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The map label for this gene is lpxB [H]

Identifier: 170023328

GI number: 170023328

Start: 1217695

End: 1218879

Strand: Direct

Name: lpxB [H]

Synonym: YPK_1079

Alternate gene names: 170023328

Gene position: 1217695-1218879 (Clockwise)

Preceding gene: 170023327

Following gene: 170023329

Centisome position: 25.97

GC content: 48.95

Gene sequence:

>1185_bases
ATGCAAAATAGCCCATTGACTGCTGATTGTTCATTAAACGCTGGACGTCCCCTAACGATTGGTTTAGTTGCCGGAGAAAC
TTCCGGCGATATCTTAGGCGCTGGATTAATTCTGGCGCTGAAAGTTCAGGTACCCAATGCCCGATTTGTCGGTGTCGCTG
GGCCTCTGATGCAAGCCGAAGGGTGTGAAGCCTGGTATGAGATGGAAGAGTTAGCCGTCATGGGCGTTGTTGAAGTATTA
GAGCGCCTGCCACGGTTATTGAAAATCAGGAAGGATCTGACTCAGCGTTTTAGTGAGCTTTCTCCCGATGTCTTTGTTGG
CATTGACGCCCCCGATTTCAACATCACCCTTGAAGGGCGCTTAAAACAACGGGGTATTCGGACTATTCATTATGTCAGCC
CATCAGTCTGGGCCTGGCGACAAAAACGTGTTTTCAAAATTGGAAAAGCGACCGACATGGTGTTGGCTTTTCTCCCTTTT
GAAAAAGCGTTTTATGATCGTTTCAATGTCCCTTGCCGTTTTATAGGCCATACCATGGCCGATGCCATGCCACTAGTACC
CGATCAGCAGGCAGCGAGAGCAGAGCTTGGCATTGCGCCTAATGCCACTTGTCTGGCGCTGTTACCGGGTAGCCGCCACT
CTGAAGTTGAAATGCTCAGCGCTGATTTTTTACGTACAGCGGTAATTCTGCGTGATAAATTGCCCAATTTGGAAGTAGTG
GTTCCCTTGGTCAACAGCAAGCGACGTGAACAATTCGAGCGAATTAAAGCGGAAATTGCGCCTGATTTATCCGTACATTT
ACTGGATGGTAAAGCGCGTGTCGCGATGATCGCCAGTGATGCAGCATTGTTAGCCTCAGGCACGGCTGCACTCGAATGTA
TGCTGGCCAAATGCCCGATGGTTGTGGGGTATCGTATGAAGCCATTTACTTTCTGGTTGGCAGAGCGATTAGTCAAAACA
CCTTATGTTTCATTACCGAATCTGTTAGCAGGGGAAGAGTTGGTGACAGAATTGTTGCAACAAGAGTGCCAGCCGCAAAA
ACTCGCTGGTGCACTTTTGCCGTTGCTACAAGGTGGTAGCGAAATAGCAGCCTTAAAAGAACGTTTTTTGGTTCTGCATC
AGAGCATCCGCTGTGGTGCGGATGAACAGGCAGCACAAGCTGTATTGGAGCTGGCAGATCGATGA

Upstream 100 bases:

>100_bases
AGTGAAACCAGAAATTGCTGAATTAGCGGAGCAATATCCAGTCGTTAAAGCATTCAATGATTTCTTTGCTCGTTCGACCC
GCGGTATTATTCGCTGACTT

Downstream 100 bases:

>100_bases
GCGAGACTTTTATTTACCCACAGGCTAATTTAATCGCAGGCGTGGATGAAGTGGGTCGTGGCCCTTTGGTGGGTGCCGTA
GTCACTGCAGCGGTGATCCT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MQNSPLTADCSLNAGRPLTIGLVAGETSGDILGAGLILALKVQVPNARFVGVAGPLMQAEGCEAWYEMEELAVMGVVEVL
ERLPRLLKIRKDLTQRFSELSPDVFVGIDAPDFNITLEGRLKQRGIRTIHYVSPSVWAWRQKRVFKIGKATDMVLAFLPF
EKAFYDRFNVPCRFIGHTMADAMPLVPDQQAARAELGIAPNATCLALLPGSRHSEVEMLSADFLRTAVILRDKLPNLEVV
VPLVNSKRREQFERIKAEIAPDLSVHLLDGKARVAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAERLVKT
PYVSLPNLLAGEELVTELLQQECQPQKLAGALLPLLQGGSEIAALKERFLVLHQSIRCGADEQAAQAVLELADR

Sequences:

>Translated_394_residues
MQNSPLTADCSLNAGRPLTIGLVAGETSGDILGAGLILALKVQVPNARFVGVAGPLMQAEGCEAWYEMEELAVMGVVEVL
ERLPRLLKIRKDLTQRFSELSPDVFVGIDAPDFNITLEGRLKQRGIRTIHYVSPSVWAWRQKRVFKIGKATDMVLAFLPF
EKAFYDRFNVPCRFIGHTMADAMPLVPDQQAARAELGIAPNATCLALLPGSRHSEVEMLSADFLRTAVILRDKLPNLEVV
VPLVNSKRREQFERIKAEIAPDLSVHLLDGKARVAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAERLVKT
PYVSLPNLLAGEELVTELLQQECQPQKLAGALLPLLQGGSEIAALKERFLVLHQSIRCGADEQAAQAVLELADR
>Mature_394_residues
MQNSPLTADCSLNAGRPLTIGLVAGETSGDILGAGLILALKVQVPNARFVGVAGPLMQAEGCEAWYEMEELAVMGVVEVL
ERLPRLLKIRKDLTQRFSELSPDVFVGIDAPDFNITLEGRLKQRGIRTIHYVSPSVWAWRQKRVFKIGKATDMVLAFLPF
EKAFYDRFNVPCRFIGHTMADAMPLVPDQQAARAELGIAPNATCLALLPGSRHSEVEMLSADFLRTAVILRDKLPNLEVV
VPLVNSKRREQFERIKAEIAPDLSVHLLDGKARVAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAERLVKT
PYVSLPNLLAGEELVTELLQQECQPQKLAGALLPLLQGGSEIAALKERFLVLHQSIRCGADEQAAQAVLELADR

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=377, Percent_Identity=82.2281167108753, Blast_Score=615, Evalue=1e-177,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43218; Mature: 43218

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNSPLTADCSLNAGRPLTIGLVAGETSGDILGAGLILALKVQVPNARFVGVAGPLMQAE
CCCCCCCEECCCCCCCCEEEEEEECCCCCCHHHCCEEEEEEEECCCCEEEECCCCCCCCC
GCEAWYEMEELAVMGVVEVLERLPRLLKIRKDLTQRFSELSPDVFVGIDAPDFNITLEGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECC
LKQRGIRTIHYVSPSVWAWRQKRVFKIGKATDMVLAFLPFEKAFYDRFNVPCRFIGHTMA
HHHCCCCEEEECCCCHHHHHHHHHHCCCCHHHHHHEECCHHHHHHHHCCCCHHHHHHHHH
DAMPLVPDQQAARAELGIAPNATCLALLPGSRHSEVEMLSADFLRTAVILRDKLPNLEVV
HCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEE
VPLVNSKRREQFERIKAEIAPDLSVHLLDGKARVAMIASDAALLASGTAALECMLAKCPM
EECCCCHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCHHHHHCCHHHHHHHHHHCCH
VVGYRMKPFTFWLAERLVKTPYVSLPNLLAGEELVTELLQQECQPQKLAGALLPLLQGGS
HCCCCCCHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCH
EIAALKERFLVLHQSIRCGADEQAAQAVLELADR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQNSPLTADCSLNAGRPLTIGLVAGETSGDILGAGLILALKVQVPNARFVGVAGPLMQAE
CCCCCCCEECCCCCCCCEEEEEEECCCCCCHHHCCEEEEEEEECCCCEEEECCCCCCCCC
GCEAWYEMEELAVMGVVEVLERLPRLLKIRKDLTQRFSELSPDVFVGIDAPDFNITLEGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECC
LKQRGIRTIHYVSPSVWAWRQKRVFKIGKATDMVLAFLPFEKAFYDRFNVPCRFIGHTMA
HHHCCCCEEEECCCCHHHHHHHHHHCCCCHHHHHHEECCHHHHHHHHCCCCHHHHHHHHH
DAMPLVPDQQAARAELGIAPNATCLALLPGSRHSEVEMLSADFLRTAVILRDKLPNLEVV
HCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEE
VPLVNSKRREQFERIKAEIAPDLSVHLLDGKARVAMIASDAALLASGTAALECMLAKCPM
EECCCCHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCHHHHHCCHHHHHHHHHHCCH
VVGYRMKPFTFWLAERLVKTPYVSLPNLLAGEELVTELLQQECQPQKLAGALLPLLQGGS
HCCCCCCHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCH
EIAALKERFLVLHQSIRCGADEQAAQAVLELADR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]