVRGPLNRAA
>Mature_510_residues
SDLTVEMVQRGRGPSTEEAARRLGVAREIRSAREKLTSQTGLERAFDYELLRHYAQYRVGAGIPLAGFAAALAAAATFWI
APPVAAAWALGVFLMITLNTTLSRRFLRADPATIPLARWRRRFLVGEVLQSLSWAAMIGLGTTGGWTFALFGLVIASAVT
TMLAATVPLAAVAALVPLALATASLAAFSRGMDLLMLVVMAGGAQVFFLGLSRRLYTSTVGALRSRAEKDAVFGELEQAK
ANSDEARRRAEEANLAKSRFLATMSHELRTPLNAILGFSEVMKNEVFGTHTAPSYREYSHDIHDSGMHLLNLINEILDLS
RIEAGRYELNEEPVQLAHVVEECRHMMGLRAKAKNQTFHDLVDGSLPRLWADERALRQIVLNLLSNAVKFTPPGGEIWLK
VGWTASGGQYVSVKDSGPGIPEDELGTVLSSFGRGSLAIKTAEQGSGLGLPIVKGLVELHGGQFQLSSKPREGTEVVVTL
PASRVMDTLPPVDVEPEFMGPVRGPLNRAA

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=244, Percent_Identity=33.6065573770492, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI48994928, Length=240, Percent_Identity=32.5, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87081816, Length=350, Percent_Identity=31.1428571428571, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=33.4710743801653, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=31.0204081632653, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI145693157, Length=261, Percent_Identity=31.0344827586207, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=32.4675324675325, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=31.7391304347826, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788549, Length=256, Percent_Identity=25.78125, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790436, Length=244, Percent_Identity=25.8196721311475, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=27.9661016949153, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786783, Length=290, Percent_Identity=26.8965517241379, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790300, Length=256, Percent_Identity=26.953125, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788279, Length=208, Percent_Identity=28.8461538461538, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790346, Length=262, Percent_Identity=24.4274809160305, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790551, Length=222, Percent_Identity=26.1261261261261, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790861, Length=234, Percent_Identity=26.4957264957265, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55263; Mature: 55132

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLTVEMVQRGRGPSTEEAARRLGVAREIRSAREKLTSQTGLERAFDYELLRHYAQYRV
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAGIPLAGFAAALAAAATFWIAPPVAAAWALGVFLMITLNTTLSRRFLRADPATIPLARW
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RRRFLVGEVLQSLSWAAMIGLGTTGGWTFALFGLVIASAVTTMLAATVPLAAVAALVPLA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATASLAAFSRGMDLLMLVVMAGGAQVFFLGLSRRLYTSTVGALRSRAEKDAVFGELEQA
HHHHHHHHHHHCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KANSDEARRRAEEANLAKSRFLATMSHELRTPLNAILGFSEVMKNEVFGTHTAPSYREYS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
HDIHDSGMHLLNLINEILDLSRIEAGRYELNEEPVQLAHVVEECRHMMGLRAKAKNQTFH
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCHHH
DLVDGSLPRLWADERALRQIVLNLLSNAVKFTPPGGEIWLKVGWTASGGQYVSVKDSGPG
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEEEEEECCCCEEEEEECCCCC
IPEDELGTVLSSFGRGSLAIKTAEQGSGLGLPIVKGLVELHGGQFQLSSKPREGTEVVVT
CCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEE
LPASRVMDTLPPVDVEPEFMGPVRGPLNRAA
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLTVEMVQRGRGPSTEEAARRLGVAREIRSAREKLTSQTGLERAFDYELLRHYAQYRV
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAGIPLAGFAAALAAAATFWIAPPVAAAWALGVFLMITLNTTLSRRFLRADPATIPLARW
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RRRFLVGEVLQSLSWAAMIGLGTTGGWTFALFGLVIASAVTTMLAATVPLAAVAALVPLA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATASLAAFSRGMDLLMLVVMAGGAQVFFLGLSRRLYTSTVGALRSRAEKDAVFGELEQA
HHHHHHHHHHHCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KANSDEARRRAEEANLAKSRFLATMSHELRTPLNAILGFSEVMKNEVFGTHTAPSYREYS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
HDIHDSGMHLLNLINEILDLSRIEAGRYELNEEPVQLAHVVEECRHMMGLRAKAKNQTFH
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCHHH
DLVDGSLPRLWADERALRQIVLNLLSNAVKFTPPGGEIWLKVGWTASGGQYVSVKDSGPG
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEEEEEECCCCEEEEEECCCCC
IPEDELGTVLSSFGRGSLAIKTAEQGSGLGLPIVKGLVELHGGQFQLSSKPREGTEVVVT
CCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEE
LPASRVMDTLPPVDVEPEFMGPVRGPLNRAA
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]