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The map label for this gene is bioA [H]

Identifier: 170747298

GI number: 170747298

Start: 907758

End: 909023

Strand: Reverse

Name: bioA [H]

Synonym: Mrad2831_0865

Alternate gene names: 170747298

Gene position: 909023-907758 (Counterclockwise)

Preceding gene: 170747302

Following gene: 170747297

Centisome position: 14.96

GC content: 74.17

Gene sequence:

>1266_bases
ATGACCCTCGCGACGCCCGCAGGCCATCTCTGGCGGCCCTACACCCAGATGCGACACGCGGCGGCGCCCCTGGAGGCGGT
CGCGACCCACGGCACCCGCATCCGCCTCGCCGACGGTCGCGAGCTCGTGGACGGCATCGCTTCCTGGTGGACCGCCGTGC
ACGGCTACAATCACCCGCACATAGCGGGCGCGGTGGCCGAGCAGCTCGCGCGCATGCCCCACGTGATGTTCGGCGGCCTC
ACCCACGCGCCGGCGGAGGCACTGGCCCGGCGGCTCGCCGCCCTGCTGCCGGGCGATCTCGACCACGTCTTCCTCAGCGA
TTCGGGCTCGGTCGCCGTGGAGGTCGCGCTCAAGATGGCGGCGCAGATGTGGATCAACCGCGGGGTGAGCGGTCGGACGA
AGGTCCTCGCGTTCCGCGGCGGCTACCACGGCGACACGATGGGGGCGATGTCCGTCTGCGACCCCGAGGAGGGCATGCAC
CGCCGGTTCGGAGCCTACCTGCCGAGCCAGATCTTCTGCGACCTGCCGCGGGGCGCGGCCGAGACCGCGGCGCTCGATGC
CGCCCTGGCGGCTTATCGCGACACCCTGGCGGCGGTGATCGTCGAGCCGCTGGTGCAGGGGGCCGGCGGGATGCGGACCC
ACCCGCCGGAGGTGCTCGCGACGATCGCCGGGCTGGCGCGCCGCCACGGCCTGCCGCTGATCGCCGACGAGATCTTCACC
GGCTTCGGGCGCACCGGCACCCTGTTCGCCTGCGAGCAGGCGGGGATCGTGCCCGACATCCTGTGCCTGTCGAAGGCGCT
CACGGGCGGCACGATGGCGCTGGCCGCCACGGTCGCCCGCACGGAGGTGTTCGCGGCGTTCTGGTCCGAGGATCCGGCGG
CGGCGCTGATGCACGGCCCGACCTTCATGGCCAATCCCCTCGCCTGCGCCGCGGCCAACGCCAGCCTCGACCTGTTCGAG
ACCGAGCCGCGCCTGAGCCAGGCCCGCGCCATCGCGGAGCGCCTCGCCGCGGGGCTGGCGCCGCTGCGGCGCGTGCCCGG
CGTGGCGGATGTCCGCGTCCTCGGGGCCATCGGGGCGGTGCAGTTCGCGCGGGCGCCCGACCTGGCCGTCCTGAAGGCGG
AGCTGCTCGCCCGCGGCGTCTGGGTGCGGCCGTTCGGCGACATCGTCTACCTCACCCCCGCCCTCACGATCGACGCGGCG
GATCTCGACCGGCTGATCGAGGCCGTCGCCGGGGTGGTGACCGAGCTGGCGCCGGGATCGACATGA

Upstream 100 bases:

>100_bases
GCTGTCCATGGGGACGGGGATGGGCGGTTCCGCGCCGGCAAAGTCAAGCGGCGGGTGCCGGACCCTTGACCCTCGTCCGA
GGCGCCCCCATGCCGGAGGC

Downstream 100 bases:

>100_bases
CGCCCGCGCGTTCCACATTCCCGTGACCGGCCCTGGCGCCGGCCTGCAACCCGGGACCGTTTCTGCCGTTGGGCCTACGG
CTGGAGATGCGTGCGGCGGC

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MTLATPAGHLWRPYTQMRHAAAPLEAVATHGTRIRLADGRELVDGIASWWTAVHGYNHPHIAGAVAEQLARMPHVMFGGL
THAPAEALARRLAALLPGDLDHVFLSDSGSVAVEVALKMAAQMWINRGVSGRTKVLAFRGGYHGDTMGAMSVCDPEEGMH
RRFGAYLPSQIFCDLPRGAAETAALDAALAAYRDTLAAVIVEPLVQGAGGMRTHPPEVLATIAGLARRHGLPLIADEIFT
GFGRTGTLFACEQAGIVPDILCLSKALTGGTMALAATVARTEVFAAFWSEDPAAALMHGPTFMANPLACAAANASLDLFE
TEPRLSQARAIAERLAAGLAPLRRVPGVADVRVLGAIGAVQFARAPDLAVLKAELLARGVWVRPFGDIVYLTPALTIDAA
DLDRLIEAVAGVVTELAPGST

Sequences:

>Translated_421_residues
MTLATPAGHLWRPYTQMRHAAAPLEAVATHGTRIRLADGRELVDGIASWWTAVHGYNHPHIAGAVAEQLARMPHVMFGGL
THAPAEALARRLAALLPGDLDHVFLSDSGSVAVEVALKMAAQMWINRGVSGRTKVLAFRGGYHGDTMGAMSVCDPEEGMH
RRFGAYLPSQIFCDLPRGAAETAALDAALAAYRDTLAAVIVEPLVQGAGGMRTHPPEVLATIAGLARRHGLPLIADEIFT
GFGRTGTLFACEQAGIVPDILCLSKALTGGTMALAATVARTEVFAAFWSEDPAAALMHGPTFMANPLACAAANASLDLFE
TEPRLSQARAIAERLAAGLAPLRRVPGVADVRVLGAIGAVQFARAPDLAVLKAELLARGVWVRPFGDIVYLTPALTIDAA
DLDRLIEAVAGVVTELAPGST
>Mature_420_residues
TLATPAGHLWRPYTQMRHAAAPLEAVATHGTRIRLADGRELVDGIASWWTAVHGYNHPHIAGAVAEQLARMPHVMFGGLT
HAPAEALARRLAALLPGDLDHVFLSDSGSVAVEVALKMAAQMWINRGVSGRTKVLAFRGGYHGDTMGAMSVCDPEEGMHR
RFGAYLPSQIFCDLPRGAAETAALDAALAAYRDTLAAVIVEPLVQGAGGMRTHPPEVLATIAGLARRHGLPLIADEIFTG
FGRTGTLFACEQAGIVPDILCLSKALTGGTMALAATVARTEVFAAFWSEDPAAALMHGPTFMANPLACAAANASLDLFET
EPRLSQARAIAERLAAGLAPLRRVPGVADVRVLGAIGAVQFARAPDLAVLKAELLARGVWVRPFGDIVYLTPALTIDAAD
LDRLIEAVAGVVTELAPGST

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=428, Percent_Identity=26.1682242990654, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI4557809, Length=418, Percent_Identity=27.9904306220096, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI284507298, Length=318, Percent_Identity=30.188679245283, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI37574042, Length=384, Percent_Identity=24.21875, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI226442709, Length=331, Percent_Identity=24.773413897281, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI226442705, Length=375, Percent_Identity=24.2666666666667, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786991, Length=420, Percent_Identity=51.1904761904762, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI145693181, Length=380, Percent_Identity=34.2105263157895, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1789016, Length=420, Percent_Identity=31.6666666666667, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1787560, Length=393, Percent_Identity=31.8066157760814, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789759, Length=410, Percent_Identity=32.9268292682927, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788044, Length=411, Percent_Identity=31.8734793187348, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786349, Length=328, Percent_Identity=32.0121951219512, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=409, Percent_Identity=26.161369193154, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=462, Percent_Identity=25.1082251082251, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25144274, Length=309, Percent_Identity=27.1844660194175, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71992977, Length=401, Percent_Identity=24.1895261845387, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=453, Percent_Identity=34.878587196468, Blast_Score=289, Evalue=4e-79,
Organism=Saccharomyces cerevisiae, GI6323470, Length=431, Percent_Identity=26.6821345707657, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=29.6296296296296, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28574759, Length=454, Percent_Identity=27.5330396475771, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI161085790, Length=442, Percent_Identity=27.6018099547511, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21357415, Length=408, Percent_Identity=25.2450980392157, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356575, Length=437, Percent_Identity=25.1716247139588, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 44209; Mature: 44077

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLATPAGHLWRPYTQMRHAAAPLEAVATHGTRIRLADGRELVDGIASWWTAVHGYNHPH
CCCCCCCCHHCCCHHHHHHHHCCHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCH
IAGAVAEQLARMPHVMFGGLTHAPAEALARRLAALLPGDLDHVFLSDSGSVAVEVALKMA
HHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHH
AQMWINRGVSGRTKVLAFRGGYHGDTMGAMSVCDPEEGMHRRFGAYLPSQIFCDLPRGAA
HHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCH
ETAALDAALAAYRDTLAAVIVEPLVQGAGGMRTHPPEVLATIAGLARRHGLPLIADEIFT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
GFGRTGTLFACEQAGIVPDILCLSKALTGGTMALAATVARTEVFAAFWSEDPAAALMHGP
CCCCCCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
TFMANPLACAAANASLDLFETEPRLSQARAIAERLAAGLAPLRRVPGVADVRVLGAIGAV
CHHCCCHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QFARAPDLAVLKAELLARGVWVRPFGDIVYLTPALTIDAADLDRLIEAVAGVVTELAPGS
HHHCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCEECHHHHHHHHHHHHHHHHHCCCCC
T
C
>Mature Secondary Structure 
TLATPAGHLWRPYTQMRHAAAPLEAVATHGTRIRLADGRELVDGIASWWTAVHGYNHPH
CCCCCCCHHCCCHHHHHHHHCCHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCH
IAGAVAEQLARMPHVMFGGLTHAPAEALARRLAALLPGDLDHVFLSDSGSVAVEVALKMA
HHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHH
AQMWINRGVSGRTKVLAFRGGYHGDTMGAMSVCDPEEGMHRRFGAYLPSQIFCDLPRGAA
HHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCH
ETAALDAALAAYRDTLAAVIVEPLVQGAGGMRTHPPEVLATIAGLARRHGLPLIADEIFT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
GFGRTGTLFACEQAGIVPDILCLSKALTGGTMALAATVARTEVFAAFWSEDPAAALMHGP
CCCCCCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
TFMANPLACAAANASLDLFETEPRLSQARAIAERLAAGLAPLRRVPGVADVRVLGAIGAV
CHHCCCHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QFARAPDLAVLKAELLARGVWVRPFGDIVYLTPALTIDAADLDRLIEAVAGVVTELAPGS
HHHCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCEECHHHHHHHHHHHHHHHHHCCCCC
T
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8890743 [H]