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The map label for this gene is dcm

Identifier: 170077805

GI number: 170077805

Start: 1230613

End: 1231359

Strand: Direct

Name: dcm

Synonym: SYNPCC7002_A1188

Alternate gene names: 170077805

Gene position: 1230613-1231359 (Clockwise)

Preceding gene: 170077803

Following gene: 302334807

Centisome position: 40.91

GC content: 43.78

Gene sequence:

>747_bases
ATGGAAAAAAAACTGATAAGCCTATTTTCCGGAGCTGGTGGCATGGACATCGGCTTTCACGCTGCTGGCTTCAGTACGGC
GGTAGCTGTGGAACAAGATCCGTCTTGCTGCAATACTCTAAGGCTTAATATGCCGGACACTCCAGTCATTGAAGGCGACA
TCACCTCAATTACAACACAGGTTATCTTAGAAGCGGCAAAAGTCAATCCTCTTGAAATTGACCTAGTTATTGGTGGCCCC
CCTTGCCAAAGTTTCAGCCTAGCAGGTAAACGTATGGGAATGGATGATCCGAGAGGAATGCTGGTACTTGAGTTTCTACG
TGTAGTCAGGGAGGCATTGCCAAAGTGTTTTGTTATGGAGAATGTCAAAGGAATGATCAATTGGTCAAAGGGAAAGGCTC
TTGAGGCTATCATGACAGAAGCATCGCAGCCTATAAAATACGCTGGAAAAGAATATAAATATGCTGTTTCGTATCATGTC
CTAAATGCTGCTGATTTTGGTGTTCCGCAATTTAGAGAAAGAGTATTCATCGTAGGTAATCGTTTGGGCAAAACATTCCA
ATTTCCTGAACCAACTCATGGGCCTAGCAACCAAGCGAGACAGATAGATCTTTTTGGCAAGCAGCTAAAACCTTACAAAA
CTGTTCAAGATGCAATTAGCACTCTCCCCCCTGCAACCCCTCCTTCAGCGATGGCACTAAGAGTTTCGCAGACCATAAAA
GATAGGATAAAGAATCATGGATATTAA

Upstream 100 bases:

>100_bases
ATCGCCTACCCTTCGAGAGACTTGATCCACTCAAGGTAGTATTGTCCTGATCCCTAAGAGATAATCTTTAGGTGAGCTGT
ACAATAACATAAAATTCATA

Downstream 100 bases:

>100_bases
AAACGTTCATATCAAAAATCACGAACAAACAGCTCATGCACCTTCCACTCTAGAAAAAATTCGTAAAGTCAAACAAGGGG
GTAAACTCTCAGAACAGACA

Product: Type II cytosine-5 DNA methyltransferase

Products: NA

Alternate protein names: M.AquI subunit alpha; M.AquiA; Cytosine-specific methyltransferase AquI subunit alpha

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MEKKLISLFSGAGGMDIGFHAAGFSTAVAVEQDPSCCNTLRLNMPDTPVIEGDITSITTQVILEAAKVNPLEIDLVIGGP
PCQSFSLAGKRMGMDDPRGMLVLEFLRVVREALPKCFVMENVKGMINWSKGKALEAIMTEASQPIKYAGKEYKYAVSYHV
LNAADFGVPQFRERVFIVGNRLGKTFQFPEPTHGPSNQARQIDLFGKQLKPYKTVQDAISTLPPATPPSAMALRVSQTIK
DRIKNHGY

Sequences:

>Translated_248_residues
MEKKLISLFSGAGGMDIGFHAAGFSTAVAVEQDPSCCNTLRLNMPDTPVIEGDITSITTQVILEAAKVNPLEIDLVIGGP
PCQSFSLAGKRMGMDDPRGMLVLEFLRVVREALPKCFVMENVKGMINWSKGKALEAIMTEASQPIKYAGKEYKYAVSYHV
LNAADFGVPQFRERVFIVGNRLGKTFQFPEPTHGPSNQARQIDLFGKQLKPYKTVQDAISTLPPATPPSAMALRVSQTIK
DRIKNHGY
>Mature_248_residues
MEKKLISLFSGAGGMDIGFHAAGFSTAVAVEQDPSCCNTLRLNMPDTPVIEGDITSITTQVILEAAKVNPLEIDLVIGGP
PCQSFSLAGKRMGMDDPRGMLVLEFLRVVREALPKCFVMENVKGMINWSKGKALEAIMTEASQPIKYAGKEYKYAVSYHV
LNAADFGVPQFRERVFIVGNRLGKTFQFPEPTHGPSNQARQIDLFGKQLKPYKTVQDAISTLPPATPPSAMALRVSQTIK
DRIKNHGY

Specific function: This methylase recognizes the double-stranded sequence CYCGRG, causes specific methylation on C-1 on both strands, and protects the DNA from cleavage by the AquI endonuclease

COG id: COG0270

COG function: function code L; Site-specific DNA methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C5-methyltransferase family

Homologues:

Organism=Homo sapiens, GI195927037, Length=245, Percent_Identity=27.3469387755102, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4503351, Length=245, Percent_Identity=27.3469387755102, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1788271, Length=210, Percent_Identity=28.0952380952381, Blast_Score=74, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAA_SYNP2 (P34882)

Other databases:

- EMBL:   M28051
- EMBL:   CP000951
- RefSeq:   YP_001734443.1
- ProteinModelPortal:   P34882
- SMR:   P34882
- REBASE:   3283
- GeneID:   6056178
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A1188
- OMA:   ETWENTT
- InterPro:   IPR018117
- InterPro:   IPR001525
- PANTHER:   PTHR10629
- PRINTS:   PR00105
- TIGRFAMs:   TIGR00675

Pfam domain/function: PF00145 DNA_methylase

EC number: =2.1.1.37

Molecular weight: Translated: 27161; Mature: 27161

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00094 C5_MTASE_1

Important sites: ACT_SITE 82-82

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKLISLFSGAGGMDIGFHAAGFSTAVAVEQDPSCCNTLRLNMPDTPVIEGDITSITTQ
CCCHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCHHEEECCCCCCCEECCCHHHHHHH
VILEAAKVNPLEIDLVIGGPPCQSFSLAGKRMGMDDPRGMLVLEFLRVVREALPKCFVME
HHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NVKGMINWSKGKALEAIMTEASQPIKYAGKEYKYAVSYHVLNAADFGVPQFRERVFIVGN
CCHHEEECCCCHHHHHHHHHCCCCHHHCCCCEEEEEEEEEECCCCCCCHHHHHEEEEEEC
RLGKTFQFPEPTHGPSNQARQIDLFGKQLKPYKTVQDAISTLPPATPPSAMALRVSQTIK
CCCCCCCCCCCCCCCCCCCEEEHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
DRIKNHGY
HHHHHCCC
>Mature Secondary Structure
MEKKLISLFSGAGGMDIGFHAAGFSTAVAVEQDPSCCNTLRLNMPDTPVIEGDITSITTQ
CCCHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCHHEEECCCCCCCEECCCHHHHHHH
VILEAAKVNPLEIDLVIGGPPCQSFSLAGKRMGMDDPRGMLVLEFLRVVREALPKCFVME
HHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NVKGMINWSKGKALEAIMTEASQPIKYAGKEYKYAVSYHVLNAADFGVPQFRERVFIVGN
CCHHEEECCCCHHHHHHHHHCCCCHHHCCCCEEEEEEEEEECCCCCCCHHHHHEEEEEEC
RLGKTFQFPEPTHGPSNQARQIDLFGKQLKPYKTVQDAISTLPPATPPSAMALRVSQTIK
CCCCCCCCCCCCCCCCCCCEEEHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
DRIKNHGY
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2104605