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The map label for this gene is 170079303

Identifier: 170079303

GI number: 170079303

Start: 2840161

End: 2841174

Strand: Reverse

Name: 170079303

Synonym: SYNPCC7002_A2710

Alternate gene names: NA

Gene position: 2841174-2840161 (Counterclockwise)

Preceding gene: 170079304

Following gene: 170079295

Centisome position: 94.45

GC content: 45.27

Gene sequence:

>1014_bases
ATGGCAAACCAGAGCCCCCCGAATTTGGCGATCGCCTATGTCCATTTCTATGTAGACGATCTGGATTATTGGCAAACCTG
GTTTCAAACAAAATTTCAACTCAACATCACCGCTCCCCAAGCAACATTTCCGTTTTTACCTGAGAACACCATTCAACTCA
GTAGCCCAGAGTTAACCCTGATGCTCTCGGCACCCCAATCCCCTGCCGATCCGGTCGCCCAGTATTTAACCCATCATCCC
TGTGGTGTTGCGGATGTCGCCTTTTATATTGACCAAAAAGCTTTTTTTCAACCAAAAAATACTGATCAATCTGTTACCGT
ATTACGCAATAATGTTGGGTTTCAACACACCCTTATTTATCGAGATACAGTTCCTAGAACGAATACCCAAATCGATCATT
TAGTGCTCAATGTACCAGTAGGAAAACTTCAAGAAACGGTGCAATGGTACGAAGATAAATTTGGGTTTAACCGTCAGCAA
ACTTTTACGATCAAAACCAACTATTCCGGCCTCGCTTCCCAGGTTCTTTCCCATCCCAGCGGAATTCAACTACCCATTAA
TCAACCGGGAGACTGCTGTGAAAATCCGGAAACGGCACAGCGTTCCCAAATCCAAGAATTTATCGAGTTTAATCGTGGTG
CTGGGATTCAACATATCGCCCTAAAATACAAAAACTTACCGGAGCAAATCGGGCACTTTCGCCGGACAAATATGGCATTT
CTCGACGTTCCGGCCACCTATTACAAGAATCTCTATGATCGCTATCCCCACCTAGAAACATTACCCCATTGGCCCCAAAT
TCAACAGGAAAAAATCCTCGTGGATGTGGTGCGATCGCCTAAGGAAATGCTCCTACAAATTTTCACCCAGCCCATTTTTA
AAGAGCCGACATTTTTCTGGGAATTTATTGAACGCAAACAACAGGCCCAGGGGTTTGGCGAAGGGAATTTTCAAGCATTG
TTTGAAGCCATTGAACAGGCCCAACGGCAACGGCTGGTTTCCCCTCGCCCCTAA

Upstream 100 bases:

>100_bases
AAGACTTTCTCGAACGCTCCCAGCAATAACCCAAGCCATCGGTCAATCCTGAGAAAGTACGCTAAGTTGAATAGGAGCTG
TTGTTTATCTTTCCCGACAC

Downstream 100 bases:

>100_bases
ATGTCCGGCCAATAGAACTAAGCCGCTTCGGGATGTTCGATAATGCCGCCCCCCAGCACCCGATCACCGTCATAAAGTAC
GGCCGCCTGACCAGGGGTAA

Product: glyoxalase family protein

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MANQSPPNLAIAYVHFYVDDLDYWQTWFQTKFQLNITAPQATFPFLPENTIQLSSPELTLMLSAPQSPADPVAQYLTHHP
CGVADVAFYIDQKAFFQPKNTDQSVTVLRNNVGFQHTLIYRDTVPRTNTQIDHLVLNVPVGKLQETVQWYEDKFGFNRQQ
TFTIKTNYSGLASQVLSHPSGIQLPINQPGDCCENPETAQRSQIQEFIEFNRGAGIQHIALKYKNLPEQIGHFRRTNMAF
LDVPATYYKNLYDRYPHLETLPHWPQIQQEKILVDVVRSPKEMLLQIFTQPIFKEPTFFWEFIERKQQAQGFGEGNFQAL
FEAIEQAQRQRLVSPRP

Sequences:

>Translated_337_residues
MANQSPPNLAIAYVHFYVDDLDYWQTWFQTKFQLNITAPQATFPFLPENTIQLSSPELTLMLSAPQSPADPVAQYLTHHP
CGVADVAFYIDQKAFFQPKNTDQSVTVLRNNVGFQHTLIYRDTVPRTNTQIDHLVLNVPVGKLQETVQWYEDKFGFNRQQ
TFTIKTNYSGLASQVLSHPSGIQLPINQPGDCCENPETAQRSQIQEFIEFNRGAGIQHIALKYKNLPEQIGHFRRTNMAF
LDVPATYYKNLYDRYPHLETLPHWPQIQQEKILVDVVRSPKEMLLQIFTQPIFKEPTFFWEFIERKQQAQGFGEGNFQAL
FEAIEQAQRQRLVSPRP
>Mature_336_residues
ANQSPPNLAIAYVHFYVDDLDYWQTWFQTKFQLNITAPQATFPFLPENTIQLSSPELTLMLSAPQSPADPVAQYLTHHPC
GVADVAFYIDQKAFFQPKNTDQSVTVLRNNVGFQHTLIYRDTVPRTNTQIDHLVLNVPVGKLQETVQWYEDKFGFNRQQT
FTIKTNYSGLASQVLSHPSGIQLPINQPGDCCENPETAQRSQIQEFIEFNRGAGIQHIALKYKNLPEQIGHFRRTNMAFL
DVPATYYKNLYDRYPHLETLPHWPQIQQEKILVDVVRSPKEMLLQIFTQPIFKEPTFFWEFIERKQQAQGFGEGNFQALF
EAIEQAQRQRLVSPRP

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=326, Percent_Identity=30.0613496932515, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI4504477, Length=326, Percent_Identity=30.0613496932515, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI14249394, Length=213, Percent_Identity=28.6384976525822, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17555220, Length=216, Percent_Identity=37.5, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17550752, Length=209, Percent_Identity=31.1004784688995, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21356105, Length=228, Percent_Identity=33.7719298245614, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24667510, Length=207, Percent_Identity=34.7826086956522, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 39021; Mature: 38889

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANQSPPNLAIAYVHFYVDDLDYWQTWFQTKFQLNITAPQATFPFLPENTIQLSSPELTL
CCCCCCCCEEEEEEEEEECCHHHHHHHHCEEEEEEEECCCCCCCCCCCCCEEECCCCEEE
MLSAPQSPADPVAQYLTHHPCGVADVAFYIDQKAFFQPKNTDQSVTVLRNNVGFQHTLIY
EEECCCCCHHHHHHHHHCCCCCHHHHHHHHCHHHHCCCCCCCCCEEEEECCCCCEEEEEE
RDTVPRTNTQIDHLVLNVPVGKLQETVQWYEDKFGFNRQQTFTIKTNYSGLASQVLSHPS
ECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHCCCC
GIQLPINQPGDCCENPETAQRSQIQEFIEFNRGAGIQHIALKYKNLPEQIGHFRRTNMAF
CCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHCCEEE
LDVPATYYKNLYDRYPHLETLPHWPQIQQEKILVDVVRSPKEMLLQIFTQPIFKEPTFFW
EECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHH
EFIERKQQAQGFGEGNFQALFEAIEQAQRQRLVSPRP
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ANQSPPNLAIAYVHFYVDDLDYWQTWFQTKFQLNITAPQATFPFLPENTIQLSSPELTL
CCCCCCCEEEEEEEEEECCHHHHHHHHCEEEEEEEECCCCCCCCCCCCCEEECCCCEEE
MLSAPQSPADPVAQYLTHHPCGVADVAFYIDQKAFFQPKNTDQSVTVLRNNVGFQHTLIY
EEECCCCCHHHHHHHHHCCCCCHHHHHHHHCHHHHCCCCCCCCCEEEEECCCCCEEEEEE
RDTVPRTNTQIDHLVLNVPVGKLQETVQWYEDKFGFNRQQTFTIKTNYSGLASQVLSHPS
ECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHCCCC
GIQLPINQPGDCCENPETAQRSQIQEFIEFNRGAGIQHIALKYKNLPEQIGHFRRTNMAF
CCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHCCEEE
LDVPATYYKNLYDRYPHLETLPHWPQIQQEKILVDVVRSPKEMLLQIFTQPIFKEPTFFW
EECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHH
EFIERKQQAQGFGEGNFQALFEAIEQAQRQRLVSPRP
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]