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The map label for this gene is purD [H]

Identifier: 170078015

GI number: 170078015

Start: 1473640

End: 1474914

Strand: Reverse

Name: purD [H]

Synonym: SYNPCC7002_A1406

Alternate gene names: 170078015

Gene position: 1474914-1473640 (Counterclockwise)

Preceding gene: 170078017

Following gene: 170078014

Centisome position: 49.03

GC content: 53.57

Gene sequence:

>1275_bases
ATGAATGTACTCGTGGTGGGTAACGGCGGCAGAGAGCATGCGATCGCCTGGAAACTGCTCCAATCTCCCAACGTCCAGAA
AGTCGTTTGTACCCCCGGTAATGGCGGCACCGCTCTGTTAGAAAATTGCCAAAATCTACCTATTGCTGTGGATGACTTTG
CGGGAATTGCCCAAGCCTGTACCGACCACGACATTGCTTTTGTTGCCGTCGGCCCAGAAGTCCCCCTGTCCCTCGGCCTT
GCTGACTTTCTCTCAGAACGCAAGATTTCCGTATTCGGTCCGAAAAAAGATGGCGCAATCATTGAAGCCAGTAAAGCTTG
GGCCAAGGACTTAATGAACGAAGCAGGGGTTCCCACTGCCGCCGCTGGCACTTTTAACAATCCCCAAGCCGCAAAGGACT
ACATCCAAACCCAAGGCGCGCCCATCGTTCCCATCGTTGTCAAAGCCGATAGTCTCGCTGCCGGAAAGGGGGTGATCGTC
GCAGAAACCTTAGAAGAAGCCTTAAACGCCGTTGATCGCCTCTGGGCCGAAGGGTACAAAACCTTAGTCGTCGAAGAATT
TCTCGTGGGTCAGGAAGTCTCTGTCCTCGCTCTCACCGATGGGAAGACGATCCGCCCCTTGCTGCCCTCCCAAGACCACA
AACAAATTGGCGAAGGAGATACCGGGGAAAATACCGGGGGAATGGGGGTTTACGCCCCAACGCCCATCGCCACCACCGAG
ATCATGGCCCAAGTCCAAACCGATGTTCTGGAGGCCACTCTCAAAACTTTACAAAATCGCGGCATTGATTACCGGGGGAT
TCTCTACGCAGGTCTCATGGTTGCACCAAATGGCGAGGTTAAGGTGCTGGAATTTAACTGTCGCTTTGGCGATCCAGAAA
CCCAGGCGGTTTTACCCCTCCTCGAAACACCCCTTGATGAGATTATGCTCGCCTGCATTAATCAAACCCTGGCTGAACTG
CCTCCTTTGCAGTGGTATGACGGTAGTGCAGTTTGCGTCGTGGCGGCGGCGGCGGGCTATCCCGGTGCCTATGAAAAGGG
CAAGATTATCACAGGTATCCAAGCAGCTGAAGCTCTAGGTGCGACAGTTTTCCATGCAGGGACTAAATTAGAAGGAGATA
CCCTCGTCACCAATGGGGGTCGTGTCCTTGGCATTGTTTGCCGTGGTCACAGTTTTGATCAGGCGATCGCCAACGTATAC
CAGGCCGTTCCCAAAGTTCAGTTCCCAGGAATGTACTACCGTCGCGACATTGGACACCGCCTCAAAAAAGCGTAG

Upstream 100 bases:

>100_bases
TGCCCTCACCATTGCCAGAACTTTACCATAGCCTCCAATGGGGGAATCTCTTCCGATAGAATAAAAGATTGATCAATTAA
CAAAGGTTGAATTAGTAACA

Downstream 100 bases:

>100_bases
CTTGCAACAAAACGTTACATTGTATTTAATAAAGCAAACTTGATCTGGTAAGTTCACCCCCGAAAACACCTTGCTAACCC
TCATCACCAAACTCCGCAAT

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MNVLVVGNGGREHAIAWKLLQSPNVQKVVCTPGNGGTALLENCQNLPIAVDDFAGIAQACTDHDIAFVAVGPEVPLSLGL
ADFLSERKISVFGPKKDGAIIEASKAWAKDLMNEAGVPTAAAGTFNNPQAAKDYIQTQGAPIVPIVVKADSLAAGKGVIV
AETLEEALNAVDRLWAEGYKTLVVEEFLVGQEVSVLALTDGKTIRPLLPSQDHKQIGEGDTGENTGGMGVYAPTPIATTE
IMAQVQTDVLEATLKTLQNRGIDYRGILYAGLMVAPNGEVKVLEFNCRFGDPETQAVLPLLETPLDEIMLACINQTLAEL
PPLQWYDGSAVCVVAAAAGYPGAYEKGKIITGIQAAEALGATVFHAGTKLEGDTLVTNGGRVLGIVCRGHSFDQAIANVY
QAVPKVQFPGMYYRRDIGHRLKKA

Sequences:

>Translated_424_residues
MNVLVVGNGGREHAIAWKLLQSPNVQKVVCTPGNGGTALLENCQNLPIAVDDFAGIAQACTDHDIAFVAVGPEVPLSLGL
ADFLSERKISVFGPKKDGAIIEASKAWAKDLMNEAGVPTAAAGTFNNPQAAKDYIQTQGAPIVPIVVKADSLAAGKGVIV
AETLEEALNAVDRLWAEGYKTLVVEEFLVGQEVSVLALTDGKTIRPLLPSQDHKQIGEGDTGENTGGMGVYAPTPIATTE
IMAQVQTDVLEATLKTLQNRGIDYRGILYAGLMVAPNGEVKVLEFNCRFGDPETQAVLPLLETPLDEIMLACINQTLAEL
PPLQWYDGSAVCVVAAAAGYPGAYEKGKIITGIQAAEALGATVFHAGTKLEGDTLVTNGGRVLGIVCRGHSFDQAIANVY
QAVPKVQFPGMYYRRDIGHRLKKA
>Mature_424_residues
MNVLVVGNGGREHAIAWKLLQSPNVQKVVCTPGNGGTALLENCQNLPIAVDDFAGIAQACTDHDIAFVAVGPEVPLSLGL
ADFLSERKISVFGPKKDGAIIEASKAWAKDLMNEAGVPTAAAGTFNNPQAAKDYIQTQGAPIVPIVVKADSLAAGKGVIV
AETLEEALNAVDRLWAEGYKTLVVEEFLVGQEVSVLALTDGKTIRPLLPSQDHKQIGEGDTGENTGGMGVYAPTPIATTE
IMAQVQTDVLEATLKTLQNRGIDYRGILYAGLMVAPNGEVKVLEFNCRFGDPETQAVLPLLETPLDEIMLACINQTLAEL
PPLQWYDGSAVCVVAAAAGYPGAYEKGKIITGIQAAEALGATVFHAGTKLEGDTLVTNGGRVLGIVCRGHSFDQAIANVY
QAVPKVQFPGMYYRRDIGHRLKKA

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=424, Percent_Identity=44.811320754717, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI209869995, Length=424, Percent_Identity=44.811320754717, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI209869993, Length=424, Percent_Identity=44.811320754717, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI28416899, Length=424, Percent_Identity=44.811320754717, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI1790438, Length=426, Percent_Identity=43.6619718309859, Blast_Score=342, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI17567511, Length=424, Percent_Identity=42.4528301886792, Blast_Score=304, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6321203, Length=439, Percent_Identity=39.4077448747153, Blast_Score=302, Evalue=6e-83,
Organism=Drosophila melanogaster, GI62471619, Length=434, Percent_Identity=48.1566820276498, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24582400, Length=434, Percent_Identity=48.1566820276498, Blast_Score=348, Evalue=3e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 44814; Mature: 44814

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLVVGNGGREHAIAWKLLQSPNVQKVVCTPGNGGTALLENCQNLPIAVDDFAGIAQAC
CEEEEECCCCCCHHHHHHHHCCCCCCEEEEECCCCCHHHHHCCCCCCEEEHHHHHHHHHH
TDHDIAFVAVGPEVPLSLGLADFLSERKISVFGPKKDGAIIEASKAWAKDLMNEAGVPTA
CCCCEEEEEECCCCCHHHCHHHHHCCCCEEEECCCCCCCEEECHHHHHHHHHHHCCCCCC
AAGTFNNPQAAKDYIQTQGAPIVPIVVKADSLAAGKGVIVAETLEEALNAVDRLWAEGYK
CCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHCCHH
TLVVEEFLVGQEVSVLALTDGKTIRPLLPSQDHKQIGEGDTGENTGGMGVYAPTPIATTE
HHHHHHHHCCCCEEEEEEECCCEECCCCCCCCHHHCCCCCCCCCCCCEEEECCCCCHHHH
IMAQVQTDVLEATLKTLQNRGIDYRGILYAGLMVAPNGEVKVLEFNCRFGDPETQAVLPL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHH
LETPLDEIMLACINQTLAELPPLQWYDGSAVCVVAAAAGYPGAYEKGKIITGIQAAEALG
HHCCHHHHHHHHHHHHHHHCCCCEEECCCEEEEEEEECCCCCCCCCCCEEECHHHHHHHH
ATVFHAGTKLEGDTLVTNGGRVLGIVCRGHSFDQAIANVYQAVPKVQFPGMYYRRDIGHR
HHHEECCCCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LKKA
HHCC
>Mature Secondary Structure
MNVLVVGNGGREHAIAWKLLQSPNVQKVVCTPGNGGTALLENCQNLPIAVDDFAGIAQAC
CEEEEECCCCCCHHHHHHHHCCCCCCEEEEECCCCCHHHHHCCCCCCEEEHHHHHHHHHH
TDHDIAFVAVGPEVPLSLGLADFLSERKISVFGPKKDGAIIEASKAWAKDLMNEAGVPTA
CCCCEEEEEECCCCCHHHCHHHHHCCCCEEEECCCCCCCEEECHHHHHHHHHHHCCCCCC
AAGTFNNPQAAKDYIQTQGAPIVPIVVKADSLAAGKGVIVAETLEEALNAVDRLWAEGYK
CCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHCCHH
TLVVEEFLVGQEVSVLALTDGKTIRPLLPSQDHKQIGEGDTGENTGGMGVYAPTPIATTE
HHHHHHHHCCCCEEEEEEECCCEECCCCCCCCHHHCCCCCCCCCCCCEEEECCCCCHHHH
IMAQVQTDVLEATLKTLQNRGIDYRGILYAGLMVAPNGEVKVLEFNCRFGDPETQAVLPL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHH
LETPLDEIMLACINQTLAELPPLQWYDGSAVCVVAAAAGYPGAYEKGKIITGIQAAEALG
HHCCHHHHHHHHHHHHHHHCCCCEEECCCEEEEEEEECCCCCCCCCCCEEECHHHHHHHH
ATVFHAGTKLEGDTLVTNGGRVLGIVCRGHSFDQAIANVYQAVPKVQFPGMYYRRDIGHR
HHHEECCCCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LKKA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]