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The map label for this gene is pncB [H]

Identifier: 170024872

GI number: 170024872

Start: 2907685

End: 2908905

Strand: Direct

Name: pncB [H]

Synonym: YPK_2647

Alternate gene names: 170024872

Gene position: 2907685-2908905 (Clockwise)

Preceding gene: 170024867

Following gene: 170024873

Centisome position: 62.0

GC content: 47.34

Gene sequence:

>1221_bases
ATGCTGTATAGCGCCATGACTCAAGACGCCTCACCGATTTTGACTTCATTGCTTGATACGGACGCATATAAGCTTCATAT
GCAACAAGCCGTATTTCATCATTATCGTCACATTACTGTTGCCGCCGAATTCCGCTGCCGTAGTGATGAGCTGCTGGGGG
TGTATGCTGATGAAATCCGCCACCAGGTAACCCTGATGGGTCAATTAGCACTGACATCTGATGAGTTTATTTACCTCTCC
AGTCTCCCCTTCTTCCAGGATGATTATCTGCATTGGTTGCGCGATTTTCGTTTTAAACCAGAGCAAGTCTCCGTCGCTGT
TCATGACGGTAAATTAGATATTCGCATTGCCGGTTTATGGTGTGAGGTGATCATGTGGGAAGTGCCTTTGCTGGCAGTGA
TCAGCGAAATCGTTCACCGCCGCCGCTCTACCCAAGTGACAACGGATCAAGCGGTTCAACAACTGCGCACAAAACTTGAG
CAATTCAATGCCCTCAGTGCGGATATCGATATTACTCACTTTAAATTGATGGATTTCGGTACCCGCCGCCGATTCTCTCG
CGAGATACAGCACACCGTTGTCAGCACGTTAAAAGATGAGTTCCCTTATCTGGTCGGCACCAGCAACTACGACTTAGCCC
GCACATTAGCCTTAGCGCCCGTCGGGACTCAAGCCCATGAGTGGTTTCAGGCTCACCAACAAATTAGCCCAACATTGGCA
AACAGCCAGCGTGTAGCACTGCAAGTCTGGCTGGATGAATACCCCAATCAACTGGGCATCGCACTAACTGATTGCATTAC
TATGGATGCTTTCCTACGCGATTTTGATCTGGCTTTCGCCAACCGCTATCAAGGCCTACGCCATGACTCTGGTGACCCGA
TCGAGTGGGGGGAGAAGGCTATCGCGCATTATGAAAAATTGGGTATTGACCCAATGAAAAAGGTATTGGTGTTTTCAGAT
AATCTAGATCTGGAGAAAGCATTATTCCTCTACCGTCACTTTTATCAGCGCATTAAGTTGGTGTTTGGTATCGGTACCCG
TTTGACCTGCGATATACCAGATGTTAAGCCATTGAATATTGTTATTAAACTGGTTGAATGTAACGATAAACCGGTGGCTA
AGCTCTCAGATAGCCCGGGTAAGACTATTTGTCAGGACCCCGCATTCGTTGATCAATTACGTAAAGCCTTTGCGCTACCG
TTAGTCAAGAAAGCCAGTTAA

Upstream 100 bases:

>100_bases
TTAGCATTTATGGTGTGATGAGGCTTCAATAACAGGATAATACCGGTATACTCCTGCAACTTTATAGATTTTGCCGACTG
TGGAAAATGCTCCTACGAGG

Downstream 100 bases:

>100_bases
TCCCCCCGTTGCCGGGTAGCGTATGTTTACCCGGTAACCCCAACACTGATATTTTTTAGCCTCTCTGTTCTTCCACAATT
AAATTTTCTACTATTAAATA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MLYSAMTQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDELLGVYADEIRHQVTLMGQLALTSDEFIYLS
SLPFFQDDYLHWLRDFRFKPEQVSVAVHDGKLDIRIAGLWCEVIMWEVPLLAVISEIVHRRRSTQVTTDQAVQQLRTKLE
QFNALSADIDITHFKLMDFGTRRRFSREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQAHQQISPTLA
NSQRVALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDSGDPIEWGEKAIAHYEKLGIDPMKKVLVFSD
NLDLEKALFLYRHFYQRIKLVFGIGTRLTCDIPDVKPLNIVIKLVECNDKPVAKLSDSPGKTICQDPAFVDQLRKAFALP
LVKKAS

Sequences:

>Translated_406_residues
MLYSAMTQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDELLGVYADEIRHQVTLMGQLALTSDEFIYLS
SLPFFQDDYLHWLRDFRFKPEQVSVAVHDGKLDIRIAGLWCEVIMWEVPLLAVISEIVHRRRSTQVTTDQAVQQLRTKLE
QFNALSADIDITHFKLMDFGTRRRFSREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQAHQQISPTLA
NSQRVALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDSGDPIEWGEKAIAHYEKLGIDPMKKVLVFSD
NLDLEKALFLYRHFYQRIKLVFGIGTRLTCDIPDVKPLNIVIKLVECNDKPVAKLSDSPGKTICQDPAFVDQLRKAFALP
LVKKAS
>Mature_406_residues
MLYSAMTQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDELLGVYADEIRHQVTLMGQLALTSDEFIYLS
SLPFFQDDYLHWLRDFRFKPEQVSVAVHDGKLDIRIAGLWCEVIMWEVPLLAVISEIVHRRRSTQVTTDQAVQQLRTKLE
QFNALSADIDITHFKLMDFGTRRRFSREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQAHQQISPTLA
NSQRVALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDSGDPIEWGEKAIAHYEKLGIDPMKKVLVFSD
NLDLEKALFLYRHFYQRIKLVFGIGTRLTCDIPDVKPLNIVIKLVECNDKPVAKLSDSPGKTICQDPAFVDQLRKAFALP
LVKKAS

Specific function: NAD biosynthesis; nicotinamide to NaMN; second step. [C]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Escherichia coli, GI1787162, Length=401, Percent_Identity=73.5660847880299, Blast_Score=613, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6324783, Length=425, Percent_Identity=31.5294117647059, Blast_Score=200, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006406
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 46588; Mature: 46588

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYSAMTQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDELLGVYADEIR
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHH
HQVTLMGQLALTSDEFIYLSSLPFFQDDYLHWLRDFRFKPEQVSVAVHDGKLDIRIAGLW
HHHHHHHHEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCEEEEEEEHHH
CEVIMWEVPLLAVISEIVHRRRSTQVTTDQAVQQLRTKLEQFNALSADIDITHFKLMDFG
HHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCH
TRRRFSREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQAHQQISPTLA
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHEECCCCCHHHHHHHHHHHCCCHHC
NSQRVALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDSGDPIEWGEKA
CCCEEEEEEEEHHCCCHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
IAHYEKLGIDPMKKVLVFSDNLDLEKALFLYRHFYQRIKLVFGIGTRLTCDIPDVKPLNI
HHHHHHHCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEE
VIKLVECNDKPVAKLSDSPGKTICQDPAFVDQLRKAFALPLVKKAS
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLYSAMTQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDELLGVYADEIR
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHH
HQVTLMGQLALTSDEFIYLSSLPFFQDDYLHWLRDFRFKPEQVSVAVHDGKLDIRIAGLW
HHHHHHHHEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCEEEEEEEHHH
CEVIMWEVPLLAVISEIVHRRRSTQVTTDQAVQQLRTKLEQFNALSADIDITHFKLMDFG
HHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCH
TRRRFSREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQAHQQISPTLA
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHEECCCCCHHHHHHHHHHHCCCHHC
NSQRVALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDSGDPIEWGEKA
CCCEEEEEEEEHHCCCHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
IAHYEKLGIDPMKKVLVFSDNLDLEKALFLYRHFYQRIKLVFGIGTRLTCDIPDVKPLNI
HHHHHHHCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEE
VIKLVECNDKPVAKLSDSPGKTICQDPAFVDQLRKAFALPLVKKAS
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA