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The map label for this gene is ilvD [H]

Identifier: 170077275

GI number: 170077275

Start: 682399

End: 684084

Strand: Reverse

Name: ilvD [H]

Synonym: SYNPCC7002_A0652

Alternate gene names: 170077275

Gene position: 684084-682399 (Counterclockwise)

Preceding gene: 170077276

Following gene: 170077274

Centisome position: 22.74

GC content: 53.32

Gene sequence:

>1686_bases
ATGAGCGACAATCGACGTAGCCGGGTAGTCACCGAAGGTCATCAGCGGAGCCCAAACCGCGCCATGCTCCGGGCTGTGGG
CTTTGGGGATGATGATTTTAGTAAACCAATTGTGGGCTTGGCGAATGGGTACAGTACGATTACGCCATGCAATATGGGAA
TCAATGACCTCGCCCAGCGAGCGGATAAGGCAATCCGGGAAGCGGGAGCGATGCCGCAGATGTTTGGGACGATCACCATT
AGTGATGGGATCTCCATGGGTACGGAGGGGATGAAGTATTCTTTGGTTTCCCGTGATGTGATCGCTGACTCCATTGAGAC
GGCTTGTAATGGCCAAAGCATGGATGCGGTTCTCGCCATTGGCGGTTGTGATAAGAATATGCCGGGGGCAGTGTTGGCGA
TCGCCCGGATGAATATCCCCGCAATTTTTGTTTACGGTGGCACGATCAAACCCGGTCATTTAGACGGGGAAGATCTCACA
GTTGTTAGTGCGTTCGAGGCTGTCGGTGAATTTAGCGCCGGAAAAATCGACGAGGAAAGATTATTAGCCGTTGAGAAAAA
TGCTTGTCCGGGGGCTGGCTCCTGTGGCGGGATGTACACGGCCAATACGATGTCCTCGGCTTTTGAGGCGATGGGGATCA
GTTTGCCCTACTCCTCGACGATGGCCGCTGAAGATGAAGAAAAAGCTGTCAGTGCGGAAGAGTCGGCACGCGTTTTGGTC
AATGCGATCAAGAAGCAGATTTTGCCGAAGGACATCCTCACGCGCAAGGCATTTGAAAACGCGATTTCCGTAATTATGGC
CGTGGGCGGCTCGACAAATTCAGTCTTACATTTGTTGGCGATCGCCAATACTATCGGTGTGGATCTGACCATCGACGACT
TTGAAACCATCCGCCAGCGCGTCCCCGTCATCTGTGACCTCAAGCCCTCTGGTCGCTACGTTGCCACCGATCTCCACAAG
GCGGGCGGCATTCCCCAGGTGATGAAAATGCTCTTGGATCACGGTCTTCTCCATGGCGACTGTCTAACAATTACTGGCAA
AACCGTCGCTGAAACCCTCGCCGATATTCCCAGCGAACCCTCTCCCGATCAGGATGTGATTCGTCCTTGGGATAAGCCAA
TGTACGAAAAAGGACACCTGGCGATCCTCAAGGGCAACTTGGCCGAAGAAGGTTCCGTGGCGAAAATTAGTGGCGTGAAA
AATCCCCGGATCACTGGCCCCGCCCGCGTTTTTGAGTCCGAAGAAGAATGTCTCGATGCAATCCTGGCTGGCAAGATTGT
TGCTGGTGATGTGGTGATTGTTCGTTACGAAGGGCCGAAGGGTGGCCCCGGGATGCGGGAAATGCTAGCGCCCACCTCCG
CAATTATTGGCGCTGGTCTGGGCGATTCTGTCGGTCTGATCACCGATGGTCGTTTCTCTGGCGGAACCTATGGTCTCGTG
GTCGGACACGTTGCCCCGGAAGCGTTTGTGGGTGGCAATATTGCCCTTGTGGAAGAAGGGGACAGCATCACCATCGATGC
CCACGAAAAACTGTTGCAAATCAATGTTCCTGATGAGGAACTGGCAAAACGTCGCGCCGCTTGGAAACCCCGTGAACCCC
GTTATAAGCGTGGTGTCCTTGGAAAGTATGCCAAGATTGTTTCCACCAGTAGTAAAGGTGCAGTGACAGATATCGATTTG
TTTTAA

Upstream 100 bases:

>100_bases
TGAGTAGTCGTGGTTAACTTTAGGCCGTCCCTATCCAAAAGCTCGAAAAAAAAGGACAATAGAAAGGTTATTTTGATGTA
AATCTTGATTTCTATTTGTT

Downstream 100 bases:

>100_bases
ATTAAAAGCGATATTTAAGCTTTACTTTATCCCTCTGTTGGCTATGCTGATAGGGGGTTATTTTTATAGTCTAGAAAAAA
ATATATTTAGTTATTATGGA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MSDNRRSRVVTEGHQRSPNRAMLRAVGFGDDDFSKPIVGLANGYSTITPCNMGINDLAQRADKAIREAGAMPQMFGTITI
SDGISMGTEGMKYSLVSRDVIADSIETACNGQSMDAVLAIGGCDKNMPGAVLAIARMNIPAIFVYGGTIKPGHLDGEDLT
VVSAFEAVGEFSAGKIDEERLLAVEKNACPGAGSCGGMYTANTMSSAFEAMGISLPYSSTMAAEDEEKAVSAEESARVLV
NAIKKQILPKDILTRKAFENAISVIMAVGGSTNSVLHLLAIANTIGVDLTIDDFETIRQRVPVICDLKPSGRYVATDLHK
AGGIPQVMKMLLDHGLLHGDCLTITGKTVAETLADIPSEPSPDQDVIRPWDKPMYEKGHLAILKGNLAEEGSVAKISGVK
NPRITGPARVFESEEECLDAILAGKIVAGDVVIVRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGLV
VGHVAPEAFVGGNIALVEEGDSITIDAHEKLLQINVPDEELAKRRAAWKPREPRYKRGVLGKYAKIVSTSSKGAVTDIDL
F

Sequences:

>Translated_561_residues
MSDNRRSRVVTEGHQRSPNRAMLRAVGFGDDDFSKPIVGLANGYSTITPCNMGINDLAQRADKAIREAGAMPQMFGTITI
SDGISMGTEGMKYSLVSRDVIADSIETACNGQSMDAVLAIGGCDKNMPGAVLAIARMNIPAIFVYGGTIKPGHLDGEDLT
VVSAFEAVGEFSAGKIDEERLLAVEKNACPGAGSCGGMYTANTMSSAFEAMGISLPYSSTMAAEDEEKAVSAEESARVLV
NAIKKQILPKDILTRKAFENAISVIMAVGGSTNSVLHLLAIANTIGVDLTIDDFETIRQRVPVICDLKPSGRYVATDLHK
AGGIPQVMKMLLDHGLLHGDCLTITGKTVAETLADIPSEPSPDQDVIRPWDKPMYEKGHLAILKGNLAEEGSVAKISGVK
NPRITGPARVFESEEECLDAILAGKIVAGDVVIVRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGLV
VGHVAPEAFVGGNIALVEEGDSITIDAHEKLLQINVPDEELAKRRAAWKPREPRYKRGVLGKYAKIVSTSSKGAVTDIDL
F
>Mature_560_residues
SDNRRSRVVTEGHQRSPNRAMLRAVGFGDDDFSKPIVGLANGYSTITPCNMGINDLAQRADKAIREAGAMPQMFGTITIS
DGISMGTEGMKYSLVSRDVIADSIETACNGQSMDAVLAIGGCDKNMPGAVLAIARMNIPAIFVYGGTIKPGHLDGEDLTV
VSAFEAVGEFSAGKIDEERLLAVEKNACPGAGSCGGMYTANTMSSAFEAMGISLPYSSTMAAEDEEKAVSAEESARVLVN
AIKKQILPKDILTRKAFENAISVIMAVGGSTNSVLHLLAIANTIGVDLTIDDFETIRQRVPVICDLKPSGRYVATDLHKA
GGIPQVMKMLLDHGLLHGDCLTITGKTVAETLADIPSEPSPDQDVIRPWDKPMYEKGHLAILKGNLAEEGSVAKISGVKN
PRITGPARVFESEEECLDAILAGKIVAGDVVIVRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGLVV
GHVAPEAFVGGNIALVEEGDSITIDAHEKLLQINVPDEELAKRRAAWKPREPRYKRGVLGKYAKIVSTSSKGAVTDIDLF

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=38.9438943894389, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1788157, Length=485, Percent_Identity=32.5773195876289, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI1786464, Length=482, Percent_Identity=34.6473029045643, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI2367371, Length=508, Percent_Identity=33.0708661417323, Blast_Score=196, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6322476, Length=562, Percent_Identity=47.864768683274, Blast_Score=533, Evalue=1e-152,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59288; Mature: 59156

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00589 PTS_HPR_SER ; PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNRRSRVVTEGHQRSPNRAMLRAVGFGDDDFSKPIVGLANGYSTITPCNMGINDLAQR
CCCCCCCCCEECCCCCCCCHHHEEEECCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHH
ADKAIREAGAMPQMFGTITISDGISMGTEGMKYSLVSRDVIADSIETACNGQSMDAVLAI
HHHHHHHHCCCCHHEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCEEEEE
GGCDKNMPGAVLAIARMNIPAIFVYGGTIKPGHLDGEDLTVVSAFEAVGEFSAGKIDEER
ECCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHH
LLAVEKNACPGAGSCGGMYTANTMSSAFEAMGISLPYSSTMAAEDEEKAVSAEESARVLV
EEEEECCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCHHHHHHHHH
NAIKKQILPKDILTRKAFENAISVIMAVGGSTNSVLHLLAIANTIGVDLTIDDFETIRQR
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEHHHHHHHHC
VPVICDLKPSGRYVATDLHKAGGIPQVMKMLLDHGLLHGDCLTITGKTVAETLADIPSEP
CCEEEEECCCCCEEEEHHHHHCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCCC
SPDQDVIRPWDKPMYEKGHLAILKGNLAEEGSVAKISGVKNPRITGPARVFESEEECLDA
CCCHHHHCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHCCHHHHHHH
ILAGKIVAGDVVIVRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGLV
HHHCCEEECCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCCEEEECCCCCCCEEEEE
VGHVAPEAFVGGNIALVEEGDSITIDAHEKLLQINVPDEELAKRRAAWKPREPRYKRGVL
EECCCCCCEECCCEEEEECCCEEEEECCCEEEEECCCHHHHHHHHHCCCCCCCCHHHHHH
GKYAKIVSTSSKGAVTDIDLF
HHHHHHHCCCCCCCEEEECCC
>Mature Secondary Structure 
SDNRRSRVVTEGHQRSPNRAMLRAVGFGDDDFSKPIVGLANGYSTITPCNMGINDLAQR
CCCCCCCCEECCCCCCCCHHHEEEECCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHH
ADKAIREAGAMPQMFGTITISDGISMGTEGMKYSLVSRDVIADSIETACNGQSMDAVLAI
HHHHHHHHCCCCHHEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCEEEEE
GGCDKNMPGAVLAIARMNIPAIFVYGGTIKPGHLDGEDLTVVSAFEAVGEFSAGKIDEER
ECCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHH
LLAVEKNACPGAGSCGGMYTANTMSSAFEAMGISLPYSSTMAAEDEEKAVSAEESARVLV
EEEEECCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCHHHHHHHHH
NAIKKQILPKDILTRKAFENAISVIMAVGGSTNSVLHLLAIANTIGVDLTIDDFETIRQR
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEHHHHHHHHC
VPVICDLKPSGRYVATDLHKAGGIPQVMKMLLDHGLLHGDCLTITGKTVAETLADIPSEP
CCEEEEECCCCCEEEEHHHHHCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCCC
SPDQDVIRPWDKPMYEKGHLAILKGNLAEEGSVAKISGVKNPRITGPARVFESEEECLDA
CCCHHHHCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHCCHHHHHHH
ILAGKIVAGDVVIVRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGLV
HHHCCEEECCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCCEEEECCCCCCCEEEEE
VGHVAPEAFVGGNIALVEEGDSITIDAHEKLLQINVPDEELAKRRAAWKPREPRYKRGVL
EECCCCCCEECCCEEEEECCCEEEEECCCEEEEECCCHHHHHHHHHCCCCCCCCHHHHHH
GKYAKIVSTSSKGAVTDIDLF
HHHHHHHCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA