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The map label for this gene is recQ [H]

Identifier: 170747560

GI number: 170747560

Start: 1188661

End: 1190502

Strand: Reverse

Name: recQ [H]

Synonym: Mrad2831_1128

Alternate gene names: 170747560

Gene position: 1190502-1188661 (Counterclockwise)

Preceding gene: 170747563

Following gene: 170747559

Centisome position: 19.59

GC content: 71.66

Gene sequence:

>1842_bases
ATGACCCGCCTCGACGAGGCCCGCGCCGCGCTGAAGAAGACGTTCGGCTACGAGGATTTTCGCCCCGGCCAGGACGAGGT
GATCGGCGCCGTGCTCGACGGGACCGACGTGTTCGCCGTGATGCCCACGGGTTCGGGCAAGTCGATGACCTACCAGCTCC
CGGCCCTGGTCGACCCGGGGCTGACCGTGGTGGTCTCGCCGCTGATCGCGCTGATGCACGATCAGGTCCAGCAGATGCGC
AGCGTCGGCATCCACGCCGCGACCCTGAACTCGACGGTCGGGGAATCCGAGTCCCGCGAGACGTGGCGCGCCCTGCGCTC
CGGCGACCTGCGGTTGCTGTTCGTCTCCCCCGAGCGCCTGCTGATGGACGGCTGCATGGACGCCCTGCGCGGGGCCGGCG
TCCGGCGGCTGGCCGTCGACGAGGCCCACTGCGTCTCGCAGTGGGGGCACGATTTCCGGCCCGAGTACCGGGAGATCGCC
CGCGCCCGGACGGCGCTGGGCAACGTCCAGACCCTGGCGCTCACCGCCACCGCCGACGCCGCGACCCGCGCCGAGATCGC
CGAGCGGCTGTTCCCGCAGGACCGGCCGCCGAAGATCTTCGTCCATTCCTTCGACCGGCCGAACATCCGGCTGACCTTCC
AGCCGAAGGACAACCCGGCCCGGCAGATCGAGCGGTTCCTGAAGCACCGGCGATCGGAGAGCGGGATCATCTACTGCTCG
TCGCGCAAGCGCACCGAGCAGCTGGCCGAGACCCTCCGGAAGGACGGGTTCGACGCCCTGCCCTACCATGCCGGCCTCGA
CCAGGCGACGCGGATGGCGAACCAGGACCGGTTCCTGCAGGAGGACGGGGTGGTGATGACCGCCACCGTCGCCTTCGGCA
TGGGCATCAACAAGCCGGACGTGCGCTTCGTCTGCCACGCCGACATGCCCAACAACGTCGAGGGCTACTACCAGGAGATC
GGCCGCGCCGGCCGCGACGGGCTGCCCGCCGACACGCTGACCCTGTACGGCCTCGACGACATGGCGCTCCGCCGCCGCCA
GATCGACGAGAAGGAGATCTCGGACGACCGCCGCCGGGTCGAGCGGCGCAAGCTCGAGGCGATGATCACCCTGTGCGAGG
GCGCGACATGCCGCCGCCAGTCGCTGCTCGCCTATTTCGGCGAGTCGAGCGGCGCTTGCGGCCGCTGCGACCTGTGCCGC
GGCGGCGTGACCCTCGTCGACGGGACCGTACCGGCCCAGAAGATCCTCTCGGCGATCGTGCGCACCGGCCAGCGCTTCGG
CGCGGCCTATATCTGCGACGTGGTCCACGGGAAGGAGAGCGACCAGATCCGCCGCAACGGCCACGCGAGCCTCAAGACCT
TCGGGGTCGGGGCGGACAAGCCGGTGGCGGCCTGGCGGGCGATCCTGCGCCAGCTCTTCGCGGCCGGGGCGATCGCCGAG
AACGCCGACGGCTACGGCGGCCTGTCCATGACCGAGAAGGGCGAGGCGATCCTGTTCGGCCGGGAGCCGGTCCAGCTCCG
CCCCGACCCGGAGCCGAAGGCCGAATCCCGCGAGCGCCGCCGGGCCGCCGCCCGCGAGGACGGCGAGATCGCCCTCTCGG
AGGCCGACGAGGCGCTGTTCCAGCACCTGCGGGGCCTGCGCGCCACGCTGGCCCGGGCCGAGGGCATCGCGGCCTTCATG
GTCTTCCCGGACCGCACCCTCATCGAGATGGCCCGCCAGAAGCCCGTCGACCTCTGGGCGCTGCGCACCGTGCACGGCGT
CGGCGAGCGCAAGCGCGAGGCCTACGGCGACAAGTTCGTGGCGGCGATCGCCGATTTTCTGGCCCATCCGCCGGCGGCGT
GA

Upstream 100 bases:

>100_bases
CGGATGTTGAGCGGCATGGCGGCTCCCGTGTAGACACGTGGAGGCTAGTGTCTACACACCCCTGCCGCAAGGGCGGCCAG
AACCCCGACCAAGGATCCCG

Downstream 100 bases:

>100_bases
GCGGCACCCATACACGGCCAGCAGGGCCGGCGTATTGCAACGCGGTGGCGGAACGCACTAATCCGTCACCGTCGCCGCGC
GCGGCCCGGTTCGGGTCGCG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MTRLDEARAALKKTFGYEDFRPGQDEVIGAVLDGTDVFAVMPTGSGKSMTYQLPALVDPGLTVVVSPLIALMHDQVQQMR
SVGIHAATLNSTVGESESRETWRALRSGDLRLLFVSPERLLMDGCMDALRGAGVRRLAVDEAHCVSQWGHDFRPEYREIA
RARTALGNVQTLALTATADAATRAEIAERLFPQDRPPKIFVHSFDRPNIRLTFQPKDNPARQIERFLKHRRSESGIIYCS
SRKRTEQLAETLRKDGFDALPYHAGLDQATRMANQDRFLQEDGVVMTATVAFGMGINKPDVRFVCHADMPNNVEGYYQEI
GRAGRDGLPADTLTLYGLDDMALRRRQIDEKEISDDRRRVERRKLEAMITLCEGATCRRQSLLAYFGESSGACGRCDLCR
GGVTLVDGTVPAQKILSAIVRTGQRFGAAYICDVVHGKESDQIRRNGHASLKTFGVGADKPVAAWRAILRQLFAAGAIAE
NADGYGGLSMTEKGEAILFGREPVQLRPDPEPKAESRERRRAAAREDGEIALSEADEALFQHLRGLRATLARAEGIAAFM
VFPDRTLIEMARQKPVDLWALRTVHGVGERKREAYGDKFVAAIADFLAHPPAA

Sequences:

>Translated_613_residues
MTRLDEARAALKKTFGYEDFRPGQDEVIGAVLDGTDVFAVMPTGSGKSMTYQLPALVDPGLTVVVSPLIALMHDQVQQMR
SVGIHAATLNSTVGESESRETWRALRSGDLRLLFVSPERLLMDGCMDALRGAGVRRLAVDEAHCVSQWGHDFRPEYREIA
RARTALGNVQTLALTATADAATRAEIAERLFPQDRPPKIFVHSFDRPNIRLTFQPKDNPARQIERFLKHRRSESGIIYCS
SRKRTEQLAETLRKDGFDALPYHAGLDQATRMANQDRFLQEDGVVMTATVAFGMGINKPDVRFVCHADMPNNVEGYYQEI
GRAGRDGLPADTLTLYGLDDMALRRRQIDEKEISDDRRRVERRKLEAMITLCEGATCRRQSLLAYFGESSGACGRCDLCR
GGVTLVDGTVPAQKILSAIVRTGQRFGAAYICDVVHGKESDQIRRNGHASLKTFGVGADKPVAAWRAILRQLFAAGAIAE
NADGYGGLSMTEKGEAILFGREPVQLRPDPEPKAESRERRRAAAREDGEIALSEADEALFQHLRGLRATLARAEGIAAFM
VFPDRTLIEMARQKPVDLWALRTVHGVGERKREAYGDKFVAAIADFLAHPPAA
>Mature_612_residues
TRLDEARAALKKTFGYEDFRPGQDEVIGAVLDGTDVFAVMPTGSGKSMTYQLPALVDPGLTVVVSPLIALMHDQVQQMRS
VGIHAATLNSTVGESESRETWRALRSGDLRLLFVSPERLLMDGCMDALRGAGVRRLAVDEAHCVSQWGHDFRPEYREIAR
ARTALGNVQTLALTATADAATRAEIAERLFPQDRPPKIFVHSFDRPNIRLTFQPKDNPARQIERFLKHRRSESGIIYCSS
RKRTEQLAETLRKDGFDALPYHAGLDQATRMANQDRFLQEDGVVMTATVAFGMGINKPDVRFVCHADMPNNVEGYYQEIG
RAGRDGLPADTLTLYGLDDMALRRRQIDEKEISDDRRRVERRKLEAMITLCEGATCRRQSLLAYFGESSGACGRCDLCRG
GVTLVDGTVPAQKILSAIVRTGQRFGAAYICDVVHGKESDQIRRNGHASLKTFGVGADKPVAAWRAILRQLFAAGAIAEN
ADGYGGLSMTEKGEAILFGREPVQLRPDPEPKAESRERRRAAAREDGEIALSEADEALFQHLRGLRATLARAEGIAAFMV
FPDRTLIEMARQKPVDLWALRTVHGVGERKREAYGDKFVAAIADFLAHPPAA

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=647, Percent_Identity=33.693972179289, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI110735439, Length=512, Percent_Identity=36.9140625, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI169218196, Length=512, Percent_Identity=36.9140625, Blast_Score=282, Evalue=5e-76,
Organism=Homo sapiens, GI14591902, Length=410, Percent_Identity=37.5609756097561, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI14591904, Length=410, Percent_Identity=37.5609756097561, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI148612816, Length=421, Percent_Identity=37.29216152019, Blast_Score=260, Evalue=3e-69,
Organism=Homo sapiens, GI51242943, Length=392, Percent_Identity=37.5, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI51242947, Length=392, Percent_Identity=37.5, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI284005309, Length=377, Percent_Identity=35.0132625994695, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI20149629, Length=342, Percent_Identity=24.5614035087719, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI188035877, Length=344, Percent_Identity=24.1279069767442, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI31542656, Length=349, Percent_Identity=24.9283667621776, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI48994977, Length=598, Percent_Identity=45.1505016722408, Blast_Score=510, Evalue=1e-145,
Organism=Escherichia coli, GI87082221, Length=328, Percent_Identity=28.0487804878049, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1787016, Length=358, Percent_Identity=24.8603351955307, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1788930, Length=332, Percent_Identity=25.6024096385542, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25145561, Length=505, Percent_Identity=37.029702970297, Blast_Score=309, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI32564293, Length=675, Percent_Identity=31.4074074074074, Blast_Score=288, Evalue=7e-78,
Organism=Caenorhabditis elegans, GI71987997, Length=543, Percent_Identity=32.4125230202578, Blast_Score=269, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI71987993, Length=543, Percent_Identity=32.4125230202578, Blast_Score=269, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17552866, Length=433, Percent_Identity=35.3348729792148, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI115533224, Length=331, Percent_Identity=25.9818731117825, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI32565321, Length=382, Percent_Identity=25.130890052356, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17555296, Length=333, Percent_Identity=24.024024024024, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI86570094, Length=341, Percent_Identity=23.1671554252199, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=545, Percent_Identity=34.6788990825688, Blast_Score=308, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6324217, Length=327, Percent_Identity=25.9938837920489, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321360, Length=332, Percent_Identity=25.9036144578313, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320119, Length=330, Percent_Identity=23.9393939393939, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646066, Length=635, Percent_Identity=32.9133858267717, Blast_Score=311, Evalue=8e-85,
Organism=Drosophila melanogaster, GI24664230, Length=426, Percent_Identity=34.9765258215962, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI62472181, Length=426, Percent_Identity=34.9765258215962, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24664226, Length=426, Percent_Identity=34.9765258215962, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI21358123, Length=402, Percent_Identity=35.5721393034826, Blast_Score=203, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 67777; Mature: 67646

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS50967 HRDC ; PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLDEARAALKKTFGYEDFRPGQDEVIGAVLDGTDVFAVMPTGSGKSMTYQLPALVDPG
CCCHHHHHHHHHHHCCCCCCCCCHHHHEEEEECCCEEEEEEECCCCCCEEEECCCCCCCC
LTVVVSPLIALMHDQVQQMRSVGIHAATLNSTVGESESRETWRALRSGDLRLLFVSPERL
HHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECHHHH
LMDGCMDALRGAGVRRLAVDEAHCVSQWGHDFRPEYREIARARTALGNVQTLALTATADA
HHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCH
ATRAEIAERLFPQDRPPKIFVHSFDRPNIRLTFQPKDNPARQIERFLKHRRSESGIIYCS
HHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEC
SRKRTEQLAETLRKDGFDALPYHAGLDQATRMANQDRFLQEDGVVMTATVAFGMGINKPD
CCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEHHCCCCCCCC
VRFVCHADMPNNVEGYYQEIGRAGRDGLPADTLTLYGLDDMALRRRQIDEKEISDDRRRV
EEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHHH
ERRKLEAMITLCEGATCRRQSLLAYFGESSGACGRCDLCRGGVTLVDGTVPAQKILSAIV
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHCCCCEEEEECCCCHHHHHHHHH
RTGQRFGAAYICDVVHGKESDQIRRNGHASLKTFGVGADKPVAAWRAILRQLFAAGAIAE
HHHHHHCHHHHHHHHCCCCHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCHHC
NADGYGGLSMTEKGEAILFGREPVQLRPDPEPKAESRERRRAAAREDGEIALSEADEALF
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHH
QHLRGLRATLARAEGIAAFMVFPDRTLIEMARQKPVDLWALRTVHGVGERKREAYGDKFV
HHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AAIADFLAHPPAA
HHHHHHHCCCCCC
>Mature Secondary Structure 
TRLDEARAALKKTFGYEDFRPGQDEVIGAVLDGTDVFAVMPTGSGKSMTYQLPALVDPG
CCHHHHHHHHHHHCCCCCCCCCHHHHEEEEECCCEEEEEEECCCCCCEEEECCCCCCCC
LTVVVSPLIALMHDQVQQMRSVGIHAATLNSTVGESESRETWRALRSGDLRLLFVSPERL
HHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECHHHH
LMDGCMDALRGAGVRRLAVDEAHCVSQWGHDFRPEYREIARARTALGNVQTLALTATADA
HHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCH
ATRAEIAERLFPQDRPPKIFVHSFDRPNIRLTFQPKDNPARQIERFLKHRRSESGIIYCS
HHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEC
SRKRTEQLAETLRKDGFDALPYHAGLDQATRMANQDRFLQEDGVVMTATVAFGMGINKPD
CCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEHHCCCCCCCC
VRFVCHADMPNNVEGYYQEIGRAGRDGLPADTLTLYGLDDMALRRRQIDEKEISDDRRRV
EEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHHH
ERRKLEAMITLCEGATCRRQSLLAYFGESSGACGRCDLCRGGVTLVDGTVPAQKILSAIV
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHCCCCEEEEECCCCHHHHHHHHH
RTGQRFGAAYICDVVHGKESDQIRRNGHASLKTFGVGADKPVAAWRAILRQLFAAGAIAE
HHHHHHCHHHHHHHHCCCCHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCHHC
NADGYGGLSMTEKGEAILFGREPVQLRPDPEPKAESRERRRAAAREDGEIALSEADEALF
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHH
QHLRGLRATLARAEGIAAFMVFPDRTLIEMARQKPVDLWALRTVHGVGERKREAYGDKFV
HHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AAIADFLAHPPAA
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]