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The map label for this gene is fbp [H]

Identifier: 170025981

GI number: 170025981

Start: 4152947

End: 4154065

Strand: Direct

Name: fbp [H]

Synonym: YPK_3766

Alternate gene names: 170025981

Gene position: 4152947-4154065 (Clockwise)

Preceding gene: 170025978

Following gene: 170025982

Centisome position: 88.56

GC content: 45.76

Gene sequence:

>1119_bases
ATGGAATTGCCTATGAATCAATCTTACCTTTGGGCTACACTGCTGACATTAGCTGTGTTGTGTATTAATAAATCGATATT
TAACCGTAGATTCAGGGATTGTGTCATGAAAACGTTAGGCGAATTCATCGTCGAGAAACAGCTCGATTTCTCTCACGCCA
CTGGCGAACTAACTGCGTTACTTTCAGCAATCAAACTCGGCGCAAAGATCATTCACCGCGATATCAACAAAGCAGGTCTG
GTTGATATCTTAGGTGCCAGCGGCGTTTCCAATATTCAGGGCGAGGACCAGATGAAACTGGATCTGTTTGCCAATGAAAA
GTTGAAAGCTGCCCTTAAAGCCCGTGGTGAAGTTGCCGGTATAGCCTCCGAAGAAGAAGATGACATTGTCATTTTTGATG
GCGGAAGAGCAGAAAATGCCAAGTATGTGGTTTTGATGGATCCACTGGATGGTTCTTCAAATATTGATGTGAATGTTTCT
GTTGGCACAATTTTCTCAATTTATCGTCGTATTACGCCATTTGGGACACCAATCACTGAAGAAGACTTCCTGCAACCGGG
TACCAAACAAGTCGCGGCAGGCTATGTCGTTTACGGTTCCTCAACCATGTTGGTCTATACCACAGGTTACGGTGTCCATG
CCTTTACCTACGATCCTTCTCTGGGTGTTTTCTGTTTATCCCACGAAAAAGTTCGCTATCCCGCAACCGGTTGCATGTAT
TCCATCAACGAAGGGAATTACATTAAATTCCCTCTGGGTGTGAAAAAATACATCAAGTATTGCCAGGAGCAAGACGAAGC
CACTAAGCGCCCATATACCTCCCGTTATATTGGTTCATTAGTTGCTGATTTTCATCGTAACCTGTTGAAGGGCGGTATTT
ATATTTACCCAAGTACCGCCAGCCACCCTCAAGGGAAACTGCGTTTGTTGTATGAGTGCAACCCAATGGCCTTCCTCGCG
GAGCAAGCCGGTGGTAAAGCCACCGATGGGGTGAACCGTATCCTGGACATCGTGCCAGAGAAACTGCATCAACGCGCACC
GTTCTTCGTGGGAACAAAATCCATGGTGGAAGATGCGGAAGGGTTTATCGCTAAATTCCCAGATGAAGAAGCCAAGTAA

Upstream 100 bases:

>100_bases
AATGTGCCGCAGATACCTAAGATGTGAATGCGCATAAATCTTCCGTATTAATAAGCTTAAAATTTGTAGCCATTCTACCG
CTCAGAATCAAAGAGAAGAA

Downstream 100 bases:

>100_bases
CTTGCAGTAATGCCGTCGCTCCCTTCAAAAATAAGCTAACAGCGGCCTTTTAAGCCGCTGTTTTTTATTTCTAACGGAAT
AAAATAGCCCGACTTCAGGC

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MELPMNQSYLWATLLTLAVLCINKSIFNRRFRDCVMKTLGEFIVEKQLDFSHATGELTALLSAIKLGAKIIHRDINKAGL
VDILGASGVSNIQGEDQMKLDLFANEKLKAALKARGEVAGIASEEEDDIVIFDGGRAENAKYVVLMDPLDGSSNIDVNVS
VGTIFSIYRRITPFGTPITEEDFLQPGTKQVAAGYVVYGSSTMLVYTTGYGVHAFTYDPSLGVFCLSHEKVRYPATGCMY
SINEGNYIKFPLGVKKYIKYCQEQDEATKRPYTSRYIGSLVADFHRNLLKGGIYIYPSTASHPQGKLRLLYECNPMAFLA
EQAGGKATDGVNRILDIVPEKLHQRAPFFVGTKSMVEDAEGFIAKFPDEEAK

Sequences:

>Translated_372_residues
MELPMNQSYLWATLLTLAVLCINKSIFNRRFRDCVMKTLGEFIVEKQLDFSHATGELTALLSAIKLGAKIIHRDINKAGL
VDILGASGVSNIQGEDQMKLDLFANEKLKAALKARGEVAGIASEEEDDIVIFDGGRAENAKYVVLMDPLDGSSNIDVNVS
VGTIFSIYRRITPFGTPITEEDFLQPGTKQVAAGYVVYGSSTMLVYTTGYGVHAFTYDPSLGVFCLSHEKVRYPATGCMY
SINEGNYIKFPLGVKKYIKYCQEQDEATKRPYTSRYIGSLVADFHRNLLKGGIYIYPSTASHPQGKLRLLYECNPMAFLA
EQAGGKATDGVNRILDIVPEKLHQRAPFFVGTKSMVEDAEGFIAKFPDEEAK
>Mature_372_residues
MELPMNQSYLWATLLTLAVLCINKSIFNRRFRDCVMKTLGEFIVEKQLDFSHATGELTALLSAIKLGAKIIHRDINKAGL
VDILGASGVSNIQGEDQMKLDLFANEKLKAALKARGEVAGIASEEEDDIVIFDGGRAENAKYVVLMDPLDGSSNIDVNVS
VGTIFSIYRRITPFGTPITEEDFLQPGTKQVAAGYVVYGSSTMLVYTTGYGVHAFTYDPSLGVFCLSHEKVRYPATGCMY
SINEGNYIKFPLGVKKYIKYCQEQDEATKRPYTSRYIGSLVADFHRNLLKGGIYIYPSTASHPQGKLRLLYECNPMAFLA
EQAGGKATDGVNRILDIVPEKLHQRAPFFVGTKSMVEDAEGFIAKFPDEEAK

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family [H]

Homologues:

Organism=Homo sapiens, GI189083692, Length=320, Percent_Identity=43.4375, Blast_Score=251, Evalue=7e-67,
Organism=Homo sapiens, GI16579888, Length=320, Percent_Identity=43.4375, Blast_Score=251, Evalue=7e-67,
Organism=Homo sapiens, GI22907028, Length=323, Percent_Identity=42.4148606811146, Blast_Score=249, Evalue=4e-66,
Organism=Escherichia coli, GI1790679, Length=333, Percent_Identity=84.3843843843844, Blast_Score=577, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI17508131, Length=331, Percent_Identity=46.8277945619335, Blast_Score=301, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6323409, Length=342, Percent_Identity=42.9824561403509, Blast_Score=267, Evalue=2e-72,
Organism=Drosophila melanogaster, GI45550998, Length=331, Percent_Identity=46.8277945619335, Blast_Score=285, Evalue=2e-77,
Organism=Drosophila melanogaster, GI19921562, Length=331, Percent_Identity=46.8277945619335, Blast_Score=285, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000146
- InterPro:   IPR020548 [H]

Pfam domain/function: PF00316 FBPase [H]

EC number: =3.1.3.11 [H]

Molecular weight: Translated: 41110; Mature: 41110

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00124 FBPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELPMNQSYLWATLLTLAVLCINKSIFNRRFRDCVMKTLGEFIVEKQLDFSHATGELTAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LSAIKLGAKIIHRDINKAGLVDILGASGVSNIQGEDQMKLDLFANEKLKAALKARGEVAG
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCEEE
IASEEEDDIVIFDGGRAENAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRITPFGTPITE
CCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHCCCCCCCCH
EDFLQPGTKQVAAGYVVYGSSTMLVYTTGYGVHAFTYDPSLGVFCLSHEKVRYPATGCMY
HHHCCCCCHHHHCCEEEECCCEEEEEEECCCEEEEEECCCCCEEEECCCCEECCCCCEEE
SINEGNYIKFPLGVKKYIKYCQEQDEATKRPYTSRYIGSLVADFHRNLLKGGIYIYPSTA
EECCCCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCC
SHPQGKLRLLYECNPMAFLAEQAGGKATDGVNRILDIVPEKLHQRAPFFVGTKSMVEDAE
CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHC
GFIAKFPDEEAK
CCEEECCCCCCC
>Mature Secondary Structure
MELPMNQSYLWATLLTLAVLCINKSIFNRRFRDCVMKTLGEFIVEKQLDFSHATGELTAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LSAIKLGAKIIHRDINKAGLVDILGASGVSNIQGEDQMKLDLFANEKLKAALKARGEVAG
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCEEE
IASEEEDDIVIFDGGRAENAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRITPFGTPITE
CCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHCCCCCCCCH
EDFLQPGTKQVAAGYVVYGSSTMLVYTTGYGVHAFTYDPSLGVFCLSHEKVRYPATGCMY
HHHCCCCCHHHHCCEEEECCCEEEEEEECCCEEEEEECCCCCEEEECCCCEECCCCCEEE
SINEGNYIKFPLGVKKYIKYCQEQDEATKRPYTSRYIGSLVADFHRNLLKGGIYIYPSTA
EECCCCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCC
SHPQGKLRLLYECNPMAFLAEQAGGKATDGVNRILDIVPEKLHQRAPFFVGTKSMVEDAE
CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHC
GFIAKFPDEEAK
CCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA