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The map label for this gene is torA [H]

Identifier: 170684290

GI number: 170684290

Start: 2134828

End: 2137374

Strand: Reverse

Name: torA [H]

Synonym: EcSMS35_2127

Alternate gene names: 170684290

Gene position: 2137374-2134828 (Counterclockwise)

Preceding gene: 170680538

Following gene: 170680043

Centisome position: 42.17

GC content: 55.05

Gene sequence:

>2547_bases
ATGAACAATAACGATCTCTTTCAGGCATCACGTCGGCGTTTTCTGGCACAACTCGGCGGCTTAACCGTCGCCGGGATGCT
GGGGCCGTCATTGTTAACGCCGCGCCGTGCGACTGCGGCGCAAGCGGCGACTGAGGCTGTCATCTCGAAAGAGGGCATTC
TTACCGGGTCGCACTGGGGGGCTATCCGCGCGACGGTGAAGGATGGTCGCTTTGTGGCGGCAAAACCGTTCGAACTGGAT
AAATATCCGTCGAAAATGATTGCCGGATTGCCGGATCACGTACACAACGCGGCGCGTATTCGTTACCCGATGGTACGCGT
GGACTGGCTACGTAAGCGCCATCTGAGCGACACTTCCCAGCGCGGTGATAACCGTTTTGTGCGCGTGAGCTGGGATGAAG
CCCTCGACATGTTCTATGAAGAACTGGAACGCGTACAGAAAACTCACGGGCCGAGTGCCTTGCTGACCGCCAGTGGTTGG
CAATCGACGGGGATGTTCCATAACGCTTCGGGGATGCTGGCGAAAGCTATTGCCTTGCATGGTAATAGCGTTGGTACGGG
CGGAGATTACTCTACCGGTGCTGCGCAGGTGATCCTGCCGCGCGTGGTTGGCTCAATGGAAGTGTATGAACAGCAAACCT
CCTGGCCGCTGGTATTGCAGAACAGCAAAACCATTGTGCTGTGGGGCTCTGATTTGCTGAAAAACCAGCAAGCGAACTGG
TGGTGCCCGGATCACGATGTTTATGAATATTACGCGCAGTTGAAAGCGAAAGTCGCCGCCGGTGAAATTGAGGTCATCAG
CATCGATCCGGTTGTCACATCCACCCATGAGTATCTGGGGCGCGAGCATGTGAAGCACATTGCTGTTAACCCGCAAACTG
ACGTGCCACTGCAACTGGCGCTGGCGTATACGCTGTACAGTGAAAACCTGTACGACAAAAACTTCCTCGCTAACTACTGT
GTGGGGTTTGAGCAGTTCCTGCCGTATCTGCTGGGTGAGAAAGACGGTCAGCCGAAAGATGCCGCATGGGCTGAAAAACT
GACCGGCATTGATGCCGAAACCATTCGTGGGCTGGCGCGGCAGATGGCGGCGAACAGAACGCAGATTATTGCTGGCTGGT
GCGTACAGCGTATGCAGCACGGTGAACAGTGGGCGTGGATGATTGTCGTTCTGGCGGCGATGCTGGGGCAAATTGGCCTG
CCAGGTGGTGGCTTTGGTTTTGGCTGGCACTATAACGGCGCAGGCACGCCGGGGCGTAAAGGCGTTATTCTGAGTGGTTT
CTCCGGCTCTACGTCGATTTCGCCTGTTCACGACAACAGTGATTACAAAGGTTACAGCAGCACCATTCCGATTGCCCGTT
TTATCGATGCGATCCTCGAACCGGGGAAAGTGATCAACTGGAACGGTAAATCGGTAAAACTGCCGCCGCTGAAAATGTGT
ATTTTTGCCGGAACTAACCCGTTCCATCGCCATCAGCAGATCAACCGCATTATTGAAGGCTGGCGCAAGCTGGAAACGGT
TATCGCCATAGATAACCAGTGGACCTCAACCTGCCGCTTTGCCGATATCGTACTGCCTGCGACCACGCAGTTTGAGCGTA
ACGATCTCGACCAGTACGGTAACCACTCTAACCGTGGCATTATCGCCATGAAACAGGTCGTGCCGCCGCAGTTTGAGGCG
CGCAACGACTTTGATATTTTCCGCGAGCTGTGCCGTCGCTTTAATCGCGAAGAAGCCTTTACCGAAGGGCTGGACGAAAT
GGGCTGGCTGAAACGCATCTGGCAGGAAGGTGTACAACAGGGCAAAGGACGCGGCGTTCATCTGCCAGCGTTTGATGACT
TCTGGAATAACAAAGAGTATGTCGAGTTTGACCATCCGCAGATGTTTGTTCGCCACCAGGCATTCCGCGAAGATCCGGAT
CTCGAACCGCTGGGCACGCCGAGTGGCCTGATTGAGATCTACTCGAAAACCATCGCCGATATGAACTACGACGATTGTCA
GGGGCATCCGATGTGGTTTGAGAAAATCGAACGCTCCCACGGCGGGCCCGGCTCGCAGAAGTATCCGTTGCATCTGCAAT
CTGTGCATCCGGATTTCCGACTTCACTCGCAGTTATGTGAGTCGGAAACTCTGCGTCAGCAATATACGGTAGCGGGTAAA
GAGCCAGTGTTCATTAACCCGCAGGATGCCAGCGCGCGCGGTATTCGTAACGGTGATGTGGTACGCGTCTTTAACGCTCG
CGGTCAGGTGTTGGCTGGGGCAGTGGTTTCTGACCGCTATGCACCCGGCGTGGCACGAATTCATGAAGGGGCATGGTACG
ATCCAGATAAAGGCGGCGAGCCTGGTGCGCTGTGCAAATACGGTAATCCCAACGTGTTGACCATTGACATCGGTACTTCG
CAGTTGGCGCAGGCGACCAGTGCGCACACTACGCTGGTGGAAATTGAGAAGTACAACGGAACAGTGGAGCAGGTAACGGC
GTTTAACGGCCCCGTGGAGATGGTGGCGCAGTGTGAATATGTTCCCGCGTCGCAGGTGAAATCATGA

Upstream 100 bases:

>100_bases
GCCTCGATAAACGTGAAGAACGCACCTTGTTGAAATATCTGCAAATGAATGCGTCTGATACCGCAGGTAAGGCTCACGGC
GATAAGAAGGAAGAAAAATA

Downstream 100 bases:

>100_bases
CCACGCTGACAGCACAACAGATTGCCTGTGTTTACGCCTGGCTGGCGCAGTTGTTCTCCCGTGAACTGGACGATGAACAA
CTGACGCAAATCGCCAGTGC

Product: trimethylamine-N-oxide reductase

Products: NA

Alternate protein names: TMAO reductase 1; Trimethylamine oxidase 1 [H]

Number of amino acids: Translated: 848; Mature: 848

Protein sequence:

>848_residues
MNNNDLFQASRRRFLAQLGGLTVAGMLGPSLLTPRRATAAQAATEAVISKEGILTGSHWGAIRATVKDGRFVAAKPFELD
KYPSKMIAGLPDHVHNAARIRYPMVRVDWLRKRHLSDTSQRGDNRFVRVSWDEALDMFYEELERVQKTHGPSALLTASGW
QSTGMFHNASGMLAKAIALHGNSVGTGGDYSTGAAQVILPRVVGSMEVYEQQTSWPLVLQNSKTIVLWGSDLLKNQQANW
WCPDHDVYEYYAQLKAKVAAGEIEVISIDPVVTSTHEYLGREHVKHIAVNPQTDVPLQLALAYTLYSENLYDKNFLANYC
VGFEQFLPYLLGEKDGQPKDAAWAEKLTGIDAETIRGLARQMAANRTQIIAGWCVQRMQHGEQWAWMIVVLAAMLGQIGL
PGGGFGFGWHYNGAGTPGRKGVILSGFSGSTSISPVHDNSDYKGYSSTIPIARFIDAILEPGKVINWNGKSVKLPPLKMC
IFAGTNPFHRHQQINRIIEGWRKLETVIAIDNQWTSTCRFADIVLPATTQFERNDLDQYGNHSNRGIIAMKQVVPPQFEA
RNDFDIFRELCRRFNREEAFTEGLDEMGWLKRIWQEGVQQGKGRGVHLPAFDDFWNNKEYVEFDHPQMFVRHQAFREDPD
LEPLGTPSGLIEIYSKTIADMNYDDCQGHPMWFEKIERSHGGPGSQKYPLHLQSVHPDFRLHSQLCESETLRQQYTVAGK
EPVFINPQDASARGIRNGDVVRVFNARGQVLAGAVVSDRYAPGVARIHEGAWYDPDKGGEPGALCKYGNPNVLTIDIGTS
QLAQATSAHTTLVEIEKYNGTVEQVTAFNGPVEMVAQCEYVPASQVKS

Sequences:

>Translated_848_residues
MNNNDLFQASRRRFLAQLGGLTVAGMLGPSLLTPRRATAAQAATEAVISKEGILTGSHWGAIRATVKDGRFVAAKPFELD
KYPSKMIAGLPDHVHNAARIRYPMVRVDWLRKRHLSDTSQRGDNRFVRVSWDEALDMFYEELERVQKTHGPSALLTASGW
QSTGMFHNASGMLAKAIALHGNSVGTGGDYSTGAAQVILPRVVGSMEVYEQQTSWPLVLQNSKTIVLWGSDLLKNQQANW
WCPDHDVYEYYAQLKAKVAAGEIEVISIDPVVTSTHEYLGREHVKHIAVNPQTDVPLQLALAYTLYSENLYDKNFLANYC
VGFEQFLPYLLGEKDGQPKDAAWAEKLTGIDAETIRGLARQMAANRTQIIAGWCVQRMQHGEQWAWMIVVLAAMLGQIGL
PGGGFGFGWHYNGAGTPGRKGVILSGFSGSTSISPVHDNSDYKGYSSTIPIARFIDAILEPGKVINWNGKSVKLPPLKMC
IFAGTNPFHRHQQINRIIEGWRKLETVIAIDNQWTSTCRFADIVLPATTQFERNDLDQYGNHSNRGIIAMKQVVPPQFEA
RNDFDIFRELCRRFNREEAFTEGLDEMGWLKRIWQEGVQQGKGRGVHLPAFDDFWNNKEYVEFDHPQMFVRHQAFREDPD
LEPLGTPSGLIEIYSKTIADMNYDDCQGHPMWFEKIERSHGGPGSQKYPLHLQSVHPDFRLHSQLCESETLRQQYTVAGK
EPVFINPQDASARGIRNGDVVRVFNARGQVLAGAVVSDRYAPGVARIHEGAWYDPDKGGEPGALCKYGNPNVLTIDIGTS
QLAQATSAHTTLVEIEKYNGTVEQVTAFNGPVEMVAQCEYVPASQVKS
>Mature_848_residues
MNNNDLFQASRRRFLAQLGGLTVAGMLGPSLLTPRRATAAQAATEAVISKEGILTGSHWGAIRATVKDGRFVAAKPFELD
KYPSKMIAGLPDHVHNAARIRYPMVRVDWLRKRHLSDTSQRGDNRFVRVSWDEALDMFYEELERVQKTHGPSALLTASGW
QSTGMFHNASGMLAKAIALHGNSVGTGGDYSTGAAQVILPRVVGSMEVYEQQTSWPLVLQNSKTIVLWGSDLLKNQQANW
WCPDHDVYEYYAQLKAKVAAGEIEVISIDPVVTSTHEYLGREHVKHIAVNPQTDVPLQLALAYTLYSENLYDKNFLANYC
VGFEQFLPYLLGEKDGQPKDAAWAEKLTGIDAETIRGLARQMAANRTQIIAGWCVQRMQHGEQWAWMIVVLAAMLGQIGL
PGGGFGFGWHYNGAGTPGRKGVILSGFSGSTSISPVHDNSDYKGYSSTIPIARFIDAILEPGKVINWNGKSVKLPPLKMC
IFAGTNPFHRHQQINRIIEGWRKLETVIAIDNQWTSTCRFADIVLPATTQFERNDLDQYGNHSNRGIIAMKQVVPPQFEA
RNDFDIFRELCRRFNREEAFTEGLDEMGWLKRIWQEGVQQGKGRGVHLPAFDDFWNNKEYVEFDHPQMFVRHQAFREDPD
LEPLGTPSGLIEIYSKTIADMNYDDCQGHPMWFEKIERSHGGPGSQKYPLHLQSVHPDFRLHSQLCESETLRQQYTVAGK
EPVFINPQDASARGIRNGDVVRVFNARGQVLAGAVVSDRYAPGVARIHEGAWYDPDKGGEPGALCKYGNPNVLTIDIGTS
QLAQATSAHTTLVEIEKYNGTVEQVTAFNGPVEMVAQCEYVPASQVKS

Specific function: Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787231, Length=848, Percent_Identity=99.5283018867924, Blast_Score=1761, Evalue=0.0,
Organism=Escherichia coli, GI87081994, Length=828, Percent_Identity=44.2028985507246, Blast_Score=669, Evalue=0.0,
Organism=Escherichia coli, GI145693196, Length=790, Percent_Identity=42.6582278481013, Blast_Score=612, Evalue=1e-176,
Organism=Escherichia coli, GI87081797, Length=760, Percent_Identity=32.1052631578947, Blast_Score=301, Evalue=1e-82,
Organism=Escherichia coli, GI1787870, Length=864, Percent_Identity=29.0509259259259, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI171474008, Length=751, Percent_Identity=29.8268974700399, Blast_Score=259, Evalue=4e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655
- InterPro:   IPR006311
- InterPro:   IPR011887 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.7.2.3 [H]

Molecular weight: Translated: 94560; Mature: 94560

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNDLFQASRRRFLAQLGGLTVAGMLGPSLLTPRRATAAQAATEAVISKEGILTGSHWG
CCCCHHHHHHHHHHHHHHCCCEEEHHCCCHHCCCCHHHHHHHHHHHHHHHCCEEECCCCC
AIRATVKDGRFVAAKPFELDKYPSKMIAGLPDHVHNAARIRYPMVRVDWLRKRHLSDTSQ
EEEEEECCCEEEEECCCCCCCCHHHHHHCCCHHHCCHHHHCCCHHHHHHHHHHHCCCHHH
RGDNRFVRVSWDEALDMFYEELERVQKTHGPSALLTASGWQSTGMFHNASGMLAKAIALH
CCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEECCCCHHHHHHHHC
GNSVGTGGDYSTGAAQVILPRVVGSMEVYEQQTSWPLVLQNSKTIVLWGSDLLKNQQANW
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEECHHHHCCCCCCC
WCPDHDVYEYYAQLKAKVAAGEIEVISIDPVVTSTHEYLGREHVKHIAVNPQTDVPLQLA
CCCCCHHHHHHHHHHHHEECCEEEEEEECCCHHHHHHHHHHHHHHEEECCCCCCCCHHHH
LAYTLYSENLYDKNFLANYCVGFEQFLPYLLGEKDGQPKDAAWAEKLTGIDAETIRGLAR
HHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
QMAANRTQIIAGWCVQRMQHGEQWAWMIVVLAAMLGQIGLPGGGFGFGWHYNGAGTPGRK
HHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCC
GVILSGFSGSTSISPVHDNSDYKGYSSTIPIARFIDAILEPGKVINWNGKSVKLPPLKMC
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCEEECCCEEEE
IFAGTNPFHRHQQINRIIEGWRKLETVIAIDNQWTSTCRFADIVLPATTQFERNDLDQYG
EEECCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEEECCCCCCCHHCHHHHC
NHSNRGIIAMKQVVPPQFEARNDFDIFRELCRRFNREEAFTEGLDEMGWLKRIWQEGVQQ
CCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHHH
GKGRGVHLPAFDDFWNNKEYVEFDHPQMFVRHQAFREDPDLEPLGTPSGLIEIYSKTIAD
CCCCEEECCCHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHC
MNYDDCQGHPMWFEKIERSHGGPGSQKYPLHLQSVHPDFRLHSQLCESETLRQQYTVAGK
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
EPVFINPQDASARGIRNGDVVRVFNARGQVLAGAVVSDRYAPGVARIHEGAWYDPDKGGE
CCEEECCCCCCCCCCCCCCEEEEECCCCCEEECHHHHCCCCCCHHHHCCCCCCCCCCCCC
PGALCKYGNPNVLTIDIGTSQLAQATSAHTTLVEIEKYNGTVEQVTAFNGPVEMVAQCEY
CCCEEECCCCCEEEEECCHHHHHHHHCCCEEEEEEECCCCCHHHHHHCCCCHHHHHHCCC
VPASQVKS
CCHHHCCC
>Mature Secondary Structure
MNNNDLFQASRRRFLAQLGGLTVAGMLGPSLLTPRRATAAQAATEAVISKEGILTGSHWG
CCCCHHHHHHHHHHHHHHCCCEEEHHCCCHHCCCCHHHHHHHHHHHHHHHCCEEECCCCC
AIRATVKDGRFVAAKPFELDKYPSKMIAGLPDHVHNAARIRYPMVRVDWLRKRHLSDTSQ
EEEEEECCCEEEEECCCCCCCCHHHHHHCCCHHHCCHHHHCCCHHHHHHHHHHHCCCHHH
RGDNRFVRVSWDEALDMFYEELERVQKTHGPSALLTASGWQSTGMFHNASGMLAKAIALH
CCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEECCCCHHHHHHHHC
GNSVGTGGDYSTGAAQVILPRVVGSMEVYEQQTSWPLVLQNSKTIVLWGSDLLKNQQANW
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEECHHHHCCCCCCC
WCPDHDVYEYYAQLKAKVAAGEIEVISIDPVVTSTHEYLGREHVKHIAVNPQTDVPLQLA
CCCCCHHHHHHHHHHHHEECCEEEEEEECCCHHHHHHHHHHHHHHEEECCCCCCCCHHHH
LAYTLYSENLYDKNFLANYCVGFEQFLPYLLGEKDGQPKDAAWAEKLTGIDAETIRGLAR
HHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
QMAANRTQIIAGWCVQRMQHGEQWAWMIVVLAAMLGQIGLPGGGFGFGWHYNGAGTPGRK
HHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCC
GVILSGFSGSTSISPVHDNSDYKGYSSTIPIARFIDAILEPGKVINWNGKSVKLPPLKMC
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCEEECCCEEEE
IFAGTNPFHRHQQINRIIEGWRKLETVIAIDNQWTSTCRFADIVLPATTQFERNDLDQYG
EEECCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEEECCCCCCCHHCHHHHC
NHSNRGIIAMKQVVPPQFEARNDFDIFRELCRRFNREEAFTEGLDEMGWLKRIWQEGVQQ
CCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHHH
GKGRGVHLPAFDDFWNNKEYVEFDHPQMFVRHQAFREDPDLEPLGTPSGLIEIYSKTIAD
CCCCEEECCCHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHC
MNYDDCQGHPMWFEKIERSHGGPGSQKYPLHLQSVHPDFRLHSQLCESETLRQQYTVAGK
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
EPVFINPQDASARGIRNGDVVRVFNARGQVLAGAVVSDRYAPGVARIHEGAWYDPDKGGE
CCEEECCCCCCCCCCCCCCEEEEECCCCCEEECHHHHCCCCCCHHHHCCCCCCCCCCCCC
PGALCKYGNPNVLTIDIGTSQLAQATSAHTTLVEIEKYNGTVEQVTAFNGPVEMVAQCEY
CCCEEECCCCCEEEEECCHHHHHHHHCCCEEEEEEECCCCCHHHHHHCCCCHHHHHHCCC
VPASQVKS
CCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]