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The map label for this gene is lysA [H]

Identifier: 170076731

GI number: 170076731

Start: 98194

End: 99582

Strand: Direct

Name: lysA [H]

Synonym: SYNPCC7002_A0097

Alternate gene names: 170076731

Gene position: 98194-99582 (Clockwise)

Preceding gene: 170076729

Following gene: 170076732

Centisome position: 3.26

GC content: 51.76

Gene sequence:

>1389_bases
ATGTTAACCGCAGCCTCCACTGACAATACAGGTCGGCAATATTTGCCCCAAAATCCAGATGGCCTGTCTCCCAACCAAGC
GTTAATGCCCCTGACCAGCACCGTAAATGGCCAGGATCACTTAGTGGTGGGAGGCTGCGATGTGACTGAATTGGTCAAGC
AATATGGTTCTCCGTTATATATCCTCGATGAATACACCCTGAGAACCACCTGCTGTCAATACCGCGACAGTTTCCAAAAA
TATTACGGTGGTGAATCCCTCGTGATTTATGCATCTAAGGCCTGGAGCTGCATGGCCATCTGCGCCATTGTTGACAGTGA
AGGGTTAGGCTTCGATGTGGTTTCTGGGGGAGAACTCTACACAACCCTCAAAGCTGGAGTCAGCCCGCAAAAAATTTATT
TCCATGGCAATAACAAATCCCGCGAGGAGCTGAATTTTGCCCTCGACCAAGGGGTGACGATCATTGTTGATAATTTCTTT
GAGCTGGAATTGCTCAAGGCACTCACAGGCGATCGCCAAACAACGGCCAAGATTATTTTGCGCCTCACCCCCGGCATCGA
GTGCCACACCCACGAATATATCCGGACGGGGCATTTAGATAGCAAATTTGGCTTTGACCCGAACCAAATTGAAGCGGCCT
TTGCCCTGGTGAGCCAGGCTGAATTTTTAAACTGCATTGGCCTCCATGCCCACATTGGGTCGCAAATTTTTGAACAACAA
CCCCACAAAGATCTCGGTGATGTCCTCGCTGGTTGGTACAAAAAAGCCGCTGACTATGGCCTAAACCCAGAAATTCTCAA
CCTTGGCGGCGGTTTAGGGATTCGTTATACCGAATCCGATGATCCTCCCAGCATTGAAGCCTGGTCGCAAAATGTTGCCC
AGTCCCTCGAAGCAGCCTGCCGGAGCCATGGGATTCCGTTACCGAAATTAATCGTAGAGCCGGGCCGTTCTCTCGTCGGT
AGTGCCTGTGTTACCGCTTACACCGTTGGGAGTCGTAAGGTTGTACCAGAAATTCGTACCTATGTTTCTGTGGATGGCGG
CATGTCTGATAATCCCCGTCCGATTACCTACCAATCTCTGTACCGGGCGGTCATTGCTAATCGCCTGTCGGCCCCCTGCG
AGGAAACAGTCACGGTAGCGGGTAAACATTGTGAGTCGGGGGATGTGGTGATCAAGGATGCCCAACTGCCCACGCCCCAA
CCGGGGGATATCCTTGTGGTGCTGGCGACGGGAGCCTATAACTACAGTATGGCCTCGAATTACAATCGCATCGGTCGCCC
GGCAGCCGTACTGGTGAATGAAGGGGAGGCCCAACTGATTATCCGTCGGGAAACCTTGGAGGATTTAGTGCGTCAAGATT
GTTTACCGGAGCGGCTACGTCAAGGCTGA

Upstream 100 bases:

>100_bases
TAGCCGCCATTTCCATAGCAAGGGTGATTATTTTTTCGGTATCCTTATTTACCTATGATTCTATTGAATCTAGTAAAAGA
TAACCACAAAGTAATTGCTT

Downstream 100 bases:

>100_bases
TCTATTTTCATTGGTTAAACATTTTTGGGGTAACGGGGTAGATGGGGTAGCCACATTGGGGCGATCGCCAACCCCGTTTT
TCTTTGCCCAAGGTTACCCC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MLTAASTDNTGRQYLPQNPDGLSPNQALMPLTSTVNGQDHLVVGGCDVTELVKQYGSPLYILDEYTLRTTCCQYRDSFQK
YYGGESLVIYASKAWSCMAICAIVDSEGLGFDVVSGGELYTTLKAGVSPQKIYFHGNNKSREELNFALDQGVTIIVDNFF
ELELLKALTGDRQTTAKIILRLTPGIECHTHEYIRTGHLDSKFGFDPNQIEAAFALVSQAEFLNCIGLHAHIGSQIFEQQ
PHKDLGDVLAGWYKKAADYGLNPEILNLGGGLGIRYTESDDPPSIEAWSQNVAQSLEAACRSHGIPLPKLIVEPGRSLVG
SACVTAYTVGSRKVVPEIRTYVSVDGGMSDNPRPITYQSLYRAVIANRLSAPCEETVTVAGKHCESGDVVIKDAQLPTPQ
PGDILVVLATGAYNYSMASNYNRIGRPAAVLVNEGEAQLIIRRETLEDLVRQDCLPERLRQG

Sequences:

>Translated_462_residues
MLTAASTDNTGRQYLPQNPDGLSPNQALMPLTSTVNGQDHLVVGGCDVTELVKQYGSPLYILDEYTLRTTCCQYRDSFQK
YYGGESLVIYASKAWSCMAICAIVDSEGLGFDVVSGGELYTTLKAGVSPQKIYFHGNNKSREELNFALDQGVTIIVDNFF
ELELLKALTGDRQTTAKIILRLTPGIECHTHEYIRTGHLDSKFGFDPNQIEAAFALVSQAEFLNCIGLHAHIGSQIFEQQ
PHKDLGDVLAGWYKKAADYGLNPEILNLGGGLGIRYTESDDPPSIEAWSQNVAQSLEAACRSHGIPLPKLIVEPGRSLVG
SACVTAYTVGSRKVVPEIRTYVSVDGGMSDNPRPITYQSLYRAVIANRLSAPCEETVTVAGKHCESGDVVIKDAQLPTPQ
PGDILVVLATGAYNYSMASNYNRIGRPAAVLVNEGEAQLIIRRETLEDLVRQDCLPERLRQG
>Mature_462_residues
MLTAASTDNTGRQYLPQNPDGLSPNQALMPLTSTVNGQDHLVVGGCDVTELVKQYGSPLYILDEYTLRTTCCQYRDSFQK
YYGGESLVIYASKAWSCMAICAIVDSEGLGFDVVSGGELYTTLKAGVSPQKIYFHGNNKSREELNFALDQGVTIIVDNFF
ELELLKALTGDRQTTAKIILRLTPGIECHTHEYIRTGHLDSKFGFDPNQIEAAFALVSQAEFLNCIGLHAHIGSQIFEQQ
PHKDLGDVLAGWYKKAADYGLNPEILNLGGGLGIRYTESDDPPSIEAWSQNVAQSLEAACRSHGIPLPKLIVEPGRSLVG
SACVTAYTVGSRKVVPEIRTYVSVDGGMSDNPRPITYQSLYRAVIANRLSAPCEETVTVAGKHCESGDVVIKDAQLPTPQ
PGDILVVLATGAYNYSMASNYNRIGRPAAVLVNEGEAQLIIRRETLEDLVRQDCLPERLRQG

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=373, Percent_Identity=23.3243967828418, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1789203, Length=416, Percent_Identity=30.0480769230769, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789307, Length=325, Percent_Identity=23.6923076923077, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24586472, Length=358, Percent_Identity=25.1396648044693, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24586474, Length=352, Percent_Identity=27.5568181818182, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 50413; Mature: 50413

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTAASTDNTGRQYLPQNPDGLSPNQALMPLTSTVNGQDHLVVGGCDVTELVKQYGSPLY
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHCCCCCCEEEEECCCHHHHHHHHCCCEE
ILDEYTLRTTCCQYRDSFQKYYGGESLVIYASKAWSCMAICAIVDSEGLGFDVVSGGELY
EEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEECCCCCCEEEECCCCEE
TTLKAGVSPQKIYFHGNNKSREELNFALDQGVTIIVDNFFELELLKALTGDRQTTAKIIL
EEECCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCEEEEEE
RLTPGIECHTHEYIRTGHLDSKFGFDPNQIEAAFALVSQAEFLNCIGLHAHIGSQIFEQQ
EECCCCEECCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PHKDLGDVLAGWYKKAADYGLNPEILNLGGGLGIRYTESDDPPSIEAWSQNVAQSLEAAC
CCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
RSHGIPLPKLIVEPGRSLVGSACVTAYTVGSRKVVPEIRTYVSVDGGMSDNPRPITYQSL
HHCCCCCHHHHHCCCHHHHHHHHHHEEECCCCCCCHHHHHEEEECCCCCCCCCCCCHHHH
YRAVIANRLSAPCEETVTVAGKHCESGDVVIKDAQLPTPQPGDILVVLATGAYNYSMASN
HHHHHHHHHCCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCHHHCC
YNRIGRPAAVLVNEGEAQLIIRRETLEDLVRQDCLPERLRQG
CCCCCCCEEEEEECCCEEEEEEHHHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure
MLTAASTDNTGRQYLPQNPDGLSPNQALMPLTSTVNGQDHLVVGGCDVTELVKQYGSPLY
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHCCCCCCEEEEECCCHHHHHHHHCCCEE
ILDEYTLRTTCCQYRDSFQKYYGGESLVIYASKAWSCMAICAIVDSEGLGFDVVSGGELY
EEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEECCCCCCEEEECCCCEE
TTLKAGVSPQKIYFHGNNKSREELNFALDQGVTIIVDNFFELELLKALTGDRQTTAKIIL
EEECCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCEEEEEE
RLTPGIECHTHEYIRTGHLDSKFGFDPNQIEAAFALVSQAEFLNCIGLHAHIGSQIFEQQ
EECCCCEECCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PHKDLGDVLAGWYKKAADYGLNPEILNLGGGLGIRYTESDDPPSIEAWSQNVAQSLEAAC
CCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
RSHGIPLPKLIVEPGRSLVGSACVTAYTVGSRKVVPEIRTYVSVDGGMSDNPRPITYQSL
HHCCCCCHHHHHCCCHHHHHHHHHHEEECCCCCCCHHHHHEEEECCCCCCCCCCCCHHHH
YRAVIANRLSAPCEETVTVAGKHCESGDVVIKDAQLPTPQPGDILVVLATGAYNYSMASN
HHHHHHHHHCCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCHHHCC
YNRIGRPAAVLVNEGEAQLIIRRETLEDLVRQDCLPERLRQG
CCCCCCCEEEEEECCCEEEEEEHHHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]