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The map label for this gene is yqeF [H]

Identifier: 170680410

GI number: 170680410

Start: 3073044

End: 3074225

Strand: Reverse

Name: yqeF [H]

Synonym: EcSMS35_2992

Alternate gene names: 170680410

Gene position: 3074225-3073044 (Counterclockwise)

Preceding gene: 170683156

Following gene: 170680558

Centisome position: 60.65

GC content: 53.47

Gene sequence:

>1182_bases
ATGAAAGACGTTGTGATTGTCGGGGCGTTACGGACACCTATCGGCTGCTTTCGTGGTGCGTTAGCGGGTCATTCCGCCGT
GGAACTTGGCAGCCTGGTCGTGAAAGCGTTAATAGAACGTACCGGTGTTCCTGCATATGCGGTGGATGAAGTGATTCTTG
GTCAGGTGTTGACTGCAGGGGCAGGGCAGAATCCGGCAAGGCAATCGGCTATTAAAGGTGGTCTTCCTAACAGCGTTTCT
GCAATCACTATTAATGACGTTTGCGGTTCCGGGCTTAAAGCACTGCATCTGGCTACTCAGGCGATACAGTGTGGCGAGGC
TGATATTGTCATCGCCGGTGGCCAGGAAAACATGAGCCGCGCACCACATGTTCTGACTGATAGCCGCACCGGTGCACAGC
TTGGCAATAGCCAGTTGGTTGATAGTCTTGTGCACGATGGGTTGTGGGATGCCTTCAATGATTATCATATTGGTGTCACC
GCCGAAAATCTGGCTCGCGAATATGGCATCAGCCGTCAGTTGCAGGATGCTTACGCACTTAGCTCGCAACAAAAAGCGCG
AGCGGCGATTGACGCCGGACGATTTAAAGATGAGATCGTCCCGGTAATGACCCAAAGTAACGGTCAGACGTTGGTTGTAG
ATACCGATGAACAGCCACGCACTGACGCCAGTGCAGAAGGCTTAGCCCGTTTAAATCCTTCATTTGATAGTCTCGGCTCT
GTGACAGCGGGTAATGCATCATCCATAAACGATGGCGCAGCTGCAGTAATGATGATGAGCGAAGCCAAAGCACGAGCGTT
GAATTTACCCGTGCTGGCCCGCATCCGCGCATTTGCCAGCGTTGGTGTAGATCCGGCATTGATGGGAATTGCGCCGGTGT
ATGCGACCCGCCGTTGCCTGGAGCGTGTTGGCTGGCAGTTGGCTGATGTCGATCTTATCGAGGCTAATGAAGCGTTTGCT
GCACAGGCGCTTTCGGTTGGCAAGATGCTTGAATGGGATGAGCGTCGGGTCAATGTCAATGGTGGCGCGATCGCACTCGG
TCATCCAATAGGCGCTTCCGGTTGCCGAATCCTCGTTTCTCTGGTTCATGAAATGGTGAAACGTAATGCCCGCAAAGGAC
TGGCTACGCTTTGTATCGGCGGGGGCCAGGGCGTGGCATTGACCATTGAACGTGACGAATAG

Upstream 100 bases:

>100_bases
CGTATTTCCTTTGTGATAAAAATCACTTTTTTTTAAACAATTAAGATAACTGTTATTAACAATCATTTACTATTGCACTG
TTAATTGGTGCGAGGTTGTG

Downstream 100 bases:

>100_bases
CTCTGCATTTCCTCCTTACCGATAAATATCAGCCGTCATTAATCTGTTGAATAATGGTGGCTGGCGAGTCGACATACATT
TTCAGGGCTCCCTGATTTTT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKDVVIVGALRTPIGCFRGALAGHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAGAGQNPARQSAIKGGLPNSVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRQLQDAYALSSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPRTDASAEGLARLNPSFDSLGS
VTAGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCLERVGWQLADVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRNARKGLATLCIGGGQGVALTIERDE

Sequences:

>Translated_393_residues
MKDVVIVGALRTPIGCFRGALAGHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAGAGQNPARQSAIKGGLPNSVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRQLQDAYALSSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPRTDASAEGLARLNPSFDSLGS
VTAGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCLERVGWQLADVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRNARKGLATLCIGGGQGVALTIERDE
>Mature_393_residues
MKDVVIVGALRTPIGCFRGALAGHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAGAGQNPARQSAIKGGLPNSVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRQLQDAYALSSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPRTDASAEGLARLNPSFDSLGS
VTAGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCLERVGWQLADVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRNARKGLATLCIGGGQGVALTIERDE

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=48.849104859335, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=44.4162436548223, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=42.8211586901763, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=38.3838383838384, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=31.3953488372093, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI194353979, Length=396, Percent_Identity=28.7878787878788, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=99.7455470737914, Blast_Score=790, Evalue=0.0,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=58.1632653061224, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=44.25, Blast_Score=291, Evalue=7e-80,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=41.1471321695761, Blast_Score=262, Evalue=2e-71,
Organism=Escherichia coli, GI1788683, Length=408, Percent_Identity=32.5980392156863, Blast_Score=194, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=44.2455242966752, Blast_Score=318, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=41.5384615384615, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17535921, Length=392, Percent_Identity=40.3061224489796, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=33.6734693877551, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=30.0469483568075, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=41.2060301507538, Blast_Score=285, Evalue=9e-78,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=37.3737373737374, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=51.150895140665, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=42.0512820512821, Blast_Score=300, Evalue=9e-82,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=41.9437340153453, Blast_Score=284, Evalue=7e-77,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=31.3084112149533, Blast_Score=175, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41005; Mature: 41005

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDVVIVGALRTPIGCFRGALAGHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAG
CCCEEEEECHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
AGQNPARQSAIKGGLPNSVSAITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSR
CCCCHHHHHHHCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVTAENLAREYGISRQLQDAYAL
CCCEEECCCCCHHCCHHHHHHHHHHCCHHHCCCCEEEEEEHHHHHHHHCCHHHHHHHHHH
SSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPRTDASAEGLARLNPSFDSLGS
HHHHHHHHHHHHHCCHHHCEEEEECCCCCEEEEECCCCCCCCCCCCCHHHCCCCHHHCCC
VTAGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCL
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERVGWQLADVDLIEANEAFAAQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVS
HHHCCEEECEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCHHHHHHHH
LVHEMVKRNARKGLATLCIGGGQGVALTIERDE
HHHHHHHHHHHCCEEEEEEECCCEEEEEEECCC
>Mature Secondary Structure
MKDVVIVGALRTPIGCFRGALAGHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAG
CCCEEEEECHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
AGQNPARQSAIKGGLPNSVSAITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSR
CCCCHHHHHHHCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVTAENLAREYGISRQLQDAYAL
CCCEEECCCCCHHCCHHHHHHHHHHCCHHHCCCCEEEEEEHHHHHHHHCCHHHHHHHHHH
SSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPRTDASAEGLARLNPSFDSLGS
HHHHHHHHHHHHHCCHHHCEEEEECCCCCEEEEECCCCCCCCCCCCCHHHCCCCHHHCCC
VTAGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCL
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERVGWQLADVDLIEANEAFAAQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVS
HHHCCEEECEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCHHHHHHHH
LVHEMVKRNARKGLATLCIGGGQGVALTIERDE
HHHHHHHHHHHCCEEEEEEECCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]