Click here to switch to the map view.

The map label for this gene is gntP [H]

Identifier: 170023011

GI number: 170023011

Start: 857971

End: 859452

Strand: Direct

Name: gntP [H]

Synonym: YPK_0762

Alternate gene names: 170023011

Gene position: 857971-859452 (Clockwise)

Preceding gene: 170023010

Following gene: 170023012

Centisome position: 18.3

GC content: 50.13

Gene sequence:

>1482_bases
ATGACAAGGCATCTTAGACTGTATTGCCAGTCTGAAGGTGAATTTGAATCCATAAAAACAATCAAATTTGGTCCGACCAA
TATCGCGGCGGATACAAAAGCAAGAATACTGAGATTCAACTACTGGGGAAAACAAGAGATGGAATGGATTAATATCCTGT
GGGTCATGTTGGGTATTGGCTTAATGCTAGTGCTCAATATCCGCTACCAGATTAACTCAATGGTCGCATTGCTGCTGGCA
GCTCTGCTAGTAGGGACTCTCGCGGGCATGGACCTGCTTAAGCTGCTGCATACCATTAAGGCTGGGTTTGGTGGCACGCT
AGGTGAACTGGCGATAATCGTCGTATTTGGTGCGGTGATCGGCAAACTGATGGTGGACTCTGGCGCTGCTCATCAGATAG
CCCAGACGCTATTGCGCCGATTCGGGCTTAAATATGTTGAAGCCGCGGTAATTATCATCGGCCTGATCTTTGGTCTGGCG
ATGTTTTATGAGGTTGCCTTTATTATTTTGGCACCACTGGTCATTGCTATTGCGGTCGAAGCCAAGATACCGTTCCTCAA
ACTGGCGATCCCGGCGGTTGCGGCAGCGACGACGGCTCACTCCCTATTCCCACCACAGCCGGGGCCGGTTGCGCTGGTTG
CCGCTTATGGCGCAGACATGGGGATGGTTTATATCTATGGAGTTCTGGTTGCTATTCCTTCAGTGATCTGTGCCGGGCTT
ATTTTGCCAAAGTTCTTGGGCAATCTGGAGCGGCCAATTCCGACTTTCCTGAAGTCTGACAACCCGATTGATGAAAACAA
TCTGCCGTCGTTCAGTACCTCGATTTTGGTACCGTTAATTCCCGCTTTCATCATGATTTTTACCACCATAGCCAATATCT
GGTTGGTTAAAGGGACCACGTCGTACACCATTCTCAATTTCATTGGCTCATCACCTATTGCCATGTTTATCGCCATGTTG
GTTGCCTTCGTGCTTTTCGGCACCGGACGCGGTCATAAAATGGAATGGGTCATGCACTCATTTGAAGGGGCGGTAAAAGG
CGTTGCCATGGTCATCCTGATCATCGGTGCGGGCGGTGCGCTGAAGCAGGTGATCATTGATACCGGGATCGGCGATACGA
TTGGCATGCTGATGTCTGCTGGTGGTGTATCACCTTATATTATGGCTTGGCTGATTACGGTGCTGATTCGTCTGACAACG
GGCCAAGGCGTGGTTTCGGCGATGACCGCCGCAGGGATTATCGGTGCTGCGGTAATGGACCCGGTCACTGGGACCATTAC
CTCAGTCGATCCGGCACTGTTGGTGCTGGCGACAGCGGCAGGTTCTAACACCTTTACTCATATCAATGACGCCTCATTCT
GGCTGTTTAAAGGTTATTTTGAGCTGTCGATTAAAGATACGCTGAAGACTTGGGGCCTGCTCGAATTGACCAACTCGGTG
GTTGGTTTGGCGGTGGTACTGCTGATCAGCATGTTTGTCTAG

Upstream 100 bases:

>100_bases
GATCTGTCCGACAACTTGGTTAACCAATACTTCATTTGGTTATCCACTTAGTGATATCTGTAATACCAAAGCGTAGGCCT
CTACAGGCTGAGTAGCTTGG

Downstream 100 bases:

>100_bases
TTTAGGGTGAGCTAACTGCCATTGTCGCGTGTAGGCGAATTGGCAACTTAATCATTGGCAACTTAAGCATTGGCAACTTA
AGCATTGGCAAATCATCGCT

Product: fructuronate transporter

Products: Proton [Cytoplasm]; gluconate [Cytoplasm] [C]

Alternate protein names: Gluconate permease 3; Gnt-III system [H]

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MTRHLRLYCQSEGEFESIKTIKFGPTNIAADTKARILRFNYWGKQEMEWINILWVMLGIGLMLVLNIRYQINSMVALLLA
ALLVGTLAGMDLLKLLHTIKAGFGGTLGELAIIVVFGAVIGKLMVDSGAAHQIAQTLLRRFGLKYVEAAVIIIGLIFGLA
MFYEVAFIILAPLVIAIAVEAKIPFLKLAIPAVAAATTAHSLFPPQPGPVALVAAYGADMGMVYIYGVLVAIPSVICAGL
ILPKFLGNLERPIPTFLKSDNPIDENNLPSFSTSILVPLIPAFIMIFTTIANIWLVKGTTSYTILNFIGSSPIAMFIAML
VAFVLFGTGRGHKMEWVMHSFEGAVKGVAMVILIIGAGGALKQVIIDTGIGDTIGMLMSAGGVSPYIMAWLITVLIRLTT
GQGVVSAMTAAGIIGAAVMDPVTGTITSVDPALLVLATAAGSNTFTHINDASFWLFKGYFELSIKDTLKTWGLLELTNSV
VGLAVVLLISMFV

Sequences:

>Translated_493_residues
MTRHLRLYCQSEGEFESIKTIKFGPTNIAADTKARILRFNYWGKQEMEWINILWVMLGIGLMLVLNIRYQINSMVALLLA
ALLVGTLAGMDLLKLLHTIKAGFGGTLGELAIIVVFGAVIGKLMVDSGAAHQIAQTLLRRFGLKYVEAAVIIIGLIFGLA
MFYEVAFIILAPLVIAIAVEAKIPFLKLAIPAVAAATTAHSLFPPQPGPVALVAAYGADMGMVYIYGVLVAIPSVICAGL
ILPKFLGNLERPIPTFLKSDNPIDENNLPSFSTSILVPLIPAFIMIFTTIANIWLVKGTTSYTILNFIGSSPIAMFIAML
VAFVLFGTGRGHKMEWVMHSFEGAVKGVAMVILIIGAGGALKQVIIDTGIGDTIGMLMSAGGVSPYIMAWLITVLIRLTT
GQGVVSAMTAAGIIGAAVMDPVTGTITSVDPALLVLATAAGSNTFTHINDASFWLFKGYFELSIKDTLKTWGLLELTNSV
VGLAVVLLISMFV
>Mature_492_residues
TRHLRLYCQSEGEFESIKTIKFGPTNIAADTKARILRFNYWGKQEMEWINILWVMLGIGLMLVLNIRYQINSMVALLLAA
LLVGTLAGMDLLKLLHTIKAGFGGTLGELAIIVVFGAVIGKLMVDSGAAHQIAQTLLRRFGLKYVEAAVIIIGLIFGLAM
FYEVAFIILAPLVIAIAVEAKIPFLKLAIPAVAAATTAHSLFPPQPGPVALVAAYGADMGMVYIYGVLVAIPSVICAGLI
LPKFLGNLERPIPTFLKSDNPIDENNLPSFSTSILVPLIPAFIMIFTTIANIWLVKGTTSYTILNFIGSSPIAMFIAMLV
AFVLFGTGRGHKMEWVMHSFEGAVKGVAMVILIIGAGGALKQVIIDTGIGDTIGMLMSAGGVSPYIMAWLITVLIRLTTG
QGVVSAMTAAGIIGAAVMDPVTGTITSVDPALLVLATAAGSNTFTHINDASFWLFKGYFELSIKDTLKTWGLLELTNSVV
GLAVVLLISMFV

Specific function: High-affinity gluconate transporter with fairly broad specificity, including low affinity for glucuronate, several disaccharides, and some hexoses, but not glucose [H]

COG id: COG2610

COG function: function code GE; H+/gluconate symporter and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gntP permease family [H]

Homologues:

Organism=Escherichia coli, GI1790776, Length=445, Percent_Identity=82.9213483146067, Blast_Score=733, Evalue=0.0,
Organism=Escherichia coli, GI48994935, Length=439, Percent_Identity=41.6856492027335, Blast_Score=341, Evalue=7e-95,
Organism=Escherichia coli, GI1790716, Length=433, Percent_Identity=40.8775981524249, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI2367370, Length=433, Percent_Identity=37.6443418013857, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1788707, Length=447, Percent_Identity=32.2147651006711, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI48994939, Length=423, Percent_Identity=31.9148936170213, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1789097, Length=445, Percent_Identity=31.2359550561798, Blast_Score=168, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003474 [H]

Pfam domain/function: PF02447 GntP_permease [H]

EC number: NA

Molecular weight: Translated: 52622; Mature: 52491

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRHLRLYCQSEGEFESIKTIKFGPTNIAADTKARILRFNYWGKQEMEWINILWVMLGIG
CCCEEEEEECCCCCCCCEEEEEECCCCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHHH
LMLVLNIRYQINSMVALLLAALLVGTLAGMDLLKLLHTIKAGFGGTLGELAIIVVFGAVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GKLMVDSGAAHQIAQTLLRRFGLKYVEAAVIIIGLIFGLAMFYEVAFIILAPLVIAIAVE
HHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKIPFLKLAIPAVAAATTAHSLFPPQPGPVALVAAYGADMGMVYIYGVLVAIPSVICAGL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
ILPKFLGNLERPIPTFLKSDNPIDENNLPSFSTSILVPLIPAFIMIFTTIANIWLVKGTT
HHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
SYTILNFIGSSPIAMFIAMLVAFVLFGTGRGHKMEWVMHSFEGAVKGVAMVILIIGAGGA
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LKQVIIDTGIGDTIGMLMSAGGVSPYIMAWLITVLIRLTTGQGVVSAMTAAGIIGAAVMD
HHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
PVTGTITSVDPALLVLATAAGSNTFTHINDASFWLFKGYFELSIKDTLKTWGLLELTNSV
CCCCCCCCCCHHHHEEEECCCCCCEEEECCCCEEEEEEEEEEEEHHHHHHHHHHHHHHHH
VGLAVVLLISMFV
HHHHHHHHHHHHC
>Mature Secondary Structure 
TRHLRLYCQSEGEFESIKTIKFGPTNIAADTKARILRFNYWGKQEMEWINILWVMLGIG
CCEEEEEECCCCCCCCEEEEEECCCCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHHH
LMLVLNIRYQINSMVALLLAALLVGTLAGMDLLKLLHTIKAGFGGTLGELAIIVVFGAVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GKLMVDSGAAHQIAQTLLRRFGLKYVEAAVIIIGLIFGLAMFYEVAFIILAPLVIAIAVE
HHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKIPFLKLAIPAVAAATTAHSLFPPQPGPVALVAAYGADMGMVYIYGVLVAIPSVICAGL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
ILPKFLGNLERPIPTFLKSDNPIDENNLPSFSTSILVPLIPAFIMIFTTIANIWLVKGTT
HHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
SYTILNFIGSSPIAMFIAMLVAFVLFGTGRGHKMEWVMHSFEGAVKGVAMVILIIGAGGA
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LKQVIIDTGIGDTIGMLMSAGGVSPYIMAWLITVLIRLTTGQGVVSAMTAAGIIGAAVMD
HHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
PVTGTITSVDPALLVLATAAGSNTFTHINDASFWLFKGYFELSIKDTLKTWGLLELTNSV
CCCCCCCCCCHHHHEEEECCCCCCEEEECCCCEEEEEEEEEEEEHHHHHHHHHHHHHHHH
VGLAVVLLISMFV
HHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; gluconate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + gluconate [Periplasm] = Proton [Cytoplasm] + gluconate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]