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The map label for this gene is chbR [H]

Identifier: 170023393

GI number: 170023393

Start: 1285132

End: 1285974

Strand: Direct

Name: chbR [H]

Synonym: YPK_1147

Alternate gene names: 170023393

Gene position: 1285132-1285974 (Clockwise)

Preceding gene: 170023392

Following gene: 170023394

Centisome position: 27.4

GC content: 40.81

Gene sequence:

>843_bases
ATGGTGACTAAGATGGACGTCAGATTAGTACGTGAAAGAGACTTTTTTAACGGTAAAGAATTCCATCTGTTTATTTACAA
CAAAACGGAGAGTGCGACCGGTTTACATCAGCATGATTATTATGAATATACGCTGATATTAACCGGGATGTGCTACCAAG
AAATTAACGGAAAGCGTGTTTTTTTGGAGCGTGGGGACTTTATCTTTATTCCTCTTGGTTCTCATCATCAAAGTTTCTAT
GAGTTTGGTGCCACCCGGATCCTGAATGTCGGGATCAGTAAAGCTTTCTTTGAAGAACATTATTTCCATTTACTGTCTCG
GCCTATTGTGGCCTCTCAGGCGTATCGCTTAAGAGGTGATTTTCTTTCCTATATCGAATCGGCGATCTCTGCTCCACACT
ACAGAGAAAATGAGCAAACAGAACTTTTAGAGCTACTGACCTTTTATGTGACTAACCGCATCAGTCATTACAAAGAGAGT
GAAGTTAACGACGATATACCTTCGTGGCTGAAGGCCACAATCGACAAAATGCATGATAACGCGATGTTTAGTGAGAAGGC
GTTGGTGAATATGGTCGAGCTTTCTGGCAAAACCCAAGAATATCTCACCAGAGCGACACGGCGCTATTATCAGAAAACGC
CCATGCAGATTATCAATGAAATTAGAATAAATTTTGCCAAAACCCAACTTGAAGTGACGAACTATTTAGTTTCGGATATT
GCATTTGAAGCAGGCTACAGCGACACCACGTTATTCATCAAAAACTTCAAAAAATTAACCTCTTTTACGCCAGGAAACTA
TCGCAAGAACTTCTACAGCGCCAGAGAGAGTTTATCCCATTAG

Upstream 100 bases:

>100_bases
GAATGCCATGTTAGCGCGAGAATTGATTACTGAGCTTATCGAGCTGCATCAAAAAATTCAGTGATACGCCGACGGGGCGA
TAATTCTCAATGGTAGAGCG

Downstream 100 bases:

>100_bases
TTTTCCAACCGGTTATTCCCATAGTGGGAGAGGGTTGGCAAGGAACCTTTAATGGAAAAATTACTTATTGTTAATGCTGA
TGATTTTGGTCTGTGTAAAG

Product: DNA-binding transcriptional regulator ChbR

Products: NA

Alternate protein names: Chb operon repressor [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MVTKMDVRLVRERDFFNGKEFHLFIYNKTESATGLHQHDYYEYTLILTGMCYQEINGKRVFLERGDFIFIPLGSHHQSFY
EFGATRILNVGISKAFFEEHYFHLLSRPIVASQAYRLRGDFLSYIESAISAPHYRENEQTELLELLTFYVTNRISHYKES
EVNDDIPSWLKATIDKMHDNAMFSEKALVNMVELSGKTQEYLTRATRRYYQKTPMQIINEIRINFAKTQLEVTNYLVSDI
AFEAGYSDTTLFIKNFKKLTSFTPGNYRKNFYSARESLSH

Sequences:

>Translated_280_residues
MVTKMDVRLVRERDFFNGKEFHLFIYNKTESATGLHQHDYYEYTLILTGMCYQEINGKRVFLERGDFIFIPLGSHHQSFY
EFGATRILNVGISKAFFEEHYFHLLSRPIVASQAYRLRGDFLSYIESAISAPHYRENEQTELLELLTFYVTNRISHYKES
EVNDDIPSWLKATIDKMHDNAMFSEKALVNMVELSGKTQEYLTRATRRYYQKTPMQIINEIRINFAKTQLEVTNYLVSDI
AFEAGYSDTTLFIKNFKKLTSFTPGNYRKNFYSARESLSH
>Mature_280_residues
MVTKMDVRLVRERDFFNGKEFHLFIYNKTESATGLHQHDYYEYTLILTGMCYQEINGKRVFLERGDFIFIPLGSHHQSFY
EFGATRILNVGISKAFFEEHYFHLLSRPIVASQAYRLRGDFLSYIESAISAPHYRENEQTELLELLTFYVTNRISHYKES
EVNDDIPSWLKATIDKMHDNAMFSEKALVNMVELSGKTQEYLTRATRRYYQKTPMQIINEIRINFAKTQLEVTNYLVSDI
AFEAGYSDTTLFIKNFKKLTSFTPGNYRKNFYSARESLSH

Specific function: Dual-function repressor/activator of the chbBCARFG operon. In the absence of the inducing sugar chitobiose, together with NagC, represses the chbBCARFG operon for the uptake and metabolism of chitobiose. In association with Crp, and probably in the presen

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788030, Length=269, Percent_Identity=68.4014869888476, Blast_Score=393, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013096
- InterPro:   IPR011051
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060
- InterPro:   IPR014710 [H]

Pfam domain/function: PF07883 Cupin_2; PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 32998; Mature: 32998

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTKMDVRLVRERDFFNGKEFHLFIYNKTESATGLHQHDYYEYTLILTGMCYQEINGKRV
CCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEHEEHHHHHHHCCCCEE
FLERGDFIFIPLGSHHQSFYEFGATRILNVGISKAFFEEHYFHLLSRPIVASQAYRLRGD
EEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
FLSYIESAISAPHYRENEQTELLELLTFYVTNRISHYKESEVNDDIPSWLKATIDKMHDN
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AMFSEKALVNMVELSGKTQEYLTRATRRYYQKTPMQIINEIRINFAKTQLEVTNYLVSDI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFEAGYSDTTLFIKNFKKLTSFTPGNYRKNFYSARESLSH
HHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MVTKMDVRLVRERDFFNGKEFHLFIYNKTESATGLHQHDYYEYTLILTGMCYQEINGKRV
CCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEHEEHHHHHHHCCCCEE
FLERGDFIFIPLGSHHQSFYEFGATRILNVGISKAFFEEHYFHLLSRPIVASQAYRLRGD
EEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
FLSYIESAISAPHYRENEQTELLELLTFYVTNRISHYKESEVNDDIPSWLKATIDKMHDN
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AMFSEKALVNMVELSGKTQEYLTRATRRYYQKTPMQIINEIRINFAKTQLEVTNYLVSDI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFEAGYSDTTLFIKNFKKLTSFTPGNYRKNFYSARESLSH
HHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2179047; 9097039; 9278503; 9405618 [H]