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The map label for this gene is hemL

Identifier: 170078804

GI number: 170078804

Start: 2296092

End: 2297390

Strand: Reverse

Name: hemL

Synonym: SYNPCC7002_A2206

Alternate gene names: 170078804

Gene position: 2297390-2296092 (Counterclockwise)

Preceding gene: 170078813

Following gene: 170078803

Centisome position: 76.37

GC content: 50.65

Gene sequence:

>1299_bases
TTGGTGACTACAGCCTTAAACACAACCAAATCCGAAGAGATTTTTAGTGCCGCCCAAAAGCTGATGCCTGGTGGTGTTAG
CTCCCCGGTGCGGGCCTTTAAATCCGTTGGCGGACAGCCCATTGTTTTTGATCGCGTCAAAGGCTCCCGCGTTTGGGACG
TCGATGGCAACGAGTACATTGACTATGTGGGCACTTGGGGGCCAGCCATCTGCGGCCATGCCAATGATGAAGTTAATGCA
GCACTCCGGGAAACCCTCGAAAAAGGAACAAGCTTTGGTGCCCCTTGCCTCAAAGAAAATATCTTGGCTGAAATGGTGAT
CAATGCAGTTCCCAGCATTGAAATGGTGCGCTTTGTGAATTCCGGTACGGAAGCTTGCATGTCGGTGTTACGTTTGATGC
GAGCTTTCACGGGGCGAGAAAAAATCATCAAATTTGAAGGTTGCTACCACGGCCATGCTGATATGTTCCTGGTGCAGGCC
GGATCTGGAGTGGCAACCCTCGGTTTACCTGATTCTCCTGGTGTGCCCAAAACCACCACCGCCGCCACATTGACTGCCCC
TTATAATGACCTTGAAGCGGTCAAAAAATTATTCGCAGAAAATCCCGGTGAAATTGCCGGGGTGATCCTAGAGCCTGTGG
TCGGTAATTCTGGGTTTGTGCTTCCCGATGCCGGTTTCCTCGAAGGATTGCGGGAAATTACCAAAGAACATGACGCCTTA
CTGGTTTTTGATGAGGTGATGACAGGCTTCCGAATTTCCTATGGTGGTGCCCAAGAAAAATTTGGCGTGACCCCAGATCT
CACCACCCTGGGTAAAGTAATTGGTGGCGGGCTACCTGTGGGAGCCTATGGTGGCCGCAAAGACATTATGTCCATGGTGG
CTCCGGCGGGGCCGATGTACCAGGCAGGCACCCTCTCAGGGAACCCCTTGGCGATGACAGCGGGCATTAAAACCCTTGAA
TTACTCCAACGTCCTGGTATGTACGGGCAATTGGAAACCATCACGAAAAAGTTAATTGATGGCTTGTTGAGCATTGCCCG
GGAAGCGGGTCATGAAGTCACGGGTGGTAACATCAGTGGTATGTTCGGCATGTTTTTCACGGGAGAACCTGTCCGTAATT
ACGAAGATGCGAAGAAATCGGACTTACACAAGTTCAGCCGCTATCACCGTGGGATGTTGGAACAGGGAATTTATCTTGCC
CCCTCTCAGTTTGAGGCTGGTTTTACCTCCCTTGCCCACACTGATGAAGATATTGAAAAAACCTTGGCCGCAGCTAAAGT
GGTCTTGAATAATCTCTAA

Upstream 100 bases:

>100_bases
ATAATGGCTCCCTGCATTGGGATGCTTTCCACAAAGCCATCAGAGCCACTCATTTTAACAAAAATAAGCTTTAAGAAAAT
TTGCGACAAGGAGAAAACGT

Downstream 100 bases:

>100_bases
AGCCTAAATTTCGGTTCTATTTTTGAGATATAGTGTTCCCTCTTTCTGTCACGAAAGGGGGAATTTTTCTGGGAATCGCG
GGGGGATGAATCCGCTACAA

Product: glutamate-1-semialdehyde-2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MVTTALNTTKSEEIFSAAQKLMPGGVSSPVRAFKSVGGQPIVFDRVKGSRVWDVDGNEYIDYVGTWGPAICGHANDEVNA
ALRETLEKGTSFGAPCLKENILAEMVINAVPSIEMVRFVNSGTEACMSVLRLMRAFTGREKIIKFEGCYHGHADMFLVQA
GSGVATLGLPDSPGVPKTTTAATLTAPYNDLEAVKKLFAENPGEIAGVILEPVVGNSGFVLPDAGFLEGLREITKEHDAL
LVFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGRKDIMSMVAPAGPMYQAGTLSGNPLAMTAGIKTLE
LLQRPGMYGQLETITKKLIDGLLSIAREAGHEVTGGNISGMFGMFFTGEPVRNYEDAKKSDLHKFSRYHRGMLEQGIYLA
PSQFEAGFTSLAHTDEDIEKTLAAAKVVLNNL

Sequences:

>Translated_432_residues
MVTTALNTTKSEEIFSAAQKLMPGGVSSPVRAFKSVGGQPIVFDRVKGSRVWDVDGNEYIDYVGTWGPAICGHANDEVNA
ALRETLEKGTSFGAPCLKENILAEMVINAVPSIEMVRFVNSGTEACMSVLRLMRAFTGREKIIKFEGCYHGHADMFLVQA
GSGVATLGLPDSPGVPKTTTAATLTAPYNDLEAVKKLFAENPGEIAGVILEPVVGNSGFVLPDAGFLEGLREITKEHDAL
LVFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGRKDIMSMVAPAGPMYQAGTLSGNPLAMTAGIKTLE
LLQRPGMYGQLETITKKLIDGLLSIAREAGHEVTGGNISGMFGMFFTGEPVRNYEDAKKSDLHKFSRYHRGMLEQGIYLA
PSQFEAGFTSLAHTDEDIEKTLAAAKVVLNNL
>Mature_432_residues
MVTTALNTTKSEEIFSAAQKLMPGGVSSPVRAFKSVGGQPIVFDRVKGSRVWDVDGNEYIDYVGTWGPAICGHANDEVNA
ALRETLEKGTSFGAPCLKENILAEMVINAVPSIEMVRFVNSGTEACMSVLRLMRAFTGREKIIKFEGCYHGHADMFLVQA
GSGVATLGLPDSPGVPKTTTAATLTAPYNDLEAVKKLFAENPGEIAGVILEPVVGNSGFVLPDAGFLEGLREITKEHDAL
LVFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGRKDIMSMVAPAGPMYQAGTLSGNPLAMTAGIKTLE
LLQRPGMYGQLETITKKLIDGLLSIAREAGHEVTGGNISGMFGMFFTGEPVRNYEDAKKSDLHKFSRYHRGMLEQGIYLA
PSQFEAGFTSLAHTDEDIEKTLAAAKVVLNNL

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=298, Percent_Identity=30.2013422818792, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI37574042, Length=364, Percent_Identity=27.7472527472527, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI226442705, Length=363, Percent_Identity=26.9972451790634, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI24119277, Length=317, Percent_Identity=25.5520504731861, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI284507298, Length=171, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI226442709, Length=322, Percent_Identity=28.2608695652174, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786349, Length=425, Percent_Identity=54.3529411764706, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1789016, Length=339, Percent_Identity=33.0383480825959, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788044, Length=320, Percent_Identity=34.0625, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1789759, Length=314, Percent_Identity=31.8471337579618, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI145693181, Length=321, Percent_Identity=30.5295950155763, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1787560, Length=344, Percent_Identity=29.9418604651163, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786991, Length=369, Percent_Identity=26.0162601626016, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25144271, Length=333, Percent_Identity=27.6276276276276, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=180, Percent_Identity=31.6666666666667, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323470, Length=340, Percent_Identity=27.6470588235294, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324432, Length=363, Percent_Identity=23.4159779614325, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21357415, Length=294, Percent_Identity=25.5102040816327, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21356575, Length=336, Percent_Identity=25.8928571428571, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_SYNP2 (B1XIT5)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001735442.1
- ProteinModelPortal:   B1XIT5
- SMR:   B1XIT5
- GeneID:   6055724
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A2206
- HOGENOM:   HBG725944
- OMA:   VGCFGGK
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46096; Mature: 46096

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTTALNTTKSEEIFSAAQKLMPGGVSSPVRAFKSVGGQPIVFDRVKGSRVWDVDGNEYI
CCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCC
DYVGTWGPAICGHANDEVNAALRETLEKGTSFGAPCLKENILAEMVINAVPSIEMVRFVN
HHHCCCCCHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
SGTEACMSVLRLMRAFTGREKIIKFEGCYHGHADMFLVQAGSGVATLGLPDSPGVPKTTT
CCHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCC
AATLTAPYNDLEAVKKLFAENPGEIAGVILEPVVGNSGFVLPDAGFLEGLREITKEHDAL
CEEEECCCHHHHHHHHHHCCCCCCEEHHHEECEECCCCEECCCHHHHHHHHHHHHHCCEE
LVFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGRKDIMSMVAPAGPMY
EEEHHHHHCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCC
QAGTLSGNPLAMTAGIKTLELLQRPGMYGQLETITKKLIDGLLSIAREAGHEVTGGNISG
CCCCCCCCCEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
MFGMFFTGEPVRNYEDAKKSDLHKFSRYHRGMLEQGIYLAPSQFEAGFTSLAHTDEDIEK
CEEEEECCCCHHCHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCHHHHHH
TLAAAKVVLNNL
HHHHHHHHHHCC
>Mature Secondary Structure
MVTTALNTTKSEEIFSAAQKLMPGGVSSPVRAFKSVGGQPIVFDRVKGSRVWDVDGNEYI
CCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCC
DYVGTWGPAICGHANDEVNAALRETLEKGTSFGAPCLKENILAEMVINAVPSIEMVRFVN
HHHCCCCCHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
SGTEACMSVLRLMRAFTGREKIIKFEGCYHGHADMFLVQAGSGVATLGLPDSPGVPKTTT
CCHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCC
AATLTAPYNDLEAVKKLFAENPGEIAGVILEPVVGNSGFVLPDAGFLEGLREITKEHDAL
CEEEECCCHHHHHHHHHHCCCCCCEEHHHEECEECCCCEECCCHHHHHHHHHHHHHCCEE
LVFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGRKDIMSMVAPAGPMY
EEEHHHHHCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCC
QAGTLSGNPLAMTAGIKTLELLQRPGMYGQLETITKKLIDGLLSIAREAGHEVTGGNISG
CCCCCCCCCEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
MFGMFFTGEPVRNYEDAKKSDLHKFSRYHRGMLEQGIYLAPSQFEAGFTSLAHTDEDIEK
CEEEEECCCCHHCHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCHHHHHH
TLAAAKVVLNNL
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA