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The map label for this gene is ycbL [H]

Identifier: 170680350

GI number: 170680350

Start: 2202960

End: 2203607

Strand: Reverse

Name: ycbL [H]

Synonym: EcSMS35_2193

Alternate gene names: 170680350

Gene position: 2203607-2202960 (Counterclockwise)

Preceding gene: 170680996

Following gene: 170684174

Centisome position: 43.48

GC content: 52.16

Gene sequence:

>648_bases
ATGAACTATCGTATTATTCCGGTCACCGCATTCTCCCAGAACTGTTCATTGATCTGGTGTGAACAAACCCGACTGGCCGC
ACTGGTCGATCCTGGCGGCGATGCGGAAAAAATCAAACAGGAAGTTGATGCCAGCGGCCTGACACTGATGCAGATCCTGC
TGACTCATGGTCATCTGGACCACGTTGGCGCAGCGGCGGAACTGGCGCAACATTACGGCGTGCCGGTTTTTGGCCCGGAA
AAAGAAGATGAGTTCTGGCTGCAAGGCTTGCCTGCGCAAAGTCGTATGTTTGGTCTGGAAGAGTGCCAGCCGCTGACGCC
AGATCGTTGGCTGAACGAAGGCGATACCATCAGCATAGGGAATGTGACTTTACAGGTGTTACATTGCCCTGGGCATACGC
CGGGTCATGTCGTGTTTTTTGATGAGCGGGCAAGGCTGCTGATTTCTGGCGACGTTATTTTCAAAGGCGGAGTAGGGCGC
AGTGACTTTCCGCGTGGCGATCATAATCAACTGATTTCTTCAATCAAAGATAAATTGCTGCCCCTGGGGGATGACGTGAC
ATTTATTCCGGGTCACGGACCATTATCAACTCTTGGTTACGAACGCCTGCATAATCCCTTCCTGCAAGACGAAATGCCCG
TCTGGTAA

Upstream 100 bases:

>100_bases
GCGCAGGTGGTGTAGGATATTACCCACGTAGTAACTTTGTGCATATTGATACCGGGCCAGCACGGCACTGGTAGTAATCG
CTTAACGAAACAGGGGCAGT

Downstream 100 bases:

>100_bases
AGACGTATAAAAAAGCCCGCTTTCACAGCGGGCTTCGTTTAACTAGCCTTTACAGCACGGCCACAATCGCTTCGCACAGC
GGAGCCATGTTATCTGGCGT

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MNYRIIPVTAFSQNCSLIWCEQTRLAALVDPGGDAEKIKQEVDASGLTLMQILLTHGHLDHVGAAAELAQHYGVPVFGPE
KEDEFWLQGLPAQSRMFGLEECQPLTPDRWLNEGDTISIGNVTLQVLHCPGHTPGHVVFFDERARLLISGDVIFKGGVGR
SDFPRGDHNQLISSIKDKLLPLGDDVTFIPGHGPLSTLGYERLHNPFLQDEMPVW

Sequences:

>Translated_215_residues
MNYRIIPVTAFSQNCSLIWCEQTRLAALVDPGGDAEKIKQEVDASGLTLMQILLTHGHLDHVGAAAELAQHYGVPVFGPE
KEDEFWLQGLPAQSRMFGLEECQPLTPDRWLNEGDTISIGNVTLQVLHCPGHTPGHVVFFDERARLLISGDVIFKGGVGR
SDFPRGDHNQLISSIKDKLLPLGDDVTFIPGHGPLSTLGYERLHNPFLQDEMPVW
>Mature_215_residues
MNYRIIPVTAFSQNCSLIWCEQTRLAALVDPGGDAEKIKQEVDASGLTLMQILLTHGHLDHVGAAAELAQHYGVPVFGPE
KEDEFWLQGLPAQSRMFGLEECQPLTPDRWLNEGDTISIGNVTLQVLHCPGHTPGHVVFFDERARLLISGDVIFKGGVGR
SDFPRGDHNQLISSIKDKLLPLGDDVTFIPGHGPLSTLGYERLHNPFLQDEMPVW

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI21703352, Length=196, Percent_Identity=32.1428571428571, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI116642887, Length=196, Percent_Identity=32.1428571428571, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI41327741, Length=194, Percent_Identity=29.3814432989691, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1787158, Length=215, Percent_Identity=98.1395348837209, Blast_Score=436, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17538952, Length=202, Percent_Identity=29.2079207920792, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221330176, Length=192, Percent_Identity=26.0416666666667, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 23770; Mature: 23770

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYRIIPVTAFSQNCSLIWCEQTRLAALVDPGGDAEKIKQEVDASGLTLMQILLTHGHLD
CCEEEEEEEEECCCCCEEEECCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHCCCHH
HVGAAAELAQHYGVPVFGPEKEDEFWLQGLPAQSRMFGLEECQPLTPDRWLNEGDTISIG
HHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCHHHHHCCHHHCCCCCCHHHCCCCCEEEEC
NVTLQVLHCPGHTPGHVVFFDERARLLISGDVIFKGGVGRSDFPRGDHNQLISSIKDKLL
CEEEEEEECCCCCCCEEEEECCCCEEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHHC
PLGDDVTFIPGHGPLSTLGYERLHNPFLQDEMPVW
CCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNYRIIPVTAFSQNCSLIWCEQTRLAALVDPGGDAEKIKQEVDASGLTLMQILLTHGHLD
CCEEEEEEEEECCCCCEEEECCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHCCCHH
HVGAAAELAQHYGVPVFGPEKEDEFWLQGLPAQSRMFGLEECQPLTPDRWLNEGDTISIG
HHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCHHHHHCCHHHCCCCCCHHHCCCCCEEEEC
NVTLQVLHCPGHTPGHVVFFDERARLLISGDVIFKGGVGRSDFPRGDHNQLISSIKDKLL
CEEEEEEECCCCCCCEEEEECCCCEEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHHC
PLGDDVTFIPGHGPLSTLGYERLHNPFLQDEMPVW
CCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]