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The map label for this gene is iscS [H]

Identifier: 170024349

GI number: 170024349

Start: 2345994

End: 2347193

Strand: Direct

Name: iscS [H]

Synonym: YPK_2115

Alternate gene names: 170024349

Gene position: 2345994-2347193 (Clockwise)

Preceding gene: 170024348

Following gene: 170024350

Centisome position: 50.03

GC content: 52.08

Gene sequence:

>1200_bases
ATGTACAGTCAGAACCCACCGATATATCTCGATAATAACGCGACAACGGCACTAGACCCTGCCGTCCTGCAGGCGATGAT
GCCATACCTAACCCACGCTTATGGCAATGCCGCCAGTAAGAGCCACCCCTTTGGCTGGGAAGCGAGCCAGGCTGTTCAAC
GGGCCAGAACATTAATCGCAACCGCTATCAATGCAGTCAGTCCCGCCGATATCATCTTCACCTCTGGCGCGACAGAATCC
ATCAATCTTGCCATCTTAGGCCTTCAGTATCAGGGGAATTGGGGGCATATCATCACCTCCATGATTGAACACAAGTCAGT
TCTGGACTGCTGTGCCAAACTTGCCGACAGTGGGGTTAGTGTGACTTATCTGCAGCCACAGCGTGACGGTATTGTTTCCC
TTGATACCCTATTCCAAGCTATCCGGCCCGATACGCGTCTGGTCTCAATCATGACTGCCAACAACGAGACAGGTACCTTG
CAAAAAGTGGCAAAAATTGGCGCACTCTGCCGGGATAAGGGCATTTTATTTCATACCGATGCCACACAGGCGTTCGGGAA
AATCGCTTTAGATATGCAACGGATGAATATCAGTATGGCCACTTTTTCCGCACATAAAGTTTACGGCCCCATGGGGGTCG
GGGCACTTTATGTCAATACCGCCGATCCGCATCTTATGCTTTCACCACTCATCGTTGGCGGAGGGAATGAGCGAGGTTTA
CGCTCCGGCACACTCAATGTACCGGGCATTGTCGGCTTTGGACGCGCCGCCGAACTGGCGATGGAAAACATGTCAGTAGA
ATCGGCCAGGCTATGTGATTTACGAAACAGGCTACGGCAGCACATTCTCGATACCGTACCGAATGTGCAGGTCAACGGCC
ACCTTACTGAATGCCTGCCCGGCGTGTTAAACGTGTCCTTTGAGGGTATCGATGCCGACTCGCTGTTGCTCGAACTCTCT
GACGTTGCCTTGTCCTCAGGATCCGCCTGCACCTCCGATCAACAGATACCATCACACGTGTTACAGGCTCTAGGGGTGAG
TGATGAGCAGATCCGGGGGAGTGTGCGCTTTGGACTCGGACGGTTTAATAACGAAAGTGAAATCGATTACGTCTGCCAGC
GTCTGGAAAATACGGTGAAAATGCTGAGATCAATGGCTCCGCTCTCATCTGCTACAACCACAAACGAGACAGGAGTCTGA

Upstream 100 bases:

>100_bases
GAGGCCGGTGAAGTCAGTCGGGGGGAGAAAATAATCGCTCAATTCACCTCTGCCCCAAAAAAGCCGTTGTCGTCTCGCTC
ATGATTAAGGAAAAATCATT

Downstream 100 bases:

>100_bases
ATCATGCGAAAAACTTCATCACTGTTTCTCCTGTTTGGCACGTTGTTCAGCGCAGGAGGCTATGGTGCCACATTTCTCAT
TTCTGCTTGGTTTCACTCGC

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MYSQNPPIYLDNNATTALDPAVLQAMMPYLTHAYGNAASKSHPFGWEASQAVQRARTLIATAINAVSPADIIFTSGATES
INLAILGLQYQGNWGHIITSMIEHKSVLDCCAKLADSGVSVTYLQPQRDGIVSLDTLFQAIRPDTRLVSIMTANNETGTL
QKVAKIGALCRDKGILFHTDATQAFGKIALDMQRMNISMATFSAHKVYGPMGVGALYVNTADPHLMLSPLIVGGGNERGL
RSGTLNVPGIVGFGRAAELAMENMSVESARLCDLRNRLRQHILDTVPNVQVNGHLTECLPGVLNVSFEGIDADSLLLELS
DVALSSGSACTSDQQIPSHVLQALGVSDEQIRGSVRFGLGRFNNESEIDYVCQRLENTVKMLRSMAPLSSATTTNETGV

Sequences:

>Translated_399_residues
MYSQNPPIYLDNNATTALDPAVLQAMMPYLTHAYGNAASKSHPFGWEASQAVQRARTLIATAINAVSPADIIFTSGATES
INLAILGLQYQGNWGHIITSMIEHKSVLDCCAKLADSGVSVTYLQPQRDGIVSLDTLFQAIRPDTRLVSIMTANNETGTL
QKVAKIGALCRDKGILFHTDATQAFGKIALDMQRMNISMATFSAHKVYGPMGVGALYVNTADPHLMLSPLIVGGGNERGL
RSGTLNVPGIVGFGRAAELAMENMSVESARLCDLRNRLRQHILDTVPNVQVNGHLTECLPGVLNVSFEGIDADSLLLELS
DVALSSGSACTSDQQIPSHVLQALGVSDEQIRGSVRFGLGRFNNESEIDYVCQRLENTVKMLRSMAPLSSATTTNETGV
>Mature_399_residues
MYSQNPPIYLDNNATTALDPAVLQAMMPYLTHAYGNAASKSHPFGWEASQAVQRARTLIATAINAVSPADIIFTSGATES
INLAILGLQYQGNWGHIITSMIEHKSVLDCCAKLADSGVSVTYLQPQRDGIVSLDTLFQAIRPDTRLVSIMTANNETGTL
QKVAKIGALCRDKGILFHTDATQAFGKIALDMQRMNISMATFSAHKVYGPMGVGALYVNTADPHLMLSPLIVGGGNERGL
RSGTLNVPGIVGFGRAAELAMENMSVESARLCDLRNRLRQHILDTVPNVQVNGHLTECLPGVLNVSFEGIDADSLLLELS
DVALSSGSACTSDQQIPSHVLQALGVSDEQIRGSVRFGLGRFNNESEIDYVCQRLENTVKMLRSMAPLSSATTTNETGV

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for NAD, biotin and Fe-S cluster synthesis. Transfers sulfur on 'Cys-456' of ThiI in a transpersulfida

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=384, Percent_Identity=48.6979166666667, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI156713448, Length=417, Percent_Identity=34.7721822541966, Blast_Score=209, Evalue=3e-54,
Organism=Escherichia coli, GI48994898, Length=386, Percent_Identity=50.259067357513, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1787970, Length=317, Percent_Identity=27.4447949526814, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789175, Length=401, Percent_Identity=24.9376558603491, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25143064, Length=385, Percent_Identity=45.4545454545455, Blast_Score=342, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17533177, Length=322, Percent_Identity=34.1614906832298, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319831, Length=384, Percent_Identity=47.3958333333333, Blast_Score=358, Evalue=1e-99,
Organism=Drosophila melanogaster, GI20129463, Length=388, Percent_Identity=48.4536082474227, Blast_Score=364, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42807; Mature: 42807

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSQNPPIYLDNNATTALDPAVLQAMMPYLTHAYGNAASKSHPFGWEASQAVQRARTLIA
CCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
TAINAVSPADIIFTSGATESINLAILGLQYQGNWGHIITSMIEHKSVLDCCAKLADSGVS
HHHHCCCCCCEEEECCCCCEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCE
VTYLQPQRDGIVSLDTLFQAIRPDTRLVSIMTANNETGTLQKVAKIGALCRDKGILFHTD
EEEECCCCCCEEEHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECC
ATQAFGKIALDMQRMNISMATFSAHKVYGPMGVGALYVNTADPHLMLSPLIVGGGNERGL
HHHHHHHHHHHHHHHEEEEEEEEHHHCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCC
RSGTLNVPGIVGFGRAAELAMENMSVESARLCDLRNRLRQHILDTVPNVQVNGHLTECLP
CCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHH
GVLNVSFEGIDADSLLLELSDVALSSGSACTSDQQIPSHVLQALGVSDEQIRGSVRFGLG
HHHCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHCCHHEECCC
RFNNESEIDYVCQRLENTVKMLRSMAPLSSATTTNETGV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MYSQNPPIYLDNNATTALDPAVLQAMMPYLTHAYGNAASKSHPFGWEASQAVQRARTLIA
CCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
TAINAVSPADIIFTSGATESINLAILGLQYQGNWGHIITSMIEHKSVLDCCAKLADSGVS
HHHHCCCCCCEEEECCCCCEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCE
VTYLQPQRDGIVSLDTLFQAIRPDTRLVSIMTANNETGTLQKVAKIGALCRDKGILFHTD
EEEECCCCCCEEEHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECC
ATQAFGKIALDMQRMNISMATFSAHKVYGPMGVGALYVNTADPHLMLSPLIVGGGNERGL
HHHHHHHHHHHHHHHEEEEEEEEHHHCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCC
RSGTLNVPGIVGFGRAAELAMENMSVESARLCDLRNRLRQHILDTVPNVQVNGHLTECLP
CCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHH
GVLNVSFEGIDADSLLLELSDVALSSGSACTSDQQIPSHVLQALGVSDEQIRGSVRFGLG
HHHCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHCCHHEECCC
RFNNESEIDYVCQRLENTVKMLRSMAPLSSATTTNETGV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA