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The map label for this gene is ggt [H]

Identifier: 170025486

GI number: 170025486

Start: 3572783

End: 3574546

Strand: Direct

Name: ggt [H]

Synonym: YPK_3269

Alternate gene names: 170025486

Gene position: 3572783-3574546 (Clockwise)

Preceding gene: 170025484

Following gene: 170025494

Centisome position: 76.19

GC content: 50.57

Gene sequence:

>1764_bases
ATGTTTTTAACAAAATGGAATAAGCCATTAGCAGTATTAGCTTTACTGGTAAGTGGCACGCTGCATGCCGCCTCCACACC
CGCGGTAGAAGCGAAAAATGGCATGGTTGTGACCTCCCAATATCTGGCTTCACAGGTTGGGGCTGATATTTTAAAAATGG
GCGGTAATGCTGTTGATGCCGCGGTAGCAGTAGGATATGCCCAGGCAGTAGTCAATCCTTGCTGTGGCAATATTGGCGGG
GGGGGTTTTATGACCATTCATCTTGCCGATGGAACCGATACATTTATTAACTTTCGTGAAACCGCCCCTTCCACGGCTAA
TGCTGATATGTACTTGGATAAAGACGGTAACGTTACCAAGGATGCCAGTTTGTATGGCTATCTGGCGGTAGGTGTACCTG
GCACGGTATTGGGCATGGATAGTGCGCAAAAGAAATACGGCAAATTAACCCGTCAGCAAGTCATGGCACCGGCTATCCGT
TTGGCCCGTGACGGCTTTATCCTGACTCGCGCCGATACCGATATTCTGGACACCACCGTCAAACGTTTCCGTCAGGATCC
TGAGTCTGCACGTATCTTCCTGCGTAAAGATGGAGAGGCACTACAACCGGGCGATCGTCTGGTTCAGGCCGATCTCGCGG
ATACGTTAAGCGCGATTTCAGAAAAAGGGCCGGATGCGTTCTATCAAGGTAAAATACCGCAAGCTGTGGAAGCAGCGGCT
AAAAAGGGAGGCGGAATACTGACTGCCGCCGATTTCGCCGATTATAAAATCACCGAAACCGCACCGATTACCTGTAGTTA
TCGCGGTTATAAATTCGTTTCAGCCCCACCGCCGAGTTCCGGTGGCGTCACATTATGTGAAACGCTAAATGTTTTGGAGG
GCTATAACCTCAAAAGTATGGGCTTTAACTCCGCTGACTATATCCATACGCTAACGGAGGCAATGCGCCATGCCTATATG
GACCGCAATACCTTCCTCGGTGATCCAGAGTTTGTTAAAAATCCGCTTGACCGCCTACTGAGCAAAAGCTATGCCGCCGA
TATCCGTAAACAGATCGTCGCCAACAAAGCAACACCATCAGTAGAAGTACAACCGGGTATGCAACCTCACGAAAAACCGG
AGACGACACACTACTCCATCGTCGATCATGAGGGTAATGCCGTTTCTACCACGTATACCGTTAATGGGCGCTTTGGCGCG
GTGGTCATTGCTCCTGGTACTGGCTTCTTCCTCAATAATGAAATGGATGATTTTACAGTTAAAGTGGGTGAACAAAATCT
GTATGGATTGGTACAAGGTGCAACCAACGCTATCGCCCCCGGTAAGCGCCCACTATCGTCAATGAGCCCGACACTAGTGA
CCAAAGATGGAAAAACATTTATGGTCTTGGGTTCACCGGGTGGCTCACGGATTATCAGCATCACGCTGCAAACCGCCCTG
AACGTCATTGACCACGGTATGGCCCCGCAAGAAGCGGTTGATGCACCACGTATTCACCATCAGTGGCTACCCGATGAAGT
CTATTATGAGCAACGCGGTGTCTCAGCGGACAGTCTCAATATCCTGAAGAGTATGGGATATAAGATGGTTGAACAGAGCC
CTTGGGGCGCAGCGGAGTTGATTTTAGTCGGCCTGGCCGGTGTTGAGGGCGTCAGCCCGGCTAACTCGGGTAATGATTCT
GCTGTCTCCGGCAAAGTCCGTGAGGGCTACCTGTACGGTGCCAATGATGTCCGTCGCCCCGCAGGGGCTGCTATTGGCTA
CTAA

Upstream 100 bases:

>100_bases
ACAAATTTTTTATATTCCACATACAAAGCAGCGTTTTTAGTGCTGCCAGACAACGATGACCGGGTAACTCCCGGCAGGCA
GGAGCACAATAGGAGTTCGT

Downstream 100 bases:

>100_bases
TCAATCTAATGACTACTAATCAATCTAATGGTTATTAATTAAGATTAAGCCATGGGTCGTTAATTAAGCTATTGGTTATT
GATTTAGCTATTGACCGATG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MFLTKWNKPLAVLALLVSGTLHAASTPAVEAKNGMVVTSQYLASQVGADILKMGGNAVDAAVAVGYAQAVVNPCCGNIGG
GGFMTIHLADGTDTFINFRETAPSTANADMYLDKDGNVTKDASLYGYLAVGVPGTVLGMDSAQKKYGKLTRQQVMAPAIR
LARDGFILTRADTDILDTTVKRFRQDPESARIFLRKDGEALQPGDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAA
KKGGGILTAADFADYKITETAPITCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSMGFNSADYIHTLTEAMRHAYM
DRNTFLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPSVEVQPGMQPHEKPETTHYSIVDHEGNAVSTTYTVNGRFGA
VVIAPGTGFFLNNEMDDFTVKVGEQNLYGLVQGATNAIAPGKRPLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTAL
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADSLNILKSMGYKMVEQSPWGAAELILVGLAGVEGVSPANSGNDS
AVSGKVREGYLYGANDVRRPAGAAIGY

Sequences:

>Translated_587_residues
MFLTKWNKPLAVLALLVSGTLHAASTPAVEAKNGMVVTSQYLASQVGADILKMGGNAVDAAVAVGYAQAVVNPCCGNIGG
GGFMTIHLADGTDTFINFRETAPSTANADMYLDKDGNVTKDASLYGYLAVGVPGTVLGMDSAQKKYGKLTRQQVMAPAIR
LARDGFILTRADTDILDTTVKRFRQDPESARIFLRKDGEALQPGDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAA
KKGGGILTAADFADYKITETAPITCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSMGFNSADYIHTLTEAMRHAYM
DRNTFLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPSVEVQPGMQPHEKPETTHYSIVDHEGNAVSTTYTVNGRFGA
VVIAPGTGFFLNNEMDDFTVKVGEQNLYGLVQGATNAIAPGKRPLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTAL
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADSLNILKSMGYKMVEQSPWGAAELILVGLAGVEGVSPANSGNDS
AVSGKVREGYLYGANDVRRPAGAAIGY
>Mature_587_residues
MFLTKWNKPLAVLALLVSGTLHAASTPAVEAKNGMVVTSQYLASQVGADILKMGGNAVDAAVAVGYAQAVVNPCCGNIGG
GGFMTIHLADGTDTFINFRETAPSTANADMYLDKDGNVTKDASLYGYLAVGVPGTVLGMDSAQKKYGKLTRQQVMAPAIR
LARDGFILTRADTDILDTTVKRFRQDPESARIFLRKDGEALQPGDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAA
KKGGGILTAADFADYKITETAPITCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSMGFNSADYIHTLTEAMRHAYM
DRNTFLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPSVEVQPGMQPHEKPETTHYSIVDHEGNAVSTTYTVNGRFGA
VVIAPGTGFFLNNEMDDFTVKVGEQNLYGLVQGATNAIAPGKRPLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTAL
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADSLNILKSMGYKMVEQSPWGAAELILVGLAGVEGVSPANSGNDS
AVSGKVREGYLYGANDVRRPAGAAIGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=478, Percent_Identity=34.7280334728033, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI73915090, Length=478, Percent_Identity=34.7280334728033, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI73915096, Length=478, Percent_Identity=34.7280334728033, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI73915094, Length=478, Percent_Identity=34.7280334728033, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI113429324, Length=479, Percent_Identity=33.4029227557411, Blast_Score=222, Evalue=9e-58,
Organism=Homo sapiens, GI113429326, Length=484, Percent_Identity=32.8512396694215, Blast_Score=216, Evalue=7e-56,
Organism=Homo sapiens, GI109148539, Length=517, Percent_Identity=30.5609284332689, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI153266885, Length=477, Percent_Identity=29.769392033543, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI153266901, Length=478, Percent_Identity=29.7071129707113, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI153266907, Length=476, Percent_Identity=28.3613445378151, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI30581157, Length=213, Percent_Identity=35.6807511737089, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI30581155, Length=213, Percent_Identity=35.6807511737089, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI218505805, Length=174, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI310124095, Length=174, Percent_Identity=30.4597701149425, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789856, Length=560, Percent_Identity=48.75, Blast_Score=526, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI212646519, Length=482, Percent_Identity=35.2697095435685, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI72000294, Length=482, Percent_Identity=35.2697095435685, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI17506189, Length=489, Percent_Identity=33.3333333333333, Blast_Score=240, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17542894, Length=508, Percent_Identity=33.8582677165354, Blast_Score=235, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI193208247, Length=505, Percent_Identity=32.6732673267327, Blast_Score=222, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI193208245, Length=505, Percent_Identity=33.0693069306931, Blast_Score=222, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17564448, Length=425, Percent_Identity=27.7647058823529, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI72001497, Length=378, Percent_Identity=25.1322751322751, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI72001495, Length=246, Percent_Identity=26.0162601626016, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323330, Length=512, Percent_Identity=30.46875, Blast_Score=176, Evalue=8e-45,
Organism=Drosophila melanogaster, GI161077496, Length=529, Percent_Identity=31.3799621928166, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI161077880, Length=510, Percent_Identity=31.1764705882353, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI161077878, Length=510, Percent_Identity=31.1764705882353, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24642670, Length=510, Percent_Identity=31.1764705882353, Blast_Score=226, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24642666, Length=510, Percent_Identity=31.1764705882353, Blast_Score=226, Evalue=4e-59,
Organism=Drosophila melanogaster, GI45551474, Length=510, Percent_Identity=31.1764705882353, Blast_Score=226, Evalue=4e-59,
Organism=Drosophila melanogaster, GI18859893, Length=536, Percent_Identity=31.1567164179104, Blast_Score=223, Evalue=4e-58,
Organism=Drosophila melanogaster, GI18859741, Length=517, Percent_Identity=28.6266924564797, Blast_Score=191, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62481; Mature: 62481

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLTKWNKPLAVLALLVSGTLHAASTPAVEAKNGMVVTSQYLASQVGADILKMGGNAVDA
CCCCCCCCHHHHHHHHHHCCCCCCCCCCEECCCCEEEEHHHHHHHHHHHHHHHCCCHHHH
AVAVGYAQAVVNPCCGNIGGGGFMTIHLADGTDTFINFRETAPSTANADMYLDKDGNVTK
HHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEECCCCCCCC
DASLYGYLAVGVPGTVLGMDSAQKKYGKLTRQQVMAPAIRLARDGFILTRADTDILDTTV
CCCEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
KRFRQDPESARIFLRKDGEALQPGDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAA
HHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHH
KKGGGILTAADFADYKITETAPITCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSM
HCCCCEEEECCCCCEEEECCCCEEEECCCEEEEECCCCCCCCEEHHHHHHHHCCCCCCCC
GFNSADYIHTLTEAMRHAYMDRNTFLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPS
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VEVQPGMQPHEKPETTHYSIVDHEGNAVSTTYTVNGRFGAVVIAPGTGFFLNNEMDDFTV
EEECCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCEEEEEEECCCCEEECCCCCCEEE
KVGEQNLYGLVQGATNAIAPGKRPLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTAL
EECCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCEEEEEEHHHHH
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADSLNILKSMGYKMVEQSPWGAAEL
HHHHCCCCCHHHCCCCCHHHCCCCHHHHHHHCCCCHHHHHHHHHCCHHHHHCCCCCHHHE
ILVGLAGVEGVSPANSGNDSAVSGKVREGYLYGANDVRRPAGAAIGY
EEEEECCCCCCCCCCCCCCCCCCCCEECCEEECCCHHCCCCCCCCCC
>Mature Secondary Structure
MFLTKWNKPLAVLALLVSGTLHAASTPAVEAKNGMVVTSQYLASQVGADILKMGGNAVDA
CCCCCCCCHHHHHHHHHHCCCCCCCCCCEECCCCEEEEHHHHHHHHHHHHHHHCCCHHHH
AVAVGYAQAVVNPCCGNIGGGGFMTIHLADGTDTFINFRETAPSTANADMYLDKDGNVTK
HHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEECCCCCCCC
DASLYGYLAVGVPGTVLGMDSAQKKYGKLTRQQVMAPAIRLARDGFILTRADTDILDTTV
CCCEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
KRFRQDPESARIFLRKDGEALQPGDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAA
HHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHH
KKGGGILTAADFADYKITETAPITCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSM
HCCCCEEEECCCCCEEEECCCCEEEECCCEEEEECCCCCCCCEEHHHHHHHHCCCCCCCC
GFNSADYIHTLTEAMRHAYMDRNTFLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPS
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VEVQPGMQPHEKPETTHYSIVDHEGNAVSTTYTVNGRFGAVVIAPGTGFFLNNEMDDFTV
EEECCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCEEEEEEECCCCEEECCCCCCEEE
KVGEQNLYGLVQGATNAIAPGKRPLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTAL
EECCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCEEEEEEHHHHH
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADSLNILKSMGYKMVEQSPWGAAEL
HHHHCCCCCHHHCCCCCHHHCCCCHHHHHHHCCCCHHHHHHHHHCCHHHHHCCCCCHHHE
ILVGLAGVEGVSPANSGNDSAVSGKVREGYLYGANDVRRPAGAAIGY
EEEEECCCCCCCCCCCCCCCCCCCCEECCEEECCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765305 [H]