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The map label for this gene is hom [H]

Identifier: 170078730

GI number: 170078730

Start: 2213566

End: 2214861

Strand: Direct

Name: hom [H]

Synonym: SYNPCC7002_A2131

Alternate gene names: 170078730

Gene position: 2213566-2214861 (Clockwise)

Preceding gene: 170078729

Following gene: 170078731

Centisome position: 73.59

GC content: 54.32

Gene sequence:

>1296_bases
GTGGCTATCGGAATTGGTTTACTTGGCTTAGGAACGGTTGGCACGGGCACTGCAGAAATTTTGCTGTCGCCCCAGGGCCG
CCACCCGCTGTTGGGGGAAGTGGTTTTGAAACGGGCAGGGGTGCGCTCCCTAGACAAGCCCCGCAACATTGATTTACCAG
CGGGTTGCCTAACCACTGATCTAGAGGCCATCGTCAAAGATCCAGAGATTCAGGTGGTGGTTGAGTTGTTGGGTGGCCTG
GAGCCAGCGCGGACTCTCATCCTGGCGGCGATCGCCAATGGGAAACATGTGGTCACGGCCAACAAAGCAGTGATTGCCAA
ATATGGCGAAGAAATTTACACCGCAGCGAACCAAGCAGGGGTCTATGTGCTCCTTGAGGCGGCGGTGGGCGGTGGCATTC
CGATCATTAAACCCCTCAAGCAATCTTTAGGAGTGAACCGCATTACCCGTGTCATTGGCATTATCAATGGCACCACCAAC
TATATCCTCACCCAGATGGCCCAGCACGGGGCAGACTTTGGGGAAGTATTAGCGGAAGCCCAAAAATTGGGTTATGCCGA
AGCCGATCCCAGTGCCGATGTGGATGGGGGCGACGCGGCGGACAAAATTGCGATTCTCGCTTCCTTGGCCTTTGGGGGAC
GAATTCGGCGCGAAGATGTCTACTGCGAAGGGATTCGTTCCATTAGTGCGGCAGATATCAGTTTTGCGAAAAAGCTCGGT
TTTGTGATCAAATTATTGGCGATCGCCGAACGACCAGACCTCGAAGAAGATGCCCTACAGTTGCGCGTTCACCCGACTTT
GGTGCCAGAAGATCATCCCATCGCCAGCGTCAATGGTGTCTTTAATGCGATCCTCGTGGAAGGGGAACCCCTCGGCCAGG
TAATGTTCTATGGCCCTGGGGCTGGGGCTGGGGCAACGGCCAGCGCCGTAGTTTCTGACATTGTTCATGTGGTGGGTCTG
TTGCATTCTGACCAGGTGATCCAGAAACTCAACCCTCTCCTGGGCTGCACCCATGAGCATTACAGCAAAATTTTACCCAT
TGATACCCTAAAAACTCGTTTTTATGCGCGCTTCTTGTCGCGGGATTTGCCCGGTGTGATCGGCGATCTGGGGACTTGCT
TTGGGCAGCACCAAGTGAGCTTGGAATCAGTCGTGCAGATTGGTCTTCAGGATGATTGCGCTGAGATCGTCGTCGTGACC
CATGATGTCCATGAGGCGAATTTCCGGGAAGCCATGCGAGAAATCGAAGGCCTAGAGGCGATCAAGGAAGTGCCGAGTAT
TCTCCGCGTCCTTTAG

Upstream 100 bases:

>100_bases
TTAGAAATTCACCATCGGAAGTAGTTGATCCCTAAGTTGGGAGATCAGGTAATGGGGGATAATGGAAACATTATCTTGAT
GTTGCACTAGAGAAAACATT

Downstream 100 bases:

>100_bases
TAATCATTCAACTGCAAAATTCTTGATCCTCCACATTTCTGGAGGATTTTTTGTTAATTTGTCTACAATTCTGACGATGT
TTTCCAGAGTTGGGCTAAGT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MAIGIGLLGLGTVGTGTAEILLSPQGRHPLLGEVVLKRAGVRSLDKPRNIDLPAGCLTTDLEAIVKDPEIQVVVELLGGL
EPARTLILAAIANGKHVVTANKAVIAKYGEEIYTAANQAGVYVLLEAAVGGGIPIIKPLKQSLGVNRITRVIGIINGTTN
YILTQMAQHGADFGEVLAEAQKLGYAEADPSADVDGGDAADKIAILASLAFGGRIRREDVYCEGIRSISAADISFAKKLG
FVIKLLAIAERPDLEEDALQLRVHPTLVPEDHPIASVNGVFNAILVEGEPLGQVMFYGPGAGAGATASAVVSDIVHVVGL
LHSDQVIQKLNPLLGCTHEHYSKILPIDTLKTRFYARFLSRDLPGVIGDLGTCFGQHQVSLESVVQIGLQDDCAEIVVVT
HDVHEANFREAMREIEGLEAIKEVPSILRVL

Sequences:

>Translated_431_residues
MAIGIGLLGLGTVGTGTAEILLSPQGRHPLLGEVVLKRAGVRSLDKPRNIDLPAGCLTTDLEAIVKDPEIQVVVELLGGL
EPARTLILAAIANGKHVVTANKAVIAKYGEEIYTAANQAGVYVLLEAAVGGGIPIIKPLKQSLGVNRITRVIGIINGTTN
YILTQMAQHGADFGEVLAEAQKLGYAEADPSADVDGGDAADKIAILASLAFGGRIRREDVYCEGIRSISAADISFAKKLG
FVIKLLAIAERPDLEEDALQLRVHPTLVPEDHPIASVNGVFNAILVEGEPLGQVMFYGPGAGAGATASAVVSDIVHVVGL
LHSDQVIQKLNPLLGCTHEHYSKILPIDTLKTRFYARFLSRDLPGVIGDLGTCFGQHQVSLESVVQIGLQDDCAEIVVVT
HDVHEANFREAMREIEGLEAIKEVPSILRVL
>Mature_430_residues
AIGIGLLGLGTVGTGTAEILLSPQGRHPLLGEVVLKRAGVRSLDKPRNIDLPAGCLTTDLEAIVKDPEIQVVVELLGGLE
PARTLILAAIANGKHVVTANKAVIAKYGEEIYTAANQAGVYVLLEAAVGGGIPIIKPLKQSLGVNRITRVIGIINGTTNY
ILTQMAQHGADFGEVLAEAQKLGYAEADPSADVDGGDAADKIAILASLAFGGRIRREDVYCEGIRSISAADISFAKKLGF
VIKLLAIAERPDLEEDALQLRVHPTLVPEDHPIASVNGVFNAILVEGEPLGQVMFYGPGAGAGATASAVVSDIVHVVGLL
HSDQVIQKLNPLLGCTHEHYSKILPIDTLKTRFYARFLSRDLPGVIGDLGTCFGQHQVSLESVVQIGLQDDCAEIVVVTH
DVHEANFREAMREIEGLEAIKEVPSILRVL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=365, Percent_Identity=27.6712328767123, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786183, Length=255, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322599, Length=127, Percent_Identity=30.7086614173228, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45636; Mature: 45505

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIGIGLLGLGTVGTGTAEILLSPQGRHPLLGEVVLKRAGVRSLDKPRNIDLPAGCLTTD
CEEEEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
LEAIVKDPEIQVVVELLGGLEPARTLILAAIANGKHVVTANKAVIAKYGEEIYTAANQAG
HHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCC
VYVLLEAAVGGGIPIIKPLKQSLGVNRITRVIGIINGTTNYILTQMAQHGADFGEVLAEA
EEEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHH
QKLGYAEADPSADVDGGDAADKIAILASLAFGGRIRREDVYCEGIRSISAADISFAKKLG
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEECCHHHHHHHHHCHHHHHHHHHHHH
FVIKLLAIAERPDLEEDALQLRVHPTLVPEDHPIASVNGVFNAILVEGEPLGQVMFYGPG
HHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHEEEEEECCCCCCEEEEECCC
AGAGATASAVVSDIVHVVGLLHSDQVIQKLNPLLGCTHEHYSKILPIDTLKTRFYARFLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHH
RDLPGVIGDLGTCFGQHQVSLESVVQIGLQDDCAEIVVVTHDVHEANFREAMREIEGLEA
CCCCHHHHHHHHHHCCCHHCHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHH
IKEVPSILRVL
HHHHHHHHHHC
>Mature Secondary Structure 
AIGIGLLGLGTVGTGTAEILLSPQGRHPLLGEVVLKRAGVRSLDKPRNIDLPAGCLTTD
EEEEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
LEAIVKDPEIQVVVELLGGLEPARTLILAAIANGKHVVTANKAVIAKYGEEIYTAANQAG
HHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCC
VYVLLEAAVGGGIPIIKPLKQSLGVNRITRVIGIINGTTNYILTQMAQHGADFGEVLAEA
EEEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHH
QKLGYAEADPSADVDGGDAADKIAILASLAFGGRIRREDVYCEGIRSISAADISFAKKLG
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEECCHHHHHHHHHCHHHHHHHHHHHH
FVIKLLAIAERPDLEEDALQLRVHPTLVPEDHPIASVNGVFNAILVEGEPLGQVMFYGPG
HHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHEEEEEECCCCCCEEEEECCC
AGAGATASAVVSDIVHVVGLLHSDQVIQKLNPLLGCTHEHYSKILPIDTLKTRFYARFLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHH
RDLPGVIGDLGTCFGQHQVSLESVVQIGLQDDCAEIVVVTHDVHEANFREAMREIEGLEA
CCCCHHHHHHHHHHCCCHHCHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHH
IKEVPSILRVL
HHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]