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The map label for this gene is hldE [H]

Identifier: 170022896

GI number: 170022896

Start: 706097

End: 707527

Strand: Direct

Name: hldE [H]

Synonym: YPK_0645

Alternate gene names: 170022896

Gene position: 706097-707527 (Clockwise)

Preceding gene: 170022895

Following gene: 170022897

Centisome position: 15.06

GC content: 52.97

Gene sequence:

>1431_bases
ATGAAAGTCACGCTGCCTGATTTTCGCCGTGCTGGTGTATTAGTCGTGGGTGATGTCATGTTAGACCGCTACTGGTACGG
GCCAACCAGCCGGATTTCACCAGAAGCACCTGTGCCTGTAGTGAAAGTCGATACCATCGAAGAGCGCCCTGGTGGTGCAG
CAAACGTTGCGATGAATATTGCCTCCCTTGGCGCGGTTGCGCGCTTAGTCGGGTTGACCGGCATTGACGATGCGGCGCGT
GCGCTGATCTGCAAGCTGAGCGAAGTTCGGGTGCGTTGCGATTTTGTCTCGGTACCCACTCACCCGACCATTACCAAATT
ACGGGTACTTTCCCGTAACCAGCAGTTAATCCGCCTGGATTTTGAAGAGGGCTTTGACGGTGTTGATCCCACGCCGATAT
TCGAGCGCATTCAACTGGCGTTGCCACAGATTGGCGCGCTGGTGCTGTCCGATTATGCCAAGGGGGCATTGAACAGCGTA
CAGCCGATGATCCAACTGGCACGTAAAGCGAATGTCCCGGTTTTGATTGATCCGAAAGGCAGTGATTTTGAGCGCTACCG
TGGTGCCACATTGTTGACGCCGAATTTGTCTGAATTTGAAGCAGTGGTAGGGCGCTGTAAAAATGAAGAAGAGTTGGTTA
ACCGCGGTATGCAACTGGTGGCAGATTTCGAACTTTCAGCATTGCTGGTGACCCGTTCTGAACAAGGCATGACCTTGTTG
CAACTGGGTAAACCGCCGCTACATTTGCCGACTCAGGCAAAAGAAGTGTTTGATGTGACCGGTGCTGGCGATACGGTTAT
TGGCGTGCTGGCTGCCGCGCTGGCTGCAGGTAACAGCCTGGAAGAGTCATGTTTCCTGGCTAATGCTGCCGCCGGTGTAG
TGGTGGGTAAATTGGGTACCTCGACCGTTTCTCCGATTGAGTTGGAAAACGCGATCCGTGGCCGTGCAGAAACCGGTTTT
GGGGTGATGGATGAGCAGCAACTGAAAATAGCGGTTGCGCAGGCTCGCCAGCGTGGGGAGAAGGTGGTCATGACCAATGG
CATTTTTGACATCCTCCATGCAGGCCATGTTTCTTATCTGGCCAATGCCCGTAAGCTGGGGGATCGCCTGATTGTGGCGG
TGAACAGCGATGCTTCCACCAAGCGGCTGAAAGGTGAAAAGCGGCCGGTTAATCCATTAGAACAACGTATGGTTGTCTTG
GGTGCGTTGGAAGCGGTGGATTGGGTCGTGCCCTTTGAAGAAGATACGCCACAGCGTTTAATTGCTGATATTTTGCCCGA
TCTGTTAGTCAAAGGCGGCGATTATAAGCCCCATGAAATTGCAGGTAGCGAAGAAGTCTGGGCCGCCGGTGGCGAGGTTA
AGGTACTGAATTTTGAAGATGGTGTCTCTACCACCAATATTATTCAGTCGATCAAAAACGGCCGCGGCTAA

Upstream 100 bases:

>100_bases
TGCCTGTGATATTATTTGGCGCTATATGATGAACACAATATTGGAGCGAAGGGATGGGTGCATTCGGGGTTAATAACAAC
TCAGGTTGGGGGGCAAATGT

Downstream 100 bases:

>100_bases
GTCAGCGCCAGAGCGCTGGCGCATAAGGATGTGGCAGTGGGTGGGTTAAAGCAAGAGTTAAGTCTGGCGCAAGGCGTTGG
GTTGTTATCCACTTCCCTGT

Product: bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKVTLPDFRRAGVLVVGDVMLDRYWYGPTSRISPEAPVPVVKVDTIEERPGGAANVAMNIASLGAVARLVGLTGIDDAAR
ALICKLSEVRVRCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFDGVDPTPIFERIQLALPQIGALVLSDYAKGALNSV
QPMIQLARKANVPVLIDPKGSDFERYRGATLLTPNLSEFEAVVGRCKNEEELVNRGMQLVADFELSALLVTRSEQGMTLL
QLGKPPLHLPTQAKEVFDVTGAGDTVIGVLAAALAAGNSLEESCFLANAAAGVVVGKLGTSTVSPIELENAIRGRAETGF
GVMDEQQLKIAVAQARQRGEKVVMTNGIFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGEKRPVNPLEQRMVVL
GALEAVDWVVPFEEDTPQRLIADILPDLLVKGGDYKPHEIAGSEEVWAAGGEVKVLNFEDGVSTTNIIQSIKNGRG

Sequences:

>Translated_476_residues
MKVTLPDFRRAGVLVVGDVMLDRYWYGPTSRISPEAPVPVVKVDTIEERPGGAANVAMNIASLGAVARLVGLTGIDDAAR
ALICKLSEVRVRCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFDGVDPTPIFERIQLALPQIGALVLSDYAKGALNSV
QPMIQLARKANVPVLIDPKGSDFERYRGATLLTPNLSEFEAVVGRCKNEEELVNRGMQLVADFELSALLVTRSEQGMTLL
QLGKPPLHLPTQAKEVFDVTGAGDTVIGVLAAALAAGNSLEESCFLANAAAGVVVGKLGTSTVSPIELENAIRGRAETGF
GVMDEQQLKIAVAQARQRGEKVVMTNGIFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGEKRPVNPLEQRMVVL
GALEAVDWVVPFEEDTPQRLIADILPDLLVKGGDYKPHEIAGSEEVWAAGGEVKVLNFEDGVSTTNIIQSIKNGRG
>Mature_476_residues
MKVTLPDFRRAGVLVVGDVMLDRYWYGPTSRISPEAPVPVVKVDTIEERPGGAANVAMNIASLGAVARLVGLTGIDDAAR
ALICKLSEVRVRCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFDGVDPTPIFERIQLALPQIGALVLSDYAKGALNSV
QPMIQLARKANVPVLIDPKGSDFERYRGATLLTPNLSEFEAVVGRCKNEEELVNRGMQLVADFELSALLVTRSEQGMTLL
QLGKPPLHLPTQAKEVFDVTGAGDTVIGVLAAALAAGNSLEESCFLANAAAGVVVGKLGTSTVSPIELENAIRGRAETGF
GVMDEQQLKIAVAQARQRGEKVVMTNGIFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGEKRPVNPLEQRMVVL
GALEAVDWVVPFEEDTPQRLIADILPDLLVKGGDYKPHEIAGSEEVWAAGGEVKVLNFEDGVSTTNIIQSIKNGRG

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=475, Percent_Identity=86.3157894736842, Blast_Score=837, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 51203; Mature: 51203

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVTLPDFRRAGVLVVGDVMLDRYWYGPTSRISPEAPVPVVKVDTIEERPGGAANVAMNI
CCCCCCCHHHCCEEEEEHHHHHHEECCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHH
ASLGAVARLVGLTGIDDAARALICKLSEVRVRCDFVSVPTHPTITKLRVLSRNQQLIRLD
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHCCCCEEEEEE
FEEGFDGVDPTPIFERIQLALPQIGALVLSDYAKGALNSVQPMIQLARKANVPVLIDPKG
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
SDFERYRGATLLTPNLSEFEAVVGRCKNEEELVNRGMQLVADFELSALLVTRSEQGMTLL
CCHHHHCCCEEECCCHHHHHHHHHCCCCHHHHHHCCHHEEECCCEEEEEEEECCCCCEEE
QLGKPPLHLPTQAKEVFDVTGAGDTVIGVLAAALAAGNSLEESCFLANAAAGVVVGKLGT
ECCCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCCC
STVSPIELENAIRGRAETGFGVMDEQQLKIAVAQARQRGEKVVMTNGIFDILHAGHVSYL
CCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHH
ANARKLGDRLIVAVNSDASTKRLKGEKRPVNPLEQRMVVLGALEAVDWVVPFEEDTPQRL
HHHHHCCCEEEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHH
IADILPDLLVKGGDYKPHEIAGSEEVWAAGGEVKVLNFEDGVSTTNIIQSIKNGRG
HHHHHHHHHHCCCCCCCHHCCCCCCEEECCCEEEEEEECCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKVTLPDFRRAGVLVVGDVMLDRYWYGPTSRISPEAPVPVVKVDTIEERPGGAANVAMNI
CCCCCCCHHHCCEEEEEHHHHHHEECCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHH
ASLGAVARLVGLTGIDDAARALICKLSEVRVRCDFVSVPTHPTITKLRVLSRNQQLIRLD
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHCCCCEEEEEE
FEEGFDGVDPTPIFERIQLALPQIGALVLSDYAKGALNSVQPMIQLARKANVPVLIDPKG
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
SDFERYRGATLLTPNLSEFEAVVGRCKNEEELVNRGMQLVADFELSALLVTRSEQGMTLL
CCHHHHCCCEEECCCHHHHHHHHHCCCCHHHHHHCCHHEEECCCEEEEEEEECCCCCEEE
QLGKPPLHLPTQAKEVFDVTGAGDTVIGVLAAALAAGNSLEESCFLANAAAGVVVGKLGT
ECCCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCCC
STVSPIELENAIRGRAETGFGVMDEQQLKIAVAQARQRGEKVVMTNGIFDILHAGHVSYL
CCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHH
ANARKLGDRLIVAVNSDASTKRLKGEKRPVNPLEQRMVVLGALEAVDWVVPFEEDTPQRL
HHHHHCCCEEEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHH
IADILPDLLVKGGDYKPHEIAGSEEVWAAGGEVKVLNFEDGVSTTNIIQSIKNGRG
HHHHHHHHHHCCCCCCCHHCCCCCCEEECCCEEEEEEECCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA