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The map label for this gene is purE [H]

Identifier: 170747496

GI number: 170747496

Start: 1122939

End: 1123439

Strand: Reverse

Name: purE [H]

Synonym: Mrad2831_1064

Alternate gene names: 170747496

Gene position: 1123439-1122939 (Counterclockwise)

Preceding gene: 170747497

Following gene: 170747495

Centisome position: 18.48

GC content: 75.45

Gene sequence:

>501_bases
ATGGCGTCGCCTCCTCCGGTCGCGATCATCATGGGCAGCCAGTCCGACTGGGCGACCATGCGTCATGCCGCCGAGACGCT
CGACGCGCTCGGCGTGCCGTACGACGCGCGCATCGTGTCGGCCCACCGCACGCCGGACCGGCTCGTGGCCTTCGCCAAGG
GCGCGGTCGCGGCCGGTCTCAAGGTCGTGATCGCGGGCGCGGGCGGCGCCGCGCACCTGCCCGGCATGGCGGCCGCGATG
ACCCGCCTGCCGGTCTTCGGCGTGCCGGTCGAATCGAAGGCCCTGTCCGGCCAGGACAGCCTGCTCTCCATCGTCCAGAT
GCCGGCCGGCATCCCGGTGGGGACCCTGGCGATCGGCCGGGCCGGGGCCGTCAACGCGGCCCTGCTCGCCGCGGCGGTCC
TGGCGCTGACCGACCCGGGCCTGGCGGAGCGCCTGGAGGCGTGGCGCGCGGCCCAGAGCGCCTCGGTGGCCGAACGGCCG
GTGACGGAAGAGAACGCGTGA

Upstream 100 bases:

>100_bases
CACGCCGGACATCATCGCCTGATGCCGGTGGACGCCCTCGGGCCCCGCCTTGCCGCCGGCCCGCACCGCCTGTAAGCGCC
CTCTTTTGCCGGGATCAACG

Downstream 100 bases:

>100_bases
CGGACAAGATCCTCGGCCCCGGCTTCACCCTCGGCATCGTCGGCGGGGGTCAGCTCGGGCGCATGATCGCGCTCGCGGCG
GCCGATTACGGCCTCAAGGC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MASPPPVAIIMGSQSDWATMRHAAETLDALGVPYDARIVSAHRTPDRLVAFAKGAVAAGLKVVIAGAGGAAHLPGMAAAM
TRLPVFGVPVESKALSGQDSLLSIVQMPAGIPVGTLAIGRAGAVNAALLAAAVLALTDPGLAERLEAWRAAQSASVAERP
VTEENA

Sequences:

>Translated_166_residues
MASPPPVAIIMGSQSDWATMRHAAETLDALGVPYDARIVSAHRTPDRLVAFAKGAVAAGLKVVIAGAGGAAHLPGMAAAM
TRLPVFGVPVESKALSGQDSLLSIVQMPAGIPVGTLAIGRAGAVNAALLAAAVLALTDPGLAERLEAWRAAQSASVAERP
VTEENA
>Mature_165_residues
ASPPPVAIIMGSQSDWATMRHAAETLDALGVPYDARIVSAHRTPDRLVAFAKGAVAAGLKVVIAGAGGAAHLPGMAAAMT
RLPVFGVPVESKALSGQDSLLSIVQMPAGIPVGTLAIGRAGAVNAALLAAAVLALTDPGLAERLEAWRAAQSASVAERPV
TEENA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=158, Percent_Identity=64.5569620253165, Blast_Score=169, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6324702, Length=152, Percent_Identity=53.2894736842105, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16661; Mature: 16530

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPPPVAIIMGSQSDWATMRHAAETLDALGVPYDARIVSAHRTPDRLVAFAKGAVAAGL
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCE
KVVIAGAGGAAHLPGMAAAMTRLPVFGVPVESKALSGQDSLLSIVQMPAGIPVGTLAIGR
EEEEECCCCCCCCCHHHHHHHHCCEECCCCCCHHCCCHHHHHHHHHCCCCCCCHHHCCCC
AGAVNAALLAAAVLALTDPGLAERLEAWRAAQSASVAERPVTEENA
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ASPPPVAIIMGSQSDWATMRHAAETLDALGVPYDARIVSAHRTPDRLVAFAKGAVAAGL
CCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCE
KVVIAGAGGAAHLPGMAAAMTRLPVFGVPVESKALSGQDSLLSIVQMPAGIPVGTLAIGR
EEEEECCCCCCCCCHHHHHHHHCCEECCCCCCHHCCCHHHHHHHHHCCCCCCCHHHCCCC
AGAVNAALLAAAVLALTDPGLAERLEAWRAAQSASVAERPVTEENA
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]