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The map label for this gene is nqrE

Identifier: 170024487

GI number: 170024487

Start: 2509544

End: 2510143

Strand: Direct

Name: nqrE

Synonym: YPK_2258

Alternate gene names: 170024487

Gene position: 2509544-2510143 (Clockwise)

Preceding gene: 170024485

Following gene: 170024489

Centisome position: 53.51

GC content: 41.17

Gene sequence:

>600_bases
ATGACCGAGAGTTATTTGACCATTTTTATTAGAGCTGTTTTTGTTGAAAATATGGCATTAAATTTCTTTCTTGGAATGTG
CACATTTCTGGCAATATCTAAAAAAGTAGAAACAGCCTTTGGCCTTGGGTTGACAGTTACAGCCCTGCTGGCGATAGCAA
CACCTCTCAATAATCTTATTTACACCTATATACTCAGAGAGAATGCTCTGATTGATGGAGTGGATCTTAGTTTTCTTGAT
TTCATTACCTTCATCGGGGTGCTTGCGGCATTAGTCCAAATACTTGAAATGGTACTTGAGCGATTTTTGCCAAGCTTACA
TCACACCCTGGGGGCCTTTTTACCACTACTGACGATCCACTGTGCAATATTTGGTGCAACCATTTTTATGGTTCAGCGAG
AATATACGTTCACCGAATCTTTTGTTTACGGGACTGGCTGTGGTTTAGGTTGGATGCTGGCCATTATATCCATGGCAGGT
TTACGAGAAAAAATGAAGTACTCTAACATTCCAAAAGGGTTGCAAGGGCTCGGCATCGTCTTTATGACGGCAGGGCTGAT
GTCCTTAGGATTTATGTCATTTTCAGGTATTCGGCTCTAA

Upstream 100 bases:

>100_bases
GATAATTCTAAAAAAGCCGCCAGGATGAAATATATTAAGAAATAATCAGTAACATAATGATACAATGTAACTCCATATGG
ACGATTTAGGAGTGTGTGTA

Downstream 100 bases:

>100_bases
CGCGGACGTGGATGACATTCAGTTATTTATGATAGACAATGCGGCTCAGAAGTCATTTCTTCTTTCTAAACTAGAATCAT
TGTTCATCATCAGAATTAGC

Product: Na(+)-translocating NADH-quinone reductase subunit E

Products: NA

Alternate protein names: Na(+)-NQR subunit E; Na(+)-translocating NQR subunit E; NQR complex subunit E; NQR-1 subunit E

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MTESYLTIFIRAVFVENMALNFFLGMCTFLAISKKVETAFGLGLTVTALLAIATPLNNLIYTYILRENALIDGVDLSFLD
FITFIGVLAALVQILEMVLERFLPSLHHTLGAFLPLLTIHCAIFGATIFMVQREYTFTESFVYGTGCGLGWMLAIISMAG
LREKMKYSNIPKGLQGLGIVFMTAGLMSLGFMSFSGIRL

Sequences:

>Translated_199_residues
MTESYLTIFIRAVFVENMALNFFLGMCTFLAISKKVETAFGLGLTVTALLAIATPLNNLIYTYILRENALIDGVDLSFLD
FITFIGVLAALVQILEMVLERFLPSLHHTLGAFLPLLTIHCAIFGATIFMVQREYTFTESFVYGTGCGLGWMLAIISMAG
LREKMKYSNIPKGLQGLGIVFMTAGLMSLGFMSFSGIRL
>Mature_198_residues
TESYLTIFIRAVFVENMALNFFLGMCTFLAISKKVETAFGLGLTVTALLAIATPLNNLIYTYILRENALIDGVDLSFLDF
ITFIGVLAALVQILEMVLERFLPSLHHTLGAFLPLLTIHCAIFGATIFMVQREYTFTESFVYGTGCGLGWMLAIISMAGL
REKMKYSNIPKGLQGLGIVFMTAGLMSLGFMSFSGIRL

Specific function: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to nqrE are probably involved in the second step, the conversion of ubisemiqui

COG id: COG2209

COG function: function code C; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nqrDE/rnfAE family

Homologues:

Organism=Escherichia coli, GI1787914, Length=197, Percent_Identity=39.0862944162437, Blast_Score=136, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NQRE_YERPE (Q9ZC45)

Other databases:

- EMBL:   AL031866
- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AB0236
- PIR:   T47023
- RefSeq:   NP_669683.1
- RefSeq:   NP_993030.1
- RefSeq:   YP_002346924.1
- ProteinModelPortal:   Q9ZC45
- GeneID:   1147323
- GeneID:   1174774
- GeneID:   2764391
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO1935
- KEGG:   ypk:y2376
- KEGG:   ypm:YP_1677
- HOGENOM:   HBG624915
- OMA:   NINTAFG
- ProtClustDB:   PRK12456
- BioCyc:   YPES187410:Y2376-MONOMER
- BioCyc:   YPES214092:YPO1935-MONOMER
- HAMAP:   MF_00429
- InterPro:   IPR003667
- InterPro:   IPR010967
- PIRSF:   PIRSF006102
- TIGRFAMs:   TIGR01940

Pfam domain/function: PF02508 Rnf-Nqr

EC number: NA

Molecular weight: Translated: 21941; Mature: 21809

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x186645d8)-; HASH(0x18493f00)-; HASH(0x180ea6a4)-; HASH(0x185d47c0)-; HASH(0x185df8b0)-; HASH(0x17e6a360)-;

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESYLTIFIRAVFVENMALNFFLGMCTFLAISKKVETAFGLGLTVTALLAIATPLNNLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTYILRENALIDGVDLSFLDFITFIGVLAALVQILEMVLERFLPSLHHTLGAFLPLLTIH
HHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CAIFGATIFMVQREYTFTESFVYGTGCGLGWMLAIISMAGLREKMKYSNIPKGLQGLGIV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FMTAGLMSLGFMSFSGIRL
HHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
TESYLTIFIRAVFVENMALNFFLGMCTFLAISKKVETAFGLGLTVTALLAIATPLNNLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTYILRENALIDGVDLSFLDFITFIGVLAALVQILEMVLERFLPSLHHTLGAFLPLLTIH
HHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CAIFGATIFMVQREYTFTESFVYGTGCGLGWMLAIISMAGLREKMKYSNIPKGLQGLGIV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FMTAGLMSLGFMSFSGIRL
HHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430