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The map label for this gene is gyaR [H]

Identifier: 170747197

GI number: 170747197

Start: 805230

End: 806195

Strand: Reverse

Name: gyaR [H]

Synonym: Mrad2831_0763

Alternate gene names: 170747197

Gene position: 806195-805230 (Counterclockwise)

Preceding gene: 170747199

Following gene: 170747196

Centisome position: 13.26

GC content: 73.5

Gene sequence:

>966_bases
ATGGCTGAGGCCCCGGCAGAGATCCTGTTGCTCCGGAAGATGCACCCGCTCGTGGAGAAAGCCTTCGACGGACGGTACGG
GGTCCACCGGCTGGCGGAGGCCGCGGACCCGGAGGCTCTGCTCGCCGAGATCGGCCCGCGGATCCGCGCGCTCTGCGTCG
GCGGCGCGGTGGACGGGGCGCTGATGGACCGGCTGCCGAACCTCGAGCTGATCGCGAATTTCGGCGTGGGCTACGATGCC
GTCGACGCCGCCGGAGCGCGGCAGCGCGGCATCGTCGTCACCAACACGCCGGACGTGCTCACCGACGAGGTCGCCGACCT
CGCCCTCGGCCTCGTCCTCGCCACCCTGCGGCGGATCCCGCAGGCCGACCGCTACCTGCGCGACGGCCACTGGCCCAAGG
CGCCCTTCCCGCTCACGGCGTCCCTGCGCGGGCGGCGGGTCGGCATCCTCGGGCTCGGCCGGATCGGGCGGGCGATCGCC
CGCCGGCTGGAGAGCTTCGGCGTCGAGATCGACTATCACGGCCGCAGCCGGCAGGCGGACGTGCCCTACACGTATCACGA
CACGCTGCTCGGCCTCGCCCGCGCGGTCCACATCCTGATCGTGGTGGCGCCCGGCGGCGCCGACACGCGCAACCTCGTGA
ACGCGGCCGTGCTGGAGGCGCTCGGTCCCGAGGGCATCCTGATCAACGTCGCCCGCGGCACCCTCGTCGACGAGGCGGCG
CTGACCGCGGCGCTGCGGGCCGGTACGATCCTCGGCGCCGGCCTCGACGTGTTCGAGAACGAGCCGCACGTGCCCGCGGA
TCTCGCCGCCCTCGACAACACGGTGCTGCTGCCGCATGTCGGGTCGGCCTCCGAGCACACCCGCGCGGCGATGGCCCAGC
TCGTCGTCGACAACGTCGTCTCGTGGTTCGAGGGGCGGGGTCCGCTGACGCCCGTGGCCGAGACCCCCTGGAGACCCACC
GCGTGA

Upstream 100 bases:

>100_bases
GCGGCGGCTCCGACGCGCTGGCGCGCCACCCCGCACAGGCTCTATGCCGGGACGGGGGAGGCGGCCGGCACCGACGAACG
GCCGAACGTGGGAGTGAACG

Downstream 100 bases:

>100_bases
GACAGGCTCAGGCCGCCCTGCTGACCGCGTCGGCACTGATCGCGACCGCCGCGATCGTCCGGCCGGCCGCCGCCCAGGAC
GTGCCCGACGCGACCGACCT

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MAEAPAEILLLRKMHPLVEKAFDGRYGVHRLAEAADPEALLAEIGPRIRALCVGGAVDGALMDRLPNLELIANFGVGYDA
VDAAGARQRGIVVTNTPDVLTDEVADLALGLVLATLRRIPQADRYLRDGHWPKAPFPLTASLRGRRVGILGLGRIGRAIA
RRLESFGVEIDYHGRSRQADVPYTYHDTLLGLARAVHILIVVAPGGADTRNLVNAAVLEALGPEGILINVARGTLVDEAA
LTAALRAGTILGAGLDVFENEPHVPADLAALDNTVLLPHVGSASEHTRAAMAQLVVDNVVSWFEGRGPLTPVAETPWRPT
A

Sequences:

>Translated_321_residues
MAEAPAEILLLRKMHPLVEKAFDGRYGVHRLAEAADPEALLAEIGPRIRALCVGGAVDGALMDRLPNLELIANFGVGYDA
VDAAGARQRGIVVTNTPDVLTDEVADLALGLVLATLRRIPQADRYLRDGHWPKAPFPLTASLRGRRVGILGLGRIGRAIA
RRLESFGVEIDYHGRSRQADVPYTYHDTLLGLARAVHILIVVAPGGADTRNLVNAAVLEALGPEGILINVARGTLVDEAA
LTAALRAGTILGAGLDVFENEPHVPADLAALDNTVLLPHVGSASEHTRAAMAQLVVDNVVSWFEGRGPLTPVAETPWRPT
A
>Mature_320_residues
AEAPAEILLLRKMHPLVEKAFDGRYGVHRLAEAADPEALLAEIGPRIRALCVGGAVDGALMDRLPNLELIANFGVGYDAV
DAAGARQRGIVVTNTPDVLTDEVADLALGLVLATLRRIPQADRYLRDGHWPKAPFPLTASLRGRRVGILGLGRIGRAIAR
RLESFGVEIDYHGRSRQADVPYTYHDTLLGLARAVHILIVVAPGGADTRNLVNAAVLEALGPEGILINVARGTLVDEAAL
TAALRAGTILGAGLDVFENEPHVPADLAALDNTVLLPHVGSASEHTRAAMAQLVVDNVVSWFEGRGPLTPVAETPWRPTA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=247, Percent_Identity=37.6518218623482, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI23308577, Length=281, Percent_Identity=30.9608540925267, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI145580578, Length=261, Percent_Identity=30.2681992337165, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4557499, Length=261, Percent_Identity=30.2681992337165, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI61743967, Length=266, Percent_Identity=30.8270676691729, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI4557497, Length=266, Percent_Identity=30.8270676691729, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI145580575, Length=263, Percent_Identity=30.4182509505703, Blast_Score=101, Evalue=9e-22,
Organism=Escherichia coli, GI87082289, Length=260, Percent_Identity=35.7692307692308, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1789279, Length=252, Percent_Identity=30.5555555555556, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787645, Length=287, Percent_Identity=24.7386759581882, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081824, Length=299, Percent_Identity=25.752508361204, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=242, Percent_Identity=31.8181818181818, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25147481, Length=277, Percent_Identity=24.5487364620939, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324055, Length=282, Percent_Identity=36.1702127659575, Blast_Score=162, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322116, Length=311, Percent_Identity=27.3311897106109, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321253, Length=274, Percent_Identity=28.4671532846715, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=311, Percent_Identity=26.0450160771704, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325144, Length=288, Percent_Identity=25.6944444444444, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324964, Length=272, Percent_Identity=23.8970588235294, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28571528, Length=258, Percent_Identity=40.6976744186046, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI45552429, Length=257, Percent_Identity=35.408560311284, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24585514, Length=257, Percent_Identity=35.408560311284, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574282, Length=257, Percent_Identity=35.408560311284, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45551003, Length=257, Percent_Identity=35.0194552529183, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574284, Length=257, Percent_Identity=35.408560311284, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574286, Length=257, Percent_Identity=34.6303501945525, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24585516, Length=252, Percent_Identity=32.5396825396825, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646446, Length=249, Percent_Identity=30.1204819277108, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646448, Length=249, Percent_Identity=30.1204819277108, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646452, Length=249, Percent_Identity=30.1204819277108, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646450, Length=249, Percent_Identity=30.1204819277108, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI62472511, Length=254, Percent_Identity=29.5275590551181, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19921140, Length=251, Percent_Identity=27.4900398406374, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34096; Mature: 33964

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAPAEILLLRKMHPLVEKAFDGRYGVHRLAEAADPEALLAEIGPRIRALCVGGAVDGA
CCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCHHEEEEECCCCCHH
LMDRLPNLELIANFGVGYDAVDAAGARQRGIVVTNTPDVLTDEVADLALGLVLATLRRIP
HHHHCCCEEEEEECCCCCCHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
QADRYLRDGHWPKAPFPLTASLRGRRVGILGLGRIGRAIARRLESFGVEIDYHGRSRQAD
HHHHHHHCCCCCCCCCCEECCCCCCEEEEEECHHHHHHHHHHHHHHCCEEEECCCCCCCC
VPYTYHDTLLGLARAVHILIVVAPGGADTRNLVNAAVLEALGPEGILINVARGTLVDEAA
CCCHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
LTAALRAGTILGAGLDVFENEPHVPADLAALDNTVLLPHVGSASEHTRAAMAQLVVDNVV
HHHHHHHHHHHCCCCHHHCCCCCCCHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHH
SWFEGRGPLTPVAETPWRPTA
HHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AEAPAEILLLRKMHPLVEKAFDGRYGVHRLAEAADPEALLAEIGPRIRALCVGGAVDGA
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCHHEEEEECCCCCHH
LMDRLPNLELIANFGVGYDAVDAAGARQRGIVVTNTPDVLTDEVADLALGLVLATLRRIP
HHHHCCCEEEEEECCCCCCHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
QADRYLRDGHWPKAPFPLTASLRGRRVGILGLGRIGRAIARRLESFGVEIDYHGRSRQAD
HHHHHHHCCCCCCCCCCEECCCCCCEEEEEECHHHHHHHHHHHHHHCCEEEECCCCCCCC
VPYTYHDTLLGLARAVHILIVVAPGGADTRNLVNAAVLEALGPEGILINVARGTLVDEAA
CCCHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
LTAALRAGTILGAGLDVFENEPHVPADLAALDNTVLLPHVGSASEHTRAAMAQLVVDNVV
HHHHHHHHHHHCCCCHHHCCCCCCCHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHH
SWFEGRGPLTPVAETPWRPTA
HHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA