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The map label for this gene is pyrD [H]

Identifier: 170078793

GI number: 170078793

Start: 2282843

End: 2283988

Strand: Direct

Name: pyrD [H]

Synonym: SYNPCC7002_A2195

Alternate gene names: 170078793

Gene position: 2282843-2283988 (Clockwise)

Preceding gene: 170078792

Following gene: 170078794

Centisome position: 75.89

GC content: 53.14

Gene sequence:

>1146_bases
ATGGCATTCCTGAACTTTGCAAAACCCGGTTATCCCCTCGTCCTGGCAGCCTTTAAGGACAATCCAGAACAGGGACACCG
TCAACTCATTAACGCCCTCCATTGGTTGGAGCGATCGCCGGATTTGCTTTGGAGTCGCCTGGCAAAGGAGCAGATGGTCG
CGGAATTTTGCGTCCAAAATCCGCGCTTAAGCCAGACCCTCTGGGGCCTCGATTTTCCGAATCCGGTGGGACTTTCGGCG
GGCTGTGATAAAGATGCAATGGCGGCAGGGATGTGGTCACGCTTTGGTTTCGGGTTTGCGGAAATGGGCGCAGTGACGCT
CCATGCCCAACCGGGAAATCCTCTACCAAGGCTGTTTCGTTTACCTGCTGACCAAGCGGCCCTTAATCGTTTGGGCGCGA
ATAATCTAGGGGCCGCCGTGATGGCGAAAACCCTAGGGGAAAGTTGGCAAATCGAACCCCGCACCATTCCCATCGGCATT
AACCTCTGTAAGTCAAAGGTGACGCCCCTTGAGGCCGCAGCCCAGGATTATCTGGGGAGCTTTGAGGCATTGCAAGCGGT
GGCCGATTACTTTGTGGTGAATGTGAGTTCTCCCAATACCCCAGGCTTGCGATCACTGCAAGGTGGGGAACAAATTCAAC
CGATCCTTGAAACACTTCAGCAAGCCAATCACAAACAACAGCCGATTTTTATTAAAATTTCCCCGGATCTCGACTGGGAG
GCGATCGCCAATATCGTAAAAATTGCCCAGGATTATCAACTTGCTGGGATTATTGCCACCAACACCACCACCAGACGGGA
CGGCCTCAAGACCCAAATCCTCGAAAAAACTGGCAATCCCGTCACCGAGGAAGCGGGGGGGATCAGTGGCGCGCCCGTGC
GTCAACGTTCCACCGAAGTAATTCGTTTTATCTACGGACAAACCCAAGGCAGCTTGCCGATTATCGGTGTTGGGGGGATT
TTTACCGCTGACCATGCCTGGGAAAAAATGACGGCTGGCGCGAGTTTGCTGCAGCTTTATACAGGCTGGATTTACAAAGG
CCCCTGGATTATCCCCAATATCCTCCGGGGTCTGCTGGAAAAATTAGAGACCCACAACCTCAATCACATTTCCGAGGCGA
TTGGGATGGCCAACAAGCACAACTAG

Upstream 100 bases:

>100_bases
TCGATAGAAAATTAATTAATCAACATCTCAAGGATTTTCCTGGGGCCTCGTTCCCCGACAAGCGATTCCTCAAGCCAACA
TTTCTTTTCTTCCCAAGCCT

Downstream 100 bases:

>100_bases
CAAATTACTGTTGACTGCCATCTGTCTATGGCAAGATAGGAGTGATTTTTTCGGACATGATTCTATGTTTCGTCGCTCCC
AACGTCGTCATCCGTTCAAG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MAFLNFAKPGYPLVLAAFKDNPEQGHRQLINALHWLERSPDLLWSRLAKEQMVAEFCVQNPRLSQTLWGLDFPNPVGLSA
GCDKDAMAAGMWSRFGFGFAEMGAVTLHAQPGNPLPRLFRLPADQAALNRLGANNLGAAVMAKTLGESWQIEPRTIPIGI
NLCKSKVTPLEAAAQDYLGSFEALQAVADYFVVNVSSPNTPGLRSLQGGEQIQPILETLQQANHKQQPIFIKISPDLDWE
AIANIVKIAQDYQLAGIIATNTTTRRDGLKTQILEKTGNPVTEEAGGISGAPVRQRSTEVIRFIYGQTQGSLPIIGVGGI
FTADHAWEKMTAGASLLQLYTGWIYKGPWIIPNILRGLLEKLETHNLNHISEAIGMANKHN

Sequences:

>Translated_381_residues
MAFLNFAKPGYPLVLAAFKDNPEQGHRQLINALHWLERSPDLLWSRLAKEQMVAEFCVQNPRLSQTLWGLDFPNPVGLSA
GCDKDAMAAGMWSRFGFGFAEMGAVTLHAQPGNPLPRLFRLPADQAALNRLGANNLGAAVMAKTLGESWQIEPRTIPIGI
NLCKSKVTPLEAAAQDYLGSFEALQAVADYFVVNVSSPNTPGLRSLQGGEQIQPILETLQQANHKQQPIFIKISPDLDWE
AIANIVKIAQDYQLAGIIATNTTTRRDGLKTQILEKTGNPVTEEAGGISGAPVRQRSTEVIRFIYGQTQGSLPIIGVGGI
FTADHAWEKMTAGASLLQLYTGWIYKGPWIIPNILRGLLEKLETHNLNHISEAIGMANKHN
>Mature_380_residues
AFLNFAKPGYPLVLAAFKDNPEQGHRQLINALHWLERSPDLLWSRLAKEQMVAEFCVQNPRLSQTLWGLDFPNPVGLSAG
CDKDAMAAGMWSRFGFGFAEMGAVTLHAQPGNPLPRLFRLPADQAALNRLGANNLGAAVMAKTLGESWQIEPRTIPIGIN
LCKSKVTPLEAAAQDYLGSFEALQAVADYFVVNVSSPNTPGLRSLQGGEQIQPILETLQQANHKQQPIFIKISPDLDWEA
IANIVKIAQDYQLAGIIATNTTTRRDGLKTQILEKTGNPVTEEAGGISGAPVRQRSTEVIRFIYGQTQGSLPIIGVGGIF
TADHAWEKMTAGASLLQLYTGWIYKGPWIIPNILRGLLEKLETHNLNHISEAIGMANKHN

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=328, Percent_Identity=39.9390243902439, Blast_Score=224, Evalue=9e-59,
Organism=Escherichia coli, GI1787177, Length=353, Percent_Identity=39.0934844192635, Blast_Score=228, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI17509475, Length=371, Percent_Identity=40.1617250673854, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI281361352, Length=327, Percent_Identity=37.9204892966361, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI17137316, Length=327, Percent_Identity=37.9204892966361, Blast_Score=216, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 41647; Mature: 41516

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFLNFAKPGYPLVLAAFKDNPEQGHRQLINALHWLERSPDLLWSRLAKEQMVAEFCVQN
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
PRLSQTLWGLDFPNPVGLSAGCDKDAMAAGMWSRFGFGFAEMGAVTLHAQPGNPLPRLFR
CCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCEEEEEECCCCCCHHHHC
LPADQAALNRLGANNLGAAVMAKTLGESWQIEPRTIPIGINLCKSKVTPLEAAAQDYLGS
CCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHH
FEALQAVADYFVVNVSSPNTPGLRSLQGGEQIQPILETLQQANHKQQPIFIKISPDLDWE
HHHHHHHHHHEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHH
AIANIVKIAQDYQLAGIIATNTTTRRDGLKTQILEKTGNPVTEEAGGISGAPVRQRSTEV
HHHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHCCCCCCHHCCCCCCCCCHHHHHHH
IRFIYGQTQGSLPIIGVGGIFTADHAWEKMTAGASLLQLYTGWIYKGPWIIPNILRGLLE
HHHHHCCCCCCCCEEECCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
KLETHNLNHISEAIGMANKHN
HHHHCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AFLNFAKPGYPLVLAAFKDNPEQGHRQLINALHWLERSPDLLWSRLAKEQMVAEFCVQN
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
PRLSQTLWGLDFPNPVGLSAGCDKDAMAAGMWSRFGFGFAEMGAVTLHAQPGNPLPRLFR
CCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCEEEEEECCCCCCHHHHC
LPADQAALNRLGANNLGAAVMAKTLGESWQIEPRTIPIGINLCKSKVTPLEAAAQDYLGS
CCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHH
FEALQAVADYFVVNVSSPNTPGLRSLQGGEQIQPILETLQQANHKQQPIFIKISPDLDWE
HHHHHHHHHHEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHH
AIANIVKIAQDYQLAGIIATNTTTRRDGLKTQILEKTGNPVTEEAGGISGAPVRQRSTEV
HHHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHCCCCCCHHCCCCCCCCCHHHHHHH
IRFIYGQTQGSLPIIGVGGIFTADHAWEKMTAGASLLQLYTGWIYKGPWIIPNILRGLLE
HHHHHCCCCCCCCEEECCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
KLETHNLNHISEAIGMANKHN
HHHHCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA