Click here to switch to the map view.

The map label for this gene is clcB [H]

Identifier: 170024216

GI number: 170024216

Start: 2198672

End: 2199952

Strand: Direct

Name: clcB [H]

Synonym: YPK_1979

Alternate gene names: 170024216

Gene position: 2198672-2199952 (Clockwise)

Preceding gene: 170024215

Following gene: 170024220

Centisome position: 46.89

GC content: 52.38

Gene sequence:

>1281_bases
ATGAAACGGCCAATCCATCTCTATTACTACCGTGCGATGCTGCGTCGATTAGTGATCTCCATCATGCTCGGCATGGTATC
CGCGCTCATCGTTTGGCTGTTTCATCAGGCGATGCTGGGGCTGGAGTGGCTGCTCTTCTCACGAACAGATGGTAGCCTGG
TTGCTGCTGCGGCCTCTATTACTGGGTGGCGGCGGGCATTAACTCCTGCTTTGGGGGGATTGGCGGCAGGTTTGCTGTTA
TGGGCATACCAACGTTATCAACACCGTAAACCCAGTGCGCCCACTGATTATATGGAAGCCATTGAAATCGGTGATGGCCG
ATTAGATGTTTCCGCCAGCCTAGTGAAGTCCCTCGCCTCTTTGTTAGTCGTATCCAGCGGCAGTGCCATTGGTCGTGAAG
GCGCTATGGTATTGTTGGCCGCCCTGTTCGCTTCGGGTTTCGCTCAACGCTATGCAAAACCTAAAGAGTGGAAGTTGTGG
GTCGCCTGTGGGGCCGCTGCGGGAATGGCAAGTGCTTACCATGCTCCGTTGGCTGGCAGCCTGTTTATTGCAGAAATTCT
ATTTGGAACACTGATGTTGGCTTCACTCGGCCCGGTAGTGATCGCCGCGGTCAGTGCGTTATTGACGACCAACTTGCTAC
AAGGTGGTCAGGAAACCCTTTATCAAGTGCAGACACTCCCTTCTCCTTGGCCGGTACAATATTTCCTGATGGCGCTTCTA
GGATTAATGGCGGGCTTCAGCGGCCCTTTATTTTTAAAAGCGATGGCGGCTAGCAGTCATGCTTTCCGCTCCCTGAATTT
ATTGCCACCTCTGCAATTGGCGCTGGGGGGGATAATTGTTGGTTTACTATCATTGATATTTCCAGAGGTCTGGGGCAATG
GCTACAGCGTAGTGCAATCACTCCTCACCACGCCGCCGGGGGTGTTACTGATAGGCGGCATATTGATCTGTAAGTTATTG
GCCGTGCTTGCCAGTAGTGGGTCCGGCGCTCCGGGAGGGGTATTTACACCTACATTGTTTGTCGGTGCCGCACTCGGCAT
GTTATGTGGGCAGATATTTTCTTTGTGGCCCGTGCTGGGCGACAATATTGGGTTATTAATGGCACTGACCGGCATGGCAA
CATTACTGGCAGCAACGACCCATGCGCCCATTATGGCCGCTTTAATGGTTTGTGAAATGACCGGCGAGTACACCTTATTG
CCAGGGCTATTATTATCTTGTGTTATCGCGACAACAATAGCCCGCTGGTTGCGCCCAATATCGGTATATCGGTCTCACTA
A

Upstream 100 bases:

>100_bases
ATATTGAACAATATTTACTGGCCATTCATTTGCTAGCAAGTAACAATGTCCTTATCTAAAAGAACAGAGTTTACTTCAAC
ATGTCAGTCAGTTGTCTTGC

Downstream 100 bases:

>100_bases
ATGATGGGCCGAGTAACGAAAGCAGCCAACATACATTCAGCTTGAAACACACATTCCAGCTTGAAACACACATTCAGCTT
GAAATAGGATGGATATAAAT

Product: putative voltage-gated ClC-type chloride channel ClcB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKRPIHLYYYRAMLRRLVISIMLGMVSALIVWLFHQAMLGLEWLLFSRTDGSLVAAAASITGWRRALTPALGGLAAGLLL
WAYQRYQHRKPSAPTDYMEAIEIGDGRLDVSASLVKSLASLLVVSSGSAIGREGAMVLLAALFASGFAQRYAKPKEWKLW
VACGAAAGMASAYHAPLAGSLFIAEILFGTLMLASLGPVVIAAVSALLTTNLLQGGQETLYQVQTLPSPWPVQYFLMALL
GLMAGFSGPLFLKAMAASSHAFRSLNLLPPLQLALGGIIVGLLSLIFPEVWGNGYSVVQSLLTTPPGVLLIGGILICKLL
AVLASSGSGAPGGVFTPTLFVGAALGMLCGQIFSLWPVLGDNIGLLMALTGMATLLAATTHAPIMAALMVCEMTGEYTLL
PGLLLSCVIATTIARWLRPISVYRSH

Sequences:

>Translated_426_residues
MKRPIHLYYYRAMLRRLVISIMLGMVSALIVWLFHQAMLGLEWLLFSRTDGSLVAAAASITGWRRALTPALGGLAAGLLL
WAYQRYQHRKPSAPTDYMEAIEIGDGRLDVSASLVKSLASLLVVSSGSAIGREGAMVLLAALFASGFAQRYAKPKEWKLW
VACGAAAGMASAYHAPLAGSLFIAEILFGTLMLASLGPVVIAAVSALLTTNLLQGGQETLYQVQTLPSPWPVQYFLMALL
GLMAGFSGPLFLKAMAASSHAFRSLNLLPPLQLALGGIIVGLLSLIFPEVWGNGYSVVQSLLTTPPGVLLIGGILICKLL
AVLASSGSGAPGGVFTPTLFVGAALGMLCGQIFSLWPVLGDNIGLLMALTGMATLLAATTHAPIMAALMVCEMTGEYTLL
PGLLLSCVIATTIARWLRPISVYRSH
>Mature_426_residues
MKRPIHLYYYRAMLRRLVISIMLGMVSALIVWLFHQAMLGLEWLLFSRTDGSLVAAAASITGWRRALTPALGGLAAGLLL
WAYQRYQHRKPSAPTDYMEAIEIGDGRLDVSASLVKSLASLLVVSSGSAIGREGAMVLLAALFASGFAQRYAKPKEWKLW
VACGAAAGMASAYHAPLAGSLFIAEILFGTLMLASLGPVVIAAVSALLTTNLLQGGQETLYQVQTLPSPWPVQYFLMALL
GLMAGFSGPLFLKAMAASSHAFRSLNLLPPLQLALGGIIVGLLSLIFPEVWGNGYSVVQSLLTTPPGVLLIGGILICKLL
AVLASSGSGAPGGVFTPTLFVGAALGMLCGQIFSLWPVLGDNIGLLMALTGMATLLAATTHAPIMAALMVCEMTGEYTLL
PGLLLSCVIATTIARWLRPISVYRSH

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081943, Length=414, Percent_Identity=63.5265700483092, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1786350, Length=252, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 45028; Mature: 45028

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCC
>Mature Secondary Structure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HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA