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The map label for this gene is guaC [H]

Identifier: 170025716

GI number: 170025716

Start: 3848518

End: 3849561

Strand: Reverse

Name: guaC [H]

Synonym: YPK_3501

Alternate gene names: 170025716

Gene position: 3849561-3848518 (Counterclockwise)

Preceding gene: 170025721

Following gene: 170025711

Centisome position: 82.09

GC content: 47.32

Gene sequence:

>1044_bases
ATGCGCATTGAAGAAGGTTTGAAATTAGGCTTTAAGGATGTGTTAATCCGTCCTAAACGTTCAACGCTGAAAAGCCGTTC
TGAAGTTGCTCTGGAACGTCAGTTTACTTTCAAACATTCAGGTTGGAATTGGTCTGGTGTCCCTATCATAGCCGCTAATA
TGGATACCGTTGGTACCTTCCGCATGGCTGAGGTTTTGGCTTCATTTGATATTCTTACTGCCGTTCACAAGCATTACACT
CTCGAACAATGGGCTGAGTTCGTTAAGCGCTCACCAGAATCAGTGTTACGCCATGTCATGGTATCAACGGGCACTTCCTC
TGCTGATTTCGACAAAATGAAACAAATTTTGGCGTTATCACCATCATTAAAATTTATCTGTATTGATGTCGCGAACGGCT
ACTCAGAACACTTTGTTTCTTTCCTGCAAAGAGCGCGTGAAGCTTGTCCTGATAAAGTCATTTGTGCGGGTAATGTCGTG
ACAGGTGAAATGGTAGAGGAACTGATCCTCTCTGGTGCTGATATCGTTAAAGTCGGTATTGGCCCTGGTTCTGTTTGTAC
CACCCGTGTTAAGACTGGCGTTGGCTACCCACAACTGTCTGCTGTCATTGAGTGCGCCGACGCTGCTCATGGCCTTGGGG
GCCAAATTGTCAGCGATGGTGGCTGTTCTGTTCCAGGTGATGTGGCTAAAGCTTTTGGTGGTGGTGCCGATTTCGTGATG
CTAGGTGGCATGTTGGCAGGCCATGATGAGTGTGAAGGGCGCGTTGTCGAAGAGAATGGCGAGAAGTTCATGCTGTTTTA
CGGGATGAGTTCTGAATCTGCGATGAAACGCCATGTCGGTGGTGTTGCACAATACCGTGCGGCAGAAGGTAAAACGGTTA
AGTTGCCACTGCGTGGTTCAGTCGATAATACCGTGCGTGACATCATGGGAGGCCTACGTTCTGCATGTACTTATGTGGGC
GCTTCACATTTGAAAGAATTAACGAAGCGTACGACGTTTATTCGCGTAGCAGAGCAAGAAAACCGCGTATTTGGCACTGA
TTGA

Upstream 100 bases:

>100_bases
CGAAGAATTATTCATGCGTATGATAGCTCCACTGGGATGGCGTGTTTTACGCCCGATCACATTTTGCGATCTATCGCCAA
TAACCAGGGAATAATAAGTC

Downstream 100 bases:

>100_bases
TACGGGTTATTACGGCATGATAATTTGCCAGTAATGTCGTCATCAGGATACCTGAGCGCTGAGTTGTAGGGGGCCAACGC
AATTCAATATAGGGTTGTGT

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRIEEGLKLGFKDVLIRPKRSTLKSRSEVALERQFTFKHSGWNWSGVPIIAANMDTVGTFRMAEVLASFDILTAVHKHYT
LEQWAEFVKRSPESVLRHVMVSTGTSSADFDKMKQILALSPSLKFICIDVANGYSEHFVSFLQRAREACPDKVICAGNVV
TGEMVEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
LGGMLAGHDECEGRVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGSVDNTVRDIMGGLRSACTYVG
ASHLKELTKRTTFIRVAEQENRVFGTD

Sequences:

>Translated_347_residues
MRIEEGLKLGFKDVLIRPKRSTLKSRSEVALERQFTFKHSGWNWSGVPIIAANMDTVGTFRMAEVLASFDILTAVHKHYT
LEQWAEFVKRSPESVLRHVMVSTGTSSADFDKMKQILALSPSLKFICIDVANGYSEHFVSFLQRAREACPDKVICAGNVV
TGEMVEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
LGGMLAGHDECEGRVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGSVDNTVRDIMGGLRSACTYVG
ASHLKELTKRTTFIRVAEQENRVFGTD
>Mature_347_residues
MRIEEGLKLGFKDVLIRPKRSTLKSRSEVALERQFTFKHSGWNWSGVPIIAANMDTVGTFRMAEVLASFDILTAVHKHYT
LEQWAEFVKRSPESVLRHVMVSTGTSSADFDKMKQILALSPSLKFICIDVANGYSEHFVSFLQRAREACPDKVICAGNVV
TGEMVEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
LGGMLAGHDECEGRVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGSVDNTVRDIMGGLRSACTYVG
ASHLKELTKRTTFIRVAEQENRVFGTD

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541954, Length=343, Percent_Identity=68.2215743440233, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI50541952, Length=343, Percent_Identity=68.2215743440233, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI50541948, Length=343, Percent_Identity=68.2215743440233, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI50541956, Length=342, Percent_Identity=68.4210526315789, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI156104880, Length=343, Percent_Identity=66.7638483965015, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI66933016, Length=323, Percent_Identity=25.3869969040248, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI217035148, Length=265, Percent_Identity=27.5471698113208, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI217035150, Length=265, Percent_Identity=27.5471698113208, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI217035146, Length=265, Percent_Identity=27.5471698113208, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI217035152, Length=265, Percent_Identity=27.5471698113208, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI34328930, Length=265, Percent_Identity=27.5471698113208, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI156616279, Length=265, Percent_Identity=27.5471698113208, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI34328928, Length=265, Percent_Identity=27.5471698113208, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786293, Length=344, Percent_Identity=85.1744186046512, Blast_Score=610, Evalue=1e-176,
Organism=Escherichia coli, GI1788855, Length=222, Percent_Identity=35.5855855855856, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17560440, Length=343, Percent_Identity=63.265306122449, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71994385, Length=214, Percent_Identity=32.2429906542056, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71994389, Length=165, Percent_Identity=36.969696969697, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323464, Length=248, Percent_Identity=28.6290322580645, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323585, Length=235, Percent_Identity=30.6382978723404, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322012, Length=237, Percent_Identity=30.379746835443, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319352, Length=120, Percent_Identity=35, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24641071, Length=242, Percent_Identity=29.3388429752066, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24641073, Length=242, Percent_Identity=29.3388429752066, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI28571163, Length=242, Percent_Identity=29.3388429752066, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005993
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 37493; Mature: 37493

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEEGLKLGFKDVLIRPKRSTLKSRSEVALERQFTFKHSGWNWSGVPIIAANMDTVGTF
CCCCHHHHCCHHHHEECCCHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEECCCCHHHH
RMAEVLASFDILTAVHKHYTLEQWAEFVKRSPESVLRHVMVSTGTSSADFDKMKQILALS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
PSLKFICIDVANGYSEHFVSFLQRAREACPDKVICAGNVVTGEMVEELILSGADIVKVGI
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEC
GPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHCCCCCHHH
LGGMLAGHDECEGRVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGS
HCCCCCCCCCCCCEEEECCCCEEEEEEECCCHHHHHHHHCCHHHHHCCCCCEEEEECCCC
VDNTVRDIMGGLRSACTYVGASHLKELTKRTTFIRVAEQENRVFGTD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC
>Mature Secondary Structure
MRIEEGLKLGFKDVLIRPKRSTLKSRSEVALERQFTFKHSGWNWSGVPIIAANMDTVGTF
CCCCHHHHCCHHHHEECCCHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEECCCCHHHH
RMAEVLASFDILTAVHKHYTLEQWAEFVKRSPESVLRHVMVSTGTSSADFDKMKQILALS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
PSLKFICIDVANGYSEHFVSFLQRAREACPDKVICAGNVVTGEMVEELILSGADIVKVGI
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEC
GPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHCCCCCHHH
LGGMLAGHDECEGRVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGS
HCCCCCCCCCCCCEEEECCCCEEEEEEECCCHHHHHHHHCCHHHHHCCCCCEEEEECCCC
VDNTVRDIMGGLRSACTYVGASHLKELTKRTTFIRVAEQENRVFGTD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA