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The map label for this gene is hisH [H]

Identifier: 170079123

GI number: 170079123

Start: 2635219

End: 2635845

Strand: Direct

Name: hisH [H]

Synonym: SYNPCC7002_A2529

Alternate gene names: 170079123

Gene position: 2635219-2635845 (Clockwise)

Preceding gene: 170079122

Following gene: 170079124

Centisome position: 87.61

GC content: 50.88

Gene sequence:

>627_bases
ATGGTGAATATTGCGGTTGTTGACTACGACATGGGGAATCTCCACTCCGCCTGCAAAGCCCTAGAAAAAGCGGGGGCAAC
TCCCACAATCACGGATCAATCAGAACAAATCCTGGGGGCCGATGCGGTAGTTCTACCGGGGGTTGGGGCGTTTGATCCGG
CGATGCAACATCTCCGCGATCGCCACCTCGAAGCCTCGATTAACCAGGCGATCGCCAGTGGCAAACCCTTCCTCGGCATT
TGTTTGGGGATGCAAATTTTATTTGACAGTTCCGCCGAAGGCACAGAAAAAGGTTTAGGTATTATCCCTGGCAGGGTGAA
ACGCTTTCAGCCAGAGCCAGAGATTACCATTCCCCACATGGGCTGGAACCAACTGCAACTAACCCAACCGGATCATCCCA
TTTGGCAGGATTTACCGAAAGATCCCTTCGTTTATTTTGTGCATTCTTTTTATGTGGCCCCGACAGATCCTGAAGTAAAT
GCCGCCACCGTCACCCACGGCCAGCAAACTGTCACAGCGGCGATCGCCAAAGATAACTTAGTTGCGATGCAATTTCACCC
CGAAAAATCCTCAGCGATTGGCCTAAAAATCCTCGAAAATTTTGTGCACTGGGTTAAGCAGCAATGA

Upstream 100 bases:

>100_bases
TGAAAGTTAAGCGTCAACATTCTAAAGAAATTGTTAGGATCAAATTCCTTTTGTGGTGTATGTTAGGGGTTTCTAACGTG
AACGTTCGGGCAATGAGAAG

Downstream 100 bases:

>100_bases
AATTCTTCAAGTCTCTTGCAGAAAAATGATTTAGAGATTTATCAAAGTCTCCCTTCCGAAGAGAGATTTAGAGGGATGTC
CCCCTTTCCCAATCAACTTT

Product: imidazole glycerol phosphate synthase subunit HisH

Products: NA

Alternate protein names: IGP synthase glutamine amidotransferase subunit; IGP synthase subunit hisH; ImGP synthase subunit hisH; IGPS subunit hisH [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MVNIAVVDYDMGNLHSACKALEKAGATPTITDQSEQILGADAVVLPGVGAFDPAMQHLRDRHLEASINQAIASGKPFLGI
CLGMQILFDSSAEGTEKGLGIIPGRVKRFQPEPEITIPHMGWNQLQLTQPDHPIWQDLPKDPFVYFVHSFYVAPTDPEVN
AATVTHGQQTVTAAIAKDNLVAMQFHPEKSSAIGLKILENFVHWVKQQ

Sequences:

>Translated_208_residues
MVNIAVVDYDMGNLHSACKALEKAGATPTITDQSEQILGADAVVLPGVGAFDPAMQHLRDRHLEASINQAIASGKPFLGI
CLGMQILFDSSAEGTEKGLGIIPGRVKRFQPEPEITIPHMGWNQLQLTQPDHPIWQDLPKDPFVYFVHSFYVAPTDPEVN
AATVTHGQQTVTAAIAKDNLVAMQFHPEKSSAIGLKILENFVHWVKQQ
>Mature_208_residues
MVNIAVVDYDMGNLHSACKALEKAGATPTITDQSEQILGADAVVLPGVGAFDPAMQHLRDRHLEASINQAIASGKPFLGI
CLGMQILFDSSAEGTEKGLGIIPGRVKRFQPEPEITIPHMGWNQLQLTQPDHPIWQDLPKDPFVYFVHSFYVAPTDPEVN
AATVTHGQQTVTAAIAKDNLVAMQFHPEKSSAIGLKILENFVHWVKQQ

Specific function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR [H]

COG id: COG0118

COG function: function code E; Glutamine amidotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788334, Length=203, Percent_Identity=37.4384236453202, Blast_Score=122, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319725, Length=218, Percent_Identity=35.3211009174312, Blast_Score=116, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010139
- InterPro:   IPR016226 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 22713; Mature: 22713

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNIAVVDYDMGNLHSACKALEKAGATPTITDQSEQILGADAVVLPGVGAFDPAMQHLRD
CEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCHHHCCCEEEECCCCCCHHHHHHHHH
RHLEASINQAIASGKPFLGICLGMQILFDSSAEGTEKGLGIIPGRVKRFQPEPEITIPHM
HHHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHCCCCCCCEEECCC
GWNQLQLTQPDHPIWQDLPKDPFVYFVHSFYVAPTDPEVNAATVTHGQQTVTAAIAKDNL
CCCEEEEECCCCCHHHHCCCCCEEEEEEEEEECCCCCCCCEEEEECCCHHEEEEEECCCE
VAMQFHPEKSSAIGLKILENFVHWVKQQ
EEEEECCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVNIAVVDYDMGNLHSACKALEKAGATPTITDQSEQILGADAVVLPGVGAFDPAMQHLRD
CEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCHHHCCCEEEECCCCCCHHHHHHHHH
RHLEASINQAIASGKPFLGICLGMQILFDSSAEGTEKGLGIIPGRVKRFQPEPEITIPHM
HHHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHCCCCCCCEEECCC
GWNQLQLTQPDHPIWQDLPKDPFVYFVHSFYVAPTDPEVNAATVTHGQQTVTAAIAKDNL
CCCEEEEECCCCCHHHHCCCCCEEEEEEEEEECCCCCCCCEEEEECCCHHEEEEEECCCE
VAMQFHPEKSSAIGLKILENFVHWVKQQ
EEEEECCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Glycosyltransferases; Pentosyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA