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The map label for this gene is arsC [H]

Identifier: 170016322

GI number: 170016322

Start: 11798

End: 12202

Strand: Direct

Name: arsC [H]

Synonym: LCK_p100015

Alternate gene names: 170016322

Gene position: 11798-12202 (Clockwise)

Preceding gene: 170016321

Following gene: 170016323

Centisome position: 30.48

GC content: 34.57

Gene sequence:

>405_bases
ATGAAAAAAGTTTATTTTTTGTGTACGGGAAATTCGTGCCGTAGCCAAATGGCAGAAGGATATGCAAAACAAATATTGCC
AGCTAATAATTTTAAAATTGAAAGTGCGGGAGTTGAAGCTCATGGGCTAAACCCAATGACAATCAAAGTTATGGCTGAAG
ATGGAGTTGATATTAGTAAACAGTATTCAAAATTAATTGATTTACAATATTTTAATACGGCAGATATCATTATTACTTTA
TGTGGTGATGCGAAAGATAAGTGCCCAATGATTCCAGCACAAACTAAAAGCCTGCACTGGCCTTTATCGGATCCAGCACA
AACAAAGGGAACTATTGAGGAACAACTACAAGAATTCCGGAATATTCGAGATCAAATTAAAGCATTAATTACCGAATTAA
AATAG

Upstream 100 bases:

>100_bases
ACTAGTATTATTGGATTTTTTGTGTATACTTTTTATAAGAATCAGTTTATTAAAATAGGAATATTTTAAAAATGGTGAAG
AAAGAGATGGGCAGATTCAA

Downstream 100 bases:

>100_bases
AAATTCGCCCTGAATACTATACAGTAAAATTGGAGTGCATGGAAATATATTCAATGATAAAAAGAAAAAAATGTTCAAAA
AAATTTCAACGTTTATTAGT

Product: protein-tyrosine-phosphatase

Products: NA

Alternate protein names: Arsenate reductase; Arsenical pump modifier; Low molecular weight protein-tyrosine-phosphatase [H]

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MKKVYFLCTGNSCRSQMAEGYAKQILPANNFKIESAGVEAHGLNPMTIKVMAEDGVDISKQYSKLIDLQYFNTADIIITL
CGDAKDKCPMIPAQTKSLHWPLSDPAQTKGTIEEQLQEFRNIRDQIKALITELK

Sequences:

>Translated_134_residues
MKKVYFLCTGNSCRSQMAEGYAKQILPANNFKIESAGVEAHGLNPMTIKVMAEDGVDISKQYSKLIDLQYFNTADIIITL
CGDAKDKCPMIPAQTKSLHWPLSDPAQTKGTIEEQLQEFRNIRDQIKALITELK
>Mature_134_residues
MKKVYFLCTGNSCRSQMAEGYAKQILPANNFKIESAGVEAHGLNPMTIKVMAEDGVDISKQYSKLIDLQYFNTADIIITL
CGDAKDKCPMIPAQTKSLHWPLSDPAQTKGTIEEQLQEFRNIRDQIKALITELK

Specific function: Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014064
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 15010; Mature: 15010

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVYFLCTGNSCRSQMAEGYAKQILPANNFKIESAGVEAHGLNPMTIKVMAEDGVDISK
CCEEEEEEECCHHHHHHHHHHHHHCCCCCCEEEECCCCEECCCCCEEEEEEECCCCCHHH
QYSKLIDLQYFNTADIIITLCGDAKDKCPMIPAQTKSLHWPLSDPAQTKGTIEEQLQEFR
HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHH
NIRDQIKALITELK
HHHHHHHHHHHHCC
>Mature Secondary Structure
MKKVYFLCTGNSCRSQMAEGYAKQILPANNFKIESAGVEAHGLNPMTIKVMAEDGVDISK
CCEEEEEEECCHHHHHHHHHHHHHCCCCCCEEEECCCCEECCCCCEEEEEEECCCCCHHH
QYSKLIDLQYFNTADIIITLCGDAKDKCPMIPAQTKSLHWPLSDPAQTKGTIEEQLQEFR
HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHH
NIRDQIKALITELK
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]