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The map label for this gene is envR [H]

Identifier: 170683693

GI number: 170683693

Start: 3640203

End: 3640865

Strand: Reverse

Name: envR [H]

Synonym: EcSMS35_3559

Alternate gene names: 170683693

Gene position: 3640865-3640203 (Counterclockwise)

Preceding gene: 170681761

Following gene: 170679868

Centisome position: 71.83

GC content: 43.29

Gene sequence:

>663_bases
ATGGCAAAAAGAACCAAAGCCGAAGCTCTGAAGACCCGGCAAGAACTGATTGAAACTGCCATCGCCCAGTTTGCGCAACA
TGGCGTAAGCAAGACGACGCTCAACGACATTGCCGATGCCGCTAACGTTACGCGTGGCGCTATCTACTGGCACTTCGAGA
ACAAGACCCAACTGTTTAATGAGATGTGGTTGCAACAGCCTTCATTGCGGGAGTTAATCCAGGAACACTTGACGGCTGGG
TTAGAGCATGACCCGTTTCAACAATTGCGTGAAAAATTGATTGTCGGCTTGCAATATATTGCCAAAATTCCCCGCCAGCA
GGCGTTGCTGAAAATCTTATATCACAAATGTGAATTTAATGATGAGATGCTGGCAGAGGGAGTGATACGCGATAAGATGG
GCTTTAATCCGCAGACTCTCCACGAAGTATTGCAGGCATGTCAGCAACAAGGTTGTATAGCAAATAATCTCGATTTAGAT
GTTGTGATGATTATTATTGATGGTGCCTTCAGCGGAATTGTTCAAAACTGGTTAATGAATATGGCGGGTTATGATCTTTA
TAAACAAGCACCCGCACTGGTCGATAACGTATTAAGAATGTTCATGCCAGATGAAAACATAACGAAATTAATTCATCAAA
CGAATGAATTAAGTGTCATATAA

Upstream 100 bases:

>100_bases
TCAATATTAGCCTCTCGTATAAATACACATTAGGTGATAGATTAACCTTCGCTATTTTCTCACTCTGTGTCGAATATATT
TATTTCCTGAATAATTAATC

Downstream 100 bases:

>100_bases
ATTCACATTCTGTCCTGAAAATTCAGTTCGTCACAGTTAACCAGTTTTAGTGGATTAACTGAGTTCATATTGCGGCATTT
GTCTGTTTCTGTTGCCAGCA

Product: DNA-binding transcriptional regulator EnvR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MAKRTKAEALKTRQELIETAIAQFAQHGVSKTTLNDIADAANVTRGAIYWHFENKTQLFNEMWLQQPSLRELIQEHLTAG
LEHDPFQQLREKLIVGLQYIAKIPRQQALLKILYHKCEFNDEMLAEGVIRDKMGFNPQTLHEVLQACQQQGCIANNLDLD
VVMIIIDGAFSGIVQNWLMNMAGYDLYKQAPALVDNVLRMFMPDENITKLIHQTNELSVI

Sequences:

>Translated_220_residues
MAKRTKAEALKTRQELIETAIAQFAQHGVSKTTLNDIADAANVTRGAIYWHFENKTQLFNEMWLQQPSLRELIQEHLTAG
LEHDPFQQLREKLIVGLQYIAKIPRQQALLKILYHKCEFNDEMLAEGVIRDKMGFNPQTLHEVLQACQQQGCIANNLDLD
VVMIIIDGAFSGIVQNWLMNMAGYDLYKQAPALVDNVLRMFMPDENITKLIHQTNELSVI
>Mature_219_residues
AKRTKAEALKTRQELIETAIAQFAQHGVSKTTLNDIADAANVTRGAIYWHFENKTQLFNEMWLQQPSLRELIQEHLTAGL
EHDPFQQLREKLIVGLQYIAKIPRQQALLKILYHKCEFNDEMLAEGVIRDKMGFNPQTLHEVLQACQQQGCIANNLDLDV
VMIIIDGAFSGIVQNWLMNMAGYDLYKQAPALVDNVLRMFMPDENITKLIHQTNELSVI

Specific function: Potential regulator protein for the acrEF/envCD genes [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789664, Length=220, Percent_Identity=98.1818181818182, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1786669, Length=204, Percent_Identity=38.2352941176471, Blast_Score=136, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 25161; Mature: 25030

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRTKAEALKTRQELIETAIAQFAQHGVSKTTLNDIADAANVTRGAIYWHFENKTQLFN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCEEEEEECCHHHHHH
EMWLQQPSLRELIQEHLTAGLEHDPFQQLREKLIVGLQYIAKIPRQQALLKILYHKCEFN
HHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
DEMLAEGVIRDKMGFNPQTLHEVLQACQQQGCIANNLDLDVVMIIIDGAFSGIVQNWLMN
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MAGYDLYKQAPALVDNVLRMFMPDENITKLIHQTNELSVI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AKRTKAEALKTRQELIETAIAQFAQHGVSKTTLNDIADAANVTRGAIYWHFENKTQLFN
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCEEEEEECCHHHHHH
EMWLQQPSLRELIQEHLTAGLEHDPFQQLREKLIVGLQYIAKIPRQQALLKILYHKCEFN
HHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
DEMLAEGVIRDKMGFNPQTLHEVLQACQQQGCIANNLDLDVVMIIIDGAFSGIVQNWLMN
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MAGYDLYKQAPALVDNVLRMFMPDENITKLIHQTNELSVI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]