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The map label for this gene is guaA

Identifier: 170077976

GI number: 170077976

Start: 1421964

End: 1423586

Strand: Direct

Name: guaA

Synonym: SYNPCC7002_A1362

Alternate gene names: 170077976

Gene position: 1421964-1423586 (Clockwise)

Preceding gene: 170077973

Following gene: 170077982

Centisome position: 47.27

GC content: 52.06

Gene sequence:

>1623_bases
TTGCTGAACGTGACTACGACTCCACTCCAAAAACCGATTGACGCCACCAATACAGGCAATAGTCTTCAACGCCAAATCAT
CGTTATCTTAGATTTTGGCTCCCAATACTCTGAACTAATTGCCAGAAGAATTCGCGAAACGGAAGTTTACTCTGAGGTCA
TTTCCTATCGCACCAGCGCCGAACAATTGCGGCAACTTAATCCCAGCGGCATCATCCTCTCCGGTGGCCCCAGTTCTGTC
TATGACGACTATGCCCCGGCCTGTGACCCTGAAATTTGGAATCTTGGGATTCCTGTCCTTGGGGTCTGCTACGGGATGCA
GCTAATGGTGAAACAACTCGGCGGTACCGTCGAGCGCGCCAAGCACGCAGAGTATGGCAAAGCATCAATCTTTATCGATG
ATCCCACCGATCTGCTGACCAATGTGGAGGAAGGCTCCACCATGTGGATGAGCCACGGGGACTCCTGTGTGCACCTGCCC
GAAGGGTTTGAAATTTTAGCCCATACGGACAATACTCCTTGTGCGGCGATCGCCCACCATGGCCGCCAACTTTACGGGGT
GCAGTTCCACCCAGAAGTGGTTCATTCCCAGGACGGTATGGCCCTGATCCGCAACTTTGTTTATCACATTTGTAAATGTG
AACCCACCTGGACCACAGAAGCCTTCGTTGAAGAAGCAATTCGTGAGATCCGAGCCCGGGTCGGTGATCAACGGGTACTC
CTCGCCCTTTCTGGAGGCGTCGATTCTTCTACCTTGGCCTTTTTGCTCCACCAAGCGATCGGCGATCAACTGACCTGTAT
GTTCATCGACCAAGGCTTTATGCGGAAAGGGGAACCGGAACGCCTTGTGGAAATCTTTGATGAGCAATTTCACATTCCCG
TCGCCTATATCAACGCCCGCGATCGCTTTATCGACAAGCTCAAAGGGGTTACCGATCCCGAAGAAAAGCGCCGCCTCATT
GGCCACGAATTTATCGCCGTCTTCGAGGAAGAATCAAAACGCCTTGGCCCCTTTGATTACCTCGCCCAGGGGACTCTATA
TCCCGATGTAATCGAATCGGCGGATACCAACGTTGACCCCAAAACGGGAGAACGGGTCGCGGTCAAAATCAAGAGTCACC
ACAACGTCGGCGGTTTACCAGAAGACCTGCGTTTTAAATTGGTTGAACCCCTCCGCAAACTCTTCAAAGATGAAGTGCGT
AAGGTAGCAGCCAGCATTGGTTTGCCCGAAGAGATTATTCGCCGTCACCCCTTCCCTGGCCCTGGCCTCGCGATTCGGAT
CATTGGCGAAGTCACCGCAGAACGGTTAAATATTCTCCGGGATGCAGACTGGGTTGTGCGGGATGAAATCAAAAAGCAAG
GGGTTTACAGTGATTTTTGGCAAGCCTTTGCGGTCTTACTACCGATTCGTAGTGTGGGTGTGATGGGCGATAAGCGCACC
TATGCTCACCCCGTCGTACTGCGGATGATTACCAGTGAAGATGGGATGACAGCGGATTGGGCTCGTCCCCCCTATGAGCT
TTTGGAAACCATTTCTAATCGCATGGTGAATGAGGTGAAAGGGGTTAACCGCGTGGTCTATGACATCACTTCTAAGCCTC
CTGGCACCATCGAGTGGGAGTAA

Upstream 100 bases:

>100_bases
CCAATCTCCACAGCAACCCGGCGATCGCTGGTGCTGGGAAATACGAGGCCTTGGATTTTTCCCTGGCTTATTTTATCTGT
TAACTTCCACTAGGGATTTT

Downstream 100 bases:

>100_bases
CTACACCTCCTTAGCTCCCCCCTTCAGGAACACCCATCTAGCTCCCCTCAAGGGGAGATTAAGAGTCCCGCAGGTTAAAA
CTGTTGGGGCTTTTTTCTTG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MLNVTTTPLQKPIDATNTGNSLQRQIIVILDFGSQYSELIARRIRETEVYSEVISYRTSAEQLRQLNPSGIILSGGPSSV
YDDYAPACDPEIWNLGIPVLGVCYGMQLMVKQLGGTVERAKHAEYGKASIFIDDPTDLLTNVEEGSTMWMSHGDSCVHLP
EGFEILAHTDNTPCAAIAHHGRQLYGVQFHPEVVHSQDGMALIRNFVYHICKCEPTWTTEAFVEEAIREIRARVGDQRVL
LALSGGVDSSTLAFLLHQAIGDQLTCMFIDQGFMRKGEPERLVEIFDEQFHIPVAYINARDRFIDKLKGVTDPEEKRRLI
GHEFIAVFEEESKRLGPFDYLAQGTLYPDVIESADTNVDPKTGERVAVKIKSHHNVGGLPEDLRFKLVEPLRKLFKDEVR
KVAASIGLPEEIIRRHPFPGPGLAIRIIGEVTAERLNILRDADWVVRDEIKKQGVYSDFWQAFAVLLPIRSVGVMGDKRT
YAHPVVLRMITSEDGMTADWARPPYELLETISNRMVNEVKGVNRVVYDITSKPPGTIEWE

Sequences:

>Translated_540_residues
MLNVTTTPLQKPIDATNTGNSLQRQIIVILDFGSQYSELIARRIRETEVYSEVISYRTSAEQLRQLNPSGIILSGGPSSV
YDDYAPACDPEIWNLGIPVLGVCYGMQLMVKQLGGTVERAKHAEYGKASIFIDDPTDLLTNVEEGSTMWMSHGDSCVHLP
EGFEILAHTDNTPCAAIAHHGRQLYGVQFHPEVVHSQDGMALIRNFVYHICKCEPTWTTEAFVEEAIREIRARVGDQRVL
LALSGGVDSSTLAFLLHQAIGDQLTCMFIDQGFMRKGEPERLVEIFDEQFHIPVAYINARDRFIDKLKGVTDPEEKRRLI
GHEFIAVFEEESKRLGPFDYLAQGTLYPDVIESADTNVDPKTGERVAVKIKSHHNVGGLPEDLRFKLVEPLRKLFKDEVR
KVAASIGLPEEIIRRHPFPGPGLAIRIIGEVTAERLNILRDADWVVRDEIKKQGVYSDFWQAFAVLLPIRSVGVMGDKRT
YAHPVVLRMITSEDGMTADWARPPYELLETISNRMVNEVKGVNRVVYDITSKPPGTIEWE
>Mature_540_residues
MLNVTTTPLQKPIDATNTGNSLQRQIIVILDFGSQYSELIARRIRETEVYSEVISYRTSAEQLRQLNPSGIILSGGPSSV
YDDYAPACDPEIWNLGIPVLGVCYGMQLMVKQLGGTVERAKHAEYGKASIFIDDPTDLLTNVEEGSTMWMSHGDSCVHLP
EGFEILAHTDNTPCAAIAHHGRQLYGVQFHPEVVHSQDGMALIRNFVYHICKCEPTWTTEAFVEEAIREIRARVGDQRVL
LALSGGVDSSTLAFLLHQAIGDQLTCMFIDQGFMRKGEPERLVEIFDEQFHIPVAYINARDRFIDKLKGVTDPEEKRRLI
GHEFIAVFEEESKRLGPFDYLAQGTLYPDVIESADTNVDPKTGERVAVKIKSHHNVGGLPEDLRFKLVEPLRKLFKDEVR
KVAASIGLPEEIIRRHPFPGPGLAIRIIGEVTAERLNILRDADWVVRDEIKKQGVYSDFWQAFAVLLPIRSVGVMGDKRT
YAHPVVLRMITSEDGMTADWARPPYELLETISNRMVNEVKGVNRVVYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=555, Percent_Identity=37.8378378378378, Blast_Score=323, Evalue=2e-88,
Organism=Escherichia coli, GI1788854, Length=528, Percent_Identity=48.2954545454545, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1789760, Length=171, Percent_Identity=30.9941520467836, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787517, Length=207, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=587, Percent_Identity=36.7972742759796, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71992710, Length=587, Percent_Identity=36.7972742759796, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI133901714, Length=587, Percent_Identity=36.7972742759796, Blast_Score=312, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6323873, Length=521, Percent_Identity=47.6007677543186, Blast_Score=495, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6322638, Length=194, Percent_Identity=28.3505154639175, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI281365319, Length=559, Percent_Identity=36.3148479427549, Blast_Score=307, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_SYNP2 (B1XLR5)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001734614.1
- ProteinModelPortal:   B1XLR5
- SMR:   B1XLR5
- GeneID:   6055399
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A1362
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C

EC number: =6.3.5.2

Molecular weight: Translated: 60707; Mature: 60707

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 103-103 ACT_SITE 190-190 ACT_SITE 192-192

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNVTTTPLQKPIDATNTGNSLQRQIIVILDFGSQYSELIARRIRETEVYSEVISYRTSA
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCH
EQLRQLNPSGIILSGGPSSVYDDYAPACDPEIWNLGIPVLGVCYGMQLMVKQLGGTVERA
HHHHHCCCCCEEEECCCCCHHHCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCCHHHHH
KHAEYGKASIFIDDPTDLLTNVEEGSTMWMSHGDSCVHLPEGFEILAHTDNTPCAAIAHH
HHCCCCCEEEEEECCHHHHCCCCCCCEEEECCCCCEEECCCCCEEEEECCCCCHHHHHHC
GRQLYGVQFHPEVVHSQDGMALIRNFVYHICKCEPTWTTEAFVEEAIREIRARVGDQRVL
CCEEEEEEECHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEE
LALSGGVDSSTLAFLLHQAIGDQLTCMFIDQGFMRKGEPERLVEIFDEQFHIPVAYINAR
EEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHCCCCHHHHHHHHHHCCCCEEEEECHH
DRFIDKLKGVTDPEEKRRLIGHEFIAVFEEESKRLGPFDYLAQGTLYPDVIESADTNVDP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHCCCCCCC
KTGERVAVKIKSHHNVGGLPEDLRFKLVEPLRKLFKDEVRKVAASIGLPEEIIRRHPFPG
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCC
PGLAIRIIGEVTAERLNILRDADWVVRDEIKKQGVYSDFWQAFAVLLPIRSVGVMGDKRT
CCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCC
YAHPVVLRMITSEDGMTADWARPPYELLETISNRMVNEVKGVNRVVYDITSKPPGTIEWE
CCCHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
>Mature Secondary Structure
MLNVTTTPLQKPIDATNTGNSLQRQIIVILDFGSQYSELIARRIRETEVYSEVISYRTSA
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCH
EQLRQLNPSGIILSGGPSSVYDDYAPACDPEIWNLGIPVLGVCYGMQLMVKQLGGTVERA
HHHHHCCCCCEEEECCCCCHHHCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCCHHHHH
KHAEYGKASIFIDDPTDLLTNVEEGSTMWMSHGDSCVHLPEGFEILAHTDNTPCAAIAHH
HHCCCCCEEEEEECCHHHHCCCCCCCEEEECCCCCEEECCCCCEEEEECCCCCHHHHHHC
GRQLYGVQFHPEVVHSQDGMALIRNFVYHICKCEPTWTTEAFVEEAIREIRARVGDQRVL
CCEEEEEEECHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEE
LALSGGVDSSTLAFLLHQAIGDQLTCMFIDQGFMRKGEPERLVEIFDEQFHIPVAYINAR
EEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHCCCCHHHHHHHHHHCCCCEEEEECHH
DRFIDKLKGVTDPEEKRRLIGHEFIAVFEEESKRLGPFDYLAQGTLYPDVIESADTNVDP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHCCCCCCC
KTGERVAVKIKSHHNVGGLPEDLRFKLVEPLRKLFKDEVRKVAASIGLPEEIIRRHPFPG
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCC
PGLAIRIIGEVTAERLNILRDADWVVRDEIKKQGVYSDFWQAFAVLLPIRSVGVMGDKRT
CCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCC
YAHPVVLRMITSEDGMTADWARPPYELLETISNRMVNEVKGVNRVVYDITSKPPGTIEWE
CCCHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA