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The map label for this gene is 170078798

Identifier: 170078798

GI number: 170078798

Start: 2289334

End: 2290788

Strand: Reverse

Name: 170078798

Synonym: SYNPCC7002_A2200

Alternate gene names: NA

Gene position: 2290788-2289334 (Counterclockwise)

Preceding gene: 170078800

Following gene: 170078795

Centisome position: 76.16

GC content: 52.23

Gene sequence:

>1455_bases
ATGGTTGCTGCGCCAAATTCTCCACAACTATCGACCCAACCGGCTTGGTCACGACTTTTTGCGAACCCCGCCCGACCGTT
TGATTTAACGCCTCTGCTCGTTCTAGAGGGGGCAATTCCACCAGGATTGCGGGGGAGTTTGTTTCGCAATGGCCCCGGAC
GTTTGACACGGGGAAGGCAGGCCATGGGCCATTGGTTTGACGGCGATGGTGGCATTCTAGGGGTGTATTTTACAGAAGCA
GGTGCCCAGGCCCAATATCGCTATGTAGAAACCCCCTACTTTCAACAGGAAGCAGCAGCAGAAAGCTTAATCTATCCCAA
CTATGGCACCCTTGCCCTGGGACAAATTTGGCAGCGGTGGGGGAAGCCCGCCAAAAATTCGGCCAATACTTCTGTGTTGC
CCCTAGGCGATCGCCTTTTAGCCCTGTGGGAAGGGGGGAAACCCTATGGCCTCAATGCCCAAACCCTTAAAACCTTGGGA
GAGATGGATCTTGGCTTTGCCCACTCTAGCGATACCTTTTCGGCCCACCACAAAATCCAGCCTGAAACTGGGGAAATTTA
CAATTTTGGCGTGACCTTCGGCCCCAAGGCGACATTCCAGCTTTACCGTTGTCACCCCCAGGGCGAAGTTTCACAGCAGA
CTCATTTTTCTGTACCAGGCTTAAAAGGATTGCCGCTGGTGCATGATTTTGTCTTGGCCGGAGATTACCTCGTGTTTTGT
ATTCCGCCGGTGCGCTTGCAGCTGGTGCCGACACTATTGGGCCTAAAAACCGTTAGCGATGCCCTTCAATGGCGGCCAGA
ACTGGGAACGACGATTGTGATCATTGATCGCCATACCCTCCAACCGATCAGCTTTTGCCAACAGGAGGCTTGGTTCCAGT
GGCACTTTACCAATGGCTATGTTGATGATCATGGCGAAATTGTGCTGGAAATGGTGCGGTTTCCGGATTTTGCCAGCAAC
CAGCAGTTTGTGGAAATTCCCCAAGGTAAAATTCACACCTATACAAAGGGCACCCTCTGGCGCTACCGACTGGCACCGAA
AACAGCCAAGGTCATTGAAGCCTACGAAATTTGCGATCGCTCCTGTGAATTTCCGATCACCCTCGAATCCCGCACCGGGC
AGCCTTGGCTCAAAACCTTTATGGGGGTCCATCGCCAGGAAACAGACATTGGTCACGAGATCATTAATGCGATCGCCGCT
TTTGACCACCGTACAGAAACCTTCACTATGGCAGATATGGGCGCCAACCATTACCCCTCCGAACCCATCCCCGTCCAAAA
TCCCCAGAATTCCGATGAAATCTGGCTCTTAACTGTTGTCTTTAATGCCCCAGCTAACCGGAGTGAACTCAGAATCTACG
GTGGCGATCGCCTGGAGGCTGAACCCCTTTGTATCCTAGAATTTCCTGAAATTATTCCCCCCAGCTTCCATGGCAAATGG
CAGCCTGCTCTTTAA

Upstream 100 bases:

>100_bases
AAAATCTCCCTCATTTTATGCACAAACCCCAGGATGCAACCCCAAGAAAGGGGAGAAGGCGATTTACAATAGTTAACATT
GCTTGAGGGTAAAACTGACT

Downstream 100 bases:

>100_bases
AATTCCTCGGTAAAAGTTCCAAGAAAAAACCCTCCAACTTGGAGGGTAAGGGCTAAACAATTGAATCTTTGAAAAATGTT
CTTAGAGCGCGTTACCACGG

Product: retinal pigment epithelial membrane protein

Products: NA

Alternate protein names: ACO; 8'-apo-beta-carotenal 15,15'-oxygenase; Diox1 [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MVAAPNSPQLSTQPAWSRLFANPARPFDLTPLLVLEGAIPPGLRGSLFRNGPGRLTRGRQAMGHWFDGDGGILGVYFTEA
GAQAQYRYVETPYFQQEAAAESLIYPNYGTLALGQIWQRWGKPAKNSANTSVLPLGDRLLALWEGGKPYGLNAQTLKTLG
EMDLGFAHSSDTFSAHHKIQPETGEIYNFGVTFGPKATFQLYRCHPQGEVSQQTHFSVPGLKGLPLVHDFVLAGDYLVFC
IPPVRLQLVPTLLGLKTVSDALQWRPELGTTIVIIDRHTLQPISFCQQEAWFQWHFTNGYVDDHGEIVLEMVRFPDFASN
QQFVEIPQGKIHTYTKGTLWRYRLAPKTAKVIEAYEICDRSCEFPITLESRTGQPWLKTFMGVHRQETDIGHEIINAIAA
FDHRTETFTMADMGANHYPSEPIPVQNPQNSDEIWLLTVVFNAPANRSELRIYGGDRLEAEPLCILEFPEIIPPSFHGKW
QPAL

Sequences:

>Translated_484_residues
MVAAPNSPQLSTQPAWSRLFANPARPFDLTPLLVLEGAIPPGLRGSLFRNGPGRLTRGRQAMGHWFDGDGGILGVYFTEA
GAQAQYRYVETPYFQQEAAAESLIYPNYGTLALGQIWQRWGKPAKNSANTSVLPLGDRLLALWEGGKPYGLNAQTLKTLG
EMDLGFAHSSDTFSAHHKIQPETGEIYNFGVTFGPKATFQLYRCHPQGEVSQQTHFSVPGLKGLPLVHDFVLAGDYLVFC
IPPVRLQLVPTLLGLKTVSDALQWRPELGTTIVIIDRHTLQPISFCQQEAWFQWHFTNGYVDDHGEIVLEMVRFPDFASN
QQFVEIPQGKIHTYTKGTLWRYRLAPKTAKVIEAYEICDRSCEFPITLESRTGQPWLKTFMGVHRQETDIGHEIINAIAA
FDHRTETFTMADMGANHYPSEPIPVQNPQNSDEIWLLTVVFNAPANRSELRIYGGDRLEAEPLCILEFPEIIPPSFHGKW
QPAL
>Mature_484_residues
MVAAPNSPQLSTQPAWSRLFANPARPFDLTPLLVLEGAIPPGLRGSLFRNGPGRLTRGRQAMGHWFDGDGGILGVYFTEA
GAQAQYRYVETPYFQQEAAAESLIYPNYGTLALGQIWQRWGKPAKNSANTSVLPLGDRLLALWEGGKPYGLNAQTLKTLG
EMDLGFAHSSDTFSAHHKIQPETGEIYNFGVTFGPKATFQLYRCHPQGEVSQQTHFSVPGLKGLPLVHDFVLAGDYLVFC
IPPVRLQLVPTLLGLKTVSDALQWRPELGTTIVIIDRHTLQPISFCQQEAWFQWHFTNGYVDDHGEIVLEMVRFPDFASN
QQFVEIPQGKIHTYTKGTLWRYRLAPKTAKVIEAYEICDRSCEFPITLESRTGQPWLKTFMGVHRQETDIGHEIINAIAA
FDHRTETFTMADMGANHYPSEPIPVQNPQNSDEIWLLTVVFNAPANRSELRIYGGDRLEAEPLCILEFPEIIPPSFHGKW
QPAL

Specific function: Cleaves a number of carotenals and carotenols in the all-trans configuration at the 15-15' double bond producing retinal or retinol, respectively. Also shows activity toward lycopenals and the corresponding alcohols. Does not cleave beta- carotene or lyco

COG id: COG3670

COG function: function code Q; Lignostilbene-alpha,beta-dioxygenase and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carotenoid oxygenase family [H]

Homologues:

Organism=Homo sapiens, GI74027270, Length=325, Percent_Identity=23.3846153846154, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4506591, Length=307, Percent_Identity=24.1042345276873, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI82617624, Length=303, Percent_Identity=23.1023102310231, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI82617628, Length=303, Percent_Identity=23.1023102310231, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71998242, Length=306, Percent_Identity=27.4509803921569, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI32564756, Length=329, Percent_Identity=23.4042553191489, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24646669, Length=299, Percent_Identity=26.0869565217391, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004294 [H]

Pfam domain/function: PF03055 RPE65 [H]

EC number: =1.14.99.41 [H]

Molecular weight: Translated: 54271; Mature: 54271

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAAPNSPQLSTQPAWSRLFANPARPFDLTPLLVLEGAIPPGLRGSLFRNGPGRLTRGRQ
CCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCHH
AMGHWFDGDGGILGVYFTEAGAQAQYRYVETPYFQQEAAAESLIYPNYGTLALGQIWQRW
HHCCEECCCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHHEECCCCCCHHHHHHHHHH
GKPAKNSANTSVLPLGDRLLALWEGGKPYGLNAQTLKTLGEMDLGFAHSSDTFSAHHKIQ
CCCCCCCCCCEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEECC
PETGEIYNFGVTFGPKATFQLYRCHPQGEVSQQTHFSVPGLKGLPLVHDFVLAGDYLVFC
CCCCCEEEEEEEECCCCEEEEEEECCCCCCCCCCEECCCCCCCCCHHHHHHHHCCEEEEE
IPPVRLQLVPTLLGLKTVSDALQWRPELGTTIVIIDRHTLQPISFCQQEAWFQWHFTNGY
ECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCEEEEEECCCE
VDDHGEIVLEMVRFPDFASNQQFVEIPQGKIHTYTKGTLWRYRLAPKTAKVIEAYEICDR
ECCCHHHHHHHHHCCCCCCCCCEEECCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHCC
SCEFPITLESRTGQPWLKTFMGVHRQETDIGHEIINAIAAFDHRTETFTMADMGANHYPS
CCCCCEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
EPIPVQNPQNSDEIWLLTVVFNAPANRSELRIYGGDRLEAEPLCILEFPEIIPPSFHGKW
CCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCC
QPAL
CCCC
>Mature Secondary Structure
MVAAPNSPQLSTQPAWSRLFANPARPFDLTPLLVLEGAIPPGLRGSLFRNGPGRLTRGRQ
CCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCHH
AMGHWFDGDGGILGVYFTEAGAQAQYRYVETPYFQQEAAAESLIYPNYGTLALGQIWQRW
HHCCEECCCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHHEECCCCCCHHHHHHHHHH
GKPAKNSANTSVLPLGDRLLALWEGGKPYGLNAQTLKTLGEMDLGFAHSSDTFSAHHKIQ
CCCCCCCCCCEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEECC
PETGEIYNFGVTFGPKATFQLYRCHPQGEVSQQTHFSVPGLKGLPLVHDFVLAGDYLVFC
CCCCCEEEEEEEECCCCEEEEEEECCCCCCCCCCEECCCCCCCCCHHHHHHHHCCEEEEE
IPPVRLQLVPTLLGLKTVSDALQWRPELGTTIVIIDRHTLQPISFCQQEAWFQWHFTNGY
ECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCEEEEEECCCE
VDDHGEIVLEMVRFPDFASNQQFVEIPQGKIHTYTKGTLWRYRLAPKTAKVIEAYEICDR
ECCCHHHHHHHHHCCCCCCCCCEEECCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHCC
SCEFPITLESRTGQPWLKTFMGVHRQETDIGHEIINAIAAFDHRTETFTMADMGANHYPS
CCCCCEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
EPIPVQNPQNSDEIWLLTVVFNAPANRSELRIYGGDRLEAEPLCILEFPEIIPPSFHGKW
CCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCC
QPAL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]