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The map label for this gene is menB [H]

Identifier: 170076896

GI number: 170076896

Start: 281010

End: 281846

Strand: Direct

Name: menB [H]

Synonym: SYNPCC7002_A0268

Alternate gene names: 170076896

Gene position: 281010-281846 (Clockwise)

Preceding gene: 170076893

Following gene: 170076897

Centisome position: 9.34

GC content: 52.81

Gene sequence:

>837_bases
ATGGAATCTCTTGCTTGGCAAGCCGTTAAAGCTTACGAAGATATTTTGTATCAAAAGTTAGATGGGATTGCAAAAATCAC
GATTAATCGTCCCCACAAGCGCAATGCCTTTCGACCCCAGACAATCTTTGAAATGTATGAGGCCTTCTGCGATGCCCGGG
AAGATCAAGACATCGGTGTCATCCTGCTCACGGGGGCTGGCCCCCATACGGATGGGAAATATGCGTTCTGCTCTGGTGGC
GACCAATCGGTGCGGGGTGAGGGCGGCTATGTCGATCAAGCCGGGGTACCGCGCCTAAACGTGCTGGATCTGCAGAAACT
GATTCGCTCGATGCCCAAGGTGGTGATCGCTTTGGTGGCGGGCTACGCGATCGGCGGCGGCCATGTACTGCATCTTCTTT
GTGATCTAACGATTGCCGCAGATAATGCAATTTTTGGGCAAACGGGGCCAAAAGTAGGCAGTTTTGACGGTGGATTTGGG
GCGAGTTACATGGCGCGCATTGTTGGACAAAAAAAAGCCCGGGAAATTTGGTTTCTTTGTCGTCAGTATGATGCCCAGCA
AGCGCTGCAAATGGGCCTAGTAAATCAAGTGGTTCCCATCGCCCAGCTAGAGGCTGAGGGGGTGCAGTGGGCCAGGGAAG
TGTTGAGTAAAAGCCCCATTGCGATTCGCTGCCTCAAGGCGGCGCTGAATGCTGATTGTGACGGGCAAGCGGGCCTCCAG
GAGCTAGCGGGGAATGCCACTATGCTTTATTACATGACAGAAGAGGGCAGAGAAGGGAAGCAGGCTTTTTTGGAAAAGCG
ATCGCCAAATTTCCGCCAATATCCCTGGTTGCCGTAA

Upstream 100 bases:

>100_bases
AGTGTGAGCCTCCGTCGGGACACATCTTTCACAAGGCCAGTGAACCTTAGCAGTGGGGGAATGGGATAAGATGACGGGCA
GTCATTGTCTATGAAAAATT

Downstream 100 bases:

>100_bases
AAAACCCTAGGCGATCGCCCAGGTAAGATGAGGATTCATTACCACTAAAGGATCCCAATTTGGTAGAGTAGATACCGATA
TAAAACCGGATAGCTTGTCC

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MESLAWQAVKAYEDILYQKLDGIAKITINRPHKRNAFRPQTIFEMYEAFCDAREDQDIGVILLTGAGPHTDGKYAFCSGG
DQSVRGEGGYVDQAGVPRLNVLDLQKLIRSMPKVVIALVAGYAIGGGHVLHLLCDLTIAADNAIFGQTGPKVGSFDGGFG
ASYMARIVGQKKAREIWFLCRQYDAQQALQMGLVNQVVPIAQLEAEGVQWAREVLSKSPIAIRCLKAALNADCDGQAGLQ
ELAGNATMLYYMTEEGREGKQAFLEKRSPNFRQYPWLP

Sequences:

>Translated_278_residues
MESLAWQAVKAYEDILYQKLDGIAKITINRPHKRNAFRPQTIFEMYEAFCDAREDQDIGVILLTGAGPHTDGKYAFCSGG
DQSVRGEGGYVDQAGVPRLNVLDLQKLIRSMPKVVIALVAGYAIGGGHVLHLLCDLTIAADNAIFGQTGPKVGSFDGGFG
ASYMARIVGQKKAREIWFLCRQYDAQQALQMGLVNQVVPIAQLEAEGVQWAREVLSKSPIAIRCLKAALNADCDGQAGLQ
ELAGNATMLYYMTEEGREGKQAFLEKRSPNFRQYPWLP
>Mature_278_residues
MESLAWQAVKAYEDILYQKLDGIAKITINRPHKRNAFRPQTIFEMYEAFCDAREDQDIGVILLTGAGPHTDGKYAFCSGG
DQSVRGEGGYVDQAGVPRLNVLDLQKLIRSMPKVVIALVAGYAIGGGHVLHLLCDLTIAADNAIFGQTGPKVGSFDGGFG
ASYMARIVGQKKAREIWFLCRQYDAQQALQMGLVNQVVPIAQLEAEGVQWAREVLSKSPIAIRCLKAALNADCDGQAGLQ
ELAGNATMLYYMTEEGREGKQAFLEKRSPNFRQYPWLP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=257, Percent_Identity=32.295719844358, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI31542718, Length=269, Percent_Identity=30.4832713754647, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI45643119, Length=221, Percent_Identity=27.1493212669683, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI260275230, Length=221, Percent_Identity=27.1493212669683, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI260274832, Length=221, Percent_Identity=27.1493212669683, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI4502327, Length=270, Percent_Identity=29.2592592592593, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI157694516, Length=226, Percent_Identity=24.7787610619469, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI213417737, Length=226, Percent_Identity=24.7787610619469, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI70995211, Length=218, Percent_Identity=28.4403669724771, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1788597, Length=271, Percent_Identity=72.3247232472325, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1787659, Length=263, Percent_Identity=30.7984790874525, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI221142681, Length=272, Percent_Identity=30.5147058823529, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082183, Length=270, Percent_Identity=27.7777777777778, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1787660, Length=274, Percent_Identity=31.7518248175182, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788682, Length=212, Percent_Identity=28.3018867924528, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25145438, Length=253, Percent_Identity=33.201581027668, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17554946, Length=266, Percent_Identity=29.6992481203008, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17540714, Length=216, Percent_Identity=29.1666666666667, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17549921, Length=213, Percent_Identity=29.5774647887324, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17535521, Length=207, Percent_Identity=28.0193236714976, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=201, Percent_Identity=29.3532338308458, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=221, Percent_Identity=27.1493212669683, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17536985, Length=240, Percent_Identity=25.4166666666667, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129971, Length=248, Percent_Identity=32.258064516129, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24653477, Length=248, Percent_Identity=32.258064516129, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24653139, Length=271, Percent_Identity=27.3062730627306, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357171, Length=191, Percent_Identity=29.8429319371728, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24654903, Length=207, Percent_Identity=28.0193236714976, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19922422, Length=276, Percent_Identity=23.5507246376812, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30532; Mature: 30532

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESLAWQAVKAYEDILYQKLDGIAKITINRPHKRNAFRPQTIFEMYEAFCDAREDQDIGV
CCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEE
ILLTGAGPHTDGKYAFCSGGDQSVRGEGGYVDQAGVPRLNVLDLQKLIRSMPKVVIALVA
EEEECCCCCCCCCEEEECCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GYAIGGGHVLHLLCDLTIAADNAIFGQTGPKVGSFDGGFGASYMARIVGQKKAREIWFLC
HHCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RQYDAQQALQMGLVNQVVPIAQLEAEGVQWAREVLSKSPIAIRCLKAALNADCDGQAGLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHH
ELAGNATMLYYMTEEGREGKQAFLEKRSPNFRQYPWLP
HHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MESLAWQAVKAYEDILYQKLDGIAKITINRPHKRNAFRPQTIFEMYEAFCDAREDQDIGV
CCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEE
ILLTGAGPHTDGKYAFCSGGDQSVRGEGGYVDQAGVPRLNVLDLQKLIRSMPKVVIALVA
EEEECCCCCCCCCEEEECCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GYAIGGGHVLHLLCDLTIAADNAIFGQTGPKVGSFDGGFGASYMARIVGQKKAREIWFLC
HHCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RQYDAQQALQMGLVNQVVPIAQLEAEGVQWAREVLSKSPIAIRCLKAALNADCDGQAGLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHH
ELAGNATMLYYMTEEGREGKQAFLEKRSPNFRQYPWLP
HHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]