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The map label for this gene is tyrB [H]

Identifier: 170026066

GI number: 170026066

Start: 4244103

End: 4245296

Strand: Reverse

Name: tyrB [H]

Synonym: YPK_3853

Alternate gene names: 170026066

Gene position: 4245296-4244103 (Counterclockwise)

Preceding gene: 170026067

Following gene: 170026065

Centisome position: 90.53

GC content: 50.5

Gene sequence:

>1194_bases
GTGTTCCAGAATGTTGACGCCTACGCAGGTGACCCCATCCTTTCACTGATGGAAAGTTTTAAAGCCGATAACCGGGCACA
TAAGGTGAATCTGAGTATTGGGCTTTATTACAATGAACAAGGTGAAATCCCGCAAATGCAGGCTGTGGATGCTGCCGAAG
CGCAATTGAGTACTCAACCTCATGGGACACCGGTTTATTTACCGATGGAAGGTCTGCAATCTTACCGTACTGCTATCCAG
CAATTATTATTTGGTCACGACCATCCAATGCTGGTTCAGCAACGGGTGGCGACAATACAGACGGTGGGCGGTTCTGGTGC
GTTGAAAGTCGGGGCTGATTTCCTTAATCACTATTTCCCTGATTCACAGGTGTGGGTCAGCGATCCTACCTGGGAAAACC
ACGTGGCTATTTTTAGCGGCGCAGGTTTTAAAGTGAACACCTATCCGTATTTCGACAATGATAAGCTGGCGGTGAAGTTT
GACCCGATGCTGGCAACCTTGCAGCAATTGCCCGCCAGAAGCATCGTGTTGTTACATCCTTGCTGCCACAATCCAACCGG
TTCTGATCTGACCAATGCCCAATGGGATCGCCTCATTGATGTGGTAAAAGAGCGTGAACTGATCCCGTTCCTGGATATAG
CGTACCAAGGCTTTGGGGCAGGGCTGAATGAAGATGCTTATGCTATCCGCGCTATGGCCGCAGCTGGATTGCCATGCCTC
ATCAGCAACTCCTTCTCAAAAATCTTCTCGCTCTATAACGAGCGGGTCGGTGGTTTATCTGTGGTGTGTGAAAGTGACGA
GGCCGCAGGGCGTGTATTGGGCCAATTGAAAGCGACAGTGCGCCGTAACTATTCCAGCCCGCCAAACTTTGGTGCGCAGG
TCGTTTCGAAAGTCCTAAATGATACGGTATTGCGCGCGCAATGGCAGGCAGAGGTGGAACAGATGCGCCTACGGATCCTT
GATATGCGCCACACGCTGGTGGAAGCCTTAAAAGCCTCGTTACCAGAGCGCAATTTTGATTATCTGTTGCAACAACGCGG
CATGTTCAGCTACACCGGCTTTAGTGAGGCACAGGTAGATCGCTTACGTGAAGAGTTTGGTGTGTATCTGATTGCGAGCG
GAAGAATGTGTATGGCGGGAGTCAATCACCAGAATGTTGAGCAGGTTGCGGTTGCTTTTGCGGCGGTACAGTAA

Upstream 100 bases:

>100_bases
CTTACTCATGTAAGCCCTAGGAGGGCCGCTCCGTTGCCGCCTTTCTGCAATTCGGATGATTGCAGGTATAGAATTATTAT
CAATTTAGGAGAGCAGCACC

Downstream 100 bases:

>100_bases
TGTTCAGCCTTTAACCGCGGGCAAACGGGTGGCCACAATAAAATAAGCAGGCAGTAAGATATTGATATCGCCCATGGAAG
GGCCGCTATATTTTTACGGC

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQPHGTPVYLPMEGLQSYRTAIQ
QLLFGHDHPMLVQQRVATIQTVGGSGALKVGADFLNHYFPDSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKF
DPMLATLQQLPARSIVLLHPCCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAAGLPCL
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLNDTVLRAQWQAEVEQMRLRIL
DMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVDRLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ

Sequences:

>Translated_397_residues
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQPHGTPVYLPMEGLQSYRTAIQ
QLLFGHDHPMLVQQRVATIQTVGGSGALKVGADFLNHYFPDSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKF
DPMLATLQQLPARSIVLLHPCCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAAGLPCL
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLNDTVLRAQWQAEVEQMRLRIL
DMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVDRLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ
>Mature_397_residues
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQPHGTPVYLPMEGLQSYRTAIQ
QLLFGHDHPMLVQQRVATIQTVGGSGALKVGADFLNHYFPDSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKF
DPMLATLQQLPARSIVLLHPCCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAAGLPCL
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLNDTVLRAQWQAEVEQMRLRIL
DMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVDRLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=388, Percent_Identity=39.1752577319588, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI4504067, Length=387, Percent_Identity=39.5348837209302, Blast_Score=288, Evalue=5e-78,
Organism=Homo sapiens, GI117414139, Length=378, Percent_Identity=27.7777777777778, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1790488, Length=396, Percent_Identity=76.5151515151515, Blast_Score=639, Evalue=0.0,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=42.9292929292929, Blast_Score=347, Evalue=7e-97,
Organism=Caenorhabditis elegans, GI71981858, Length=396, Percent_Identity=37.3737373737374, Blast_Score=298, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI25147133, Length=387, Percent_Identity=38.5012919896641, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17569539, Length=368, Percent_Identity=39.4021739130435, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17569537, Length=391, Percent_Identity=30.9462915601023, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17550384, Length=264, Percent_Identity=35.9848484848485, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI25147136, Length=212, Percent_Identity=35.377358490566, Blast_Score=147, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6323055, Length=404, Percent_Identity=36.6336633663366, Blast_Score=280, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6322743, Length=424, Percent_Identity=33.2547169811321, Blast_Score=231, Evalue=2e-61,
Organism=Drosophila melanogaster, GI19922362, Length=385, Percent_Identity=40.2597402597403, Blast_Score=301, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24654046, Length=385, Percent_Identity=40.2597402597403, Blast_Score=301, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24580970, Length=397, Percent_Identity=37.7833753148615, Blast_Score=288, Evalue=5e-78,
Organism=Drosophila melanogaster, GI24580972, Length=397, Percent_Identity=37.7833753148615, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI19920542, Length=388, Percent_Identity=38.1443298969072, Blast_Score=287, Evalue=8e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 44060; Mature: 44060

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQP
CCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCHHHCCHHHHHHCCCC
HGTPVYLPMEGLQSYRTAIQQLLFGHDHPMLVQQRVATIQTVGGSGALKVGADFLNHYFP
CCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
DSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKFDPMLATLQQLPARSIVLLHP
CCCEEECCCCCCCCEEEEECCCEEEECCCEECCCEEEEEECHHHHHHHHCCCCCEEEEEC
CCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAAGLPCL
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCE
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLN
EHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
DTVLRAQWQAEVEQMRLRILDMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCHHHHH
RLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ
HHHHHCCEEEEECCCEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQP
CCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCHHHCCHHHHHHCCCC
HGTPVYLPMEGLQSYRTAIQQLLFGHDHPMLVQQRVATIQTVGGSGALKVGADFLNHYFP
CCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
DSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKFDPMLATLQQLPARSIVLLHP
CCCEEECCCCCCCCEEEEECCCEEEECCCEECCCEEEEEECHHHHHHHHCCCCCEEEEEC
CCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAAGLPCL
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCE
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLN
EHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
DTVLRAQWQAEVEQMRLRILDMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCHHHHH
RLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ
HHHHHCCEEEEECCCEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]