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The map label for this gene is trpA [H]

Identifier: 170024282

GI number: 170024282

Start: 2279252

End: 2280058

Strand: Direct

Name: trpA [H]

Synonym: YPK_2047

Alternate gene names: 170024282

Gene position: 2279252-2280058 (Clockwise)

Preceding gene: 170024281

Following gene: 170024283

Centisome position: 48.6

GC content: 50.19

Gene sequence:

>807_bases
ATGGAGCGTTATCAGCAACTTTTTAAGCAGTTAGCCGCCAAAAAAGAAGGTGCCTTTGTTCCTTTCGTCCAGCTTGGCGA
TCCCTCTCCGGCGATGTCACTCAATATTATTGATACGTTAATTGCGGCAGGTGCAGATGCATTAGAGTTAGGGATTCCGT
TCTCTGATCCGTTGGCTGATGGCCCTACCATACAAAATGCGGCGTTGCGTGCCTTTGCTGCGGGTGTCACTCCGGCTATT
TGTTTTGAAATACTGGCCGAAATCCGCCAAAAACACCCCACAATACCTATTGGCCTGTTGATGTATGCAAATCTGGTATT
CCACAATGGTATTGATCACTTCTACCAGCGCTGTGCTGAGGTGGGTGTCGATTCGGTGCTAATTGCTGATGTGCCATTTG
AAGAGTCTGCCCCTTTCCGGGCAGCGGCCTTACGTCACGGGATTGCACCCATTTTCATCTGCCCGCCTAATGCCGACGGT
GACTTACTGCGAGAAATCGCTTCTCATGGTCGTGGTTACACTTACCTGTTATCACGTGCCGGAGTCACCGGTGCAGAAAA
TCACGGCCAGTTACCGTTAAACCATCTGGTAGATAAACTGCGTGAATATAATGCAGCGCCCGCATTGCAGGGCTTTGGTA
TTTCAGAACCCGCGCAAGTAAAAGCCAGCCTGGCGGCGGGCGCGGCGGGTGCTATTTCAGGCTCAGCAATCGTCAAAATC
ATTGAAAAAAATGTTGCACAACCAGTTGAAATGTTAGTTCAGCTAACCCGCTTCGTCACAGAGATGAAAGCGGCAACCCG
CAGCTAG

Upstream 100 bases:

>100_bases
ATCCGGATAAAGAACAAATACTGGTGGTGAATCTCTCCGGCCGGGGTGACAAAGATATTTTCACCGTTCACGATATTCTG
AAAGCACGGGGAGAGATTTA

Downstream 100 bases:

>100_bases
TTATTATTTACAATTGGTTACTATTGAGAGTGAGTTACCGTTTAGAATTAATTACTATTTACCGTTAACTGCTGTCATTA
CCGCCCTTCAGCGCCTGTTT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MERYQQLFKQLAAKKEGAFVPFVQLGDPSPAMSLNIIDTLIAAGADALELGIPFSDPLADGPTIQNAALRAFAAGVTPAI
CFEILAEIRQKHPTIPIGLLMYANLVFHNGIDHFYQRCAEVGVDSVLIADVPFEESAPFRAAALRHGIAPIFICPPNADG
DLLREIASHGRGYTYLLSRAGVTGAENHGQLPLNHLVDKLREYNAAPALQGFGISEPAQVKASLAAGAAGAISGSAIVKI
IEKNVAQPVEMLVQLTRFVTEMKAATRS

Sequences:

>Translated_268_residues
MERYQQLFKQLAAKKEGAFVPFVQLGDPSPAMSLNIIDTLIAAGADALELGIPFSDPLADGPTIQNAALRAFAAGVTPAI
CFEILAEIRQKHPTIPIGLLMYANLVFHNGIDHFYQRCAEVGVDSVLIADVPFEESAPFRAAALRHGIAPIFICPPNADG
DLLREIASHGRGYTYLLSRAGVTGAENHGQLPLNHLVDKLREYNAAPALQGFGISEPAQVKASLAAGAAGAISGSAIVKI
IEKNVAQPVEMLVQLTRFVTEMKAATRS
>Mature_268_residues
MERYQQLFKQLAAKKEGAFVPFVQLGDPSPAMSLNIIDTLIAAGADALELGIPFSDPLADGPTIQNAALRAFAAGVTPAI
CFEILAEIRQKHPTIPIGLLMYANLVFHNGIDHFYQRCAEVGVDSVLIADVPFEESAPFRAAALRHGIAPIFICPPNADG
DLLREIASHGRGYTYLLSRAGVTGAENHGQLPLNHLVDKLREYNAAPALQGFGISEPAQVKASLAAGAAGAISGSAIVKI
IEKNVAQPVEMLVQLTRFVTEMKAATRS

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=268, Percent_Identity=79.1044776119403, Blast_Score=410, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321412, Length=240, Percent_Identity=31.25, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 28535; Mature: 28535

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERYQQLFKQLAAKKEGAFVPFVQLGDPSPAMSLNIIDTLIAAGADALELGIPFSDPLAD
CHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCC
GPTIQNAALRAFAAGVTPAICFEILAEIRQKHPTIPIGLLMYANLVFHNGIDHFYQRCAE
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHH
VGVDSVLIADVPFEESAPFRAAALRHGIAPIFICPPNADGDLLREIASHGRGYTYLLSRA
CCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEEHHHC
GVTGAENHGQLPLNHLVDKLREYNAAPALQGFGISEPAQVKASLAAGAAGAISGSAIVKI
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHCCHHHHHHH
IEKNVAQPVEMLVQLTRFVTEMKAATRS
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MERYQQLFKQLAAKKEGAFVPFVQLGDPSPAMSLNIIDTLIAAGADALELGIPFSDPLAD
CHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCC
GPTIQNAALRAFAAGVTPAICFEILAEIRQKHPTIPIGLLMYANLVFHNGIDHFYQRCAE
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHH
VGVDSVLIADVPFEESAPFRAAALRHGIAPIFICPPNADGDLLREIASHGRGYTYLLSRA
CCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEEHHHC
GVTGAENHGQLPLNHLVDKLREYNAAPALQGFGISEPAQVKASLAAGAAGAISGSAIVKI
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHCCHHHHHHH
IEKNVAQPVEMLVQLTRFVTEMKAATRS
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA