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The map label for this gene is ltaE [H]

Identifier: 170024930

GI number: 170024930

Start: 2988156

End: 2989211

Strand: Direct

Name: ltaE [H]

Synonym: YPK_2705

Alternate gene names: 170024930

Gene position: 2988156-2989211 (Clockwise)

Preceding gene: 170024929

Following gene: 170024931

Centisome position: 63.72

GC content: 51.89

Gene sequence:

>1056_bases
ATGATGAAATCTATTTTTCTAGCCAATGAGAAAACGATGCTGATCGATTTACGCAGTGACACAGTAACGCAACCCTGTGC
CGCCATGCGCGCCGCAATGGCGAATGCCGAGGTCGGCGATGATGTGTATGGCGATGACCCAACCGTCAATGCGCTTGAAG
CCAAAGCCGCCAGTTTATCCGGTAAAGAAGCCGCGCTGTTTCTGCCAACAGGCACTCAGGCAAATTTGGTGGCGCTATTG
ACCCATTGTCAGCGTGGTGAAGAGTATATTGTCGGCCAAAAAGCCCATAACTATTTGTATGAAGCCGGGGGTGCCGCCGT
TTTGGGCAGTATCCAACCACAACCTATTGATGCCAACGATGACGGCACACTACCACTGGATAACGTTCTGGCCGCCATCA
AACCCGATGACATTCACTTTGCCCCCACCCGGCTGTTAAGTTTGGAAAATACTCACAATGGCAAAGTCTTGCCTTTGCGT
TATTTACAGCAAGCCTGGGCGTTGACCCGCGAAAAAAAACTGGCGTTACATATTGATGGCGCACGTGTTTTTAATGCTGC
GGTGGCGCTGAATGTGCCACTGAACGATATTAGCCAGTATTGCGATACCCTGACAATTTGTCTGTCAAAAGGATTAGGGA
CGCCTGTTGGTTCCCTGCTCTGTGGCAGCGCAGAATTCATTCATCGCGCCCGGCGCTGGCGAAAAATGACCGGTGGTGGT
ATGCGTCAGGCCGGTATTTTAGCGGCAGCCGGGTTGTATGCGCTGCAACATAATGTGGCGAGACTCAAAGATGATCACGA
TAACGCCCAGTGGTTGGAGCAGCAATTACGTGACTTAGGCATTGAGATAGCCGCCCCCGGCGCGCAAACAAACGTGCTGT
ACATTACGCAATCTGCCGAATCAGCGTTGAAACTTGGCCCCTGGATGCGTGAGCGTGGTGTGCTGATCAGTGCCGGGCCG
CTCACCCGCCTGATTACTCACCTTAACGTGAGCCGAAAAAATCTGGAAAAAGTCGTCGCGCTGTGGCGTGAATTTATTGC
CGAGCAACATTCATGA

Upstream 100 bases:

>100_bases
ATGTATTTACGGCGTCTTTACGATCTGCCTGTTCTCTCCGTCGCGGGCACTTTGTCAATAACCTCGAGCCAGTAGGCTTT
TTTGTTTCGATATTCTCGCT

Downstream 100 bases:

>100_bases
CACCACAACGGATATTAGTATTAGGTGCCAGTGGCTATATTGGCCAACATTTGGTCCCCTTGCTAAGCCAGCAAGGCCAT
CAAGTCACGGCTGCTGGCCG

Product: L-threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MMKSIFLANEKTMLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLSGKEAALFLPTGTQANLVALL
THCQRGEEYIVGQKAHNYLYEAGGAAVLGSIQPQPIDANDDGTLPLDNVLAAIKPDDIHFAPTRLLSLENTHNGKVLPLR
YLQQAWALTREKKLALHIDGARVFNAAVALNVPLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGG
MRQAGILAAAGLYALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAESALKLGPWMRERGVLISAGP
LTRLITHLNVSRKNLEKVVALWREFIAEQHS

Sequences:

>Translated_351_residues
MMKSIFLANEKTMLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLSGKEAALFLPTGTQANLVALL
THCQRGEEYIVGQKAHNYLYEAGGAAVLGSIQPQPIDANDDGTLPLDNVLAAIKPDDIHFAPTRLLSLENTHNGKVLPLR
YLQQAWALTREKKLALHIDGARVFNAAVALNVPLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGG
MRQAGILAAAGLYALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAESALKLGPWMRERGVLISAGP
LTRLITHLNVSRKNLEKVVALWREFIAEQHS
>Mature_351_residues
MMKSIFLANEKTMLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLSGKEAALFLPTGTQANLVALL
THCQRGEEYIVGQKAHNYLYEAGGAAVLGSIQPQPIDANDDGTLPLDNVLAAIKPDDIHFAPTRLLSLENTHNGKVLPLR
YLQQAWALTREKKLALHIDGARVFNAAVALNVPLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGG
MRQAGILAAAGLYALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAESALKLGPWMRERGVLISAGP
LTRLITHLNVSRKNLEKVVALWREFIAEQHS

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=334, Percent_Identity=69.1616766467066, Blast_Score=483, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI193206522, Length=353, Percent_Identity=41.9263456090652, Blast_Score=259, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI193206520, Length=353, Percent_Identity=41.9263456090652, Blast_Score=259, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI193206524, Length=353, Percent_Identity=41.9263456090652, Blast_Score=259, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6320789, Length=329, Percent_Identity=38.2978723404255, Blast_Score=202, Evalue=9e-53,
Organism=Drosophila melanogaster, GI21355439, Length=296, Percent_Identity=47.972972972973, Blast_Score=266, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 38114; Mature: 38114

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKSIFLANEKTMLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLS
CCCCEEEECCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCC
GKEAALFLPTGTQANLVALLTHCQRGEEYIVGQKAHNYLYEAGGAAVLGSIQPQPIDAND
CCCEEEEECCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCEEECCCCCCCCCCCC
DGTLPLDNVLAAIKPDDIHFAPTRLLSLENTHNGKVLPLRYLQQAWALTREKKLALHIDG
CCCCCHHHHHHHCCCCCCEECCHHEEEECCCCCCCEEHHHHHHHHHHHHHCCEEEEEECC
ARVFNAAVALNVPLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGG
HHEEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCC
MRQAGILAAAGLYALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAE
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCCEEEEEECCCH
SALKLGPWMRERGVLISAGPLTRLITHLNVSRKNLEKVVALWREFIAEQHS
HHHHHCCCHHHCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMKSIFLANEKTMLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLS
CCCCEEEECCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCC
GKEAALFLPTGTQANLVALLTHCQRGEEYIVGQKAHNYLYEAGGAAVLGSIQPQPIDAND
CCCEEEEECCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCEEECCCCCCCCCCCC
DGTLPLDNVLAAIKPDDIHFAPTRLLSLENTHNGKVLPLRYLQQAWALTREKKLALHIDG
CCCCCHHHHHHHCCCCCCEECCHHEEEECCCCCCCEEHHHHHHHHHHHHHCCEEEEEECC
ARVFNAAVALNVPLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGG
HHEEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCC
MRQAGILAAAGLYALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAE
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCCEEEEEECCCH
SALKLGPWMRERGVLISAGPLTRLITHLNVSRKNLEKVVALWREFIAEQHS
HHHHHCCCHHHCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]