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The map label for this gene is ywrD [H]

Identifier: 170747302

GI number: 170747302

Start: 911773

End: 913371

Strand: Reverse

Name: ywrD [H]

Synonym: Mrad2831_0869

Alternate gene names: 170747302

Gene position: 913371-911773 (Counterclockwise)

Preceding gene: 170747305

Following gene: 170747298

Centisome position: 15.03

GC content: 73.86

Gene sequence:

>1599_bases
ATGCCCGAGACTCCCGTCTTCACGTCCGCCGCCGTCGCCGCGCCCCACAGCCTCGCCGCCCAGGCCGGCCAGACCGTCCT
GGCGCAGGGCGGCAACGCCATCGAGGCGATGGTGGCGATGGCCGCCTCCATCGCGGTGGTCTACCCGCACATGAACGGCA
TCGGCGGCGACGGCTTCTGGCTGGTGCGCGAGCGCGGCGGTCGGGTGCGCGGCATCGAGGCCTGCGGTCCGGCCGGGCGC
CTCGCCACGATCCCGCGCTACCGGGAGAAGGGCTACGACGCGATACCGGCCCGCGGCCCCGACGCGATGGTGACGGTCGC
GGGCGCGGTGGGCGGCTGGCGCCTCGCCCTCGAGCTGGCGCGGGCGCTCGGCGGCCGCCTTCCCCTGGAGACCCTGCTCG
CCGACGCGATCGCGCAGGCGCGCGGCGGCGTCCCGGTCTCGCCCTCCGAGGCGCGCTACGTGCCCCAGGAGCTCGATACC
CTCCACGACGCCCCGAACTTCGCGGGGACGTTCCTGAAGGACGGCAAGCCCTACCCGGCCGGCGAGACCCGCGCCCTGCC
GCTGCTCGCCGCCACTCTGGAGCAGCTCGCCCATGCGGGCCTCGGGGACTTCTATCGCGGCGATATCGGCCGGGAGATCG
CCGCCGACCTGGAGCGCCTCGGCGCGCCGGTCACCCGGGCGGATCTCGAGGCCTTCGCGGCGGTGGAGCGGGCGCCCCTG
TCGATCCGGCGCCGCGACGCGACCCTCTACAACTTCCCGCCGCCGACCCAGGGGCTCGCCGCCCTGCTGATCCTCGGGAT
CTTCGACCGGCTGAACGTCACGGAGCCCGAGACCACAGCTCATTACCACGGCCTGATCGAGGCGACGAAGCGGGCCTTCG
CGATCCGCGACCGGGTGGTCACCGATTTCGCCCGCTTGCGGCACGACCCGGCCACCTTCCTCACGCCGGAGCGGCTCGCC
CGCGAGGCCGCACTCGTCGACATGGGCCGCGCCGGTCGGGTGCCCCTGCCCGACCCGAGTCACGGCGACACGGTGTGGAT
GGGCGCGATCGACAAGGACGGCCTCGCGGTCTCCTACATCCAGTCGGTCTACTGGGAGTACGGCTCGGGGACGGTCCTGC
CCGCCACCGGCATCTGCTGGCAGAACCGGGGCATGTCGTTCTCCCTCGACCCGAAGGCCGTGAACCCCCTGGAGCCGGGG
CGGCGCCCGTTCCACACGCTGATCCCCGCGCTCGCCGCCTTCGACGACGGGCGGGTGATGAGCTACGGCAGCATGGGCGG
CGACGGGCAGCCGCAGTTCCAGGCCCAGATCTTCACCCGCTACGCCGATTACGGGCTGTCGGTGGCGGATGCCGTCGACG
CGCCGCGCCTGCTCTACGGGCGCACCTGGGGGGCGCCCTCGCTCAGCGTGAAGGTGGAGGACCGGTTCGATCCGGCCTGC
ATCGCGGCCCTCGGCCGCCTCGGCCACGAGATCGAGGAGCTCGGCGGCCCCTACATCGACTCGCTCGGGCACGCGGGCAT
GCTTGTCCGCCATCCCCGGAACGGTCGGATCGAGGCGACCCACGACCCGCGCTCGGACGGCGGCGCCCTCGGGCTCTGA

Upstream 100 bases:

>100_bases
GCGCGCGCAGCATAGCACGGCGCACCGCTTGTACACGGCCGGCCTTTGCAGGAGGCACCGGCTCGCCTAACCCTGCGGCC
GGTACAGCACAGGACCGTCG

Downstream 100 bases:

>100_bases
GAGGACGCGCCGCCCGCCCGGCGGCGCGGGACGCCGGCTCAGCCCGCCTGCACGAGCCAGCACGCGGCGCGCAGGCGCAC
GGCGCCGCCCGCCGCGTGCC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MPETPVFTSAAVAAPHSLAAQAGQTVLAQGGNAIEAMVAMAASIAVVYPHMNGIGGDGFWLVRERGGRVRGIEACGPAGR
LATIPRYREKGYDAIPARGPDAMVTVAGAVGGWRLALELARALGGRLPLETLLADAIAQARGGVPVSPSEARYVPQELDT
LHDAPNFAGTFLKDGKPYPAGETRALPLLAATLEQLAHAGLGDFYRGDIGREIAADLERLGAPVTRADLEAFAAVERAPL
SIRRRDATLYNFPPPTQGLAALLILGIFDRLNVTEPETTAHYHGLIEATKRAFAIRDRVVTDFARLRHDPATFLTPERLA
REAALVDMGRAGRVPLPDPSHGDTVWMGAIDKDGLAVSYIQSVYWEYGSGTVLPATGICWQNRGMSFSLDPKAVNPLEPG
RRPFHTLIPALAAFDDGRVMSYGSMGGDGQPQFQAQIFTRYADYGLSVADAVDAPRLLYGRTWGAPSLSVKVEDRFDPAC
IAALGRLGHEIEELGGPYIDSLGHAGMLVRHPRNGRIEATHDPRSDGGALGL

Sequences:

>Translated_532_residues
MPETPVFTSAAVAAPHSLAAQAGQTVLAQGGNAIEAMVAMAASIAVVYPHMNGIGGDGFWLVRERGGRVRGIEACGPAGR
LATIPRYREKGYDAIPARGPDAMVTVAGAVGGWRLALELARALGGRLPLETLLADAIAQARGGVPVSPSEARYVPQELDT
LHDAPNFAGTFLKDGKPYPAGETRALPLLAATLEQLAHAGLGDFYRGDIGREIAADLERLGAPVTRADLEAFAAVERAPL
SIRRRDATLYNFPPPTQGLAALLILGIFDRLNVTEPETTAHYHGLIEATKRAFAIRDRVVTDFARLRHDPATFLTPERLA
REAALVDMGRAGRVPLPDPSHGDTVWMGAIDKDGLAVSYIQSVYWEYGSGTVLPATGICWQNRGMSFSLDPKAVNPLEPG
RRPFHTLIPALAAFDDGRVMSYGSMGGDGQPQFQAQIFTRYADYGLSVADAVDAPRLLYGRTWGAPSLSVKVEDRFDPAC
IAALGRLGHEIEELGGPYIDSLGHAGMLVRHPRNGRIEATHDPRSDGGALGL
>Mature_531_residues
PETPVFTSAAVAAPHSLAAQAGQTVLAQGGNAIEAMVAMAASIAVVYPHMNGIGGDGFWLVRERGGRVRGIEACGPAGRL
ATIPRYREKGYDAIPARGPDAMVTVAGAVGGWRLALELARALGGRLPLETLLADAIAQARGGVPVSPSEARYVPQELDTL
HDAPNFAGTFLKDGKPYPAGETRALPLLAATLEQLAHAGLGDFYRGDIGREIAADLERLGAPVTRADLEAFAAVERAPLS
IRRRDATLYNFPPPTQGLAALLILGIFDRLNVTEPETTAHYHGLIEATKRAFAIRDRVVTDFARLRHDPATFLTPERLAR
EAALVDMGRAGRVPLPDPSHGDTVWMGAIDKDGLAVSYIQSVYWEYGSGTVLPATGICWQNRGMSFSLDPKAVNPLEPGR
RPFHTLIPALAAFDDGRVMSYGSMGGDGQPQFQAQIFTRYADYGLSVADAVDAPRLLYGRTWGAPSLSVKVEDRFDPACI
AALGRLGHEIEELGGPYIDSLGHAGMLVRHPRNGRIEATHDPRSDGGALGL

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=517, Percent_Identity=28.4332688588008, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI73915090, Length=517, Percent_Identity=28.4332688588008, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI73915096, Length=517, Percent_Identity=28.4332688588008, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI73915094, Length=517, Percent_Identity=28.4332688588008, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI113429324, Length=515, Percent_Identity=27.7669902912621, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI113429326, Length=520, Percent_Identity=27.3076923076923, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI109148539, Length=554, Percent_Identity=26.3537906137184, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI153266885, Length=480, Percent_Identity=26.25, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI153266901, Length=385, Percent_Identity=27.5324675324675, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI153266907, Length=477, Percent_Identity=24.9475890985325, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789856, Length=539, Percent_Identity=27.8293135435993, Blast_Score=175, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI193208245, Length=494, Percent_Identity=27.5303643724696, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193208247, Length=494, Percent_Identity=27.5303643724696, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17506189, Length=531, Percent_Identity=23.728813559322, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI72000294, Length=490, Percent_Identity=25.7142857142857, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI212646519, Length=490, Percent_Identity=25.7142857142857, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17542894, Length=524, Percent_Identity=25, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI18859893, Length=521, Percent_Identity=25.5278310940499, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24642670, Length=564, Percent_Identity=25.531914893617, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24642666, Length=564, Percent_Identity=25.531914893617, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45551474, Length=564, Percent_Identity=25.531914893617, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI161077878, Length=564, Percent_Identity=25.531914893617, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161077880, Length=564, Percent_Identity=25.531914893617, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161077496, Length=526, Percent_Identity=24.5247148288973, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 56694; Mature: 56563

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETPVFTSAAVAAPHSLAAQAGQTVLAQGGNAIEAMVAMAASIAVVYPHMNGIGGDGFW
CCCCCCCCCHHHHCCHHHHHHHCCCHHHCCCCHHHHHHHHHHHHEEEECCCCCCCCCCEE
LVRERGGRVRGIEACGPAGRLATIPRYREKGYDAIPARGPDAMVTVAGAVGGWRLALELA
EEEECCCCEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHH
RALGGRLPLETLLADAIAQARGGVPVSPSEARYVPQELDTLHDAPNFAGTFLKDGKPYPA
HHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHCCCCCCCC
GETRALPLLAATLEQLAHAGLGDFYRGDIGREIAADLERLGAPVTRADLEAFAAVERAPL
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SIRRRDATLYNFPPPTQGLAALLILGIFDRLNVTEPETTAHYHGLIEATKRAFAIRDRVV
CEEECCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TDFARLRHDPATFLTPERLAREAALVDMGRAGRVPLPDPSHGDTVWMGAIDKDGLAVSYI
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHH
QSVYWEYGSGTVLPATGICWQNRGMSFSLDPKAVNPLEPGRRPFHTLIPALAAFDDGRVM
HHHHHHCCCCCEECCCCCEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEE
SYGSMGGDGQPQFQAQIFTRYADYGLSVADAVDAPRLLYGRTWGAPSLSVKVEDRFDPAC
EECCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCHHHHCCCCCCCCEEEEECCCCCHHH
IAALGRLGHEIEELGGPYIDSLGHAGMLVRHPRNGRIEATHDPRSDGGALGL
HHHHHHHHHHHHHHCCCHHHHCCCCCEEEECCCCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure 
PETPVFTSAAVAAPHSLAAQAGQTVLAQGGNAIEAMVAMAASIAVVYPHMNGIGGDGFW
CCCCCCCCHHHHCCHHHHHHHCCCHHHCCCCHHHHHHHHHHHHEEEECCCCCCCCCCEE
LVRERGGRVRGIEACGPAGRLATIPRYREKGYDAIPARGPDAMVTVAGAVGGWRLALELA
EEEECCCCEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHH
RALGGRLPLETLLADAIAQARGGVPVSPSEARYVPQELDTLHDAPNFAGTFLKDGKPYPA
HHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHCCCCCCCC
GETRALPLLAATLEQLAHAGLGDFYRGDIGREIAADLERLGAPVTRADLEAFAAVERAPL
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SIRRRDATLYNFPPPTQGLAALLILGIFDRLNVTEPETTAHYHGLIEATKRAFAIRDRVV
CEEECCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TDFARLRHDPATFLTPERLAREAALVDMGRAGRVPLPDPSHGDTVWMGAIDKDGLAVSYI
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHH
QSVYWEYGSGTVLPATGICWQNRGMSFSLDPKAVNPLEPGRRPFHTLIPALAAFDDGRVM
HHHHHHCCCCCEECCCCCEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEE
SYGSMGGDGQPQFQAQIFTRYADYGLSVADAVDAPRLLYGRTWGAPSLSVKVEDRFDPAC
EECCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCHHHHCCCCCCCCEEEEECCCCCHHH
IAALGRLGHEIEELGGPYIDSLGHAGMLVRHPRNGRIEATHDPRSDGGALGL
HHHHHHHHHHHHHHCCCHHHHCCCCCEEEECCCCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]