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The map label for this gene is hutC [H]

Identifier: 170024450

GI number: 170024450

Start: 2461392

End: 2462159

Strand: Direct

Name: hutC [H]

Synonym: YPK_2221

Alternate gene names: 170024450

Gene position: 2461392-2462159 (Clockwise)

Preceding gene: 170024447

Following gene: 170024451

Centisome position: 52.49

GC content: 50.78

Gene sequence:

>768_bases
GTGGCAGAACAATCAACGGTTTTACAATTGAGCGCAGCAATGGACGACATTCCTGCACCAATTTACCAACGGGTTAAATT
GGCCATTATTCGCCAGATCAGAACAGGAACCTGGCAGCCCCACCAACGCGTGCCATCAGAAAGTGAACTGGTGACCGAGT
TAGGGGTCAGCCGTATGACGATCAACCGTGCTCTACGTGAACTCACCAATGAAGGTTTCCTTATCCGCATGCAAGGTGTT
GGTACTTTCGTTGCTGAAGCGAAAGCCCACAGTGCTCTACTTGAAGTTCATAATATTGCCGATGAAATCGCCGCCCGTGG
TCACCGCCATAGCAGTCAAGTTCTGCATCTGGAGGCTCGCCCTGCAAGCCCCGAAGAAGCCATCGCGCTAGGCATTCAAC
CGGGTCAACAACTGTTCTATTCACAAATAGTGCACTATGAGAATGATTTCCCCGTTCAGGTTGAAAACCGTTGCGTAAAC
CCAAGTACCGCCCCCGATTATATGAAACAGGATTTCAACCAAATCACCCCGTACAGCTACCTGACACAAGCCGCCCCGCT
CACCGAAGGTGAACACATTGTTGAAGCCGTAATGCCAAGCCCAATCGAGCGACAACTACTGGAACTGAGTGAACATGAAC
CTTGCTTGTTGATCCGCCGTAGAACTTGGTATAGGAAAGCCATCGTCACCGCCGCACAATTGCTCTATCCAGGCCCTCGT
TATCAGCTCTATGGTCGTTTTACCCCACAAGGTACGGTGACGTCCTGA

Upstream 100 bases:

>100_bases
GCGTCAATTAATTAAATCGCTTACTTGTATATACATATACACACGCTAAATTCAACCGTAGACTTAGCATATAAATATTC
TATTTGACGAGGTTAACGCC

Downstream 100 bases:

>100_bases
ACAATTTTGTTTCTCTGTGAGAACTGCGAAGTGTTACGCAATTGTGAATTCGCTATCTTGCTGATAGTGAATTTATAGGC
TAGGTTGTCCATGATTGTAT

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MAEQSTVLQLSAAMDDIPAPIYQRVKLAIIRQIRTGTWQPHQRVPSESELVTELGVSRMTINRALRELTNEGFLIRMQGV
GTFVAEAKAHSALLEVHNIADEIAARGHRHSSQVLHLEARPASPEEAIALGIQPGQQLFYSQIVHYENDFPVQVENRCVN
PSTAPDYMKQDFNQITPYSYLTQAAPLTEGEHIVEAVMPSPIERQLLELSEHEPCLLIRRRTWYRKAIVTAAQLLYPGPR
YQLYGRFTPQGTVTS

Sequences:

>Translated_255_residues
MAEQSTVLQLSAAMDDIPAPIYQRVKLAIIRQIRTGTWQPHQRVPSESELVTELGVSRMTINRALRELTNEGFLIRMQGV
GTFVAEAKAHSALLEVHNIADEIAARGHRHSSQVLHLEARPASPEEAIALGIQPGQQLFYSQIVHYENDFPVQVENRCVN
PSTAPDYMKQDFNQITPYSYLTQAAPLTEGEHIVEAVMPSPIERQLLELSEHEPCLLIRRRTWYRKAIVTAAQLLYPGPR
YQLYGRFTPQGTVTS
>Mature_254_residues
AEQSTVLQLSAAMDDIPAPIYQRVKLAIIRQIRTGTWQPHQRVPSESELVTELGVSRMTINRALRELTNEGFLIRMQGVG
TFVAEAKAHSALLEVHNIADEIAARGHRHSSQVLHLEARPASPEEAIALGIQPGQQLFYSQIVHYENDFPVQVENRCVNP
STAPDYMKQDFNQITPYSYLTQAAPLTEGEHIVEAVMPSPIERQLLELSEHEPCLLIRRRTWYRKAIVTAAQLLYPGPRY
QLYGRFTPQGTVTS

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=147, Percent_Identity=32.6530612244898, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786950, Length=199, Percent_Identity=27.6381909547739, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1790118, Length=201, Percent_Identity=24.8756218905473, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 28764; Mature: 28633

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQSTVLQLSAAMDDIPAPIYQRVKLAIIRQIRTGTWQPHQRVPSESELVTELGVSRMT
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHCHHHHH
INRALRELTNEGFLIRMQGVGTFVAEAKAHSALLEVHNIADEIAARGHRHSSQVLHLEAR
HHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
PASPEEAIALGIQPGQQLFYSQIVHYENDFPVQVENRCVNPSTAPDYMKQDFNQITPYSY
CCCCHHHEEECCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCHHH
LTQAAPLTEGEHIVEAVMPSPIERQLLELSEHEPCLLIRRRTWYRKAIVTAAQLLYPGPR
HHHCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCC
YQLYGRFTPQGTVTS
EEEEEEECCCCCCCC
>Mature Secondary Structure 
AEQSTVLQLSAAMDDIPAPIYQRVKLAIIRQIRTGTWQPHQRVPSESELVTELGVSRMT
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHCHHHHH
INRALRELTNEGFLIRMQGVGTFVAEAKAHSALLEVHNIADEIAARGHRHSSQVLHLEAR
HHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
PASPEEAIALGIQPGQQLFYSQIVHYENDFPVQVENRCVNPSTAPDYMKQDFNQITPYSY
CCCCHHHEEECCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCHHH
LTQAAPLTEGEHIVEAVMPSPIERQLLELSEHEPCLLIRRRTWYRKAIVTAAQLLYPGPR
HHHCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCC
YQLYGRFTPQGTVTS
EEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]