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The map label for this gene is csgA [H]

Identifier: 170077005

GI number: 170077005

Start: 402848

End: 403585

Strand: Direct

Name: csgA [H]

Synonym: SYNPCC7002_A0377

Alternate gene names: 170077005

Gene position: 402848-403585 (Clockwise)

Preceding gene: 170077004

Following gene: 170077006

Centisome position: 13.39

GC content: 53.39

Gene sequence:

>738_bases
ATGGAAGCCCTTGTTATTGGTGCTGGTCGCGGCATCGGTCTAGAATTTGTCCGGCAATACCTCGCCTCAGATCTGTATCA
GCGGGTCTATGGCACCTACCGCCAGCCCTCCGCCGATCTCCTGGCGTTACAGGCGCGCTACCCTGATCGACTCCAACTAA
TCCCCGTGGATGTGACCCAGGAAGCGCAAATCACAGCGGCGATCGCCACCCTCAAAGCCCAAACCTCTCGCCTTGATGAA
GTAATTTATTGCGTCGGTCTTCTGCATCACCAAACCCTCCAACCGGAAAAAAGTCTCCGCCATATCCAAACAGAAAATTT
ACTGACCTATTTTCAAGTCAATGCCATCGGTGCCGTCCTCTGGGCCAAACATCTCCTCCCCTTTCTCCGTCACCCAGAAC
CCGCAATTTTTGCCGCTATTTCCGCTAAAGTCGGCAGCATCGAAGACAATCGCCTAGGGGGATGGTATGGCTACCGTGCC
TCGAAAGCAGCCTTGAATATGTTTTTGAAAAATATCGCCATTGAATGGAGTCGCGTTGCCCCAAATATCATTGTGGCGGC
CCTGCACCCAGGGACAACGGCTACCGATCTCTCCCAGCCTTTCCAAAAAAATGTCCCCCCGGAAAAGCTCTTTTCGCCCG
CACGGACAGTGAGCCAACTGCGCCAAGTGATCGCCAATCTGCACCCCCAGGATACGGGTAAATTTTTTAACTGGGATGGT
GAGCCTTTGCCCTGGTAG

Upstream 100 bases:

>100_bases
GCGCAGCCTTATACCTTGCCCTGCGTCCCCCCACCCTAGAGCATGAAAACCCCGTAACCTCCAGTCAGCCCCCAAATACT
GCGGAGGTAAGCCGTTCATA

Downstream 100 bases:

>100_bases
CGGCAGAAAATAGAACGATTTTGCCATGAAATGCTGAAATGATGGTGCGTTTTGCGGCAAAAACTTCCACAATAGGGAAC
GTTCTTTAGCACCAAATTAA

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: 2,3-Dihydroxybenzoate; H+; Nicotinamide adenine dinucleotide - reduced [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MEALVIGAGRGIGLEFVRQYLASDLYQRVYGTYRQPSADLLALQARYPDRLQLIPVDVTQEAQITAAIATLKAQTSRLDE
VIYCVGLLHHQTLQPEKSLRHIQTENLLTYFQVNAIGAVLWAKHLLPFLRHPEPAIFAAISAKVGSIEDNRLGGWYGYRA
SKAALNMFLKNIAIEWSRVAPNIIVAALHPGTTATDLSQPFQKNVPPEKLFSPARTVSQLRQVIANLHPQDTGKFFNWDG
EPLPW

Sequences:

>Translated_245_residues
MEALVIGAGRGIGLEFVRQYLASDLYQRVYGTYRQPSADLLALQARYPDRLQLIPVDVTQEAQITAAIATLKAQTSRLDE
VIYCVGLLHHQTLQPEKSLRHIQTENLLTYFQVNAIGAVLWAKHLLPFLRHPEPAIFAAISAKVGSIEDNRLGGWYGYRA
SKAALNMFLKNIAIEWSRVAPNIIVAALHPGTTATDLSQPFQKNVPPEKLFSPARTVSQLRQVIANLHPQDTGKFFNWDG
EPLPW
>Mature_245_residues
MEALVIGAGRGIGLEFVRQYLASDLYQRVYGTYRQPSADLLALQARYPDRLQLIPVDVTQEAQITAAIATLKAQTSRLDE
VIYCVGLLHHQTLQPEKSLRHIQTENLLTYFQVNAIGAVLWAKHLLPFLRHPEPAIFAAISAKVGSIEDNRLGGWYGYRA
SKAALNMFLKNIAIEWSRVAPNIIVAALHPGTTATDLSQPFQKNVPPEKLFSPARTVSQLRQVIANLHPQDTGKFFNWDG
EPLPW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Caenorhabditis elegans, GI72001658, Length=213, Percent_Identity=28.6384976525822, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322779, Length=252, Percent_Identity=26.5873015873016, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322227, Length=236, Percent_Identity=26.6949152542373, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24640547, Length=259, Percent_Identity=27.7992277992278, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.3.1.28 [C]

Molecular weight: Translated: 27377; Mature: 27377

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEALVIGAGRGIGLEFVRQYLASDLYQRVYGTYRQPSADLLALQARYPDRLQLIPVDVTQ
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHEEEEECCCCCCEEEEEECCCC
EAQITAAIATLKAQTSRLDEVIYCVGLLHHQTLQPEKSLRHIQTENLLTYFQVNAIGAVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WAKHLLPFLRHPEPAIFAAISAKVGSIEDNRLGGWYGYRASKAALNMFLKNIAIEWSRVA
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PNIIVAALHPGTTATDLSQPFQKNVPPEKLFSPARTVSQLRQVIANLHPQDTGKFFNWDG
CEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
EPLPW
CCCCC
>Mature Secondary Structure
MEALVIGAGRGIGLEFVRQYLASDLYQRVYGTYRQPSADLLALQARYPDRLQLIPVDVTQ
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHEEEEECCCCCCEEEEEECCCC
EAQITAAIATLKAQTSRLDEVIYCVGLLHHQTLQPEKSLRHIQTENLLTYFQVNAIGAVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WAKHLLPFLRHPEPAIFAAISAKVGSIEDNRLGGWYGYRASKAALNMFLKNIAIEWSRVA
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PNIIVAALHPGTTATDLSQPFQKNVPPEKLFSPARTVSQLRQVIANLHPQDTGKFFNWDG
CEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
EPLPW
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): 5550 [C]

Specific activity: 66

Km value (mM): 0.26 {methyl-2,3-dehydro-3-hydroxybenzoate}} 0.2 {3-oxocyclohexane-1-carboxylic} 0.3 {2,3-dihydro-2,3-dihydroxybenzoate}} [C]

Substrates: 2,3-Dihydro-2,3-dihydroxybenzoate; Nicotinamide adenine dinucleotide [C]

Specific reaction: 2,3-Dihydro-2,3-dihydroxybenzoate + Nicotinamide adenine dinucleotide <==> 2,3-Dihydroxybenzoate + H+ + Nicotinamide adenine dinucleotide - reduced [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]