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The map label for this gene is trpR [H]

Identifier: 170025827

GI number: 170025827

Start: 3982153

End: 3982545

Strand: Reverse

Name: trpR [H]

Synonym: YPK_3612

Alternate gene names: 170025827

Gene position: 3982545-3982153 (Counterclockwise)

Preceding gene: 170025828

Following gene: 170025825

Centisome position: 84.93

GC content: 49.62

Gene sequence:

>393_bases
ATGACAAAACAATTTTTGACTGACGAAAAACAAGTGTCGGATTCACTTAATAGGCAGACGGCTGGGAACCCTTACTCTGC
CGCTGATCCGGCATTGTCTGCCGAAGATAATCAGCACTGGTTGAGCTTTGTCGCGTTGTTGCAAAACGCGATTACACAAG
ATCTTCATCTGCCTTTACTGCAACTGATGCTAACACCTGATGAGCGAACCGCCTTGGGGACGCGTGTGCGCATTATTGAA
GAGTTAATGCGCGGTGAGCTAAGCCAGCGTGAGCTGAAAAGTCAGTTAGGTGCAGGTATTGCGACGATCACCCGTGGCTC
TAATAGCTTGAAAACGGCCCCACCACAGCTGAAAAGCTGGCTCGAAGCCCAGTTGCTAGCCAACAAACGCTAA

Upstream 100 bases:

>100_bases
AACTAAAATGGCCGCTTTCTTGCCTCTTGAAATCTAGTGAGTATAGATAACTCTATGGTATGCTTGTTGTACTAGTTAAA
TAGTACTTTGGGTGGTTATC

Downstream 100 bases:

>100_bases
ATGGCTGGTTTAGAGGGCGATGGGCGTTGGTAAATCTCATTGTGGAACGGCACCAGTGCCAACAAGAGGGCCTGGTGATA
GACACTGGTTCGAGTTAATT

Product: Trp operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 130; Mature: 129

Protein sequence:

>130_residues
MTKQFLTDEKQVSDSLNRQTAGNPYSAADPALSAEDNQHWLSFVALLQNAITQDLHLPLLQLMLTPDERTALGTRVRIIE
ELMRGELSQRELKSQLGAGIATITRGSNSLKTAPPQLKSWLEAQLLANKR

Sequences:

>Translated_130_residues
MTKQFLTDEKQVSDSLNRQTAGNPYSAADPALSAEDNQHWLSFVALLQNAITQDLHLPLLQLMLTPDERTALGTRVRIIE
ELMRGELSQRELKSQLGAGIATITRGSNSLKTAPPQLKSWLEAQLLANKR
>Mature_129_residues
TKQFLTDEKQVSDSLNRQTAGNPYSAADPALSAEDNQHWLSFVALLQNAITQDLHLPLLQLMLTPDERTALGTRVRIIEE
LMRGELSQRELKSQLGAGIATITRGSNSLKTAPPQLKSWLEAQLLANKR

Specific function: This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regula

COG id: COG2973

COG function: function code K; Trp operon repressor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpR family [H]

Homologues:

Organism=Escherichia coli, GI1790854, Length=104, Percent_Identity=70.1923076923077, Blast_Score=125, Evalue=6e-31,

Paralogues:

None

Copy number: 250-750 50-300 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000831
- InterPro:   IPR013335
- InterPro:   IPR010921
- ProDom:   PD012582 [H]

Pfam domain/function: PF01371 Trp_repressor [H]

EC number: NA

Molecular weight: Translated: 14436; Mature: 14304

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQFLTDEKQVSDSLNRQTAGNPYSAADPALSAEDNQHWLSFVALLQNAITQDLHLPLL
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLMLTPDERTALGTRVRIIEELMRGELSQRELKSQLGAGIATITRGSNSLKTAPPQLKSW
HHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHH
LEAQLLANKR
HHHHHHHCCC
>Mature Secondary Structure 
TKQFLTDEKQVSDSLNRQTAGNPYSAADPALSAEDNQHWLSFVALLQNAITQDLHLPLL
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLMLTPDERTALGTRVRIIEELMRGELSQRELKSQLGAGIATITRGSNSLKTAPPQLKSW
HHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHH
LEAQLLANKR
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]