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The map label for this gene is tmk [H]

Identifier: 170077931

GI number: 170077931

Start: 1372405

End: 1373064

Strand: Direct

Name: tmk [H]

Synonym: SYNPCC7002_A1316

Alternate gene names: 170077931

Gene position: 1372405-1373064 (Clockwise)

Preceding gene: 170077930

Following gene: 170077936

Centisome position: 45.62

GC content: 48.64

Gene sequence:

>660_bases
ATGCAGCGTGAAACCCAAGCAAAATTTATCGTTTTTGAAGGGATTGACGGTTCCGGTAGCTCTACCCAAGCCGAGCTTTT
GTATCAACATTTTCAGCGACAAAAGATCCCCGCCGTCCTCAGTCCCGAACCCTCCAACGGCATTATCGGCAACCTCGTTC
GAGAAACTCTGCGGCAACGGCTGCGCTTTACCACCGACCCAGTCCAACTAAATCGGCAACTGGCTTATCTCTTCGCTGGC
GATCGCCATGATCATCTTTACAACGAAATTGACGGCGTCTTCAAACAACTTGCCGCTGGGATCCAGGTGATTACGACCCG
CTATTATTTTTCTTCCCTCGCCTACAACGCCAACAATGCCGCCGAATACGAATTTATTTACCGTCTCAACCAAGATTTTC
CTAATCCCGATCTGGTGTTTTATTGCGATCTTCCCGTGGAGGTGGCCCTAGAGCGCGTCCAAAGGCGATCGCACCAAGAA
ATCTACGAAACCAAAGCCAAACTTACCCAAGTGCGCCAAAACTACCAACAAATTTTTCAAACCTATCCAGGGAATTGGCA
ACAACTCGATGCTACCCAACCCCCTGAAACCATCCACCAGCAAATTCTCCAAACTATTGCTGATTATTTTGTAACTGCTC
CTGAATCTGGGTCGGACTAG

Upstream 100 bases:

>100_bases
TAATTTACCATTGCCGTGATTTGATTCAAAACCAAAAACCTTTCCAGACGTGGGACAATCTCCTAGAAAATGCGGGCCTT
TTGGCGGAGATGGTGTGGTG

Downstream 100 bases:

>100_bases
GTGGCGTCCCGAACTCCTCTAGGGGCTGTAACTCCAAATCAAACCCATTCCCATTGGGCGGCGGTAACGGTGTGCCACTG
TCGAGGGGCTCAAGCTGAAA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MQRETQAKFIVFEGIDGSGSSTQAELLYQHFQRQKIPAVLSPEPSNGIIGNLVRETLRQRLRFTTDPVQLNRQLAYLFAG
DRHDHLYNEIDGVFKQLAAGIQVITTRYYFSSLAYNANNAAEYEFIYRLNQDFPNPDLVFYCDLPVEVALERVQRRSHQE
IYETKAKLTQVRQNYQQIFQTYPGNWQQLDATQPPETIHQQILQTIADYFVTAPESGSD

Sequences:

>Translated_219_residues
MQRETQAKFIVFEGIDGSGSSTQAELLYQHFQRQKIPAVLSPEPSNGIIGNLVRETLRQRLRFTTDPVQLNRQLAYLFAG
DRHDHLYNEIDGVFKQLAAGIQVITTRYYFSSLAYNANNAAEYEFIYRLNQDFPNPDLVFYCDLPVEVALERVQRRSHQE
IYETKAKLTQVRQNYQQIFQTYPGNWQQLDATQPPETIHQQILQTIADYFVTAPESGSD
>Mature_219_residues
MQRETQAKFIVFEGIDGSGSSTQAELLYQHFQRQKIPAVLSPEPSNGIIGNLVRETLRQRLRFTTDPVQLNRQLAYLFAG
DRHDHLYNEIDGVFKQLAAGIQVITTRYYFSSLAYNANNAAEYEFIYRLNQDFPNPDLVFYCDLPVEVALERVQRRSHQE
IYETKAKLTQVRQNYQQIFQTYPGNWQQLDATQPPETIHQQILQTIADYFVTAPESGSD

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Drosophila melanogaster, GI28573735, Length=204, Percent_Identity=27.9411764705882, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 25358; Mature: 25358

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRETQAKFIVFEGIDGSGSSTQAELLYQHFQRQKIPAVLSPEPSNGIIGNLVRETLRQR
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHH
LRFTTDPVQLNRQLAYLFAGDRHDHLYNEIDGVFKQLAAGIQVITTRYYFSSLAYNANNA
HCCCCCHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AEYEFIYRLNQDFPNPDLVFYCDLPVEVALERVQRRSHQEIYETKAKLTQVRQNYQQIFQ
HHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TYPGNWQQLDATQPPETIHQQILQTIADYFVTAPESGSD
HCCCCCEECCCCCCHHHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure
MQRETQAKFIVFEGIDGSGSSTQAELLYQHFQRQKIPAVLSPEPSNGIIGNLVRETLRQR
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHH
LRFTTDPVQLNRQLAYLFAGDRHDHLYNEIDGVFKQLAAGIQVITTRYYFSSLAYNANNA
HCCCCCHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AEYEFIYRLNQDFPNPDLVFYCDLPVEVALERVQRRSHQEIYETKAKLTQVRQNYQQIFQ
HHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TYPGNWQQLDATQPPETIHQQILQTIADYFVTAPESGSD
HCCCCCEECCCCCCHHHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]