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The map label for this gene is glyA [H]

Identifier: 170079025

GI number: 170079025

Start: 2523804

End: 2525087

Strand: Direct

Name: glyA [H]

Synonym: SYNPCC7002_A2430

Alternate gene names: 170079025

Gene position: 2523804-2525087 (Clockwise)

Preceding gene: 170079023

Following gene: 170079026

Centisome position: 83.9

GC content: 53.5

Gene sequence:

>1284_bases
GTGACCCAAACTAACCTTGATTTCTTAGCCCAAACCGATAGCGTTGTTGCTGGGATGATTGCCAGTGAACTCAACCGCCA
GCGGGTACACCTCGAACTCATCGCCAGCGAAAACTTCACCTCCCCAGCGGTGATGGCGGCCCAGGGTTCTGTCCTCACGA
ATAAGTACGCCGAAGGTCTTCCCAATAAGCGTTATTACGGTGGCTGCGAATTTGTCGATCAAGTAGAGCAAATTGCCATT
GATCGCGTCAAGGAATTGTTTGGAGCGGCCCATGCCAATGTTCAACCCCACTCCGGCGCCCAGGCCAACTTTGCGGTGTT
CCTGACGCTCCTGGAACCTGGCGACAAAATTATGGGGATGGACTTGTCCCATGGGGGCCACTTGACCCACGGTTCGCCGG
TGAATGTGTCGGGGAAATGGTTTGAAGTGGTGCAGTATGGCGTTAATAAAGAGACAGAACGCCTCGATTATGATGAAATC
CGCGAAATTGCCCTGCGGGAAAAACCGAAGCTGATCATCTGTGGTTATTCTGCTTACCCGCGCATTATTGAGTTTGATAA
ATTCCGGGCGATCGCCGATGAAGTAGGTGCCTATTTGATGGCGGACATTGCCCACATTGCGGGATTAGTCGCAACAGGCC
ATCACCCCAACCCAATTCCCCACTGTGATGTGGTGACAACTACCACCCATAAAACGCTCCGTGGCCCCCGGGGTGGTTCG
ATCATGACCCGCGACGCCGAACTGGGCAAGAAATTTGATAAATCGGTGTTCCCTGGTAGCCAAGGCGGCCCCCTCGAACA
TGTGATTGCGGGGAAAGCGGTGGCCTTCGGCGAAGCCCTCAAGCCGGAATTTAAAGCCTATTCTGCCCAGGTAATTGCTA
ATGCCCAGGCGATGGCCAATACCCTCGTCAGCCGTGGCTTCAAACTCGTTTCTAACGGGACAGATAACCACCTGATGCTT
GTGGATATGCGCTCCATTGGCATGAACGGGAAGCGGGCTGATGCTTTGATTAGTGAGATCAACATCACCGCCAACAAAAA
CACCGTTCCCTTCGATCCTGAGAAGCCTTGGATTGGGAGCGGCATCCGTCTCGGTTCTCCGGCGATGACCACCCGGGGCC
TCAAGGAAGTAGACTTTGCCGAAATTGCCAACATCATTGCGGATCGTCTGTTAAATCCCGATGATGAAGCGGTGAAACAG
GATTGTCTGGGTCGCGTTGCGGATCTTTGTGAAAAGTTCCCCCTCTACCCCCATTTGCAGATTCCGGTAGCGGCGATCGC
CTAA

Upstream 100 bases:

>100_bases
GGAATGTTTGTTAAAATTTTAGCGATGCCGATGGTATAATGCGCCATCCGCAGGAAGTATTTTTAAATTTTATTTGCGAT
TGCGAAAGGAAGACCTCACC

Downstream 100 bases:

>100_bases
ATTCTTTAATATCTTTTTAAATAATGGAAAGCTCAGGTTTAATGAAAAAGGTAACCTGAGTTTTTTCTTATTTCGGTTTT
GCTCTACTCTCTCTGTTCTT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTQTNLDFLAQTDSVVAGMIASELNRQRVHLELIASENFTSPAVMAAQGSVLTNKYAEGLPNKRYYGGCEFVDQVEQIAI
DRVKELFGAAHANVQPHSGAQANFAVFLTLLEPGDKIMGMDLSHGGHLTHGSPVNVSGKWFEVVQYGVNKETERLDYDEI
REIALREKPKLIICGYSAYPRIIEFDKFRAIADEVGAYLMADIAHIAGLVATGHHPNPIPHCDVVTTTTHKTLRGPRGGS
IMTRDAELGKKFDKSVFPGSQGGPLEHVIAGKAVAFGEALKPEFKAYSAQVIANAQAMANTLVSRGFKLVSNGTDNHLML
VDMRSIGMNGKRADALISEINITANKNTVPFDPEKPWIGSGIRLGSPAMTTRGLKEVDFAEIANIIADRLLNPDDEAVKQ
DCLGRVADLCEKFPLYPHLQIPVAAIA

Sequences:

>Translated_427_residues
MTQTNLDFLAQTDSVVAGMIASELNRQRVHLELIASENFTSPAVMAAQGSVLTNKYAEGLPNKRYYGGCEFVDQVEQIAI
DRVKELFGAAHANVQPHSGAQANFAVFLTLLEPGDKIMGMDLSHGGHLTHGSPVNVSGKWFEVVQYGVNKETERLDYDEI
REIALREKPKLIICGYSAYPRIIEFDKFRAIADEVGAYLMADIAHIAGLVATGHHPNPIPHCDVVTTTTHKTLRGPRGGS
IMTRDAELGKKFDKSVFPGSQGGPLEHVIAGKAVAFGEALKPEFKAYSAQVIANAQAMANTLVSRGFKLVSNGTDNHLML
VDMRSIGMNGKRADALISEINITANKNTVPFDPEKPWIGSGIRLGSPAMTTRGLKEVDFAEIANIIADRLLNPDDEAVKQ
DCLGRVADLCEKFPLYPHLQIPVAAIA
>Mature_426_residues
TQTNLDFLAQTDSVVAGMIASELNRQRVHLELIASENFTSPAVMAAQGSVLTNKYAEGLPNKRYYGGCEFVDQVEQIAID
RVKELFGAAHANVQPHSGAQANFAVFLTLLEPGDKIMGMDLSHGGHLTHGSPVNVSGKWFEVVQYGVNKETERLDYDEIR
EIALREKPKLIICGYSAYPRIIEFDKFRAIADEVGAYLMADIAHIAGLVATGHHPNPIPHCDVVTTTTHKTLRGPRGGSI
MTRDAELGKKFDKSVFPGSQGGPLEHVIAGKAVAFGEALKPEFKAYSAQVIANAQAMANTLVSRGFKLVSNGTDNHLMLV
DMRSIGMNGKRADALISEINITANKNTVPFDPEKPWIGSGIRLGSPAMTTRGLKEVDFAEIANIIADRLLNPDDEAVKQD
CLGRVADLCEKFPLYPHLQIPVAAIA

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=406, Percent_Identity=46.3054187192118, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI261862350, Length=406, Percent_Identity=46.3054187192118, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI261862348, Length=406, Percent_Identity=46.3054187192118, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI22547186, Length=403, Percent_Identity=49.1315136476427, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI19923315, Length=406, Percent_Identity=46.3054187192118, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI261862346, Length=407, Percent_Identity=45.945945945946, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI22547189, Length=389, Percent_Identity=47.3007712082262, Blast_Score=320, Evalue=1e-87,
Organism=Escherichia coli, GI1788902, Length=410, Percent_Identity=58.0487804878049, Blast_Score=476, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI25144732, Length=403, Percent_Identity=46.1538461538462, Blast_Score=350, Evalue=6e-97,
Organism=Caenorhabditis elegans, GI25144729, Length=403, Percent_Identity=46.1538461538462, Blast_Score=350, Evalue=9e-97,
Organism=Saccharomyces cerevisiae, GI6319739, Length=435, Percent_Identity=41.6091954022989, Blast_Score=344, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6323087, Length=401, Percent_Identity=43.142144638404, Blast_Score=332, Evalue=5e-92,
Organism=Drosophila melanogaster, GI24640005, Length=400, Percent_Identity=48, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI221329721, Length=400, Percent_Identity=48, Blast_Score=374, Evalue=1e-104,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 46357; Mature: 46225

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00096 SHMT ; PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTNLDFLAQTDSVVAGMIASELNRQRVHLELIASENFTSPAVMAAQGSVLTNKYAEGL
CCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCEEEECCCCHHHHHHHHCC
PNKRYYGGCEFVDQVEQIAIDRVKELFGAAHANVQPHSGAQANFAVFLTLLEPGDKIMGM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCEEEE
DLSHGGHLTHGSPVNVSGKWFEVVQYGVNKETERLDYDEIREIALREKPKLIICGYSAYP
ECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHCCCHHHHHHHHHCCCCCEEEECCCCCC
RIIEFDKFRAIADEVGAYLMADIAHIAGLVATGHHPNPIPHCDVVTTTTHKTLRGPRGGS
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHCCCCCCC
IMTRDAELGKKFDKSVFPGSQGGPLEHVIAGKAVAFGEALKPEFKAYSAQVIANAQAMAN
EEECCHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHH
TLVSRGFKLVSNGTDNHLMLVDMRSIGMNGKRADALISEINITANKNTVPFDPEKPWIGS
HHHHCCEEEECCCCCCEEEEEEHHHCCCCCHHHHHHHHHEEEEECCCCCCCCCCCCCCCC
GIRLGSPAMTTRGLKEVDFAEIANIIADRLLNPDDEAVKQDCLGRVADLCEKFPLYPHLQ
CEECCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
IPVAAIA
CCHHHCC
>Mature Secondary Structure 
TQTNLDFLAQTDSVVAGMIASELNRQRVHLELIASENFTSPAVMAAQGSVLTNKYAEGL
CCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCEEEECCCCHHHHHHHHCC
PNKRYYGGCEFVDQVEQIAIDRVKELFGAAHANVQPHSGAQANFAVFLTLLEPGDKIMGM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCEEEE
DLSHGGHLTHGSPVNVSGKWFEVVQYGVNKETERLDYDEIREIALREKPKLIICGYSAYP
ECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHCCCHHHHHHHHHCCCCCEEEECCCCCC
RIIEFDKFRAIADEVGAYLMADIAHIAGLVATGHHPNPIPHCDVVTTTTHKTLRGPRGGS
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHCCCCCCC
IMTRDAELGKKFDKSVFPGSQGGPLEHVIAGKAVAFGEALKPEFKAYSAQVIANAQAMAN
EEECCHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHH
TLVSRGFKLVSNGTDNHLMLVDMRSIGMNGKRADALISEINITANKNTVPFDPEKPWIGS
HHHHCCEEEECCCCCCEEEEEEHHHCCCCCHHHHHHHHHEEEEECCCCCCCCCCCCCCCC
GIRLGSPAMTTRGLKEVDFAEIANIIADRLLNPDDEAVKQDCLGRVADLCEKFPLYPHLQ
CEECCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
IPVAAIA
CCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA