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The map label for this gene is cobF [H]

Identifier: 170747956

GI number: 170747956

Start: 1621764

End: 1622552

Strand: Reverse

Name: cobF [H]

Synonym: Mrad2831_1538

Alternate gene names: 170747956

Gene position: 1622552-1621764 (Counterclockwise)

Preceding gene: 170747957

Following gene: 170747955

Centisome position: 26.7

GC content: 74.9

Gene sequence:

>789_bases
ATGCAGGACAGGCAGATCCGGGTCATCGGCATCGGCACGGGCGATCCCGAGCACCTGACCCTCCAGGCGGTGCGGGCGCT
CGCCGACGTCGACGCGGTGTTCGTCCTCGACAAGCGCGCCGAGACCGCCGACCTCGTCGAGATCCGCCGCCGGATCTGCG
CGGCCCATATCCGAAAACCCCACCGGGTCGTCACCGTCGAGGACCCGCCCCGGGAGCGCCGCCCGGCCGATTACGGGCGC
ACCGTCGAGGCCTGGCACGCGGCCCGGGCCGAGCGGCTGGAGGCGGCCTTCGCGGCCCATCTCGGGCCCGGGGAGGTGGG
GGCGATCCTGGCCTGGGGGGACCCGGCCCTCTACGACAGCGTCCTGCGCATCCTCGACCACATCCTGGCCCGCGGACGCG
TGCCGTTCCGGCGCCGCGTCGTGCCCGGTCTGTCCAGCGTGCAGGTCCTCGCTGCCCGCCACGGCGTGCCGCTGAACGGC
ATCGGCGGGTCGGTGCTGATCACCACCGGCCGCCGCCTCGCCGCGGGGTGGCCGGCGGAGGCGGAGAGCGTCGTGGTGAT
GCTCGACGGCGACCCGTCCTTCGCGCATCTCGACCCGGACCTGACGATCCACTGGGGCGCCTATCTCGGCAGCCCGGACG
AGATCCTGATCTCCGGCCGGTTGGGCGACGCGGGCGCCGAGATCCGCCGGGTCCGCGCCGAGGCCCGGGCCCGGCACGGC
TGGATCATGGACATCTACCTGCTGCGCCGTGACCGCGCCGCCACGGACAGGGCCGGCGCGGCCGGCTAG

Upstream 100 bases:

>100_bases
CCTGCAGGACCTGACCATCGCCCGGGCGATCCTCGCCAAAGCCGACGCGCGCTTGTAGGGGAGGCCGGCGCCGGCCCTCC
CCGCCCCGGCGGAGGACGGC

Downstream 100 bases:

>100_bases
ACCGCCGCCATGCTGCGCCTGCGGGACTACCAGCGCGCCAGCCTCGACGCGCTCTCGGCCGCCTGGGCGCGGGGAGGGGC
GGACGACGCGGCGCCCGGCC

Product: precorrin 6A synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MQDRQIRVIGIGTGDPEHLTLQAVRALADVDAVFVLDKRAETADLVEIRRRICAAHIRKPHRVVTVEDPPRERRPADYGR
TVEAWHAARAERLEAAFAAHLGPGEVGAILAWGDPALYDSVLRILDHILARGRVPFRRRVVPGLSSVQVLAARHGVPLNG
IGGSVLITTGRRLAAGWPAEAESVVVMLDGDPSFAHLDPDLTIHWGAYLGSPDEILISGRLGDAGAEIRRVRAEARARHG
WIMDIYLLRRDRAATDRAGAAG

Sequences:

>Translated_262_residues
MQDRQIRVIGIGTGDPEHLTLQAVRALADVDAVFVLDKRAETADLVEIRRRICAAHIRKPHRVVTVEDPPRERRPADYGR
TVEAWHAARAERLEAAFAAHLGPGEVGAILAWGDPALYDSVLRILDHILARGRVPFRRRVVPGLSSVQVLAARHGVPLNG
IGGSVLITTGRRLAAGWPAEAESVVVMLDGDPSFAHLDPDLTIHWGAYLGSPDEILISGRLGDAGAEIRRVRAEARARHG
WIMDIYLLRRDRAATDRAGAAG
>Mature_262_residues
MQDRQIRVIGIGTGDPEHLTLQAVRALADVDAVFVLDKRAETADLVEIRRRICAAHIRKPHRVVTVEDPPRERRPADYGR
TVEAWHAARAERLEAAFAAHLGPGEVGAILAWGDPALYDSVLRILDHILARGRVPFRRRVVPGLSSVQVLAARHGVPLNG
IGGSVLITTGRRLAAGWPAEAESVVVMLDGDPSFAHLDPDLTIHWGAYLGSPDEILISGRLGDAGAEIRRVRAEARARHG
WIMDIYLLRRDRAATDRAGAAG

Specific function: Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A [H]

COG id: COG2243

COG function: function code H; Precorrin-2 methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR012797 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.152 [H]

Molecular weight: Translated: 28559; Mature: 28559

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00024 HEMOPEXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDRQIRVIGIGTGDPEHLTLQAVRALADVDAVFVLDKRAETADLVEIRRRICAAHIRKP
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCC
HRVVTVEDPPRERRPADYGRTVEAWHAARAERLEAAFAAHLGPGEVGAILAWGDPALYDS
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHH
VLRILDHILARGRVPFRRRVVPGLSSVQVLAARHGVPLNGIGGSVLITTGRRLAAGWPAE
HHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCEEECCCCCC
AESVVVMLDGDPSFAHLDPDLTIHWGAYLGSPDEILISGRLGDAGAEIRRVRAEARARHG
CCEEEEEECCCCCEEEECCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHCC
WIMDIYLLRRDRAATDRAGAAG
EEEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MQDRQIRVIGIGTGDPEHLTLQAVRALADVDAVFVLDKRAETADLVEIRRRICAAHIRKP
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCC
HRVVTVEDPPRERRPADYGRTVEAWHAARAERLEAAFAAHLGPGEVGAILAWGDPALYDS
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHH
VLRILDHILARGRVPFRRRVVPGLSSVQVLAARHGVPLNGIGGSVLITTGRRLAAGWPAE
HHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCEEECCCCCC
AESVVVMLDGDPSFAHLDPDLTIHWGAYLGSPDEILISGRLGDAGAEIRRVRAEARARHG
CCEEEEEECCCCCEEEECCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHCC
WIMDIYLLRRDRAATDRAGAAG
EEEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521 [H]