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The map label for this gene is prlC [H]

Identifier: 170022377

GI number: 170022377

Start: 138969

End: 141011

Strand: Direct

Name: prlC [H]

Synonym: YPK_0116

Alternate gene names: 170022377

Gene position: 138969-141011 (Clockwise)

Preceding gene: 170022371

Following gene: 170022378

Centisome position: 2.96

GC content: 52.13

Gene sequence:

>2043_bases
ATGACAAACCCGCTGTTGACTCCGTTCTCCCTGCCACCGTTTTCTGCTATTCGGCCTGAAGATATCGTGCCTGCGGTGAA
ATCCGCGCTGGATGAATGCCGTCAAGCGGTAGAGCGTGTGGTTGCCCAACCAGGGCCGTTCACTTGGGATAATCTGTGCC
AGCCACTGGCCGAATCCGATGACCGCTTATCGCGCATTTGGTCACCCGTAGGCCACTTGAACTCAGTAAAAAATAGCCCT
GAGCTGCGTACCGCTTATGAACAAAGCTTGCCATTGCTGTCGGAATACGGCACTTGGGTGGGGCAGCATAAAGGTTTGTA
TCAGGCGTATGTCAGCCTGAAAGAGGGGCCGGGTTTTGCCGCCTTGACCGCACCGCAGCGCAAAGCGGTAGAAAATGCCC
TGCGTGACTTCCAGCTATCCGGTATTGGTCTGGCGCCTGAACAACAAAAGCGTTACGGCGAAATCGTGGCTCGCTTGTCG
GAGCTTGGCTCGACTTACAGCAATAACGTGCTTGATGCCACCATGGGGTGGAGCAAACTGATTACCGATGTTGAGCAACT
GAAAGGTTTGCCAGAAAGCGCGCTAGCAGCGGCCAAAGCCATGGCAGAAGCCAAAGAGCAGGACGGCTGGTTGCTGACAC
TGGATATGCCAAGCTATCTGCCGGTACTGACTTATGCCGATAACGCGGAACTGCGCGAAGAGATGTACCGCGCATTTGCC
ACCCGTGCTTCTGATCAGGGGCCAAACGCGGGGAAATGGGATAACAGCGAGATCATGGCGGAAATTCTGACACTGCGTCA
TGAATTAGCGCAGTTGCTCGGTTTTAACAGTTATGCCGATAAATCGCTGGCCACCAAAATGGCAGAAAACCCACAGCAGG
TGTTGGGCTTCCTGAACGATCTGGCGAAGCGCGCCCGCCCGCAAGCAGAAGAAGAGCTGGCTCAGTTACGTGCTTTTGCT
AAAGAGCATTATGGTGTCAGTGAACTCCAGGCTTGGGATATCACCTATTATTCCGAGAAACAGAAACAGCATTTGTTTGC
TATCAGTGATGAACAACTTCGTCCTTATTTCCCGGAACAGCGGGTGGTGGAAGGTTTATTCGAAGTGGTGAAACGCATTT
ATGGCATTACAGCCAAAGAGCGCCATGATGTCGATACCTGGCATCCGGATGTCCGCTTCTTCGATTTGTTTGATGCCGAT
GGTGAACTGCGCGGTAGTTTCTACCTTGATTTGTATGCGCGCGAAAACAAGCGTGGCGGAGCCTGGATGGATGACTGCGT
AGGTAGCCTGCGTTTGGCTAATGGCCAACTGCAAAAACCAGTCGCTTATCTGACTTGCAATTTTAACGGGCCCGTTGGCG
GCAAACCGGCGCTGTTTACTCACAATGAAGTGACCACCTTGTTCCATGAGTTCGGCCATGGTTTACATCATATGCTGACC
AAAATTGATACCGCAGGCGTTTCTGGTATCAATGGCGTGCCTTGGGATGCAGTCGAGCTGCCAAGTCAGTTTATGGAAAA
CTGGTGCTGGGAGCCAGAGGCGCTGGCCTTTATTTCTGGTCATTACCAAACTCATGAGCCTTTGCCGCAAGAGATGCTGG
ATAAACTACTGGCGGCGAAAAACTATCAGGCGGCGTTGTTTATTCTGCGCCAACTGGAGTTTGGTCTGTTCGATTTCCGG
ATGCATTATGAGTTCGACCCGCTGACCGGTGCGCAGATCCTGCCTATTTTGTATGAAGTGAAAAAACAGGTTGCTGTGGT
GCCATCACCGGAATGGGGCCGCTTCCCTCATGCCTTCAGCCATATTTTTGCTGGCGGTTATGCGGCCGGTTATTACAGCT
ATTTATGGGCTGAAGTGCTCTCGGCGGATGCGTTCTCACGCTTTGAAGAAGAAGGGATTTTTAATGCCGCTACCGGTCAG
TCCTTCCTCGACAACATTCTGTCTCAAGGGGGCTCAGAGGAGCCAATGACACTGTTCAAACGCTTCCGTGGCCGTGAACC
GCAGTTAGATGCCATGTTGCGTCATTACGGTATTAAGGGCTAA

Upstream 100 bases:

>100_bases
ATGTTAATTGTTCATTCGTAATTTATTCTCCGTCGCTGGATGCGTCTGGCGTTTGGTATATAAACGTTATTAAAATTCAA
ATCATAACCAGGACTGCCCT

Downstream 100 bases:

>100_bases
TACGTGTCACACGTCAGTATTTGTTTATTATCTGAAGCAGGCGCCGATCCCGGCGCCTTATCTATTCTGGCTGATCGCTG
GGGGCTAGTCTCTGACGATC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTNPLLTPFSLPPFSAIRPEDIVPAVKSALDECRQAVERVVAQPGPFTWDNLCQPLAESDDRLSRIWSPVGHLNSVKNSP
ELRTAYEQSLPLLSEYGTWVGQHKGLYQAYVSLKEGPGFAALTAPQRKAVENALRDFQLSGIGLAPEQQKRYGEIVARLS
ELGSTYSNNVLDATMGWSKLITDVEQLKGLPESALAAAKAMAEAKEQDGWLLTLDMPSYLPVLTYADNAELREEMYRAFA
TRASDQGPNAGKWDNSEIMAEILTLRHELAQLLGFNSYADKSLATKMAENPQQVLGFLNDLAKRARPQAEEELAQLRAFA
KEHYGVSELQAWDITYYSEKQKQHLFAISDEQLRPYFPEQRVVEGLFEVVKRIYGITAKERHDVDTWHPDVRFFDLFDAD
GELRGSFYLDLYARENKRGGAWMDDCVGSLRLANGQLQKPVAYLTCNFNGPVGGKPALFTHNEVTTLFHEFGHGLHHMLT
KIDTAGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQTHEPLPQEMLDKLLAAKNYQAALFILRQLEFGLFDFR
MHYEFDPLTGAQILPILYEVKKQVAVVPSPEWGRFPHAFSHIFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNAATGQ
SFLDNILSQGGSEEPMTLFKRFRGREPQLDAMLRHYGIKG

Sequences:

>Translated_680_residues
MTNPLLTPFSLPPFSAIRPEDIVPAVKSALDECRQAVERVVAQPGPFTWDNLCQPLAESDDRLSRIWSPVGHLNSVKNSP
ELRTAYEQSLPLLSEYGTWVGQHKGLYQAYVSLKEGPGFAALTAPQRKAVENALRDFQLSGIGLAPEQQKRYGEIVARLS
ELGSTYSNNVLDATMGWSKLITDVEQLKGLPESALAAAKAMAEAKEQDGWLLTLDMPSYLPVLTYADNAELREEMYRAFA
TRASDQGPNAGKWDNSEIMAEILTLRHELAQLLGFNSYADKSLATKMAENPQQVLGFLNDLAKRARPQAEEELAQLRAFA
KEHYGVSELQAWDITYYSEKQKQHLFAISDEQLRPYFPEQRVVEGLFEVVKRIYGITAKERHDVDTWHPDVRFFDLFDAD
GELRGSFYLDLYARENKRGGAWMDDCVGSLRLANGQLQKPVAYLTCNFNGPVGGKPALFTHNEVTTLFHEFGHGLHHMLT
KIDTAGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQTHEPLPQEMLDKLLAAKNYQAALFILRQLEFGLFDFR
MHYEFDPLTGAQILPILYEVKKQVAVVPSPEWGRFPHAFSHIFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNAATGQ
SFLDNILSQGGSEEPMTLFKRFRGREPQLDAMLRHYGIKG
>Mature_679_residues
TNPLLTPFSLPPFSAIRPEDIVPAVKSALDECRQAVERVVAQPGPFTWDNLCQPLAESDDRLSRIWSPVGHLNSVKNSPE
LRTAYEQSLPLLSEYGTWVGQHKGLYQAYVSLKEGPGFAALTAPQRKAVENALRDFQLSGIGLAPEQQKRYGEIVARLSE
LGSTYSNNVLDATMGWSKLITDVEQLKGLPESALAAAKAMAEAKEQDGWLLTLDMPSYLPVLTYADNAELREEMYRAFAT
RASDQGPNAGKWDNSEIMAEILTLRHELAQLLGFNSYADKSLATKMAENPQQVLGFLNDLAKRARPQAEEELAQLRAFAK
EHYGVSELQAWDITYYSEKQKQHLFAISDEQLRPYFPEQRVVEGLFEVVKRIYGITAKERHDVDTWHPDVRFFDLFDADG
ELRGSFYLDLYARENKRGGAWMDDCVGSLRLANGQLQKPVAYLTCNFNGPVGGKPALFTHNEVTTLFHEFGHGLHHMLTK
IDTAGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQTHEPLPQEMLDKLLAAKNYQAALFILRQLEFGLFDFRM
HYEFDPLTGAQILPILYEVKKQVAVVPSPEWGRFPHAFSHIFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNAATGQS
FLDNILSQGGSEEPMTLFKRFRGREPQLDAMLRHYGIKG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=617, Percent_Identity=34.0356564019449, Blast_Score=326, Evalue=5e-89,
Organism=Homo sapiens, GI14149738, Length=676, Percent_Identity=30.1775147928994, Blast_Score=287, Evalue=3e-77,
Organism=Homo sapiens, GI156105687, Length=679, Percent_Identity=26.6568483063328, Blast_Score=191, Evalue=2e-48,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=80.7352941176471, Blast_Score=1134, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=685, Percent_Identity=30.8029197080292, Blast_Score=301, Evalue=7e-83,
Organism=Caenorhabditis elegans, GI71999758, Length=589, Percent_Identity=25.6366723259762, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32565901, Length=618, Percent_Identity=22.9773462783171, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319793, Length=692, Percent_Identity=28.9017341040462, Blast_Score=300, Evalue=7e-82,
Organism=Saccharomyces cerevisiae, GI6322715, Length=699, Percent_Identity=23.3190271816881, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI21356111, Length=551, Percent_Identity=29.4010889292196, Blast_Score=249, Evalue=5e-66,
Organism=Drosophila melanogaster, GI20129717, Length=685, Percent_Identity=24.963503649635, Blast_Score=179, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76514; Mature: 76383

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLTPFSLPPFSAIRPEDIVPAVKSALDECRQAVERVVAQPGPFTWDNLCQPLAESD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCH
DRLSRIWSPVGHLNSVKNSPELRTAYEQSLPLLSEYGTWVGQHKGLYQAYVSLKEGPGFA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEE
ALTAPQRKAVENALRDFQLSGIGLAPEQQKRYGEIVARLSELGSTYSNNVLDATMGWSKL
EECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCCCHHHHCCHHHH
ITDVEQLKGLPESALAAAKAMAEAKEQDGWLLTLDMPSYLPVLTYADNAELREEMYRAFA
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSEIMAEILTLRHELAQLLGFNSYADKSLATKMAENPQQVLGFLND
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQAEEELAQLRAFAKEHYGVSELQAWDITYYSEKQKQHLFAISDEQLRPYFPEQ
HHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCCEEECCCHHHHHEEEECCCCCCCCCCHH
RVVEGLFEVVKRIYGITAKERHDVDTWHPDVRFFDLFDADGELRGSFYLDLYARENKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEECCCCCC
AWMDDCVGSLRLANGQLQKPVAYLTCNFNGPVGGKPALFTHNEVTTLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHH
KIDTAGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQTHEPLPQEMLDKLLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCC
NYQAALFILRQLEFGLFDFRMHYEFDPLTGAQILPILYEVKKQVAVVPSPEWGRFPHAFS
CHHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHEEECCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNAATGQSFLDNILSQGGSEEPMTLFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLRHYGIKG
HHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TNPLLTPFSLPPFSAIRPEDIVPAVKSALDECRQAVERVVAQPGPFTWDNLCQPLAESD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCH
DRLSRIWSPVGHLNSVKNSPELRTAYEQSLPLLSEYGTWVGQHKGLYQAYVSLKEGPGFA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEE
ALTAPQRKAVENALRDFQLSGIGLAPEQQKRYGEIVARLSELGSTYSNNVLDATMGWSKL
EECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCCCHHHHCCHHHH
ITDVEQLKGLPESALAAAKAMAEAKEQDGWLLTLDMPSYLPVLTYADNAELREEMYRAFA
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSEIMAEILTLRHELAQLLGFNSYADKSLATKMAENPQQVLGFLND
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQAEEELAQLRAFAKEHYGVSELQAWDITYYSEKQKQHLFAISDEQLRPYFPEQ
HHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCCEEECCCHHHHHEEEECCCCCCCCCCHH
RVVEGLFEVVKRIYGITAKERHDVDTWHPDVRFFDLFDADGELRGSFYLDLYARENKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEECCCCCC
AWMDDCVGSLRLANGQLQKPVAYLTCNFNGPVGGKPALFTHNEVTTLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHH
KIDTAGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQTHEPLPQEMLDKLLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCC
NYQAALFILRQLEFGLFDFRMHYEFDPLTGAQILPILYEVKKQVAVVPSPEWGRFPHAFS
CHHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHEEECCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNAATGQSFLDNILSQGGSEEPMTLFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLRHYGIKG
HHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]