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The map label for this gene is accC [H]

Identifier: 170078726

GI number: 170078726

Start: 2210473

End: 2211819

Strand: Direct

Name: accC [H]

Synonym: SYNPCC7002_A2127

Alternate gene names: 170078726

Gene position: 2210473-2211819 (Clockwise)

Preceding gene: 170078725

Following gene: 170078728

Centisome position: 73.49

GC content: 53.23

Gene sequence:

>1347_bases
ATGCAGTTTTCAAAGATTCTCATCGCCAATCGCGGAGAAGTTGCCCTACGCATTATCCACACCTGTCAGGAGCTCGGCAT
TGCCACAGTTGCCGTCCACTCCACCGTAGATCGCCAAGCCCTCCACGTTCAGCTCGCCGATGAGAGCATTTGCATTGGCC
CGCCCCAGAGCAGCAAAAGCTATCTCAACATTCCCAATATTATCGCTGCGGCCCTCAGCAGTAACGCCGACGCAATCCAC
CCAGGCTACGGTTTCCTCGCTGAAAATGCCAAGTTTGCAGAAATTTGTGCCGACCACCAAATCACCTTCATTGGCCCTTC
CCCAGAAGCAATGATCGCCATGGGGGACAAATCCACCGCCAAAAAAACGATGCAGGCGGCAAAAGTCCCTACCGTACCCG
GTAGTGCTGGGTTGGTGGCCTCCGAAGAACAAGCCCTAGAAATCGCCCAACAAATTGGCTACCCTGTGATGATCAAAGCC
ACGGCGGGTGGTGGTGGCCGGGGGATGCGCCTTGTGCCCAGCGCTGAGGAGTTACCCCGTTTGTACCGAGCGGCCCAGGG
GGAAGCAGAAGCAGCCTTTGGGAATGGCGGCGTTTACATCGAAAAATTTATTGAACGGCCCCGTCACATCGAATTTCAGA
TCCTCGCGGATCAGTACGGCAATGTAATTCACCTCGGCGAACGGGATTGTTCGATCCAACGGCGGCACCAAAAACTCCTC
GAAGAAGCTCCCAGCGCGATCCTCACCCCCAGACTGCGGGACAAAATGGGGAAAGCGGCAGTAAAAGCGGCGAAATCCAT
TGATTATGTCGGGGCGGGGACGGTGGAATTCCTCGTGGATAAGAATGGGGATTTCTACTTTATGGAAATGAATACCCGCA
TTCAGGTGGAACACCCGGTCACAGAGATGGTGACGGGACTAGATCTGATCGCCGAGCAAATTAAAGTTGCCCAAGGCGAT
CGCCTCAGTTTGAATCAAAATCAAGTGAACTTGAATGGTCATGCCATCGAGTGCCGGATTAATGCCGAAGATCCCGACCA
TGATTTCCGACCGACCCCAGGCAAAATCAGTGGCTATCTTCCCCCCGGTGGCCCTGGGGTACGGATGGATTCCCACGTTT
ACACCGACTATGAAATTTCTCCTTACTACGATTCTTTGATCGGTAAATTAATCGTTTGGGGACCAGACCGAGACACCGCC
ATTCGCCGCATGAAGCGGGCACTCCGAGAATGTGCCATTACTGGAGTATCGACCACCATTAGCTTCCACCAAAAGATTTT
GAATCATCCGGCTTTTTTGGCGGCCGATGTCGATACAAACTTTATCCAGCAGCACATGTTGCCCTAG

Upstream 100 bases:

>100_bases
AAGTCTTTTCCGGGGCGATCGCCGCTTGCCGAGGGATACCCCTTACCATGATAATGTTGGCTACCCATCACACTGGGGAC
GCAAACGCCAACGGAACACC

Downstream 100 bases:

>100_bases
GGGCGATCGCAAATAGTCTCTAACCTTGAGGGCAACCCCCATAAGTGACGATTGGGGAAATGCCCTTACTTTTTCGCGAT
GACTTGCACCAAAGTCTGGT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MQFSKILIANRGEVALRIIHTCQELGIATVAVHSTVDRQALHVQLADESICIGPPQSSKSYLNIPNIIAAALSSNADAIH
PGYGFLAENAKFAEICADHQITFIGPSPEAMIAMGDKSTAKKTMQAAKVPTVPGSAGLVASEEQALEIAQQIGYPVMIKA
TAGGGGRGMRLVPSAEELPRLYRAAQGEAEAAFGNGGVYIEKFIERPRHIEFQILADQYGNVIHLGERDCSIQRRHQKLL
EEAPSAILTPRLRDKMGKAAVKAAKSIDYVGAGTVEFLVDKNGDFYFMEMNTRIQVEHPVTEMVTGLDLIAEQIKVAQGD
RLSLNQNQVNLNGHAIECRINAEDPDHDFRPTPGKISGYLPPGGPGVRMDSHVYTDYEISPYYDSLIGKLIVWGPDRDTA
IRRMKRALRECAITGVSTTISFHQKILNHPAFLAADVDTNFIQQHMLP

Sequences:

>Translated_448_residues
MQFSKILIANRGEVALRIIHTCQELGIATVAVHSTVDRQALHVQLADESICIGPPQSSKSYLNIPNIIAAALSSNADAIH
PGYGFLAENAKFAEICADHQITFIGPSPEAMIAMGDKSTAKKTMQAAKVPTVPGSAGLVASEEQALEIAQQIGYPVMIKA
TAGGGGRGMRLVPSAEELPRLYRAAQGEAEAAFGNGGVYIEKFIERPRHIEFQILADQYGNVIHLGERDCSIQRRHQKLL
EEAPSAILTPRLRDKMGKAAVKAAKSIDYVGAGTVEFLVDKNGDFYFMEMNTRIQVEHPVTEMVTGLDLIAEQIKVAQGD
RLSLNQNQVNLNGHAIECRINAEDPDHDFRPTPGKISGYLPPGGPGVRMDSHVYTDYEISPYYDSLIGKLIVWGPDRDTA
IRRMKRALRECAITGVSTTISFHQKILNHPAFLAADVDTNFIQQHMLP
>Mature_448_residues
MQFSKILIANRGEVALRIIHTCQELGIATVAVHSTVDRQALHVQLADESICIGPPQSSKSYLNIPNIIAAALSSNADAIH
PGYGFLAENAKFAEICADHQITFIGPSPEAMIAMGDKSTAKKTMQAAKVPTVPGSAGLVASEEQALEIAQQIGYPVMIKA
TAGGGGRGMRLVPSAEELPRLYRAAQGEAEAAFGNGGVYIEKFIERPRHIEFQILADQYGNVIHLGERDCSIQRRHQKLL
EEAPSAILTPRLRDKMGKAAVKAAKSIDYVGAGTVEFLVDKNGDFYFMEMNTRIQVEHPVTEMVTGLDLIAEQIKVAQGD
RLSLNQNQVNLNGHAIECRINAEDPDHDFRPTPGKISGYLPPGGPGVRMDSHVYTDYEISPYYDSLIGKLIVWGPDRDTA
IRRMKRALRECAITGVSTTISFHQKILNHPAFLAADVDTNFIQQHMLP

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=49.0990990990991, Blast_Score=457, Evalue=1e-129,
Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=50.2262443438914, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=50.2262443438914, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=50.2262443438914, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=50.6726457399103, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=50.6726457399103, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=50.6726457399103, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI38679977, Length=506, Percent_Identity=33.00395256917, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI38679967, Length=506, Percent_Identity=33.00395256917, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI38679974, Length=506, Percent_Identity=33.00395256917, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI38679971, Length=506, Percent_Identity=33.00395256917, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI38679960, Length=506, Percent_Identity=33.00395256917, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI134142062, Length=505, Percent_Identity=32.4752475247525, Blast_Score=269, Evalue=3e-72,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=55.0561797752809, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=48.868778280543, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=48.0812641083521, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17562816, Length=451, Percent_Identity=45.8980044345898, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI133931226, Length=487, Percent_Identity=30.3901437371663, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71997168, Length=506, Percent_Identity=28.0632411067194, Blast_Score=218, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI71997163, Length=506, Percent_Identity=28.0632411067194, Blast_Score=218, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI193204318, Length=242, Percent_Identity=21.4876033057851, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319685, Length=444, Percent_Identity=44.1441441441441, Blast_Score=385, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=44.3946188340807, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321376, Length=446, Percent_Identity=46.1883408071749, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323863, Length=455, Percent_Identity=34.5054945054945, Blast_Score=259, Evalue=8e-70,
Organism=Saccharomyces cerevisiae, GI6324343, Length=507, Percent_Identity=33.7278106508876, Blast_Score=257, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24651757, Length=446, Percent_Identity=47.7578475336323, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=49.2170022371365, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=49.2170022371365, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=49.2170022371365, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=49.2170022371365, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=49.2170022371365, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=49.2170022371365, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=49.2170022371365, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=49.2170022371365, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=49.2170022371365, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=49.2170022371365, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24651759, Length=409, Percent_Identity=46.9437652811736, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI161076407, Length=500, Percent_Identity=33.4, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24586460, Length=500, Percent_Identity=33.4, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI161076409, Length=500, Percent_Identity=33.4, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24586458, Length=500, Percent_Identity=33.4, Blast_Score=275, Evalue=6e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48901; Mature: 48901

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFSKILIANRGEVALRIIHTCQELGIATVAVHSTVDRQALHVQLADESICIGPPQSSKS
CCCCEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCEEEECCCCCCCC
YLNIPNIIAAALSSNADAIHPGYGFLAENAKFAEICADHQITFIGPSPEAMIAMGDKSTA
EECCHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHCCCEEEEECCCCCEEEEECCCHHH
KKTMQAAKVPTVPGSAGLVASEEQALEIAQQIGYPVMIKATAGGGGRGMRLVPSAEELPR
HHHHHHHCCCCCCCCCCCEECHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCHHHHHH
LYRAAQGEAEAAFGNGGVYIEKFIERPRHIEFQILADQYGNVIHLGERDCSIQRRHQKLL
HHHHCCCCCCEEECCCCCHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EEAPSAILTPRLRDKMGKAAVKAAKSIDYVGAGTVEFLVDKNGDFYFMEMNTRIQVEHPV
HHCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEEECCH
TEMVTGLDLIAEQIKVAQGDRLSLNQNQVNLNGHAIECRINAEDPDHDFRPTPGKISGYL
HHHHHHHHHHHHHHHHCCCCCEECCCCEEEECCEEEEEEECCCCCCCCCCCCCCCCEEEC
PPGGPGVRMDSHVYTDYEISPYYDSLIGKLIVWGPDRDTAIRRMKRALRECAITGVSTTI
CCCCCCCEECCEEEECEECCHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHH
SFHQKILNHPAFLAADVDTNFIQQHMLP
HHHHHHHCCCCEEEECCCHHHHHHHCCC
>Mature Secondary Structure
MQFSKILIANRGEVALRIIHTCQELGIATVAVHSTVDRQALHVQLADESICIGPPQSSKS
CCCCEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCEEEECCCCCCCC
YLNIPNIIAAALSSNADAIHPGYGFLAENAKFAEICADHQITFIGPSPEAMIAMGDKSTA
EECCHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHCCCEEEEECCCCCEEEEECCCHHH
KKTMQAAKVPTVPGSAGLVASEEQALEIAQQIGYPVMIKATAGGGGRGMRLVPSAEELPR
HHHHHHHCCCCCCCCCCCEECHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCHHHHHH
LYRAAQGEAEAAFGNGGVYIEKFIERPRHIEFQILADQYGNVIHLGERDCSIQRRHQKLL
HHHHCCCCCCEEECCCCCHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EEAPSAILTPRLRDKMGKAAVKAAKSIDYVGAGTVEFLVDKNGDFYFMEMNTRIQVEHPV
HHCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEEECCH
TEMVTGLDLIAEQIKVAQGDRLSLNQNQVNLNGHAIECRINAEDPDHDFRPTPGKISGYL
HHHHHHHHHHHHHHHHCCCCCEECCCCEEEECCEEEEEEECCCCCCCCCCCCCCCCEEEC
PPGGPGVRMDSHVYTDYEISPYYDSLIGKLIVWGPDRDTAIRRMKRALRECAITGVSTTI
CCCCCCCEECCEEEECEECCHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHH
SFHQKILNHPAFLAADVDTNFIQQHMLP
HHHHHHHCCCCEEEECCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]