Click here to switch to the map view.

The map label for this gene is pth [H]

Identifier: 170078845

GI number: 170078845

Start: 2330287

End: 2330907

Strand: Direct

Name: pth [H]

Synonym: SYNPCC7002_A2249

Alternate gene names: 170078845

Gene position: 2330287-2330907 (Clockwise)

Preceding gene: 170078844

Following gene: 170078846

Centisome position: 77.47

GC content: 52.5

Gene sequence:

>621_bases
ATGGGTCAAGGCAAACCACTCGTCATTCCCCAGTTGATTGTGGGACTGGGAAATCCAGAACCAAAGTACGATCACACACG
CCATAACATTGGTTTTGAATTTGTCGATCGCCTCGCCGCAGATTGGGGTGCGACCCTCCAGGATCATCGAAAATTTCAAG
GGGTTTGGGCGGAGGTGCGCCGCAACGGCCAGAAACTCGGTTTGCTCAAACCCACCACCTATATGAATCGTTCTGGGCAG
TCTTTACGGGCTGTGATTGATTGGTACAAAATTCCCCCGGAATCGGTGCTGGTGGTCTATGACGATATGGATCTCCCCCT
AGGGCGACTGCGGTTGCGTCTGCAAGGATCAGCAGGGGGTCACAACGGGATCAAATCCATTATTTCCCACCTCGGCACCC
AGAAATTTCCCCGCTTACGTATTGGCATCGGCAAAACCCAACTCAAAGGAGACCGACCGACTATTTCCCACGTGCTTGGG
AAGTTTGCGCCAGCAGAAAAGCCCATTTTAAATGATGTCCTAGGGCTTGCGGAAGAAGCATTGGCCCTGAGTCTCCGGGA
AGGGGTGGAGAAGGCCATGAGCCTCTATAATGCCCGCAGTGTTGAATCGAGTCAGTCATAA

Upstream 100 bases:

>100_bases
ACAAACCCCACGGGAAGCAGAAAATTACCGTACCTGCGCCAGAGTATACTTAGAAACGCTCTTTGAGCAGTCGAAGTCCT
ACTAAGTATTTTGTGAGGTT

Downstream 100 bases:

>100_bases
GGGTATTGCAGGAATTTTGAAAGGAAAGTTATCGCGGCTCAAGCCCTATTTGCGTTGGTTTATTGTTGGCCTGACGCTCT
TTTTTTTGCTGGCAACCCTC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MGQGKPLVIPQLIVGLGNPEPKYDHTRHNIGFEFVDRLAADWGATLQDHRKFQGVWAEVRRNGQKLGLLKPTTYMNRSGQ
SLRAVIDWYKIPPESVLVVYDDMDLPLGRLRLRLQGSAGGHNGIKSIISHLGTQKFPRLRIGIGKTQLKGDRPTISHVLG
KFAPAEKPILNDVLGLAEEALALSLREGVEKAMSLYNARSVESSQS

Sequences:

>Translated_206_residues
MGQGKPLVIPQLIVGLGNPEPKYDHTRHNIGFEFVDRLAADWGATLQDHRKFQGVWAEVRRNGQKLGLLKPTTYMNRSGQ
SLRAVIDWYKIPPESVLVVYDDMDLPLGRLRLRLQGSAGGHNGIKSIISHLGTQKFPRLRIGIGKTQLKGDRPTISHVLG
KFAPAEKPILNDVLGLAEEALALSLREGVEKAMSLYNARSVESSQS
>Mature_205_residues
GQGKPLVIPQLIVGLGNPEPKYDHTRHNIGFEFVDRLAADWGATLQDHRKFQGVWAEVRRNGQKLGLLKPTTYMNRSGQS
LRAVIDWYKIPPESVLVVYDDMDLPLGRLRLRLQGSAGGHNGIKSIISHLGTQKFPRLRIGIGKTQLKGDRPTISHVLGK
FAPAEKPILNDVLGLAEEALALSLREGVEKAMSLYNARSVESSQS

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=178, Percent_Identity=36.5168539325843, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=40.5263157894737, Blast_Score=116, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6321983, Length=176, Percent_Identity=29.5454545454545, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 22781; Mature: 22649

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQGKPLVIPQLIVGLGNPEPKYDHTRHNIGFEFVDRLAADWGATLQDHRKFQGVWAEVR
CCCCCCCHHHHHHHHCCCCCCCCCCCHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RNGQKLGLLKPTTYMNRSGQSLRAVIDWYKIPPESVLVVYDDMDLPLGRLRLRLQGSAGG
CCCCEECCCCCHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHEEEEEECCCCC
HNGIKSIISHLGTQKFPRLRIGIGKTQLKGDRPTISHVLGKFAPAEKPILNDVLGLAEEA
CHHHHHHHHHHCCCCCCEEEECCCHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
LALSLREGVEKAMSLYNARSVESSQS
HHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GQGKPLVIPQLIVGLGNPEPKYDHTRHNIGFEFVDRLAADWGATLQDHRKFQGVWAEVR
CCCCCCHHHHHHHHCCCCCCCCCCCHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RNGQKLGLLKPTTYMNRSGQSLRAVIDWYKIPPESVLVVYDDMDLPLGRLRLRLQGSAGG
CCCCEECCCCCHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHEEEEEECCCCC
HNGIKSIISHLGTQKFPRLRIGIGKTQLKGDRPTISHVLGKFAPAEKPILNDVLGLAEEA
CHHHHHHHHHHCCCCCCEEEECCCHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
LALSLREGVEKAMSLYNARSVESSQS
HHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]