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The map label for this gene is ipdA [H]

Identifier: 170077744

GI number: 170077744

Start: 1157882

End: 1159318

Strand: Reverse

Name: ipdA [H]

Synonym: SYNPCC7002_A1126

Alternate gene names: 170077744

Gene position: 1159318-1157882 (Counterclockwise)

Preceding gene: 170077746

Following gene: 170077743

Centisome position: 38.54

GC content: 52.54

Gene sequence:

>1437_bases
ATGAGTGAAACACAGTTTGATTATGATTTGGTGATTATCGGCGCGGGGGTCGGTGGCCACGGTGCCGCGCTCCATGCCGT
GAAATGTGGCCTGAAAACGGCCATTGTTGAAGCCGCAGACATGGGCGGTACTTGCGTCAATCGTGGTTGTATTCCGTCTA
AAGCCCTCCTGGCTGCCTCCGGAAAAGTCCGGGAAATGCGCGACCAGAAGCACCTCAGCGAGATGGGTATTAATGTTGGT
GCGGTTGATTTTAGTCGTGAGGCGATCGCCGCCCATGCCACCGATTTGGTAAACAAAATCCAAAGCGATCTCACCAATAG
CCTCAAGCGTTTGAATGTCGATATTATTCGCGGTTGGGGAAAAATTGACGGCGTCCAGAAAGTCTGTGTCATTGGCGAAG
ACGGTGTGAAAAACATCACCGCCAAAGAAATTATGATTTGCACTGGCTCGAAACCCTTTGTCCCCCCCGGCATCCAAGTC
GATGGCAAAACCGTTTTCACTAGCGACGATGCAGTGCGTTTAGAAACCCTGCCCCAGTGGGTCGCAATTATTGGAAGCGG
TTACATCGGCCTCGAATTTTCCGACGTTTACACCGCCCTCGGTTGCGAAATTACGATGATCGAAGCCCTTGATGATCTGA
TGCCTGGCTTTGACCCAGAGATTGCGAAACTAGCCAAGCGCGCCTTAATTGATAGCCGTGACATCGAAACCTATACTGGC
GTCTTTGCCACGAAAGTTATGCCTGGCTCTCCGGTCAAGATCGAACTCACCGACGCAAAAACTAAAGAAGTCGTCGAAAA
TCTCGAAGTAGATGCTTGTCTGGTCGCCACCGGGCGCGTCCCCGCCACAAAAAACCTCGGCTTAGATGCCGTTGGCGTGG
AAACAGACCGCCGGGGCTTCATTGAGGTAAATGACAAAATGCAGGTGATCAAAGACGGTCAACCTGTACCCCATCTCTGG
GCTGTGGGCGATGCCACCGGAAAAATGATGTTGGCCCATGCTGCCTCTGGTCAGGGGGTTGTGGCTGTAGAAAATATGAT
CGGCAATGCCATGACCGTTGACTATGCCGCGATTCCGGCAGCAGCGTTTACTCACCCAGAAATTAGCTATGTGGGGATGA
GCGAACCCCAAGCGAAGGAAGCCGCCGCTGCAGGTGGTTTTGAAATTGCCACGGCAAAAACGTACTTTAAAGGCAATTCC
AAAGCCCTCGCTGAAAAAGAAACCGACGGCATCGCCAAGATTATCTACCGTAAGGACACCGGGGAATTGTTGGGCGTCCA
TATTATGGGGATCCACGCTTCGGATCTGATCCAAGAGGCCGCCAATGCGATCGCCGAGAAAAAACCCGTCCAAGAATTGG
CGTTTAACGTCCACGCCCACCCGACCCTCTCGGAAGTTCTCGACGAAGCCTACAAGCGAGCGAAAGTCACCGCGTAA

Upstream 100 bases:

>100_bases
ATGAGGCGAGAAGCCCGTGCTGTAATCTTGATTCAGCATCGGGAAAACGTCACGATAAGCTAACAAAAGGAAATTGGCTG
AGTAAGAGCATTAAAACTTC

Downstream 100 bases:

>100_bases
ATTACGTTAGAATTTGGCATCAAAACAGGGGTTGTTCGCTGAATAGATTCAAGGAAAACCTCTGTTTTGCCCTTATCTCA
CTCTTTTTTATAATCCCCTA

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; LPD; E3 component of pyruvate complex [H]

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MSETQFDYDLVIIGAGVGGHGAALHAVKCGLKTAIVEAADMGGTCVNRGCIPSKALLAASGKVREMRDQKHLSEMGINVG
AVDFSREAIAAHATDLVNKIQSDLTNSLKRLNVDIIRGWGKIDGVQKVCVIGEDGVKNITAKEIMICTGSKPFVPPGIQV
DGKTVFTSDDAVRLETLPQWVAIIGSGYIGLEFSDVYTALGCEITMIEALDDLMPGFDPEIAKLAKRALIDSRDIETYTG
VFATKVMPGSPVKIELTDAKTKEVVENLEVDACLVATGRVPATKNLGLDAVGVETDRRGFIEVNDKMQVIKDGQPVPHLW
AVGDATGKMMLAHAASGQGVVAVENMIGNAMTVDYAAIPAAAFTHPEISYVGMSEPQAKEAAAAGGFEIATAKTYFKGNS
KALAEKETDGIAKIIYRKDTGELLGVHIMGIHASDLIQEAANAIAEKKPVQELAFNVHAHPTLSEVLDEAYKRAKVTA

Sequences:

>Translated_478_residues
MSETQFDYDLVIIGAGVGGHGAALHAVKCGLKTAIVEAADMGGTCVNRGCIPSKALLAASGKVREMRDQKHLSEMGINVG
AVDFSREAIAAHATDLVNKIQSDLTNSLKRLNVDIIRGWGKIDGVQKVCVIGEDGVKNITAKEIMICTGSKPFVPPGIQV
DGKTVFTSDDAVRLETLPQWVAIIGSGYIGLEFSDVYTALGCEITMIEALDDLMPGFDPEIAKLAKRALIDSRDIETYTG
VFATKVMPGSPVKIELTDAKTKEVVENLEVDACLVATGRVPATKNLGLDAVGVETDRRGFIEVNDKMQVIKDGQPVPHLW
AVGDATGKMMLAHAASGQGVVAVENMIGNAMTVDYAAIPAAAFTHPEISYVGMSEPQAKEAAAAGGFEIATAKTYFKGNS
KALAEKETDGIAKIIYRKDTGELLGVHIMGIHASDLIQEAANAIAEKKPVQELAFNVHAHPTLSEVLDEAYKRAKVTA
>Mature_477_residues
SETQFDYDLVIIGAGVGGHGAALHAVKCGLKTAIVEAADMGGTCVNRGCIPSKALLAASGKVREMRDQKHLSEMGINVGA
VDFSREAIAAHATDLVNKIQSDLTNSLKRLNVDIIRGWGKIDGVQKVCVIGEDGVKNITAKEIMICTGSKPFVPPGIQVD
GKTVFTSDDAVRLETLPQWVAIIGSGYIGLEFSDVYTALGCEITMIEALDDLMPGFDPEIAKLAKRALIDSRDIETYTGV
FATKVMPGSPVKIELTDAKTKEVVENLEVDACLVATGRVPATKNLGLDAVGVETDRRGFIEVNDKMQVIKDGQPVPHLWA
VGDATGKMMLAHAASGQGVVAVENMIGNAMTVDYAAIPAAAFTHPEISYVGMSEPQAKEAAAAGGFEIATAKTYFKGNSK
ALAEKETDGIAKIIYRKDTGELLGVHIMGIHASDLIQEAANAIAEKKPVQELAFNVHAHPTLSEVLDEAYKRAKVTA

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=469, Percent_Identity=36.2473347547974, Blast_Score=275, Evalue=8e-74,
Organism=Homo sapiens, GI50301238, Length=479, Percent_Identity=29.0187891440501, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI291045266, Length=439, Percent_Identity=28.4738041002278, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI33519430, Length=484, Percent_Identity=26.2396694214876, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI33519428, Length=484, Percent_Identity=26.2396694214876, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI33519426, Length=484, Percent_Identity=26.2396694214876, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI148277065, Length=484, Percent_Identity=26.2396694214876, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI148277071, Length=484, Percent_Identity=26.2396694214876, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI22035672, Length=485, Percent_Identity=26.5979381443299, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI291045268, Length=438, Percent_Identity=25.7990867579909, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1786307, Length=463, Percent_Identity=34.341252699784, Blast_Score=249, Evalue=4e-67,
Organism=Escherichia coli, GI87082354, Length=471, Percent_Identity=29.2993630573248, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789915, Length=452, Percent_Identity=29.2035398230088, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI87081717, Length=478, Percent_Identity=26.9874476987448, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI32565766, Length=489, Percent_Identity=36.1963190184049, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17557007, Length=480, Percent_Identity=25.2083333333333, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=27.2727272727273, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI71983429, Length=455, Percent_Identity=27.9120879120879, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71982272, Length=499, Percent_Identity=25.6513026052104, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321091, Length=475, Percent_Identity=34.7368421052632, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6325240, Length=481, Percent_Identity=26.8191268191268, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6325166, Length=483, Percent_Identity=25.879917184265, Blast_Score=144, Evalue=4e-35,
Organism=Drosophila melanogaster, GI21358499, Length=473, Percent_Identity=36.3636363636364, Blast_Score=271, Evalue=5e-73,
Organism=Drosophila melanogaster, GI17737741, Length=496, Percent_Identity=27.8225806451613, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24640549, Length=492, Percent_Identity=28.0487804878049, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24640553, Length=492, Percent_Identity=28.0487804878049, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24640551, Length=492, Percent_Identity=28.0487804878049, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50700; Mature: 50569

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETQFDYDLVIIGAGVGGHGAALHAVKCGLKTAIVEAADMGGTCVNRGCIPSKALLAAS
CCCCCCCEEEEEEECCCCCCCHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCC
GKVREMRDQKHLSEMGINVGAVDFSREAIAAHATDLVNKIQSDLTNSLKRLNVDIIRGWG
CCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
KIDGVQKVCVIGEDGVKNITAKEIMICTGSKPFVPPGIQVDGKTVFTSDDAVRLETLPQW
CCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCEEECCEEEEECCCCEEHHHHHHH
VAIIGSGYIGLEFSDVYTALGCEITMIEALDDLMPGFDPEIAKLAKRALIDSRDIETYTG
HHHHCCCEEEEEHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHC
VFATKVMPGSPVKIELTDAKTKEVVENLEVDACLVATGRVPATKNLGLDAVGVETDRRGF
EEEEECCCCCCEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEECCCCCCCCE
IEVNDKMQVIKDGQPVPHLWAVGDATGKMMLAHAASGQGVVAVENMIGNAMTVDYAAIPA
EEECCCEEEEECCCCCCEEEEECCCCCCEEEEEECCCCCEEEEHHHCCCCEEEEHHHCCH
AAFTHPEISYVGMSEPQAKEAAAAGGFEIATAKTYFKGNSKALAEKETDGIAKIIYRKDT
HHCCCCCEEEECCCCCCHHHHHHCCCEEEEEEEEEECCCCCCHHHHHCCCEEEEEEECCC
GELLGVHIMGIHASDLIQEAANAIAEKKPVQELAFNVHAHPTLSEVLDEAYKRAKVTA
CCEEEEEEEEECHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SETQFDYDLVIIGAGVGGHGAALHAVKCGLKTAIVEAADMGGTCVNRGCIPSKALLAAS
CCCCCCEEEEEEECCCCCCCHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCC
GKVREMRDQKHLSEMGINVGAVDFSREAIAAHATDLVNKIQSDLTNSLKRLNVDIIRGWG
CCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
KIDGVQKVCVIGEDGVKNITAKEIMICTGSKPFVPPGIQVDGKTVFTSDDAVRLETLPQW
CCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCEEECCEEEEECCCCEEHHHHHHH
VAIIGSGYIGLEFSDVYTALGCEITMIEALDDLMPGFDPEIAKLAKRALIDSRDIETYTG
HHHHCCCEEEEEHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHC
VFATKVMPGSPVKIELTDAKTKEVVENLEVDACLVATGRVPATKNLGLDAVGVETDRRGF
EEEEECCCCCCEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEECCCCCCCCE
IEVNDKMQVIKDGQPVPHLWAVGDATGKMMLAHAASGQGVVAVENMIGNAMTVDYAAIPA
EEECCCEEEEECCCCCCEEEEECCCCCCEEEEEECCCCCEEEEHHHCCCCEEEEHHHCCH
AAFTHPEISYVGMSEPQAKEAAAAGGFEIATAKTYFKGNSKALAEKETDGIAKIIYRKDT
HHCCCCCEEEECCCCCCHHHHHHCCCEEEEEEEEEECCCCCCHHHHHCCCEEEEEEECCC
GELLGVHIMGIHASDLIQEAANAIAEKKPVQELAFNVHAHPTLSEVLDEAYKRAKVTA
CCEEEEEEEEECHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231; 9387233 [H]